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Conserved domains on  [gi|1899991540|ref|XP_035960152|]
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clathrin heavy chain 2 isoform X3 [Halichoerus grypus]

Protein Classification

clathrin heavy chain( domain architecture ID 12019188)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 8.62e-41

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 8.62e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1274 LHIVVHADELEELIRYYQDQGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899991540  1354 QAHLWAELVFLYDKYEEYDNAILTMINHPTDTwreGQFKDVITKVANVELYYKALQFYLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 4.20e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.16  E-value: 4.20e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 5.91e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 125.08  E-value: 5.91e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNPERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899991540   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 2.66e-32

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.66e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENTYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1899991540   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 1.70e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 117.76  E-value: 1.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1128 YIRADDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHE-SYIDTELIFALAKTSRLSELEDCINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1207 EEGMYEAAKLLYSSVSNFARLASTLV-HLGEYQAAVDSSRKANSTRTWKEVCFACVDGQE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
545-671 9.81e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 9.81e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   545 NIDQIVDVLMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKAGLLQ 624
Cdd:smart00299    9 DVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKAKLYE 86

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 1899991540   625 RALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   87 EAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 1.16e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 1.16e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899991540  356 NLAGAEELFVRKFSTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 1.91e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 48.60  E-value: 1.91e-07
                           10        20
                   ....*....|....*....|....
gi 1899991540  331 EDNIVNYATNVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1483 7.14e-07

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 50.33  E-value: 7.14e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1899991540 1428 PRLDHTRTVGFFAKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQDAMQH 1483
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEF 64
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.48e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.10  E-value: 3.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  296 NRISADTIFVTAPQEPTSGIIGVN--KKGQVLSICVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.80e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 7.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 1.80e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1899991540  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.74e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.74e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  198 AAAFAEFKSEGNAKPATLFCFAVRSPAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 8.62e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 8.62e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1274 LHIVVHADELEELIRYYQDQGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899991540  1354 QAHLWAELVFLYDKYEEYDNAILTMINHPTDTwreGQFKDVITKVANVELYYKALQFYLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 4.20e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.16  E-value: 4.20e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 5.91e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 125.08  E-value: 5.91e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNPERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899991540   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 2.66e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.66e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENTYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1899991540   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 8.66e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.90  E-value: 8.66e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540 1058 IAVSSALYEEAFTIFRKFDVNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 1.70e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 117.76  E-value: 1.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1128 YIRADDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHE-SYIDTELIFALAKTSRLSELEDCINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1207 EEGMYEAAKLLYSSVSNFARLASTLV-HLGEYQAAVDSSRKANSTRTWKEVCFACVDGQE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 2.35e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 117.74  E-value: 2.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1128 YIRADDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHE--SYIDTELIFALAKTSRLSELEDCINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540 1206 YEEGMYEAAKLLYSSVSNFARLASTLVHLGEYQAAVDSSRKANSTRTWKEVCFACVDGQEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
545-671 9.81e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 9.81e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   545 NIDQIVDVLMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKAGLLQ 624
Cdd:smart00299    9 DVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKAKLYE 86

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 1899991540   625 RALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   87 EAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 2.48e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.96  E-value: 2.48e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  843 DELVAEVEKRNRLKLLLPWLES-RSHEGCEEPATHNALAKIYIDSN--NSPERFLRENTYYDSRVVGRYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESaLKEDSRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  919 VAYERGQCDLELIKVCNENSLFKSEARYLVRRKDPELWAHVLEETNPSRRQL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 2.53e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.96  E-value: 2.53e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1274 LHIVVHADELEELIRYYQDQGYFEELISLLEAALGL-ERAHMGMFTELAILYSKF-KPQKMPEHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899991540 1352 AEQAHLWAELVFLYDKYEEYDNAIlTMINHPTDtWREGQfkDVITKVANVELYYKALQFYLDYKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI-SLLKKLGD-YKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 8.63e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 104.65  E-value: 8.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  688 KYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESNCYNPERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRIPAVVGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 545-667 3.62e-22

