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Conserved domains on  [gi|188502483|gb|ACD55325|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Scaptodrosophila latifasciaeformis]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-206 6.71e-57

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00163:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 445  Bit Score: 185.74  E-value: 6.71e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLLMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSSVD 80
Cdd:MTH00163   1 MLKFLFMLLFLIPLCFLKNSWWLVQSLLFLLSFLFMLLFSLSFYFSNISYFFGLDLLSFGLILLSFWICMLMILSSESVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  81 KYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFY 160
Cdd:MTH00163  81 KKNNYSNLFLFLILFLLIFLLLTFSSMNLLLFYIFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLFASLPLLVGIFY 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 188502483 161 LMYSTGTMNFYLMNNYLFNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00163 161 LYNNSGSLSFFLLNFFGSLNFLWYLSMILAFLVKMPMFFVHLWLPK 206
 
Name Accession Description Interval E-value
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-206 6.71e-57

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 185.74  E-value: 6.71e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLLMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSSVD 80
Cdd:MTH00163   1 MLKFLFMLLFLIPLCFLKNSWWLVQSLLFLLSFLFMLLFSLSFYFSNISYFFGLDLLSFGLILLSFWICMLMILSSESVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  81 KYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFY 160
Cdd:MTH00163  81 KKNNYSNLFLFLILFLLIFLLLTFSSMNLLLFYIFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLFASLPLLVGIFY 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 188502483 161 LMYSTGTMNFYLMNNYLFNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00163 161 LYNNSGSLSFFLLNFFGSLNFLWYLSMILAFLVKMPMFFVHLWLPK 206
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 48-205 1.10e-21

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 91.68  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSfkNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:COG1008   74 ISYHLGVDGISLPLVLLTALLTPLAILASWNEIKKRP--KLYYALLLLLEAGMIGVFLALDLFLFYVFWELMLIPMYFLI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 128 LGWGYqPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYL--MNNYLFNYE---LLYLCMIFAFLVKMPMFLVHL 202
Cdd:COG1008  152 GIWGG-ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTFDIaeLAAAPLPLTaqlLLFLAFFIAFAVKVPMFPFHT 230


                 ...
gi 188502483 203 WLP 205
Cdd:COG1008  231 WLP 233
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 48-206 3.40e-16

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 76.13  E-value: 3.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSfkNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:TIGR01972  69 ISYHLGVDGISLLLVLLTALLTLLAILASWESIQKRV--KEFYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLI 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  128 LGWGyQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTM----NFYLMNNYLFNYELLYLCMIFAFLVKMPMFLVHLW 203
Cdd:TIGR01972 147 GVWG-GPNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGGTfdllELLNLPLPFGVQTWLFLAFFIAFAVKVPLFPLHTW 225


                  ...
gi 188502483  204 LPK 206
Cdd:TIGR01972 226 LPD 228
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 106-206 8.92e-15

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 70.81  E-value: 8.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  106 SMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYE---- 181
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLnssg 80

                          90       100
                  ....*....|....*....|....*..
gi 188502483  182 --LLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:pfam00361  81 llLLFLLILVGFLFKSAQVPFHTWLPD 107
 
Name Accession Description Interval E-value
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-206 6.71e-57

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 185.74  E-value: 6.71e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLLMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSSVD 80
Cdd:MTH00163   1 MLKFLFMLLFLIPLCFLKNSWWLVQSLLFLLSFLFMLLFSLSFYFSNISYFFGLDLLSFGLILLSFWICMLMILSSESVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  81 KYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFY 160
Cdd:MTH00163  81 KKNNYSNLFLFLILFLLIFLLLTFSSMNLLLFYIFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLFASLPLLVGIFY 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 188502483 161 LMYSTGTMNFYLMNNYLFNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00163 161 LYNNSGSLSFFLLNFFGSLNFLWYLSMILAFLVKMPMFFVHLWLPK 206
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 36-206 1.33e-36

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 131.89  E-value: 1.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  36 LLMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLF 115
Cdd:MTH00150   4 LLLYSSFSSYESLSELFSVDSMSSLLISLSLWISGLMMLASQKSVKLRNKSSSFSLLVLLLCLILVLAFSVSSLLMFYFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 116 FESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLM---NNYLFNYELLYLCMIFAFL 192
Cdd:MTH00150  84 FEASLIPTLLLILGWGYQPERLQAGMYMMLYTVGASLPLLLVILWMSSSYGSSFMLLIsslRKLLSSMGLWGLLVFLAFL 163

