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Conserved domains on  [gi|189426|gb|AAA59980|]
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protein p18 [Homo sapiens]

Protein Classification

stathmin family protein( domain architecture ID 10467180)

stathmin family protein is a small regulatory phosphoprotein, similar to human stathmin that is involved in the regulation of the microtubule filament system by destabilizing microtubules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 5-139 5.41e-42

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


:

Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 136.32  E-value: 5.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189426       5 DIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQ 84
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 189426      85 KAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKES 139
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHVEEVRKNKEQ 136
 
Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 5-139 5.41e-42

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 136.32  E-value: 5.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189426       5 DIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQ 84
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 189426      85 KAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKES 139
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHVEEVRKNKEQ 136
PRK12704 PRK12704
phosphodiesterase; Provisional
 50-140 3.38e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 36.68  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189426     50 IQKKLEAAEERRKS------HEAEVLKQLAE----------KREHEKEVLQK--AIEENNNFSKMAEEKLTHKMEANkEN 111
Cdd:PRK12704  29 AEAKIKEAEEEAKRileeakKEAEAIKKEALleakeeihklRNEFEKELRERrnELQKLEKRLLQKEENLDRKLELL-EK 107

                         90       100
                 ....*....|....*....|....*....
gi 189426    112 REAQMAAKLERLREKDKHIEEVRKNKESK 140
Cdd:PRK12704 108 REEELEKKEKELEQKQQELEKKEEELEEL 136
 
Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 5-139 5.41e-42

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 136.32  E-value: 5.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189426       5 DIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQ 84
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 189426      85 KAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKES 139
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHVEEVRKNKEQ 136
PRK12704 PRK12704
phosphodiesterase; Provisional
 50-140 3.38e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 36.68  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189426     50 IQKKLEAAEERRKS------HEAEVLKQLAE----------KREHEKEVLQK--AIEENNNFSKMAEEKLTHKMEANkEN 111
Cdd:PRK12704  29 AEAKIKEAEEEAKRileeakKEAEAIKKEALleakeeihklRNEFEKELRERrnELQKLEKRLLQKEENLDRKLELL-EK 107

                         90       100
                 ....*....|....*....|....*....
gi 189426    112 REAQMAAKLERLREKDKHIEEVRKNKESK 140
Cdd:PRK12704 108 REEELEKKEKELEQKQQELEKKEEELEEL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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