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Conserved domains on  [gi|1886726958|gb|KAF6503058|]
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toll like receptor 1 [Molossus molossus]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 13320293)

toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 15; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-783 1.10e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.63  E-value: 1.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  640 QFHAFISYSGHDsgWVRNELLPNLEK--EGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 717
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886726958  718 AHHNLLHEGSNNLILILLEPIPKYsIPKSYHKLKTLMaQRTYLEWPKEKNKHglFWANLRASICIK 783
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
357-530 7.68e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 357 LDFSNNLLTDMvFNNCETLTRLETLSLQKNELKKLANIVhmtKEMKSLKQLDISQNSLSYDENE-GYCSwtiSLLTLNMS 435
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEElGNLT---NLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 436 SNILTD--SVFRCLPpRVKVLDLHNNRITTIPENVTSLEALQELNVASNSLAHLPGCGTFSSLSVLIIDYNSISNPSahF 513
Cdd:COG4886   191 NNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--P 267

                         170
                  ....*....|....*..
gi 1886726958 514 FQSCQKIRSINAGNNPF 530
Cdd:COG4886   268 LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELrTSDILSLSKLRILRISHNRIQYLDMSVFKFNQeLEYLDLSHNKLEKISC--HPTVNLKHLDLSFNA 129
Cdd:COG4886   162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEplANLTNLETLDLSNNQ 239

                          90       100
                  ....*....|....*....|....*.
gi 1886726958 130 FDALPickEFGNMSQLEFLGLSATQL 155
Cdd:COG4886   240 LTDLP---ELGNLTNLEELDLSNNQL 262
LRRCT smart00082
Leucine rich repeat C-terminal domain;
528-581 1.36e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1886726958  528 NPFQCTCELREFIQsiGQVSSEVVEgWPDSYKCDYPGSYKGtLLKDFHVSPLSC 581
Cdd:smart00082   1 NPFICDCELRWLLR--WLQANEHLQ-DPVDLRCASPSSLRG-PLLELLHSEFKC 50
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 49-449 1.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  49 LETtiLDISQNDISELRTSDILSLSKLRILRISHN-----------RIQYLDMSVFKFNQ-------------ELEYLDL 104
Cdd:PLN00113  142 LET--LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqiprelgqmkSLKWIYL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 105 SHNKLE---KISCHPTVNLKHLDLSFNAFDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHiNKVLLVLGDLYRE 181
Cdd:PLN00113  220 GYNNLSgeiPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ-KLISLDLSDNSLS 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 182 KEDPESLQDL-NTESLH---------------------------------IVFPTGKEFNF-ILDVSvSTAVSLELSNIK 226
Cdd:PLN00113  298 GEIPELVIQLqNLEILHlfsnnftgkipvaltslprlqvlqlwsnkfsgeIPKNLGKHNNLtVLDLS-TNNLTGEIPEGL 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 227 CvleEHGCSYFLHVLSKLQKNSRLSSL----TLNNIETTWNSF-------IMMFQLVWhtsieYFSILNVKLQGQLQVRD 295
Cdd:PLN00113  377 C---SSGNLFKLILFSNSLEGEIPKSLgacrSLRRVRLQDNSFsgelpseFTKLPLVY-----FLDISNNNLQGRINSRK 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 296 FYYPdtSLKALSIYQvvsNMFS--LSQSyiykiFANMKIQNFTVSGTQMVHMVCPSQM--SPFLHLDFSNNLLTDMVFNN 371
Cdd:PLN00113  449 WDMP--SLQMLSLAR---NKFFggLPDS-----FGSKRLENLDLSRNQFSGAVPRKLGslSELMQLKLSENKLSGEIPDE 518

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 372 CETLTRLETLSLQKNELKklANIVHMTKEMKSLKQLDISQNSLSYD--ENEGYCSwtiSLLTLNMSSNILTDSvfrcLPP 449
Cdd:PLN00113  519 LSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEipKNLGNVE---SLVQVNISHNHLHGS----LPS 589
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-783 1.10e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.63  E-value: 1.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  640 QFHAFISYSGHDsgWVRNELLPNLEK--EGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 717
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886726958  718 AHHNLLHEGSNNLILILLEPIPKYsIPKSYHKLKTLMaQRTYLEWPKEKNKHglFWANLRASICIK 783
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-794 5.24e-26

