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Conserved domains on  [gi|1907070767|ref|XP_036010343|]
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uridine-cytidine kinase 2 isoform X2 [Mus musculus]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10113977)

uridine kinase, or uridine cytidine kinase, catalyzes the ATP-dependent phosphorylation of uridine or cytidine to yield UMP or CMP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 2-196 3.03e-104

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


:

Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 299.47  E-value: 3.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:cd02023    13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:cd02023    84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKFVKPMH 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070767 162 EEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDI 196
Cdd:cd02023   164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 2-196 3.03e-104

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 299.47  E-value: 3.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:cd02023    13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:cd02023    84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKFVKPMH 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070767 162 EEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDI 196
Cdd:cd02023   164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 2-199 4.75e-80

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 238.52  E-value: 4.75e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNevdyhqkQVVILSQDSFYR---VLTSEQKAKalkgqFNFDHPDAFDNELIFKTLKEITEGKTVQIP 78
Cdd:PRK05480   20 TTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVK-----TNYDHPDAFDHDLLIEHLKALKAGKAIEIP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  79 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVK 158
Cdd:PRK05480   88 VYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLESVINQYLSTVR 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907070767 159 PAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNG 199
Cdd:PRK05480  168 PMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEK 208
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 2-198 5.99e-72

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 218.03  E-value: 5.99e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:TIGR00235  20 TTVARKIYEQLGKLEI-------VIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVYD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:TIGR00235  91 YVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVIDQYRKTVRPMY 170

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1907070767 162 EEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILN 198
Cdd:TIGR00235 171 EQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-195 4.00e-69

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 210.47  E-value: 4.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:COG0572    21 TTFARRLAEQLGADKV-------VVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:COG0572    92 FATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVIEQYWATVRPGH 171

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070767 162 EEFCLPTKKYADVIIPRG-ADNLVAINLIVQHIQD 195
Cdd:COG0572   172 EQYIEPTKEYADIVIPNGgPLNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 2-185 2.65e-55

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 175.28  E-value: 2.65e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVDYHQKQ-VVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVY 80
Cdd:pfam00485  13 TTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDKPIY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  81 DFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYItFVKPA 160
Cdd:pfam00485  93 NHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEGVTDSIL-FRKPD 171

                         170       180
                  ....*....|....*....|....*
gi 1907070767 161 FEEFCLPTKKYADVIIPRGADNLVA 185
Cdd:pfam00485 172 YVNYIDPQFSYADLIIQRVPTNDTA 196
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 2-196 3.03e-104

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 299.47  E-value: 3.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQnevdyhqKQVVILSQDSFYRVLTSEQKAKALKgqFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:cd02023    13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:cd02023    84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKFVKPMH 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070767 162 EEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDI 196
Cdd:cd02023   164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 2-199 4.75e-80

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 238.52  E-value: 4.75e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNevdyhqkQVVILSQDSFYR---VLTSEQKAKalkgqFNFDHPDAFDNELIFKTLKEITEGKTVQIP 78
Cdd:PRK05480   20 TTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVK-----TNYDHPDAFDHDLLIEHLKALKAGKAIEIP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  79 VYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVK 158
Cdd:PRK05480   88 VYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLESVINQYLSTVR 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907070767 159 PAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNG 199
Cdd:PRK05480  168 PMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEK 208
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 2-198 5.99e-72

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 218.03  E-value: 5.99e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:TIGR00235  20 TTVARKIYEQLGKLEI-------VIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVYD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:TIGR00235  91 YVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVIDQYRKTVRPMY 170

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1907070767 162 EEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILN 198
Cdd:TIGR00235 171 EQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-195 4.00e-69

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 210.47  E-value: 4.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVdyhqkqvVILSQDSFYRVLtsEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYD 81
Cdd:COG0572    21 TTFARRLAEQLGADKV-------VVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  82 FVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAF 161
Cdd:COG0572    92 FATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVIEQYWATVRPGH 171

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070767 162 EEFCLPTKKYADVIIPRG-ADNLVAINLIVQHIQD 195
Cdd:COG0572   172 EQYIEPTKEYADIVIPNGgPLNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 2-185 2.65e-55

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 175.28  E-value: 2.65e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   2 SSVCAKIVQLLGQNEVDYHQKQ-VVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVY 80
Cdd:pfam00485  13 TTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDKPIY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  81 DFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYItFVKPA 160
Cdd:pfam00485  93 NHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEGVTDSIL-FRKPD 171

