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Conserved domains on  [gi|189409128|ref|NP_110378|]
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zinc finger E-box-binding homeobox 1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
946-971 3.33e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.33e-07
                           10        20
                   ....*....|....*....|....*.
gi 189409128   946 HLIEHMRLHSGEKPYQCDKCGKRFSH 971
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-277 4.17e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.17e-07
                           10        20
                   ....*....|....*....|....
gi 189409128   254 HLKEHLRIHSGEKPYECPNCKKRF 277
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 240-262 4.08e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.21  E-value: 4.08e-06
                           10        20
                   ....*....|....*....|...
gi 189409128   240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 932-954 3.45e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 3.45e-05
                           10        20
                   ....*....|....*....|...
gi 189409128   932 HECGICKKAFKHKHHLIEHMRLH 954
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
918-943 8.18e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 8.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 189409128   918 SLLRHKYEHTGKRPHECGICKKAFKH 943
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Homeodomain super family cl47488
Homeodomain;
581-629 7.54e-04

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 7.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 189409128   581 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 629
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
GET2 super family cl07347
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 60-170 2.41e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


The actual alignment was detected with superfamily member pfam08690:

Pssm-ID: 400847  Cd Length: 308  Bit Score: 41.23  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189409128    60 DLPTDQTVLPgrSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEqnhDPNVEEFLQQQDTAvif 139
Cdd:pfam08690   45 DEPAAPSTTP--ASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESDPE---NPQLDQMFKQLLGQ--- 116

                           90       100       110
                   ....*....|....*....|....*....|.
gi 189409128   140 peapeedQRQGTPEASGHDENGTPDAFSQLL 170
Cdd:pfam08690  117 -------QQQGGGENGQPAGSSTPDLFSQMM 140
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 200-222 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.78e-03
                           10        20
                   ....*....|....*....|...
gi 189409128   200 FSCSLCSYTFAYRTQLERHMTSH 222
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
946-971 3.33e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.33e-07
                           10        20
                   ....*....|....*....|....*.
gi 189409128   946 HLIEHMRLHSGEKPYQCDKCGKRFSH 971
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-277 4.17e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.17e-07
                           10        20
                   ....*....|....*....|....
gi 189409128   254 HLKEHLRIHSGEKPYECPNCKKRF 277
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 240-262 4.08e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.21  E-value: 4.08e-06
                           10        20
                   ....*....|....*....|...
gi 189409128   240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 932-954 3.45e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 3.45e-05
                           10        20
                   ....*....|....*....|...
gi 189409128   932 HECGICKKAFKHKHHLIEHMRLH 954
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
918-943 8.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 8.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 189409128   918 SLLRHKYEHTGKRPHECGICKKAFKH 943
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
240-262 4.42e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.60  E-value: 4.42e-04
                            10        20
                    ....*....|....*....|...
gi 189409128    240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
Homeodomain pfam00046
Homeodomain;
581-629 7.54e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 7.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 189409128   581 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 629
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 60-170 2.41e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 41.23  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189409128    60 DLPTDQTVLPgrSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEqnhDPNVEEFLQQQDTAvif 139
Cdd:pfam08690   45 DEPAAPSTTP--ASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESDPE---NPQLDQMFKQLLGQ--- 116

                           90       100       110
                   ....*....|....*....|....*....|.
gi 189409128   140 peapeedQRQGTPEASGHDENGTPDAFSQLL 170
Cdd:pfam08690  117 -------QQQGGGENGQPAGSSTPDLFSQMM 140
ZnF_C2H2 smart00355
zinc finger;
932-954 2.68e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.68e-03
                            10        20
                    ....*....|....*....|...
gi 189409128    932 HECGICKKAFKHKHHLIEHMRLH 954
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 200-222 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.78e-03
                           10        20
                   ....*....|....*....|...
gi 189409128   200 FSCSLCSYTFAYRTQLERHMTSH 222
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
200-222 5.89e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 5.89e-03
                            10        20
                    ....*....|....*....|...
gi 189409128    200 FSCSLCSYTFAYRTQLERHMTSH 222
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
946-971 3.33e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.33e-07
                           10        20
                   ....*....|....*....|....*.
gi 189409128   946 HLIEHMRLHSGEKPYQCDKCGKRFSH 971
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-277 4.17e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.17e-07
                           10        20
                   ....*....|....*....|....
gi 189409128   254 HLKEHLRIHSGEKPYECPNCKKRF 277
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 240-262 4.08e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.21  E-value: 4.08e-06
                           10        20
                   ....*....|....*....|...
gi 189409128   240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 932-954 3.45e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 3.45e-05
                           10        20
                   ....*....|....*....|...
gi 189409128   932 HECGICKKAFKHKHHLIEHMRLH 954
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
918-943 8.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 8.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 189409128   918 SLLRHKYEHTGKRPHECGICKKAFKH 943
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
240-262 4.42e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.60  E-value: 4.42e-04
                            10        20
                    ....*....|....*....|...
gi 189409128    240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
Homeodomain pfam00046
Homeodomain;
581-629 7.54e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 7.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 189409128   581 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 629
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 60-170 2.41e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 41.23  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189409128    60 DLPTDQTVLPgrSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEqnhDPNVEEFLQQQDTAvif 139
Cdd:pfam08690   45 DEPAAPSTTP--ASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESDPE---NPQLDQMFKQLLGQ--- 116

                           90       100       110
                   ....*....|....*....|....*....|.
gi 189409128   140 peapeedQRQGTPEASGHDENGTPDAFSQLL 170
Cdd:pfam08690  117 -------QQQGGGENGQPAGSSTPDLFSQMM 140
ZnF_C2H2 smart00355
zinc finger;
932-954 2.68e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.68e-03
                            10        20
                    ....*....|....*....|...
gi 189409128    932 HECGICKKAFKHKHHLIEHMRLH 954
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 960-980 4.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.59e-03
                           10        20
                   ....*....|....*....|.
gi 189409128   960 YQCDKCGKRFSHSGSYSQHMN 980
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLR 21
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 240-262 4.63e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 4.63e-03
                           10        20
                   ....*....|....*....|...
gi 189409128   240 FKCTECGKAFKYKHHLKEHLRIH 262
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 200-222 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.78e-03
                           10        20
                   ....*....|....*....|...
gi 189409128   200 FSCSLCSYTFAYRTQLERHMTSH 222
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
200-222 5.89e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 5.89e-03
                            10        20
                    ....*....|....*....|...
gi 189409128    200 FSCSLCSYTFAYRTQLERHMTSH 222
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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