DENN domain-containing protein 4C isoform 12 [Homo sapiens]
Protein Classification
DENN domain-containing protein( domain architecture ID 10655419)
DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
57-130 | 4.89e-21 | ||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. : Pssm-ID: 129037 Cd Length: 69 Bit Score: 88.12 E-value: 4.89e-21
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| Name | Accession | Description | Interval | E-value | ||
| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
57-130 | 4.89e-21 | ||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 88.12 E-value: 4.89e-21
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| dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
97-146 | 1.84e-13 | ||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 65.68 E-value: 1.84e-13
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| Name | Accession | Description | Interval | E-value | ||
| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
57-130 | 4.89e-21 | ||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 88.12 E-value: 4.89e-21
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| dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
97-146 | 1.84e-13 | ||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 65.68 E-value: 1.84e-13
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