                         170       180
                  ....*....|....*....|....*
gi 1907070767 161 FEEFCLPTKKYADVIIPRGADNLVA 185
Cdd:pfam00485 172 YVNYIDPQFSYADLIIQRVPTNDTA 196
PTZ00301 PTZ00301
uridine kinase; Provisional
 50-199 1.73e-36

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 127.43  E-value: 1.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  50 NFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADT 129
Cdd:PTZ00301   60 NYDHPKSLEHDLLTTHLRELKSGKTVQIPQYDYVHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDI 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767 130 RLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNG 199
Cdd:PTZ00301  140 CLIRRAKRDMRERGRTFESVIEQYEATVRPMYYAYVEPSKVYADIIVPSWKDNSVAVGVLRAKLNHDLEN 209
PLN02348 PLN02348
phosphoribulokinase
 53-176 4.68e-23

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 95.68  E-value: 4.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  53 HPDAFDNELIFKTLKEITEGKTVQIPVYDFVShSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLS 132
Cdd:PLN02348  120 DPRANNFDLMYEQVKALKEGKAVEKPIYNHVT-GLLDPPELIEPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFA 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907070767 133 RRVLRDISERGRDLEQILSQyITFVKPAFEEFCLPTKKYADVII 176
Cdd:PLN02348  199 WKIQRDMAERGHSLESIKAS-IEARKPDFDAYIDPQKQYADVVI 241
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
 53-176 4.47e-21

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 88.55  E-value: 4.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  53 HPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHS-RKEETvtIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRL 131
Cdd:cd02026    53 DPRANNFDLMYEQLKALKEGQAIEKPIYNHVTGLiDPPEL--IKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKF 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907070767 132 SRRVLRDISERGRDLEQILSQyITFVKPAFEEFCLPTKKYADVII 176
Cdd:cd02026   131 AWKIQRDMAERGHSLEDVLAS-IEARKPDFEAYIDPQKQYADVVI 174
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 23-164 6.31e-19

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 80.81  E-value: 6.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  23 QVVILSQDSFYRVLTSEQKAkalkgQFNFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSRK-EETVTIYPADVVL 101
Cdd:cd02028    29 GPVVISLDDYYVPRKTPRDE-----DGNYDFESILDLDLLNKNLHDLLNGKEVELPIYDFRTGKRRgYRKLKLPPSGVVI 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907070767 102 FEGILAFySQEVRDLFQMKLFVDT-DADTRLSRRVLRDISERGRDLEQILSQYITFvkPAFEEF 164
Cdd:cd02028   104 LEGIYAL-NERLRSLLDIRVAVSGgVHLNRLLRRVVRDIQFRGYSAELTILMWPSV--PSGEEF 164
PRK07429 PRK07429
phosphoribulokinase; Provisional
 3-176 8.64e-18

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 80.44  E-value: 8.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   3 SVCAK------IVQLLGQNEV------DYHQkqvvilsqdsfyrvLTSEQKAK----ALkgqfnfdHPDAFDNELIFKTL 66
Cdd:PRK07429   17 SGCGKttflrgLADLLGEELVtvictdDYHS--------------YDRKQRKElgitAL-------DPRANNLDIMYEHL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  67 KEITEGKTVQIPVYDfvsHSRK--EETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGR 144
Cdd:PRK07429   76 KALKTGQPILKPIYN---HETGtfDPPEYIEPNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVKIAWKIKRDMAKRGH 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907070767 145 DLEQILSQyITFVKPAFEEFCLPTKKYADVII 176
Cdd:PRK07429  153 TYEQVLAE-IEAREPDFEAYIRPQRQWADVVI 183
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
 50-176 7.85e-15

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 72.97  E-value: 7.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  50 NFDHPDAFDNELIFKTLKEITEGKTVQIPVYDFVSHSR-KEETVTIYPADVVLFEGILAFySQEVRDLFQMKLFVDTDAD 128
Cdd:PLN02318  110 NFDDPRLTDYDTLLDNIHDLKAGKSVQVPIYDFKSSSRvGYRTLEVPSSRIVIIEGIYAL-SEKLRPLLDLRVSVTGGVH 188

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907070767 129 TRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVII 176
Cdd:PLN02318  189 FDLVKRVLRDIQRAGQEPEEIIHQISETVYPMYKAFIEPDLQTAHIKI 236
PRK08233 PRK08233
hypothetical protein; Provisional
 89-197 2.62e-09