                        170
                 ....*....|....
gi 188502483 193 VKMPMFLVHLWLPK 206
Cdd:MTH00150 164 VKLPMYPFHLWLPK 177
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-206 1.14e-35

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 129.86  E-value: 1.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQI---MLFFVSFIYLLMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASS 77
Cdd:MTH00014   1 MLKLIMPLISLLLLPLIKYPWSWALTfstLLLLSLFTLLNLYPMSAPYSMFTESLSSDMLSAPLITLTLWITALMILASF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  78 SVDKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIG 157
Cdd:MTH00014  81 KIFQNNKAPKTFMTNILILNLILLLTFSASNLLMFYIFFEASLIPTLFLILGWGYQPERLQASFYLMIYTVTASLPLLMS 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 188502483 158 IFYLMYSTGTMNFYLMNNY---LFNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00014 161 ILLIFYTNNSLSMLMSSMEppsIYLMNLWWLITILAFMVKMPLYTVHLWLPK 212
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 2-206 1.34e-34

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 127.02  E-value: 1.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   2 MKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLLMN--NCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSSV 79
Cdd:MTH00205   1 MSIFGVFSLLIILFVLKFKDWSFFSNLLLIGLFFSSFFfsNSFLMTSFISSSFSFDSLSLPLIMLSFWISLLMVLASYKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  80 DKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIF 159
Cdd:MTH00205  81 FKSNKNSKLFTVSVIMLLLILILSFSVDNLLLFYITFEASLIPTLILILGWGYQPERLQASMYMMMYTLCASLPLLIGLF 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 188502483 160 YLMYSTGTMNFYLMNNYLFNYELLYL---CMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00205 161 FLNSLNFSLSMFFNFPLNFSDFYLFLywiFLMLAFLVKLPMYFVHLWLPK 210
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-206 3.41e-33

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 123.55  E-value: 3.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYL----LMNNCWN-FWSEISYFLGFDMLSYGLILLSFWICSLMILA 75
Cdd:MTH00044   1 MITLILLSLGIAITSWIVPKNKLWPISISQSSLISLlslfLLNNHWSsSWHNLSLSLATDSLSSPLIILSCWLAPLSLLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  76 SSSVDKYNSFKN--LFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLP 153
Cdd:MTH00044  81 SINHLSNNSPNNqrTFISLIIIILTALIITFSSLELILFYIAFETTLIPTLILITRWGAQKERIQAGLYFLFYTLFGSLP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 188502483 154 MLIGIFYLMYSTGTMNFYLMN------NYLFNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00044 161 LLISLIAIYSSSSSLSIPLSElnwltsLSSNSSSIWWIFCILAFLVKMPIYGFHLWLPK 219
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-206 2.22e-32

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 121.07  E-value: 2.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLL----MNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILAS 76
Cdd:MTH00124   1 MLKIILPTIMLIPTTLLSKPKFLWTNTTTYSLLIALLslqwLKPPYYPTKNLTQWLGIDQISAPLLVLSCWLLPLMILAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  77 SSVDKYN--SFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPM 154
Cdd:MTH00124  81 QNHLQHEplQRKRTFLTTLILLQTFLILAFSATELTLFYIMFEATLIPTLILITRWGNQPERLSAGTYFLFYTLISSLPL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 188502483 155 LIGIFYLMYSTGTMNFYLM---NNYLFNY---ELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00124 161 LIAILYLHNQTGTLSLPMLqltHPTLTNSwtnLLLWLACLMAFMVKMPLYGLHLWLPK 218
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-206 1.31e-31

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 119.23  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFM--NNMYWM------VQIMLFFVSFIYLLMNNCWNFwsEISYFLgfDMLSYGLILLSFWICSLM 72
Cdd:MTH00110   1 MLKIIIPTIMLIPLTWLskNNMIWIntttysLLISLISLLLLNQPNDNSLNF--SLLFFS--DSLSTPLLILTTWLLPLM 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  73 ILASSSVDKYNSF--KNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLV 150
Cdd:MTH00110  77 LMASQHHLSKEPLtrKKLYITMLILLQLFLIMTFTATELIMFYILFEATLIPTLIIITRWGNQTERLNAGLYFLFYTLVG 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188502483 151 SLPMLIGIFYLMYSTGTMNFYLMNNYLFNYE------LLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00110 157 SLPLLVALLYIQNNLGSLNFLLLQLWAQPLPnswsnnLLWLACMMAFMVKMPLYGLHLWLPK 218
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-206 2.93e-30

