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Conserved domains on  [gi|189181732|ref|NP_112231|]
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transmembrane protein 14B isoform a [Homo sapiens]

Protein Classification

TMEM14 family protein( domain architecture ID 10508392)

TMEM14 family protein contains four hydrophobic alpha-helical regions, three of which are membrane-spanning, similar to Arabidopsis thaliana fatty acid export proteins

CATH:  1.10.10.1740
Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_14 pfam03647
Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.
 14-103 1.17e-20

Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.


:

Pssm-ID: 461004  Cd Length: 89  Bit Score: 79.08  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189181732   14 FGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQDPRNVWGFLaATSVTFVGVMGMRSYYYGKFMPVGL 93
Cdd:pfam03647   1 LGIPYGALLAVGGIMGYARAGSVPSLIAGLGFGALLLLGGYLSLNAPYGLELAL-GASAVLAGVMGPRFIKTRKFMPAGL 79

                          90
                  ....*....|
gi 189181732   94 IAGASLLMAA 103
Cdd:pfam03647  80 LALLSLLMLA 89
 
Name Accession Description Interval E-value
Tmemb_14 pfam03647
Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.
 14-103 1.17e-20

Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.


Pssm-ID: 461004  Cd Length: 89  Bit Score: 79.08  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189181732   14 FGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQDPRNVWGFLaATSVTFVGVMGMRSYYYGKFMPVGL 93
Cdd:pfam03647   1 LGIPYGALLAVGGIMGYARAGSVPSLIAGLGFGALLLLGGYLSLNAPYGLELAL-GASAVLAGVMGPRFIKTRKFMPAGL 79

                          90
                  ....*....|
gi 189181732   94 IAGASLLMAA 103
Cdd:pfam03647  80 LALLSLLMLA 89
COG5548 COG5548
Uncharacterized membrane protein, UPF0136 family [Function unknown];
12-101 6.65e-10

Uncharacterized membrane protein, UPF0136 family [Function unknown];


Pssm-ID: 444291  Cd Length: 106  Bit Score: 51.82  E-value: 6.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189181732  12 HWFGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQdpRNVWGFLAATSVTF--VGVMGMRSYYYGKFM 89
Cdd:COG5548    5 IIAALIYGILVIIGGIIGYVKAKSKVSLISGVISGILLLVAGYLQLQ--GQVWGLTLATAITAllVIFFAYRFVKTRKFM 82

                         90
                 ....*....|..
gi 189181732  90 PVGLIAGASLLM 101
Cdd:COG5548   83 PAGLMVILGLVA 94
 
Name Accession Description Interval E-value
Tmemb_14 pfam03647
Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.
 14-103 1.17e-20

Transmembrane proteins 14C; This family of short membrane proteins are as yet uncharacterized.


Pssm-ID: 461004  Cd Length: 89  Bit Score: 79.08  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189181732   14 FGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQDPRNVWGFLaATSVTFVGVMGMRSYYYGKFMPVGL 93
Cdd:pfam03647   1 LGIPYGALLAVGGIMGYARAGSVPSLIAGLGFGALLLLGGYLSLNAPYGLELAL-GASAVLAGVMGPRFIKTRKFMPAGL 79

                          90
                  ....*....|
gi 189181732   94 IAGASLLMAA 103
Cdd:pfam03647  80 LALLSLLMLA 89
COG5548 COG5548
Uncharacterized membrane protein, UPF0136 family [Function unknown];
12-101 6.65e-10

Uncharacterized membrane protein, UPF0136 family [Function unknown];


Pssm-ID: 444291  Cd Length: 106  Bit Score: 51.82  E-value: 6.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189181732  12 HWFGFGYTALVVSGGIVGYVKTGSVPSLAAGLLFGSLAGLGAYQLYQdpRNVWGFLAATSVTF--VGVMGMRSYYYGKFM 89
Cdd:COG5548    5 IIAALIYGILVIIGGIIGYVKAKSKVSLISGVISGILLLVAGYLQLQ--GQVWGLTLATAITAllVIFFAYRFVKTRKFM 82

                         90
                 ....*....|..
gi 189181732  90 PVGLIAGASLLM 101
Cdd:COG5548   83 PAGLMVILGLVA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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