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 105.14  E-value: 5.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 641 FHAFISYSGHDS-GWVRNELLPNLEKEGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 719
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 720 HNLLhEGSNNLILILLEPIPKY------SIPKSYHKLKTLMAQRTYLEWPKEKNKhglfWANLRASicIKLMDQTKEIEH 793
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGALNE----VANIWHS--KSVSDESKFWKK 153


                  .
gi 1886726958 794 I 794
Cdd:pfam01582 154 I 154
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
357-530 7.68e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 357 LDFSNNLLTDMvFNNCETLTRLETLSLQKNELKKLANIVhmtKEMKSLKQLDISQNSLSYDENE-GYCSwtiSLLTLNMS 435
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEElGNLT---NLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 436 SNILTD--SVFRCLPpRVKVLDLHNNRITTIPENVTSLEALQELNVASNSLAHLPGCGTFSSLSVLIIDYNSISNPSahF 513
Cdd:COG4886   191 NNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--P 267

                         170
                  ....*....|....*..
gi 1886726958 514 FQSCQKIRSINAGNNPF 530
Cdd:COG4886   268 LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELrTSDILSLSKLRILRISHNRIQYLDMSVFKFNQeLEYLDLSHNKLEKISC--HPTVNLKHLDLSFNA 129
Cdd:COG4886   162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEplANLTNLETLDLSNNQ 239

                          90       100
                  ....*....|....*....|....*.
gi 1886726958 130 FDALPickEFGNMSQLEFLGLSATQL 155
Cdd:COG4886   240 LTDLP---ELGNLTNLEELDLSNNQL 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
357-530 9.81e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 9.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 357 LDFSNNLLTDMVfnncETLTR-LETLSLQKNELKKLANivHMTKemkSLKQLDISQNSLSYDENegycSWTISLLTLNMS 435
Cdd:PRK15370  267 LDLFHNKISCLP----ENLPEeLRYLSVYDNSIRTLPA--HLPS---GITHLNVQSNSLTALPE----TLPPGLKTLEAG 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 436 SNILTdSVFRCLPPRVKVLDLHNNRITTIPENVTSleALQELNVASNSLAHLPGcGTFSSLSVLIIDYNSISN-PSA--H 512
Cdd:PRK15370  334 ENALT-SLPASLPPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpH 409