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 115.40  E-value: 2.93e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIML---FFVSFIYLLM-NNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILAS 76
Cdd:MTH00068   1 MLKIIIPTLMLLPTTWLSPKKWLWTLTTtnsLIIAFLSLMWfNLPSETMNFTNKYFGIDQISSPLLILTCWLLPLMILAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  77 SSVDKYN--SFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPM 154
Cdd:MTH00068  81 QNHLKNEpiNRQRTYISMLIILQLTLILAFSATELILFYIFFEATLIPTLIIITRWGNQEERLNAGTYFLFYTLAGSLPL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 188502483 155 LIGIFYLMYSTGTMNFYLMNNYLFNYELLYLCMIF------AFLVKMPMFLVHLWLPK 206
Cdd:MTH00068 161 LIALLILQNSLGSLSLILLELMSPMQLMTYTNKIWwlacllAFMVKMPLYGLHLWLPK 218
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-206 5.70e-27

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 106.18  E-value: 5.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYLL--MNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILASSS 78
Cdd:MTH00206   2 ILIPLIMLLLMTILSKKKWLWRSTTFFSFLIALLFLLwfKWSSEVGWSFSNLYLSYDPLSSPLVILSCWLLPLMFLASQN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  79 VDKYNSFKN--LFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLI 156
Cdd:MTH00206  82 HMKNEPINRqrIYITLLIVLQLFLILFFSSSNLLLFYILFEASLIPTLLLITRWGNQKERLNAGYYFLFYTLIGSLPLLI 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 188502483 157 GIFYLMYSTGTMNFYLMNNYL---FNYELLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00206 162 ALLFLQNSLGSLSLYILYFSKlttWNNNLWWLACILAFLVKLPLYGVHLWLPK 214
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-206 1.37e-26

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 105.42  E-value: 1.37e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   1 MMKIILFVLFMAPMCFMNNMYWMVQIMLFFVSFIYL-----LMNNCWNFWSEISYFLGFDMLSYGLILLSFWICSLMILA 75
Cdd:MTH00127   1 MLKILIPTLMLIPTTWLTPAKWLWTTTLAHSLLIALasltwLKNLSETGWSSLNLYMATDPLSTPLLVLTCWLLPLMILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  76 SSS--VDKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLP 153
Cdd:MTH00127  81 SQNhtAPEPINRQRMYITLLTSLQIFLILAFGATEIIMFYVMFEATLIPTLIIITRWGNQTERLNAGTYFLFYTLAGSLP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 188502483 154 MLIGIFYLMYSTGTMNFYLMNNYLFNYELLYLCMIF------AFLVKMPMFLVHLWLPK 206
Cdd:MTH00127 161 LLVALLLLQNSTGTLSMLTLQYSQPLQLSSWADKLWwagcllAFLVKMPLYGVHLWLPK 219
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 48-205 1.10e-21

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 91.68  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSfkNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:COG1008   74 ISYHLGVDGISLPLVLLTALLTPLAILASWNEIKKRP--KLYYALLLLLEAGMIGVFLALDLFLFYVFWELMLIPMYFLI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 128 LGWGYqPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYL--MNNYLFNYE---LLYLCMIFAFLVKMPMFLVHL 202
Cdd:COG1008  152 GIWGG-ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTFDIaeLAAAPLPLTaqlLLFLAFFIAFAVKVPMFPFHT 230


                 ...
gi 188502483 203 WLP 205
Cdd:COG1008  231 WLP 233
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 48-205 2.48e-20

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 87.95  E-value: 2.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNsfKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:PRK05846  74 ISYHLGVDGISLLLVVLTALLTPLAVLASWEEIKKR--VKFYMAALLWLEGGVIGVFAALDLLLFYVFFEAMLIPMYFLI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 128 LGWGYqPERLQAGIYLLFYTLLVSLPMLIGIFYLMY----STGTMNFYLMNNYLFNYE---LLYLCMIFAFLVKMPMFLV 200
Cdd:PRK05846 152 GVWGG-KNRIYAATKFFLYTLLGSLLMLVAIIYLVVvyynATGTFDIADLLNLPLPPGvqyWLFLAFFIAFAVKMPMFPL 230


