NCBI Conserved Domain Search

Conserved domains on [gi|190607|gb|AAA60202|]

View

pregnancy-specific beta-1 glycoprotein, partial [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein; immunoglobulin domain-containing family protein( domain architecture ID 10146345)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

IgV_CEACAM_D1

cd05774

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...

36-139

1.48e-41

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.

Pssm-ID: 409430 Cd Length: 105 Bit Score: 133.55 E-value: 1.48e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607    36 VIIEAKPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVV-HGQIIYGPAYSGRETVYSNASLLIQNVTQE 114
Cdd:cd05774   1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIIsTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                        90       100
                ....*....|....*....|....*
gi 190607   115 DAGSYTLHIIKRGDGTGGVTGYFTV 139
Cdd:cd05774  81 DTGFYTLQTITADLQTEQASVHLQV 105

Name

Accession

Description

Interval

E-value

IgV_CEACAM_D1

cd05774

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...

36-139

1.48e-41

Pssm-ID: 409430 Cd Length: 105 Bit Score: 133.55 E-value: 1.48e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607    36 VIIEAKPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVV-HGQIIYGPAYSGRETVYSNASLLIQNVTQE 114
Cdd:cd05774   1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIIsTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                        90       100
                ....*....|....*....|....*
gi 190607   115 DAGSYTLHIIKRGDGTGGVTGYFTV 139
Cdd:cd05774  81 DTGFYTLQTITADLQTEQASVHLQV 105

V-set

pfam07686

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...

38-132

2.26e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

Pssm-ID: 462230 Cd Length: 109 Bit Score: 59.39 E-value: 2.26e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607      38 IEAKPPKVSEGKDVLLLVHNLPQ---NLTGYIWYKGQM-----TDLYHYITSYvvhGQIIYGPAYSGRETV-YSNASLLI 108
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmseASTSVYWYRQPPgkgptFLIAYYSNGS---EEGVKKGRFSGRGDPsNGDGSLTI 77

                          90       100
                  ....*....|....*....|....
gi 190607     109 QNVTQEDAGSYTLHIIKRGDGTGG 132
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGEGVFG 101

Name

Accession

Description

Interval

E-value

IgV_CEACAM_D1

cd05774

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...

36-139

1.48e-41

Pssm-ID: 409430 Cd Length: 105 Bit Score: 133.55 E-value: 1.48e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607    36 VIIEAKPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVV-HGQIIYGPAYSGRETVYSNASLLIQNVTQE 114
Cdd:cd05774   1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIIsTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                        90       100
                ....*....|....*....|....*
gi 190607   115 DAGSYTLHIIKRGDGTGGVTGYFTV 139
Cdd:cd05774  81 DTGFYTLQTITADLQTEQASVHLQV 105

IgV_CEACAM_like

cd05741

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...

43-139

3.83e-25

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.

Pssm-ID: 409403 Cd Length: 102 Bit Score: 91.81 E-value: 3.83e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607    43 PKVSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVVHGQIIY-GPAYSGRETVYSNASLLIQNVTQEDAGSYTL 121
Cdd:cd05741   5 FYGAEGKNVLLLVPNLQTPLKSVSWYKGKQVSRNDEIAEYENSSDEFRaGSAFSGREYIYTNGSLLIQNITLSDTGFYTL 84

                        90
                ....*....|....*...
gi 190607   122 HIIKRGDGTGGVTGYFTV 139
Cdd:cd05741  85 ESTNIGGKTESATFQLHV 102

V-set

pfam07686

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...

38-132

2.26e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

Pssm-ID: 462230 Cd Length: 109 Bit Score: 59.39 E-value: 2.26e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607      38 IEAKPPKVSEGKDVLLLVHNLPQ---NLTGYIWYKGQM-----TDLYHYITSYvvhGQIIYGPAYSGRETV-YSNASLLI 108
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmseASTSVYWYRQPPgkgptFLIAYYSNGS---EEGVKKGRFSGRGDPsNGDGSLTI 77

                          90       100
                  ....*....|....*....|....
gi 190607     109 QNVTQEDAGSYTLHIIKRGDGTGG 132
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGEGVFG 101

Ig_3

pfam13927

Immunoglobulin domain; This family contains immunoglobulin-like domains.

35-120

5.57e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.

