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Conserved domains on  [gi|1888361606|gb|QNA48303|]
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NADH dehydrogenase subunit 3 (mitochondrion) [Homo sapiens subsp. 'Denisova']

Protein Classification

NADH dehydrogenase subunit 3( domain architecture ID 10009567)

NADH dehydrogenase subunit 3 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 1.18e-50

NADH dehydrogenase subunit 3; Provisional


:

Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 155.87  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106    1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00106   81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
 
Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 1.18e-50

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 155.87  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106    1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00106   81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
18-69 1.03e-18

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 74.38  E-value: 1.03e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1888361606  18 MIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:pfam00507   1 LLLSRLLGPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEV 52
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 3-69 2.17e-14

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 63.99  E-value: 2.17e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:COG0838     8 ILIFLLVALGLALAMLLLSRLLGPKRPNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEV 74
 
Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 1.18e-50

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 155.87  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106    1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00106   81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 6-115 3.36e-32

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 109.24  E-value: 3.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   6 ILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLP 85
Cdd:MTH00136    7 ILTITIALSLILAIVSFWLPQMTPDHEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPLPWGDQLPSPL 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1888361606  86 LMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00136   87 LTFFWATAVLILLTLGLIYEWLQGGLEWAE 116
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 5-115 2.35e-31

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 107.00  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   5 LILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNL 84
Cdd:MTH00069    4 LMLLISTILSLILITISFWLPLNNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPTPWASQLNTP 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1888361606  85 PLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00069   84 TNTLFWSTLILILLTLGLIYEWIQGGLEWAE 114
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 1-114 2.12e-28

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 99.57  E-value: 2.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00113    1 MNLISMLTISLALSTILTTLNFWLTQTKPDNEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWAIN 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWA 114
Cdd:MTH00113   81 LTTPTTTLTWATIILTLLTLGLIYEWLQGGLEWA 114
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 1-115 1.87e-25

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 91.97  E-value: 1.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00042    2 TNLIFFLLIILILTSLLLLAGHFLPSRSPDLEKSSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFPLPPATL 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00042   82 ITNPSTLLPISLIFLIILTIGLVYEWVNGGLEWAE 116
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-115 1.70e-20

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 79.52  E-value: 1.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYM-EKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWAL 79
Cdd:MTH00148    2 LSILLSLLFALILSPVLLLLGLVLSKRSYSDrEKSSPFECGFDPISSARSPFSLRFFLLAILFLVFDVEIVLLFPVLQSL 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1888361606  80 QTTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00148   82 GSSFSVWSLTSLFIFLLILILGLFHEWNEGSLDWVS 117
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 3-113 1.99e-19

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 76.47  E-value: 1.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTT 82
Cdd:MTH00203    4 IMLFFLIALLLSLILLFIAFWLPKVNPDGEKLSPYECGFDPLGSARLPFSLQFFLVALSFLLFDLEIALLLPLPWSNQLS 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1888361606  83 NLPLMVTssLLLIIILALSLAYEWLQKGLDW 113
Cdd:MTH00203   84 SLSLLLA--FLFLILLTLGLIYEWLQGGLEW 112
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
18-69 1.03e-18

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 74.38  E-value: 1.03e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1888361606  18 MIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:pfam00507   1 LLLSRLLGPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEV 52
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 1-114 2.03e-16

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 69.12  E-value: 2.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWL--PQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWA 78
Cdd:MTH00012    1 MSLMMIPMMISLILPPLVLGAAWVlaARSTADREKTSPFECGFDPHKTARIPFSLRFFLLAIIFIVFDIEIVLLMPVPTI 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1888361606  79 LQTTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWA 114
Cdd:MTH00012   81 LMTSTSKTVVYTSILFLLILVIGLIHEWREGSLDWS 116
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 2-113 2.63e-16

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 68.65  E-value: 2.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   2 NFALILMINTLLALLLMIITFWLPQLNGY-MEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00161    1 MILIILLIILLISIILMILASLLSKKSIMdREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDW 113
Cdd:MTH00161   81 TSNMMSWLITSSFFILILLLGLYYEWNQGALEW 113
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 1-115 2.03e-15

