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Conserved domains on  [gi|1886413237|gb|QMV34968|]
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core/precore [Equine hepatitis B virus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hepatitis_core super family cl03011
Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus ...
 30-172 7.65e-48

Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA. There is some experimental evidence to support this.


The actual alignment was detected with superfamily member pfam00906:

Pssm-ID: 279277  Cd Length: 273  Bit Score: 158.28  E-value: 7.65e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237  30 DIDPYKEFGASSQLISFLPTDFFPQLNDLLDTVVALFEEELVGKEHCSPH--HTALRVLINCWEEATRMAAWVRQNVEG- 106
Cdd:pfam00906   1 DIDASKAFAASVDLLSFLPDDFFPKIDDLLDDASALYKDALESPEHCSPHwkHDAIKKAILCAGEFMDLAEDFWQTTQGm 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237 107 --------------------------------------QVMQDAIVGY-------------------VNATVGLRVRQQM 129
Cdd:pfam00906  81 heiaenlravippttapvptgyliqheeaeedplgdlfKAQEELIVSFqpdypitarihahlkayakINEEMGDKARQLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1886413237 130 WFHLSCLTFGHSTVLEFLVSFGTWIRTPAAYRPPNAPILS--TLP 172
Cdd:pfam00906 161 WFHINCLLFGEANVLEYISRFGTWIRTPEAYRGPDAPIIEaiTLP 205
Hep_core_N super family cl07049
Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of ...
 1-26 1.76e-03

Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of some hepatitis core proteins. Its conservation of four cys and his suggests a zinc binding domain.


The actual alignment was detected with superfamily member pfam08290:

Pssm-ID: 429902  Cd Length: 27  Bit Score: 35.03  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 1886413237   1 MHLFHLCLIF-CSIPTFQASELCLQWL 26
Cdd:pfam08290   1 MQLFPLCLIIsCSCPTVQASKLCLGWL 27
 
Name Accession Description Interval E-value
Hepatitis_core pfam00906
Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus ...
 30-172 7.65e-48

Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA. There is some experimental evidence to support this.


Pssm-ID: 279277  Cd Length: 273  Bit Score: 158.28  E-value: 7.65e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237  30 DIDPYKEFGASSQLISFLPTDFFPQLNDLLDTVVALFEEELVGKEHCSPH--HTALRVLINCWEEATRMAAWVRQNVEG- 106
Cdd:pfam00906   1 DIDASKAFAASVDLLSFLPDDFFPKIDDLLDDASALYKDALESPEHCSPHwkHDAIKKAILCAGEFMDLAEDFWQTTQGm 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237 107 --------------------------------------QVMQDAIVGY-------------------VNATVGLRVRQQM 129
Cdd:pfam00906  81 heiaenlravippttapvptgyliqheeaeedplgdlfKAQEELIVSFqpdypitarihahlkayakINEEMGDKARQLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1886413237 130 WFHLSCLTFGHSTVLEFLVSFGTWIRTPAAYRPPNAPILS--TLP 172
Cdd:pfam00906 161 WFHINCLLFGEANVLEYISRFGTWIRTPEAYRGPDAPIIEaiTLP 205
Hep_core_N pfam08290
Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of ...
 1-26 1.76e-03

Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of some hepatitis core proteins. Its conservation of four cys and his suggests a zinc binding domain.


Pssm-ID: 429902  Cd Length: 27  Bit Score: 35.03  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 1886413237   1 MHLFHLCLIF-CSIPTFQASELCLQWL 26
Cdd:pfam08290   1 MQLFPLCLIIsCSCPTVQASKLCLGWL 27
 
Name Accession Description Interval E-value
Hepatitis_core pfam00906
Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus ...
 30-172 7.65e-48

Hepatitis core antigen; The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA. There is some experimental evidence to support this.


Pssm-ID: 279277  Cd Length: 273  Bit Score: 158.28  E-value: 7.65e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237  30 DIDPYKEFGASSQLISFLPTDFFPQLNDLLDTVVALFEEELVGKEHCSPH--HTALRVLINCWEEATRMAAWVRQNVEG- 106
Cdd:pfam00906   1 DIDASKAFAASVDLLSFLPDDFFPKIDDLLDDASALYKDALESPEHCSPHwkHDAIKKAILCAGEFMDLAEDFWQTTQGm 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886413237 107 --------------------------------------QVMQDAIVGY-------------------VNATVGLRVRQQM 129
Cdd:pfam00906  81 heiaenlravippttapvptgyliqheeaeedplgdlfKAQEELIVSFqpdypitarihahlkayakINEEMGDKARQLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1886413237 130 WFHLSCLTFGHSTVLEFLVSFGTWIRTPAAYRPPNAPILS--TLP 172
Cdd:pfam00906 161 WFHINCLLFGEANVLEYISRFGTWIRTPEAYRGPDAPIIEaiTLP 205
Hep_core_N pfam08290
Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of ...
 1-26 1.76e-03

Hepatitis core protein, putative zinc finger; This short region is found at the N-terminus of some hepatitis core proteins. Its conservation of four cys and his suggests a zinc binding domain.


Pssm-ID: 429902  Cd Length: 27  Bit Score: 35.03  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 1886413237   1 MHLFHLCLIF-CSIPTFQASELCLQWL 26
Cdd:pfam08290   1 MQLFPLCLIIsCSCPTVQASKLCLGWL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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