Pssm-ID: 464046 [Multi-domain] Cd Length: 78 Bit Score: 39.09 E-value: 5.57e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607      35 QVIIEAKPPKVSEGKDVLL--LVHNLPQNLtgYIWYKGqmtdlyhyitsyvvhGQIIYGPAYSGRETVYSNASLLIQNVT 112
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLtcEATGSPPPT--ITWYKN---------------GEPISSGSTRSRSLSGSNSTLTISNVT 65


                  ....*...
gi 190607     113 QEDAGSYT 120
Cdd:pfam13927  66 RSDAGTYT 73

cd00096

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

65-120

6.17e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 36.15 E-value: 6.17e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 190607    65 YIWYKGqmtdlyhyitsyvvhGQIIYGPAYSGRETVYSNASLLIQNVTQEDAGSYT 120
Cdd:cd00096  15 ITWYKN---------------GKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYT 55

IgV_HHLA2

cd16091

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...

67-123

1.21e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.

Pssm-ID: 409512 Cd Length: 107 Bit Score: 36.21 E-value: 1.21e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190607    67 WYKGQmtdlyhyiTSYVVHgQIIYG--------PAYSGRETVYS------NASLLIQNVTQEDAGSYTLHI 123
Cdd:cd16091  31 WYKQD--------SDIKVH-SYYYGkdqlesqdQRYRNRTSLFKdqisngNASLLLRRVQLQDEGRYKCYT 92

IgV_1_JAM1-like

cd20946

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...

79-129

1.32e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.

Pssm-ID: 409538 Cd Length: 102 Bit Score: 35.98 E-value: 1.32e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 190607    79 ITSYVVHGQIIYGpAYSGRETVYsNASLLIQNVTQEDAGSYTLHIIKRGDG 129
Cdd:cd20946  41 VTFVVFQNNKIQG-DYKGRAEIL-GTNITIKNVTRSDSGKYRCEVSARSDG 89

IgV_CD2_like_N

cd05775

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...

46-130

2.32e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.

Pssm-ID: 409431 Cd Length: 98 Bit Score: 35.40 E-value: 2.32e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190607    46 SEGKDVLLLVHNLPQNLTGYIWYKGqmTDLyhyITSYVVHGQIIYGPAYSGRETV-YSNASLLIQNVTQEDAGSYTLHII 124
Cdd:cd05775   8 ALGGNVTLTISSLQDDIDEIKWKKT--KDK---IVEWENNIGPTYFGSFKDRVLLdKESGSLTIKNLTKEDSGTYELEIT 82


                ....*.
gi 190607   125 KRGDGT 130
Cdd:cd05775  83 STNGKV 88

IgV_B7-H4

cd20984

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...

92-131

2.50e-03

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.

Pssm-ID: 409576 Cd Length: 110 Bit Score: 35.27 E-value: 2.50e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 190607    92 PAYSGRETVYS------NASLLIQNVTQEDAGSYTLhIIKRGDGTG 131
Cdd:cd20984  58 PMFRGRTSLFAdqvhvgNASLRLKNVQLTDAGTYLC-IISNSKGTG 102

IgV_B7-H3

cd20934

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...

91-134

3.77e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.

Pssm-ID: 409528 Cd Length: 115 Bit Score: 34.89 E-value: 3.77e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 190607    91 GPAYSGRETVYS------NASLLIQNVTQEDAGSYTLHIIKRGDGTGGVT 134
Cdd:cd20934  59 GSAYANRTALFPdllaqgNASLRLQRVRVADEGSYTCFVSVQDFGSAAVS 108

Ig5_Contactin

cd04969

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...

95-139

3.88e-03

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.

Pssm-ID: 409358 [Multi-domain] Cd Length: 89 Bit Score: 34.36 E-value: 3.88e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 190607    95 SGRETVYSNASLLIQNVTQEDAGSYTLHIIKRGdGTGGVTGYFTV 139
Cdd:cd04969  46 SSRICILPDGSLKIKNVTKSDEGKYTCFAVNFF-GKANSTGSLSV 89

IgI_5_Dscam

cd20958

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...

97-120

8.52e-03

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.

Pssm-ID: 409550 [Multi-domain] Cd Length: 89 Bit Score: 33.31 E-value: 8.52e-03

                        10        20
                ....*....|....*....|....*
gi 190607    97 RETVYSNASLLIQNVTQ-EDAGSYT 120
Cdd:cd20958  46 RQRVFPNGTLVIENVQRsSDEGEYT 70

Ig_SLAM-like_N

cd16842

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...

88-130

9.36e-03

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.

Pssm-ID: 409517 Cd Length: 102 Bit Score: 33.83 E-value: 9.36e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 190607    88 IIYGPAYSGRETVYSNA-SLLIQNVTQEDAGSYTLHIIKRGDGT 130
Cdd:cd16842  48 IITDKSYKERLNISQNDySLQISNLTMEDAGSYRARINTKNSRV 91

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01