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 94.25  E-value: 3.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  545 NIDQIVDVLMENSLIQQCTSFLLDALKNNRPAEGHLQTRLLEMNLIHAP-QVADAILgnQMFTHYDRAHIAQLCEKAGLL 623
Cdd:pfam00637    9 DVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEKADLY 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1899991540  624 QRALEHYTDLYDIKRAV-VHTHLLNPEWLVSFFGSLSVEDSLACL 667
Cdd:pfam00637   87 EEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEEL 131
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 1.16e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 1.16e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899991540  356 NLAGAEELFVRKFSTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 1.91e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 48.60  E-value: 1.91e-07
                           10        20
                   ....*....|....*....|....
gi 1899991540  331 EDNIVNYATNVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1483 7.14e-07

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 50.33  E-value: 7.14e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1899991540 1428 PRLDHTRTVGFFAKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQDAMQH 1483
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEF 64
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1521 2.70e-06

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 48.42  E-value: 2.70e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1427 APRLDHTRTVGFFAKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQD--------------------------- 1479
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDpqkeierldnksnhydiekvgklceka 82

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1480 ------------------AMQHAAEsrDAELAEKLLQWFLEEGKQECFAASLFTCYDLLP 1521
Cdd:smart00299   83 klyeeavelykkdgnfkdAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.48e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.10  E-value: 3.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  296 NRISADTIFVTAPQEPTSGIIGVN--KKGQVLSICVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.80e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 7.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 1.80e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1899991540  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.74e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.74e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  198 AAAFAEFKSEGNAKPATLFCFAVRSPAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1064-1164 1.14e-03

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 43.61  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1064 LYEEAFTIFR----KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPSSHLE 1139
Cdd:cd22947    327 LKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100
                   ....*....|....*....|....*
gi 1899991540 1140 VvqaASRSNNWEDLVKFLQMARKKG 1164
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAG 420
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1055-1219 2.55e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1055 IANIAVSSALYEEAFTIFRKF----DVNASAIQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLACAQLQKDLVK 1122
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1123 EAIDSYIRA-----DDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHESY-IDTELIFALAKTSRLSE----LEDCI-N 1191
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEalelLRKALeL 241

                          170       180
                   ....*....|....*....|....*...
gi 1899991540 1192 GPNNAHIQQVGDRCYEEGMYEAAKLLYS 1219
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1274-1416 8.62e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 8.62e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1274 LHIVVHADELEELIRYYQDQGYFEELISLLEAALGLERAHMGMFTELAILYSKFKPQKMPEHLELFWSRVNIPKVLRAAE 1353
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899991540  1354 QAHLWAELVFLYDKYEEYDNAILTMINHPTDTwreGQFKDVITKVANVELYYKALQFYLDYKP 1416
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
979-1119 4.20e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.16  E-value: 4.20e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDAPDIAN 1057
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  1058 IAVSSALYEEAFTIFRKFDVNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
686-824 5.91e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 125.08  E-value: 5.91e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   686 ASKYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESNCYNPERVKNFLK 764
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899991540   765 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRIPAVVGGLLDVDC 824
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
833-960 2.66e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.66e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   833 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLESRSHEGCEEPATHNALAKIYIDSNNSP--ERFLRENTYYDSRVVGRYCE 910
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1899991540   911 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVRRKDPELWAHVL 960
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 979-1119 8.66e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.90  E-value: 8.66e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  979 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDAPDIAN 1057
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540 1058 IAVSSALYEEAFTIFRKFDVNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLACAQLQKD 1119
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
1128-1265 1.70e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 117.76  E-value: 1.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1128 YIRADDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHE-SYIDTELIFALAKTSRLSELEDCINGPNNAHIQQVGDRCY 1206
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1207 EEGMYEAAKLLYSSVSNFARLASTLV-HLGEYQAAVDSSRKANSTRTWKEVCFACVDGQE 1265
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1128-1267 2.35e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 117.74  E-value: 2.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1128 YIRADDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHE--SYIDTELIFALAKTSRLSELEDCINGPNNAHIQQVGDRC 1205
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540 1206 YEEGMYEAAKLLYSSVSNFARLASTLVHLGEYQAAVDSSRKANSTRTWKEVCFACVDGQEFR 1267
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
545-671 9.81e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 9.81e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540   545 NIDQIVDVLMENSLIQQCTSFLLDALKNNrPAEGHLQTRLLEMNLIHAPQVADAILGNqMFTHYDRAHIAQLCEKAGLLQ 624
Cdd:smart00299    9 DVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKAKLYE 86