                 ....*
gi 188502483 201 HLWLP 205
Cdd:PRK05846 231 HTWLP 235
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 48-206 3.40e-16

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 76.13  E-value: 3.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483   48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSfkNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:TIGR01972  69 ISYHLGVDGISLLLVLLTALLTLLAILASWESIQKRV--KEFYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLI 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  128 LGWGyQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTM----NFYLMNNYLFNYELLYLCMIFAFLVKMPMFLVHLW 203
Cdd:TIGR01972 147 GVWG-GPNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGGTfdllELLNLPLPFGVQTWLFLAFFIAFAVKVPLFPLHTW 225


                  ...
gi 188502483  204 LPK 206
Cdd:TIGR01972 226 LPD 228
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 106-206 8.92e-15

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 70.81  E-value: 8.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  106 SMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYE---- 181
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLnssg 80

                          90       100
                  ....*....|....*....|....*..
gi 188502483  182 --LLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:pfam00361  81 llLLFLLILVGFLFKSAQVPFHTWLPD 107
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 51-206 5.34e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 69.71  E-value: 5.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  51 FLGFDMLSYGLILLSFWICSLMILASSSVDKYnsFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGW 130
Cdd:MTH00204  78 VFAVDGVSLFFILLTTLLIPICILISWKSIKF--LFKEFLLCLLFLEVLLIGVFSVLDLLLFYILFEGILIPMFLLIGIW 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188502483 131 GYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYELLYLCMIFAFL---VKMPMFLVHLWLPK 206
Cdd:MTH00204 156 GSREEKVRASYYFFFYTFAGSVFMLLGIFQLYSITGTTDYQILLNIKLPLSIQKWLLVGFFLslaVKIPQIPFHIWLPQ 234
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 104-206 3.40e-13

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 67.38  E-value: 3.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 104 FSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYELL 183
Cdd:MTH00217 126 FTILDLVGFYILFEGILIPMFLIIGIWGSREEKVQASYYFFFYTFIGSVFMLLGIFTLYSYAGTTDYQALCCLKIEKELQ 205

                         90       100
                 ....*....|....*....|....*.
gi 188502483 184 YLCMIFAFL---VKMPMFLVHLWLPK 206
Cdd:MTH00217 206 YFIFLGFFLslaIKIPKIPFHIWLPQ 231
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 48-205 7.64e-13

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 66.21  E-value: 7.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYnsfKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:PRK12561  51 LEWSLGVDGLSMPLVLLSGLITTLSIFASWKVTRK---PRLFYFLMLVLYSAQIGVFLAQDLLLFFLMWELELVPVYLLI 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 128 LGWGYQpERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYL----MNNYLFNYELL-YLCMIFAFLVKMPMFLVHL 202
Cdd:PRK12561 128 SIWGGQ-KRLYAATKFILYTALASIFILVAGLALALSGDTFTFDLaelgAKSYPLALELLlYAGFLIAFGVKLPIFPLHT 206


                 ...
gi 188502483 203 WLP 205
Cdd:PRK12561 207 WLP 209
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 55-206 5.59e-12

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 63.79  E-value: 5.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  55 DMLSYGLILLSFWICSLMILASSSVDKYnsFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPtLFLILG-WGYQ 133
Cdd:MTH00226 101 DGISIYFIILTGFIVPCSILISWHSVKY--LTKSFLICMLILEFLLYAVFSVLDIFMFYILFEGVLIP-MYLILGiWGSR 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188502483 134 PERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLM--NNYLFNYEL---LYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00226 178 EEKMQAAYYFFFYTLIGSVLMLLCLFSLYNIHGTTDYLTLasCSHVVSEQTqkwIFLGIFLAMAVKIPIFPFHIWLPK 255
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 104-206 2.06e-11

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 104 FSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYstgtMNFYLMNNYLFNYELL 183
Cdd:MTH00094  79 FVSSNMLMLYMFFELSMFPILIMILGYGSQIEKINSSYYLLFYAAFFSFPFLFVYLKNFF----FFSLCYFDFFLSWEMF 154

