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Conserved domains on  [gi|1893777213|ref|WP_185692235|]
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MarR family winged helix-turn-helix transcriptional regulator [Puniceicoccus vermicola]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 1.99e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 1.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213   2 SERSEAAQDLFDEVRKINNRLRWLGDTLHLDLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLV 81
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1893777213  82 ESQPNPRHRRSTLLALTSKGDRLIQKMLAKESELVKTSTYSPSTKELTVLREQLQKLRA 140
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 1.99e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 1.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213   2 SERSEAAQDLFDEVRKINNRLRWLGDTLHLDLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLV 81
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1893777213  82 ESQPNPRHRRSTLLALTSKGDRLIQKMLAKESELVKTSTYSPSTKELTVLREQLQKLRA 140
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-92 1.18e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 56.44  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213  33 LGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRRS 92
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
32-117 8.29e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 55.29  E-value: 8.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213   32 DLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRRSTLLALTSKGDRLIQKMLAK 111
Cdd:smart00347   5 PLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEA 84


                   ....*.
gi 1893777213  112 ESELVK 117
Cdd:smart00347  85 RSETLA 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 39-91 2.61e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1893777213  39 KRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRR 91
Cdd:cd00090     8 TRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVY 60
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 1.99e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 1.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213   2 SERSEAAQDLFDEVRKINNRLRWLGDTLHLDLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLV 81
Cdd:COG1846     3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1893777213  82 ESQPNPRHRRSTLLALTSKGDRLIQKMLAKESELVKTSTYSPSTKELTVLREQLQKLRA 140
Cdd:COG1846    83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-92 1.18e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 56.44  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213  33 LGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRRS 92
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
32-117 8.29e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 55.29  E-value: 8.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213   32 DLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRRSTLLALTSKGDRLIQKMLAK 111
Cdd:smart00347   5 PLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEA 84


                   ....*.
gi 1893777213  112 ESELVK 117
Cdd:smart00347  85 RSETLA 90
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
27-104 9.80e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893777213  27 DTLHLDLGVTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRH--RRSTLLALTSKGDRL 104
Cdd:COG2345     3 DTPALAALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGrgRPAKLYRLTEAGRAR 82
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-93 7.69e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 7.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1893777213  35 VTAAKRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRRST 93
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
40-108 2.24e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 2.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1893777213  40 RSLLLTLdREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVEsqpnprhRRSTLLALTSKGDRLIQKM 108
Cdd:COG4742    19 KNILLLL-AEGPKTRSELAESLDVSRSTILRQLKELEERGLIE-------RDDGEYELTTLGRLVVEEM 79
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 39-91 2.61e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1893777213  39 KRSLLLTLDREGPQTVPDLARERLVSRQVVQTQVNDLLEEGLVESQPNPRHRR 91
Cdd:cd00090     8 TRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVY 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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