                         170
                  ....*....|....*...
gi 1886726958 513 FFQSCQKIRSINAGNNPF 530
Cdd:PRK15370  410 FRGEGPQPTRIIVEYNPF 427
LRR_8 pfam13855
Leucine rich repeat;
73-128 3.29e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1886726958  73 SKLRILRISHNRIQYLDMSVFKFNQELEYLDLSHNKLEKIS---CHPTVNLKHLDLSFN 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-499 6.19e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 361 NNLLTDMvfNNCETLTRLETLSLQKNELKKLANIVHmtkeMKSLKQLDISQNSLSYDENEGYCSwtiSLLTLNMSSNILT 440
Cdd:cd21340    33 DNKITKI--ENLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLGGNRISVVEGLENLT---NLEELHIENQRLP 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886726958 441 DSVFRCLPPR--------VKVLDLHNNRITTIpENVTSLEALQELNVASNSLAHLPG-CGTFSSLSVL 499
Cdd:cd21340   104 PGEKLTFDPRslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElLDLLSSWPSL 170
LRRCT smart00082
Leucine rich repeat C-terminal domain;
528-581 1.36e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1886726958  528 NPFQCTCELREFIQsiGQVSSEVVEgWPDSYKCDYPGSYKGtLLKDFHVSPLSC 581
Cdd:smart00082   1 NPFICDCELRWLLR--WLQANEHLQ-DPVDLRCASPSSLRG-PLLELLHSEFKC 50
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-137 9.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 9.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886726958  69 ILSLSK-LRILRISHNRIQylDMSVFKFNQELEYLDLSHNKLEKI--------SCHptvNLKHLDLSFNafdalPICK 137
Cdd:cd21340   115 LAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLeelldllsSWP---SLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-449 1.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  49 LETtiLDISQNDISELRTSDILSLSKLRILRISHN-----------RIQYLDMSVFKFNQ-------------ELEYLDL 104
Cdd:PLN00113  142 LET--LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqiprelgqmkSLKWIYL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 105 SHNKLE---KISCHPTVNLKHLDLSFNAFDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHiNKVLLVLGDLYRE 181
Cdd:PLN00113  220 GYNNLSgeiPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ-KLISLDLSDNSLS 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 182 KEDPESLQDL-NTESLH---------------------------------IVFPTGKEFNF-ILDVSvSTAVSLELSNIK 226
Cdd:PLN00113  298 GEIPELVIQLqNLEILHlfsnnftgkipvaltslprlqvlqlwsnkfsgeIPKNLGKHNNLtVLDLS-TNNLTGEIPEGL 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 227 CvleEHGCSYFLHVLSKLQKNSRLSSL----TLNNIETTWNSF-------IMMFQLVWhtsieYFSILNVKLQGQLQVRD 295
Cdd:PLN00113  377 C---SSGNLFKLILFSNSLEGEIPKSLgacrSLRRVRLQDNSFsgelpseFTKLPLVY-----FLDISNNNLQGRINSRK 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 296 FYYPdtSLKALSIYQvvsNMFS--LSQSyiykiFANMKIQNFTVSGTQMVHMVCPSQM--SPFLHLDFSNNLLTDMVFNN 371
Cdd:PLN00113  449 WDMP--SLQMLSLAR---NKFFggLPDS-----FGSKRLENLDLSRNQFSGAVPRKLGslSELMQLKLSENKLSGEIPDE 518

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 372 CETLTRLETLSLQKNELKklANIVHMTKEMKSLKQLDISQNSLSYD--ENEGYCSwtiSLLTLNMSSNILTDSvfrcLPP 449
Cdd:PLN00113  519 LSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEipKNLGNVE---SLVQVNISHNHLHGS----LPS 589
LRR_8 pfam13855
Leucine rich repeat;
449-506 1.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1886726958 449 PRVKVLDLHNNRITTI-PENVTSLEALQELNVASNSLAHLPGcGTFS---SLSVLIIDYNSI 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-169 3.91e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  54 LDISQNDISELRTSDILSLSKLRILRISHNRIQYLDMSVFKFNQELEYLDLSHNKL-----EKISCHPTvnLKHLDLSFN 128
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLsgqipASFSEMPV--LSQLDLSQN 557

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1886726958 129 AFDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHIN 169
Cdd:PLN00113  558 QLSG-EIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAIN 597
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-783 1.10e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.63  E-value: 1.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  640 QFHAFISYSGHDsgWVRNELLPNLEK--EGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 717
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886726958  718 AHHNLLHEGSNNLILILLEPIPKYsIPKSYHKLKTLMaQRTYLEWPKEKNKHglFWANLRASICIK 783
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-794 5.24e-26

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 105.14  E-value: 5.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 641 FHAFISYSGHDS-GWVRNELLPNLEKEGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 719
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 720 HNLLhEGSNNLILILLEPIPKY------SIPKSYHKLKTLMAQRTYLEWPKEKNKhglfWANLRASicIKLMDQTKEIEH 793
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGALNE----VANIWHS--KSVSDESKFWKK 153


                  .
gi 1886726958 794 I 794
Cdd:pfam01582 154 I 154
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 644-737 5.66e-19

