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Conserved domains on  [gi|1903075923|dbj|GGY34435|]
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anti-anti-sigma factor [Streptomyces djakartensis]

Protein Classification

STAS domain-containing protein( domain architecture ID 10162406)

STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain-containing protein similar to Bacillus subtilis stressosome complex proteins RsbS, RsbRB, and RsbRC, which function in the environmental signaling branch of the general stress response

CATH:  3.30.750.24
Gene Ontology:  GO:0043856|GO:0006355
PubMed:  10662676|22116355
SCOP:  4003567

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 13-119 5.94e-34

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


:

Pssm-ID: 132912  Cd Length: 109  Bit Score: 114.47  E-value: 5.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  13 VPVLRLGD-VLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:cd07041     2 TPIIPVWDgVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTGI 81

                          90       100
                  ....*....|....*....|....*...
gi 1903075923  92 RPAVAITLVELGLTLPGLSTALSTEAGM 119
Cdd:cd07041    82 RPEVAQTLVELGIDLSGIRTAATLQQAL 109
 
Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 13-119 5.94e-34

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 114.47  E-value: 5.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  13 VPVLRLGD-VLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:cd07041     2 TPIIPVWDgVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTGI 81

                          90       100
                  ....*....|....*....|....*...
gi 1903075923  92 RPAVAITLVELGLTLPGLSTALSTEAGM 119
Cdd:cd07041    82 RPEVAQTLVELGIDLSGIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 12-105 3.42e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 73.73  E-value: 3.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  12 HVPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDTIvRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:COG1366     1 SIPVEVRDGVLVLPLIGELDAARAPELREALLEAL-ETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGV 79

                          90
                  ....*....|....
gi 1903075923  92 RPAVAITLVELGLT 105
Cdd:COG1366    80 SPAVARVLELTGLD 93
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 12-104 1.67e-10

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 54.16  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  12 HVPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:pfam01740   1 YPEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGP 80

                          90
                  ....*....|...
gi 1903075923  92 RPAVAITLVELGL 104
Cdd:pfam01740  81 SPEVARTLEKTGL 93
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 19-99 1.02e-08

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 49.52  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  19 GDVLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGMRPAVAIT 98
Cdd:TIGR00377  11 EGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPRVARL 90


                  .
gi 1903075923  99 L 99
Cdd:TIGR00377  91 L 91
 
Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 13-119 5.94e-34

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 114.47  E-value: 5.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  13 VPVLRLGD-VLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:cd07041     2 TPIIPVWDgVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTGI 81

                          90       100
                  ....*....|....*....|....*...
gi 1903075923  92 RPAVAITLVELGLTLPGLSTALSTEAGM 119
Cdd:cd07041    82 RPEVAQTLVELGIDLSGIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 12-105 3.42e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 73.73  E-value: 3.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  12 HVPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDTIvRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:COG1366     1 SIPVEVRDGVLVLPLIGELDAARAPELREALLEAL-ETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGV 79

                          90
                  ....*....|....
gi 1903075923  92 RPAVAITLVELGLT 105
Cdd:COG1366    80 SPAVARVLELTGLD 93
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 13-104 2.13e-16

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 69.43  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  13 VPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGMR 92
Cdd:cd06844     1 VPLEKVDDYWVVRLEGELDHHSVEQFKEELLHNITNVAGKTIVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGIS 80

                          90
                  ....*....|..
gi 1903075923  93 PAVAITLVELGL 104
Cdd:cd06844    81 PAVRITLTESGL 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 12-104 1.67e-10

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 54.16  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  12 HVPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGM 91
Cdd:pfam01740   1 YPEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGP 80

                          90
                  ....*....|...
gi 1903075923  92 RPAVAITLVELGL 104
Cdd:pfam01740  81 SPEVARTLEKTGL 93
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 19-99 1.02e-08

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 49.52  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923  19 GDVLLVTLQGDLHDSTAQQLQQDLSDTIVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLLAARTVVAGMRPAVAIT 98
Cdd:TIGR00377  11 EGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPRVARL 90


                  .
gi 1903075923  99 L 99
Cdd:TIGR00377  91 L 91
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 19-95 1.11e-05

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 41.35  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1903075923  19 GDVLLVTLQGDLHDSTAQQLQQDLsDTIVRTGVRGVLIDISGVEIVDS-FLGrVLAEIAAQAKLLAARTVVAGMRPAV 95
Cdd:cd07043     7 GGVLVVRLSGELDAATAPELREAL-EELLAEGPRRLVLDLSGVTFIDSsGLG-VLLGAYKRARAAGGRLVLVNVSPAV 82
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 3-126 7.54e-03

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 35.08  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903075923   3 DAHSRPVTGHVPVLRLGDVLLVTLQGDLHDSTAQQLQQDLSDtiVRTGVRGVLIDISGVEIVDSFLGRVLAEIAAQAKLL 82
Cdd:COG0659   405 GTHFRNVERHPEAETGPGVLVYRLDGPLFFGNAERLKERLDA--LAPDPRVVILDLSAVPFIDATALEALEELAERLRAR 482

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1903075923  83 AARTVVAGMRPAVAITLVELGLT--LPGLSTALSTEAGMELLSQQA 126
Cdd:COG0659   483 GITLELAGLKPPVRDLLERAGLLdeLGEERVFPDLDEALEAAEERA 528
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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