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Conserved domains on  [gi|1898548136|gb|QNN83943|]
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LNS2 protein, partial [Mollisia caesia]

Protein Classification

HAD family hydrolase( domain architecture ID 229399)

HAD (haloacid dehalogenase) family hydrolase; the HAD family includes phosphoesterases, ATPases, phosphonatases, dehalogenases, and sugar phosphomutases acting on a remarkably diverse set of substrates

EC:  3.6.3.-
Gene Ontology:  GO:0005524|GO:0016887|GO:0005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LNS2 super family cl46352
LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, ...
 1-94 3.37e-61

LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.


The actual alignment was detected with superfamily member pfam08235:

Pssm-ID: 480692  Cd Length: 226  Bit Score: 185.40  E-value: 3.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898548136   1 WTHIGVAKLYTDIVNNGYNIMYLTSRSVGQADTTRAYLNGVVQETYRIPKGPVILSPDRTIAALRRELYIRKPEVFKMAC 80
Cdd:pfam08235  75 WTHPGVAKLYSKIKRNGYKILYLSARAIGQADLTREYLKNVTQDGYKLPDGPVLLSPDRLFSALHREVILRKPEVFKIAC 154

                          90
                  ....*....|....
gi 1898548136  81 LRDIKNLFGPGRTP 94
Cdd:pfam08235 155 LRDIKSLFPPDVNP 168
 
Name Accession Description Interval E-value
LNS2 pfam08235
LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, ...
 1-94 3.37e-61

LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.


Pssm-ID: 462403  Cd Length: 226  Bit Score: 185.40  E-value: 3.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898548136   1 WTHIGVAKLYTDIVNNGYNIMYLTSRSVGQADTTRAYLNGVVQETYRIPKGPVILSPDRTIAALRRELYIRKPEVFKMAC 80
Cdd:pfam08235  75 WTHPGVAKLYSKIKRNGYKILYLSARAIGQADLTREYLKNVTQDGYKLPDGPVLLSPDRLFSALHREVILRKPEVFKIAC 154

                          90
                  ....*....|....
gi 1898548136  81 LRDIKNLFGPGRTP 94
Cdd:pfam08235 155 LRDIKSLFPPDVNP 168
LNS2 smart00775
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal ...
 1-94 2.01e-52

This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; SMP2 is involved in plasmid maintenance and respiration. Lipin proteins are involved in adipose tissue development and insulin resistance.


Pssm-ID: 197870  Cd Length: 157  Bit Score: 160.90  E-value: 2.01e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898548136    1 WTHIGVAKLYTDIVNNGYNIMYLTSRSVGQADTTRAYLNGVVQETYRIPKGPVILSPDRTIAALRRELYIRKPEVFKMAC 80
Cdd:smart00775  27 WTHPGVAKLYRDIQNNGYKILYLTARPIGQADRTRSYLSQIKQDGHNLPHGPVLLSPDRLFAALHREVISKKPEVFKIAC 106

                           90
                   ....*....|....
gi 1898548136   81 LRDIKNLFGPGRTP 94
Cdd:smart00775 107 LRDIKNLFPPQGNP 120
 
Name Accession Description Interval E-value
LNS2 pfam08235
LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, ...
 1-94 3.37e-61

LNS2 (Lipin/Ned1/Smp2); This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.


Pssm-ID: 462403  Cd Length: 226  Bit Score: 185.40  E-value: 3.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898548136   1 WTHIGVAKLYTDIVNNGYNIMYLTSRSVGQADTTRAYLNGVVQETYRIPKGPVILSPDRTIAALRRELYIRKPEVFKMAC 80
Cdd:pfam08235  75 WTHPGVAKLYSKIKRNGYKILYLSARAIGQADLTREYLKNVTQDGYKLPDGPVLLSPDRLFSALHREVILRKPEVFKIAC 154

                          90
                  ....*....|....
gi 1898548136  81 LRDIKNLFGPGRTP 94
Cdd:pfam08235 155 LRDIKSLFPPDVNP 168
LNS2 smart00775
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal ...
 1-94 2.01e-52

This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; SMP2 is involved in plasmid maintenance and respiration. Lipin proteins are involved in adipose tissue development and insulin resistance.


Pssm-ID: 197870  Cd Length: 157  Bit Score: 160.90  E-value: 2.01e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898548136    1 WTHIGVAKLYTDIVNNGYNIMYLTSRSVGQADTTRAYLNGVVQETYRIPKGPVILSPDRTIAALRRELYIRKPEVFKMAC 80
Cdd:smart00775  27 WTHPGVAKLYRDIQNNGYKILYLTARPIGQADRTRSYLSQIKQDGHNLPHGPVLLSPDRLFAALHREVISKKPEVFKIAC 106

                           90
                   ....*....|....
gi 1898548136   81 LRDIKNLFGPGRTP 94
Cdd:smart00775 107 LRDIKNLFPPQGNP 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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