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 83.13  E-value: 5.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 644 FISYSGHDSGWVRnELLPNLEKEGIRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlL 723
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1886726958 724 HEGSNNLILILLEP 737
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
357-530 7.68e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 357 LDFSNNLLTDMvFNNCETLTRLETLSLQKNELKKLANIVhmtKEMKSLKQLDISQNSLSYDENE-GYCSwtiSLLTLNMS 435
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEElGNLT---NLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 436 SNILTD--SVFRCLPpRVKVLDLHNNRITTIPENVTSLEALQELNVASNSLAHLPGCGTFSSLSVLIIDYNSISNPSahF 513
Cdd:COG4886   191 NNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--P 267

                         170
                  ....*....|....*..
gi 1886726958 514 FQSCQKIRSINAGNNPF 530
Cdd:COG4886   268 LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
217-545 3.69e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 217 AVSLELSNIKCVLEEHGCSYFLHVLSKLQKNSRLSSLTLNNIETTWNSFIMMFQLVWHTSIEYFSILNVKLQGQLQVRDF 296
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 297 YYPDTSLKALSIYQVvSNMFSLSQSYIYKIFANMKIQNFTVSGTQMVHMvcPSQMSPFLHL---DFSNNLLTDmVFNNCE 373
Cdd:COG4886    81 LLSLLLLGLTDLGDL-TNLTELDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 374 TLTRLETLSLQKNELKKLANIVhmtKEMKSLKQLDISQNSLSYDENE-GYCSwtiSLLTLNMSSNILTD---SVFRClpP 449
Cdd:COG4886   157 NLTNLKSLDLSNNQLTDLPEEL---GNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDlpePLANL--T 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 450 RVKVLDLHNNRITTIPEnVTSLEALQELNVASNSLAHLPGCGTFSSLSVLIIDYNSISNPSAHFFQSCQKIRSINAGNNP 529
Cdd:COG4886   229 NLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                         330
                  ....*....|....*.
gi 1886726958 530 FQCTCELREFIQSIGQ 545
Cdd:COG4886   308 LNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELrTSDILSLSKLRILRISHNRIQYLDMSVFKFNQeLEYLDLSHNKLEKISC--HPTVNLKHLDLSFNA 129
Cdd:COG4886   162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEplANLTNLETLDLSNNQ 239

                          90       100
                  ....*....|....*....|....*.
gi 1886726958 130 FDALPickEFGNMSQLEFLGLSATQL 155
Cdd:COG4886   240 LTDLP---ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 1.42e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELrTSDILSLSKLRILRISHNRIQYLDMSVFKFNQeLEYLDLSHNKLEKISCH--PTVNLKHLDLSFNA 129
Cdd:COG4886   116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                          90       100
                  ....*....|....*....|....*.
gi 1886726958 130 FDALPicKEFGNMSQLEFLGLSATQL 155
Cdd:COG4886   194 ITDLP--EPLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-261 1.86e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELrTSDILSLSKLRILRISHNRIQYLDMSVFKFNQeLEYLDLSHNKLEKIschPTV----NLKHLDLSF 127
Cdd:COG4886   185 KELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL---PELgnltNLEELDLSN 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 128 NAFDALPickEFGNMSQLEFLGLSATQ-----LQKSKVLSIAHLHINKVLLVLGDLYREKEDPESLQDLNTESLHIVFPT 202
Cdd:COG4886   260 NQLTDLP---PLANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1886726958 203 GKEFNFILDVSVSTAVSLELSNIKCVLEEHGCSYFLHVLSKLQKNSRLSSLTLNNIETT 261
Cdd:COG4886   337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
357-530 9.81e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 9.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 357 LDFSNNLLTDMVfnncETLTR-LETLSLQKNELKKLANivHMTKemkSLKQLDISQNSLSYDENegycSWTISLLTLNMS 435
Cdd:PRK15370  267 LDLFHNKISCLP----ENLPEeLRYLSVYDNSIRTLPA--HLPS---GITHLNVQSNSLTALPE----TLPPGLKTLEAG 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 436 SNILTdSVFRCLPPRVKVLDLHNNRITTIPENVTSleALQELNVASNSLAHLPGcGTFSSLSVLIIDYNSISN-PSA--H 512
Cdd:PRK15370  334 ENALT-SLPASLPPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpH 409