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 66.55  E-value: 2.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00202    3 LILFMSILSILISSLLFLVSWMLSFRSLMDREKSSPFECGFDPKESARLPFSMRFFLLAVIFLVFDIEIALLLPLPLVLK 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1888361606  81 TTNLPLMVTSSLLLIIILALSLAYEWLQKGLDWAE 115
Cdd:MTH00202   83 SSWSKGGLLGGTIFLLILIGGLIHEWKEGSLDWVK 117
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 3-69 2.17e-14

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 63.99  E-value: 2.17e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:COG0838     8 ILIFLLVALGLALAMLLLSRLLGPKRPNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEV 74
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 3-69 7.13e-14

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 62.57  E-value: 7.13e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:PRK06602   11 FLIFLIVAIGLGILLLVAGKLLGPRAPDREKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEA 77
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 32-113 4.57e-13

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 60.49  E-value: 4.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606  32 EKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLpLMVTSSLLLIIILALSLAYEWLQKGL 111
Cdd:MTH00055   37 EKVSVYECGFDPFESSRIPFSVRFFLVGILFLIFDLEISFLFPWCVVYNQIGL-FGFWVMYLFLIILTIGLIYEWVKGGL 115


                  ..
gi 1888361606 112 DW 113
Cdd:MTH00055  116 EW 117
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 1-113 8.95e-12

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 56.99  E-value: 8.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00018    1 YGLFILLIFSVVLSALFSGASYFLGVKQPDREKVSAYECGFDPFGFPGRPFSIRFFLIGILFLIFDLEISFLFPWCVLYN 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1888361606  81 TTNlPLMVTSSLLLIIILALSLAYEWLQKGLDW 113
Cdd:MTH00018   81 QIA-PFGFWTMVGFLFILTLGLIYEWIKGGLEW 112
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 32-113 5.10e-10

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 52.63  E-value: 5.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1888361606  32 EKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLpLMVTSSLLLIIILALSLAYEWLQKGL 111
Cdd:MTH00030   42 EKSSIYECGFDPFGKIRTPFTIKFVLVGILFMIFDIEISFLFPWSIVFNQLNL-FSFWIVYTFLIVLAIGLAYEWIKGGL 120


                  ..
gi 1888361606 112 DW 113
Cdd:MTH00030  121 EW 122
ndhC CHL00022
NADH dehydrogenase subunit 3
 3-68 8.62e-06

NADH dehydrogenase subunit 3


Pssm-ID: 176964 [Multi-domain]  Cd Length: 120  Bit Score: 41.51  E-value: 8.62e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLE 68
Cdd:CHL00022   10 FWAFLIISSLIPILAFLISGLLAPISKGPEKLSSYESGIEPMGDAWLQFRIRYYMFALVFVVFDVE 75
ND3 MTH00092
NADH dehydrogenase subunit 3; Provisional
 1-69 2.37e-04

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177155  Cd Length: 111  Bit Score: 37.57  E-value: 2.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1888361606   1 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEI 69
Cdd:MTH00092    2 LVLIFVFLFTLLLLMLLYLLNFFLSVKKFDLLKVSSFECGFESVGKIQNSFSIHFFKIMLMFVIFDLEI 70
PRK08489 PRK08489
NAD(P)H-quinone oxidoreductase subunit 3;
3-69 4.44e-03

NAD(P)H-quinone oxidoreductase subunit 3;


Pssm-ID: 181448 [Multi-domain]  Cd Length: 129  Bit Score: 34.26  E-value: 4.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1888361606   3 FALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM-SPARVpfSMKFFLVAITFLLFDLEI 69
Cdd:PRK08489   17 LVLTFVAFFLTTRLARFISRKLAQKNTEKLKLAIYECGPEPVkQPNRI--SSHFYIMALLFILFDVEI 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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