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 1899991540   625 RALEHYTDLYDIKRAVVHT--HLLNPEWLVSFFGS-LSVEDSLACLHALL 671
Cdd:smart00299   87 EAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 843-970 2.48e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.96  E-value: 2.48e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  843 DELVAEVEKRNRLKLLLPWLES-RSHEGCEEPATHNALAKIYIDSN--NSPERFLRENTYYDSRVVGRYCEKRDPH-LAC 918
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESaLKEDSRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  919 VAYERGQCDLELIKVCNENSLFKSEARYLVRRKDPELWAHVLEETNPSRRQL 970
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1274-1416 2.53e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.96  E-value: 2.53e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1274 LHIVVHADELEELIRYYQDQGYFEELISLLEAALGL-ERAHMGMFTELAILYSKF-KPQKMPEHLELFWSrVNIPKVLRA 1351
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899991540 1352 AEQAHLWAELVFLYDKYEEYDNAIlTMINHPTDtWREGQfkDVITKVANVELYYKALQFYLDYKP 1416
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI-SLLKKLGD-YKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 688-826 8.63e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 104.65  E-value: 8.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  688 KYHEQLGTQSLVELFESFKSYEGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESNCYNPERVKNFLKE 765
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899991540  766 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRIPAVVGGLLDVDCSE 826
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 545-667 3.62e-22

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 94.25  E-value: 3.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  545 NIDQIVDVLMENSLIQQCTSFLLDALKNNRPAEGHLQTRLLEMNLIHAP-QVADAILgnQMFTHYDRAHIAQLCEKAGLL 623
Cdd:pfam00637    9 DVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEKADLY 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1899991540  624 QRALEHYTDLYDIKRAV-VHTHLLNPEWLVSFFGSLSVEDSLACL 667
Cdd:pfam00637   87 EEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEEL 131
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-421 1.16e-19

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 1.16e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899991540  356 NLAGAEELFVRKFSTLFAQGSYAEAAKVAASAPKGVLRTSDTVRKFQSIPAQPGQASPLLQYFGIL 421
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 1.91e-07

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 48.60  E-value: 1.91e-07
                           10        20
                   ....*....|....*....|....
gi 1899991540  331 EDNIVNYATNVLQNPDLGLRLAIR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1483 7.14e-07

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 50.33  E-value: 7.14e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1899991540 1428 PRLDHTRTVGFFAKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQDAMQH 1483
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEF 64
CLH smart00299
Clathrin heavy chain repeat homology;
1427-1521 2.70e-06

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 48.42  E-value: 2.70e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1427 APRLDHTRTVGFFAKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQD--------------------------- 1479
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDpqkeierldnksnhydiekvgklceka 82

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540  1480 ------------------AMQHAAEsrDAELAEKLLQWFLEEGKQECFAASLFTCYDLLP 1521
Cdd:smart00299   83 klyeeavelykkdgnfkdAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.48e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.10  E-value: 3.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  296 NRISADTIFVTAPQEPTSGIIGVN--KKGQVLSICVE 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.80e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 7.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540   19 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1074-1185 1.39e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 46.46  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1074 KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPSSHLEVvqaASRSNNWEDL 1153
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDKLLLL---YLSTGNMEKL 388

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1899991540 1154 VKFLQMARKKGHES-------YID--TELIFALAKTSRLSE 1185
Cdd:pfam04053  389 KKLAKIAEKRGDYNsafqnalYLGdvEKCVDILIKTGRLPE 429
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 1.80e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1899991540  256 AQTDFPVAMQIGAKHGVIYLITKYGYLHLYDLE 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.74e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.94  E-value: 5.74e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1899991540  198 AAAFAEFKSEGNAKPATLFCFAVRSPAGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1064-1164 1.14e-03

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 43.61  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1064 LYEEAFTIFR----KFDVnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLACAQLQKDLVKEAIDSYIRADDPSSHLE 1139
Cdd:cd22947    327 LKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100
                   ....*....|....*....|....*
gi 1899991540 1140 VvqaASRSNNWEDLVKFLQMARKKG 1164
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAG 420
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1055-1219 2.55e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1055 IANIAVSSALYEEAFTIFRKF----DVNASAIQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLACAQLQKDLVK 1122
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899991540 1123 EAIDSYIRA-----DDPSSHLEVVQAASRSNNWEDLVKFLQMARKKGHESY-IDTELIFALAKTSRLSE----LEDCI-N 1191
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEalelLRKALeL 241

                          170       180
                   ....*....|....*....|....*...
gi 1899991540 1192 GPNNAHIQQVGDRCYEEGMYEAAKLLYS 1219
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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