                         170
                  ....*....|....*...
gi 1886726958 513 FFQSCQKIRSINAGNNPF 530
Cdd:PRK15370  410 FRGEGPQPTRIIVEYNPF 427
LRR_8 pfam13855
Leucine rich repeat;
73-128 3.29e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1886726958  73 SKLRILRISHNRIQYLDMSVFKFNQELEYLDLSHNKLEKIS---CHPTVNLKHLDLSFN 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-499 6.19e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 361 NNLLTDMvfNNCETLTRLETLSLQKNELKKLANIVHmtkeMKSLKQLDISQNSLSYDENEGYCSwtiSLLTLNMSSNILT 440
Cdd:cd21340    33 DNKITKI--ENLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLGGNRISVVEGLENLT---NLEELHIENQRLP 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886726958 441 DSVFRCLPPR--------VKVLDLHNNRITTIpENVTSLEALQELNVASNSLAHLPG-CGTFSSLSVL 499
Cdd:cd21340   104 PGEKLTFDPRslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-156 6.19e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958   5 NSTIFHFAIIFMLILEIKIQLSDKSEILVDRSKRGLIHVPKDLSLETTILDISQNDISELRTSDILSLSKLRILRISHNR 84
Cdd:COG4886    28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1886726958  85 IqyldmsvFKFNQELEYLDLSHNKLEKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLEFLGLSATQLQ 156
Cdd:COG4886   108 E-------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
LRR_8 pfam13855
Leucine rich repeat;
52-109 6.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.67e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1886726958  52 TILDISQNDISELRTSDILSLSKLRILRISHNRIQYLDMSVFKFNQELEYLDLSHNKL 109
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
383-528 1.31e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 383 LQKNELK------KLANIVHMTKEMKSLKQLDiSQNSLSYDENegycsWTISLLTLNMSSNILTdSVFRCLPPRVKVLDL 456
Cdd:PRK15370  176 LKNNKTElrlkilGLTTIPACIPEQITTLILD-NNELKSLPEN-----LQGNIKTLYANSNQLT-SIPATLPDTIQEMEL 248

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1886726958 457 HNNRITTIPENVTSleALQELNVASNSLAHLPGcGTFSSLSVLIIDYNSISNPSAHFFQScqkIRSINAGNN 528
Cdd:PRK15370  249 SINRITELPERLPS--ALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSN 314
LRRCT smart00082
Leucine rich repeat C-terminal domain;
528-581 1.36e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1886726958  528 NPFQCTCELREFIQsiGQVSSEVVEgWPDSYKCDYPGSYKGtLLKDFHVSPLSC 581
Cdd:smart00082   1 NPFICDCELRWLLR--WLQANEHLQ-DPVDLRCASPSSLRG-PLLELLHSEFKC 50
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
377-532 1.79e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 377 RLETLSLQKNELKKLANIVHmtkemKSLKQLDISQNSLSYDENegycSWTISLLTLNMSSNILTDSVFRcLPPRVKVLDL 456
Cdd:PRK15370  200 QITTLILDNNELKSLPENLQ-----GNIKTLYANSNQLTSIPA----TLPDTIQEMELSINRITELPER-LPSALQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 457 HNNRITTIPENVTslEALQELNVASNSL----AHLPgcgtfSSLSVLIIDYNSISNPSAHFFQScqkIRSINAGNNPFQC 532
Cdd:PRK15370  270 FHNKISCLPENLP--EELRYLSVYDNSIrtlpAHLP-----SGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-137 9.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 9.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886726958  69 ILSLSK-LRILRISHNRIQylDMSVFKFNQELEYLDLSHNKLEKI--------SCHptvNLKHLDLSFNafdalPICK 137
Cdd:cd21340   115 LAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLeelldllsSWP---SLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-449 1.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  49 LETtiLDISQNDISELRTSDILSLSKLRILRISHN-----------RIQYLDMSVFKFNQ-------------ELEYLDL 104
Cdd:PLN00113  142 LET--LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqiprelgqmkSLKWIYL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 105 SHNKLE---KISCHPTVNLKHLDLSFNAFDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHiNKVLLVLGDLYRE 181
Cdd:PLN00113  220 GYNNLSgeiPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ-KLISLDLSDNSLS 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 182 KEDPESLQDL-NTESLH---------------------------------IVFPTGKEFNF-ILDVSvSTAVSLELSNIK 226
Cdd:PLN00113  298 GEIPELVIQLqNLEILHlfsnnftgkipvaltslprlqvlqlwsnkfsgeIPKNLGKHNNLtVLDLS-TNNLTGEIPEGL 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 227 CvleEHGCSYFLHVLSKLQKNSRLSSL----TLNNIETTWNSF-------IMMFQLVWhtsieYFSILNVKLQGQLQVRD 295
Cdd:PLN00113  377 C---SSGNLFKLILFSNSLEGEIPKSLgacrSLRRVRLQDNSFsgelpseFTKLPLVY-----FLDISNNNLQGRINSRK 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 296 FYYPdtSLKALSIYQvvsNMFS--LSQSyiykiFANMKIQNFTVSGTQMVHMVCPSQM--SPFLHLDFSNNLLTDMVFNN 371
Cdd:PLN00113  449 WDMP--SLQMLSLAR---NKFFggLPDS-----FGSKRLENLDLSRNQFSGAVPRKLGslSELMQLKLSENKLSGEIPDE 518