                         90       100
                 ....*....|....*....|...
gi 188502483 184 YLcMIFAFLVKMPMFLVHLWLPK 206
Cdd:MTH00094 155 FI-LSLSFMMKFPVYFLHLWLPK 176
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 52-206 1.29e-10

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 59.78  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  52 LGFDMLSYGLILLSFWICSLMILASSSVDKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWG 131
Cdd:COG0651   72 LVADRLSALFLLLTALVALAVLLYSIGYMRHERRGRRFYPLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 132 YqPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYE-----LLYLCMIFAFLVKMPMFLVHLWLPK 206
Cdd:COG0651  152 T-KEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLAARLAELDpglllAAFALLLVGFGIKAALFPLHFWLPD 230
ND4 MTH00062
NADH dehydrogenase subunit 4; Provisional
 26-205 1.99e-10

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214413 [Multi-domain]  Cd Length: 417  Bit Score: 59.17  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  26 IMLFFVSFIYLLMNNCW--NFWSEISYFLGFDMLSYGLILLSfwicsLMILASSSVDKYNSFKNLFLINILMLLLLLVLT 103
Cdd:MTH00062  13 LLLLLFCLLYSSGVGCCilVVNNVFNGLFIFDSLSFYLILLV-----LFLGLYSQVMFYNLLSGVSRFFLFLSLIFSILC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 104 FSSMNLFMFYLFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYELL 183
Cdd:MTH00062  88 FCVNNSLLFWFFYELSIIPLLYLLFSESPYSERYLASWYFLGYLLLTSLPLLLCLLYLSLVNGSFNFSDWGSDDSVSLIV 167

                        170       180
                 ....*....|....*....|..
gi 188502483 184 YLCMIFAFLVKMPMFLVHLWLP 205
Cdd:MTH00062 168 YYVLSFMFITKVPLFPFHTWLP 189
Oxidored_q5_N pfam01059
NADH-ubiquinone oxidoreductase chain 4, amino terminus;
1-87 9.51e-10

NADH-ubiquinone oxidoreductase chain 4, amino terminus;


Pssm-ID: 366442 [Multi-domain]  Cd Length: 110  Bit Score: 54.07  E-value: 9.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483    1 MMKIILFVLFMAPMCFMNNMYW------MVQIMLFFVSFIYLLMNNcWNFWSEISYFLGFDMLSYGLILLSFWICSLMIL 74
Cdd:pfam01059   1 MLKILLPTLMLIPLTFLSKPKWlwttstLYSLLLALLSLLLLNNPS-NFSWSNLSYFLGIDSLSYPLIILSCWLLPLMIL 79

                          90
                  ....*....|...
gi 188502483   75 ASSSVDKYNSFKN 87
Cdd:pfam01059  80 ASQKHLKSEPNNR 92
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 52-205 2.07e-09

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 56.25  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  52 LGFDMLSYGLILLSFWICSLMILASSSVdkynSFK-NLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGW 130
Cdd:PRK02546  83 VGADGLSMPLILLTGFITTLAVLAAWPV----TFKpKLFYFLMLAMYGGQIAVFAVQDMLLFFLAWELELIPVYLLLAIW 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 131 GYQpERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMN----NYLFNYELL-YLCMIFAFLVKMPMFLVHLWLP 205
Cdd:PRK02546 159 GGK-KRQYAATKFILYTAGSSLFILLAALAMAFYGDTPTFDMTAlaakDFGLGFQLLcYAGLLIAYGVKLPIVPLHTWLP 237
ndhD CHL00011
NADH dehydrogenase subunit 4
 52-205 5.14e-09

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 54.95  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  52 LGFDMLSYGLILLSFWICSLMILASSSVDKyNSfkNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLILGWG 131
Cdd:CHL00011  80 LGIDGLSIGPILLTGFITTLATLAAWPVTR-NS--RLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWG 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 132 YQpERLQAGIYLLFYTLLVSLPMLIGIFylmystgTMNFYLMNNYLFNYE-------------LLYLCMIFAFLVKMPMF 198
Cdd:CHL00011 157 GK-KRLYSATKFILYTAGGSIFLLIGVL-------GMGLYGSNEPTLNFEtlanqsypvaleiLFYIGFLIAYAVKLPII 228