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 54.75  E-value: 2.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  89 EETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISER-GRDLEQILSQYITFVKPAFEEFCLP 167
Cdd:PRK08233   70 QELIAKSNVDYIIVDYPFAYLNSEMRQFIDVTIFIDTPLDIAMARRILRDFKEDtGNEIHNDLKHYLNYARPLYLEALHT 149

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907070767 168 TKKYADVIIprgaDNLVAINLIVQHIQDIL 197
Cdd:PRK08233  150 VKPNADIVL----DGALSVEEIINQIEEEL 175
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 3-184 7.97e-07

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 48.08  E-value: 7.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767   3 SVCAKIVQLLGQNEVDyhQKQVVILSQDSF-YRVLTSEQKAKALKGQFnfdhPDAFDNELIFKTLKEITEGK-TVQIPVY 80
Cdd:cd02025    13 STTARVLQALLSRWPD--HPNVELITTDGFlYPNKELIERGLMDRKGF----PESYDMEALLKFLKDIKSGKkNVKIPVY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  81 DFVSHSR-KEETVTIYPADVVLFEGILAF-----YSQEVRDLFQMKLFVDTDADtRLSR----RVLRDISERGRDLEQIL 150
Cdd:cd02025    87 SHLTYDViPGEKQTVDQPDILIIEGLNVLqtgqnPRLFVSDFFDFSIYVDADED-DIEKwyikRFLKLRETAFSDPDSYF 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907070767 151 SQY--------ITFVK--------PAFEEFCLPTKKYADVIIPRGADNLV 184
Cdd:cd02025   166 HRYakmseeeaIAFARevwkninlKNLRENILPTRNRADLILEKGADHSI 215
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 54-184 1.43e-06

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 47.98  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  54 PDAFDNELIFKTLKEITEGK-TVQIPVYDFVSH-SRKEETVTIYPADVVLFEGI--L---AFYSQEVRDLFQMKLFVDTD 126
Cdd:COG1072   146 PESYDRRGLLRFLARVKSGDpEVRAPVYSHLLYdIVPGAIVVVDQPDILIVEGNnvLqdePNPWLFVSDFFDFSIYVDAD 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070767 127 ADTRLSRRV-----LRDISER----------GRDLEQILSQYITFVK----PAFEEFCLPTKKYADVIIPRGADNLV 184
Cdd:COG1072   226 EEDLREWYVerflkLRETAFRdpdsyfhryaGLSEEEARAWAEEIWReinlPNLAENILPTRSRADLILRKGADHSV 302
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 25-134 8.18e-06

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 45.01  E-value: 8.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  25 VILSQDSFYRvlTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEITEGKTVQIPV--------YDFVSHSRKEETVTIYP 96
Cdd:cd02024    27 CVIHQDDFFK--PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGHFPKFLrshgnendPEKEFIEDAQIEETKAD 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907070767  97 AD------VVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRR 134
Cdd:cd02024   105 LLgaedlhILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRR 148
PRK07667 PRK07667
uridine kinase; Provisional
 63-176 2.78e-03

uridine kinase; Provisional


Pssm-ID: 169051  Cd Length: 193  Bit Score: 37.40  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  63 FKTLKEITEgktVQIPVYDFVSHSRKEETVTIYPADVVLFEGILaFYSQEVRDLFQMKLFVDTDADTRLSrRVLRDISER 142
Cdd:PRK07667   89 FRKLQNETK---LTLPFYHDETDTCEMKKVQIPIVGVIVIEGVF-LQRKEWRDFFHYMVYLDCPRETRFL-RESEETQKN 163

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907070767 143 grdleqiLSQYITFVKPAfEEFCLPT---KKYADVII 176
Cdd:PRK07667  164 -------LSKFKNRYWKA-EDYYLETespKDRADLVI 192
PRK06696 PRK06696
uridine kinase; Validated
 79-176 6.38e-03

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 36.49  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070767  79 VYDFVSHSRKEETVTIYPADVVLF-EGILAFySQEVRDLFQMKLFVDTDADTRLSRRVLRDISERG--RDLEQI-LSQYI 154
Cdd:PRK06696  109 SHDLKTDIPVHNPPLLAAPNAVLIvDGTFLL-RPELRDLWDYKIFLDTDFEVSRRRGAKRDTEAFGsyEEAEKMyLARYH 187

                          90       100
                  ....*....|....*....|....*
gi 1907070767 155 tfvkPAFE---EFCLPtKKYADVII 176
Cdd:PRK06696  188 ----PAQKlyiAEANP-KERADVVI 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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