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 372 CETLTRLETLSLQKNELKklANIVHMTKEMKSLKQLDISQNSLSYD--ENEGYCSwtiSLLTLNMSSNILTDSvfrcLPP 449
Cdd:PLN00113  519 LSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEipKNLGNVE---SLVQVNISHNHLHGS----LPS 589
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 356-506 2.86e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 356 HLDFSNNLLTDM---VFNNCETLTRLETLSLQKNEL-----KKLANIVHMTKEmkSLKQLDISQNSLSYDENE---GYCS 424
Cdd:cd00116    85 ELDLSDNALGPDgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPP--ALEKLVLGRNRLEGASCEalaKALR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 425 WTISLLTLNMSSNILTDSVFRCLPP------RVKVLDLHNNRIT-----TIPENVTSLEALQELNVASNSLAHLPGC--- 490
Cdd:cd00116   163 ANRDLKELNLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAala 242

                         170       180
                  ....*....|....*....|
gi 1886726958 491 ----GTFSSLSVLIIDYNSI 506
Cdd:cd00116   243 sallSPNISLLTLSLSCNDI 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 404-506 3.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 404 LKQLDISQNSLSYDENEGYCSWTISLLTLNMSSNILTDSVFRCLPPRVKVLDLHNNRIT-TIPENVTSLEALQELNVASN 482
Cdd:PLN00113   95 IQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGN 174

                          90       100
                  ....*....|....*....|....*.
gi 1886726958 483 SL-AHLPG-CGTFSSLSVLIIDYNSI 506
Cdd:PLN00113  175 VLvGKIPNsLTNLTSLEFLTLASNQL 200
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-507 4.94e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  52 TILDISQNDISELRTSDILSLSKLRILRISHNRIQY-LDMSVFKFNQELEYLDLSHNKLE-KISCHPTVNLKHLDLSFNA 129
Cdd:PLN00113   72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 130 FDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHINKVLLV-----LGDLYREKEDPESLQ----DLNTESLHIVF 200
Cdd:PLN00113  152 LSG-EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLasnqlVGQIPRELGQMKSLKwiylGYNNLSGEIPY 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 201 PTGK--EFNFiLDV---SVSTAVSLELSNIKCVleeHGCSYFLHVLSKLQKNSRLSSLTLNNIETTWNSFI-----MMFQ 270
Cdd:PLN00113  231 EIGGltSLNH-LDLvynNLTGPIPSSLGNLKNL---QYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipeLVIQ 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 271 LvwhTSIEYFSILNVKLQGQLQVrdfyyPDTSLKALSIYQVVSNMFSlsqsyiYKIFANM-KIQNFTV--------SGtQ 341
Cdd:PLN00113  307 L---QNLEILHLFSNNFTGKIPV-----ALTSLPRLQVLQLWSNKFS------GEIPKNLgKHNNLTVldlstnnlTG-E 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 342 MVHMVCPSQMSPFLHLdFSNNLLTDM--VFNNCETLTRLEtlsLQKN--------ELKKL--------------ANIVHM 397
Cdd:PLN00113  372 IPEGLCSSGNLFKLIL-FSNSLEGEIpkSLGACRSLRRVR---LQDNsfsgelpsEFTKLplvyfldisnnnlqGRINSR 447