                 ....*..
gi 188502483 199 LVHLWLP 205
Cdd:CHL00011 229 PLHTWLP 235
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
48-205 4.08e-08

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 52.39  E-value: 4.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  48 ISYFLGFDMLSYGLILLSFWICSLMILASSSVDKYNSFknlFLINILMLLLLLVLTFSSMNLFMFYLFFESSLIPTLFLI 127
Cdd:PRK06473  71 LSYHLGVDGLSLPLLVLNSLLTLIAIYSSDESIQRPRF---YYSLLLLLNAGVSGAFLAQDLLLFFLFYELELIPLYLLI 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 128 LGWGYQpERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNF----YLMNNYLFNYELLYLCMIF-AFLVKMPMFLVHL 202
Cdd:PRK06473 148 AIWGGQ-RRGYAATKFLLYTAISGILILVSFLGLVWLSGASSFdyepLRSHTLPLSTQLLLLAPILvGFGIKIPLVPFHT 226


                 ...
gi 188502483 203 WLP 205
Cdd:PRK06473 227 WLP 229
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
42-205 4.32e-07

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 49.33  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  42 WNFWSEISYFLGFDMLSYGLILLSfwiCSLMILASSSVDKYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFESSLI 121
Cdd:PRK07363  65 WNEPLGLSYSLGVDGLSLPLLVLN---SLLTWIAIYSIGENTERPRLYYSLILLINGGIAGALLAQNLLLFFLFYELELI 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 122 PTLFLILGWGYQpERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMN----NYLFNYELLYLCMIF-AFLVKMP 196
Cdd:PRK07363 142 PFYLLIAIWGGE-KRGYASIKFLIYTAVSGLLVLAAFLGIVWLSGSTSFDYDAistqNLSLNTQLILLTGLLlGFGIKIP 220


                 ....*....
gi 188502483 197 MFLVHLWLP 205
Cdd:PRK07363 221 LVPLHTWLP 229
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 104-205 8.86e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 42.56  E-value: 8.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 104 FSSMNLFMFYLFFESSLIPTLFLIlGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYELL 183
Cdd:PRK08375 123 LLTADLFNLFVFLEIMSLSSYALV-AMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMADLAGALAENPTV 201

                         90       100
                 ....*....|....*....|....*
gi 188502483 184 YLCMIFAFL---VKMPMFLVHLWLP 205
Cdd:PRK08375 202 VTAFGFVLLalaLKAAVFPLHTWLP 226
PRK12665 PRK12665
putative monovalent cation/H+ antiporter subunit D; Reviewed
 103-205 1.95e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237165 [Multi-domain]  Cd Length: 521  Bit Score: 41.49  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 103 TFSSMNLFMFYLFFESSLIPTlFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYE- 181
Cdd:PRK12665 127 AFLAGDLFNLYVGFEILLVAS-YVLLTLGATAARVRAGVTYVMVSMVSSLLFLIGIALVYAATGTLNMADLAVRLDELPs 205

                         90       100
                 ....*....|....*....|....*...
gi 188502483 182 ----LLYLCMIFAFLVKMPMFLVHLWLP 205
Cdd:PRK12665 206 gtrtALFAVLLVAFGIKAAVFPLSFWLP 233
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 42-205 8.49e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 39.71  E-value: 8.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483  42 WNFWSEISYFLGFDMLSYG-LILLSFWICSLMILASSSVD--KYNSFKNLFLINILMLLLLLVLTFSSMNLFMFYLFFES 118
Cdd:PRK08667  63 WGIAPGLDITFHIDRLAAFfIILIGLVSLCVAIYSLGYNEhmSSNERANLLSALTALFILSMLGVVASANTFSFLFFWEI 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188502483 119 SLIPTLFLILGWGYQPERLQAGIYLLFYTLLVSLPMLIGIFYLMYSTGTMNFYLMNNYLFNYELLYLCMIFAFLVKMPMF 198
Cdd:PRK08667 143 MALSSFFLVMNDYQEEETQRAGIFYFVMTQLSTVFLMLGIIVLFIQTGSFELSPLGASAGILSLVFLLLFLGFGIKAGII 222


                 ....*..
gi 188502483 199 LVHLWLP 205
Cdd:PRK08667 223 PFHKWLP 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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