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 398 TKEMKSLKQLDISQNSLSYDENEGYCSwtISLLTLNMSSNILTDSVFRCLP--PRVKVLDLHNNRIT-TIPENVTSLEAL 474
Cdd:PLN00113  448 KWDMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGslSELMQLKLSENKLSgEIPDELSSCKKL 525

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1886726958 475 QELNVASNSLA-HLP-GCGTFSSLSVLIIDYNSIS 507
Cdd:PLN00113  526 VSLDLSHNQLSgQIPaSFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
449-506 1.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1886726958 449 PRVKVLDLHNNRITTI-PENVTSLEALQELNVASNSLAHLPGcGTFS---SLSVLIIDYNSI 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 248-485 1.83e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 248 SRLSSLTLN--NIETTWNSFImmFQLVWhtsIEYFSILNVKLQGQLQvRDFYYPDTSLKALSIyqvVSNMF--SLSQSYI 323
Cdd:PLN00113   69 SRVVSIDLSgkNISGKISSAI--FRLPY---IQTINLSNNQLSGPIP-DDIFTTSSSLRYLNL---SNNNFtgSIPRGSI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 324 YKIFAnMKIQNFTVSGTqmvhmvCPSQMSPFLHL---DFSNNLLTDMVFNNCETLTRLETLSLQKNELkkLANIVHMTKE 400
Cdd:PLN00113  140 PNLET-LDLSNNMLSGE------IPNDIGSFSSLkvlDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL--VGQIPRELGQ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 401 MKSLKQLDISQNSLSyDENEGYCSWTISLLTLNMSSNILTDSVfrclPP------RVKVLDLHNNRIT-TIPENVTSLEA 473
Cdd:PLN00113  211 MKSLKWIYLGYNNLS-GEIPYEIGGLTSLNHLDLVYNNLTGPI----PSslgnlkNLQYLFLYQNKLSgPIPPSIFSLQK 285

                         250
                  ....*....|..
gi 1886726958 474 LQELNVASNSLA 485
Cdd:PLN00113  286 LISLDLSDNSLS 297
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-169 3.91e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958  54 LDISQNDISELRTSDILSLSKLRILRISHNRIQYLDMSVFKFNQELEYLDLSHNKL-----EKISCHPTvnLKHLDLSFN 128
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLsgqipASFSEMPV--LSQLDLSQN 557

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1886726958 129 AFDAlPICKEFGNMSQLEFLGLSATQLQKSKVLSIAHLHIN 169
Cdd:PLN00113  558 QLSG-EIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAIN 597
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 356-415 4.78e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886726958 356 HLDFSNNLLTDMvfNNCETLTRLETLSLQKNELKKLANIVHMTKEMKSLKQLDISQNSLS 415
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
428-484 5.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1886726958 428 SLLTLNMSSNILT---DSVFRCLPpRVKVLDLHNNRITTIPENV-TSLEALQELNVASNSL 484
Cdd:pfam13855   2 NLRSLDLSNNRLTsldDGAFKGLS-NLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-107 6.68e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1886726958  52 TILDISQNDISELrtSDILSLSKLRILRISHNRIQYLD---MSVFKFNQeLEYLDLSHN 107
Cdd:cd21340   123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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