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Conserved domains on  [gi|1884012929|gb|KAF6087204|]
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zinc finger protein 775 [Phyllostomus discolor]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-531 6.49e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 310 RPYPCPECGRRFSQKPNLTRHLRNHTGERPHPCPHCGRSFRQK--QHLLKHQRTHLPGAQAarcPTCGQSCPSRAALRAH 387
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD---LNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 388 QRAHDGTTTA-QLLSPGSTVPGKEPRAQVtagrsTPPCSSPAARGSRDVRWGGARVDLSGSGEQRPFICSEC-GKSFSWW 465
Cdd:COG5048   109 SLSSSSSNSNdNNLLSSHSLPPSSRDPQL-----PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSlSKDPSSN 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1884012929 466 SALTIHQRIHTGERPYPCPECGRRFSQKPNLTRHRRNHTGERPYLCAACgrGFSQKQHLLKHQRVH 531
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSS 247
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-144 1.09e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 119 SLKIHQRTHTGEKPYLCGKCGKSFSQ 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
105-186 1.08e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 105 FVCLDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLARHQQQHLGARPFCCP--ECARRFSQKQHL 176
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                          90
                  ....*....|
gi 1884012929 177 LKHQKTHSRP 186
Cdd:COG5048   370 EPPQSLQQYK 379
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-531 6.49e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 310 RPYPCPECGRRFSQKPNLTRHLRNHTGERPHPCPHCGRSFRQK--QHLLKHQRTHLPGAQAarcPTCGQSCPSRAALRAH 387
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD---LNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 388 QRAHDGTTTA-QLLSPGSTVPGKEPRAQVtagrsTPPCSSPAARGSRDVRWGGARVDLSGSGEQRPFICSEC-GKSFSWW 465
Cdd:COG5048   109 SLSSSSSNSNdNNLLSSHSLPPSSRDPQL-----PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSlSKDPSSN 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1884012929 466 SALTIHQRIHTGERPYPCPECGRRFSQKPNLTRHRRNHTGERPYLCAACgrGFSQKQHLLKHQRVH 531
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSS 247
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-351 1.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.44e-05
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 326 NLTRHLRNHTGERPHPCPHCGRSFRQ 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-144 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 119 SLKIHQRTHTGEKPYLCGKCGKSFSQ 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-186 1.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 105 FVCLDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLARHQQQHLGARPFCCP--ECARRFSQKQHL 176
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                          90
                  ....*....|
gi 1884012929 177 LKHQKTHSRP 186
Cdd:COG5048   370 EPPQSLQQYK 379
PHA00733 PHA00733
hypothetical protein
 311-358 2.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1884012929 311 PYPCPECGRRFSQKPNLTRHLRnhTGERPHPCPHCGRSFRQKQHLLKH 358
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 451-499 6.74e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1884012929 451 RPFiCSECGKSFSWWSALTIHQRIHTgerpYPCPECGRRFSQKPNLTRH 499
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
cxxc_20_cxxc TIGR04104
cxxc_20_cxxc protein; This small, uncommon, poorly conserved protein is found primarily in the ...
 454-487 7.53e-03

cxxc_20_cxxc protein; This small, uncommon, poorly conserved protein is found primarily in the Firmicutes. It features are pair of CxxC motifs separated by about 20 amino acids, followed by a highly hydrophobic region of about 45 amino acids. It has no conserved gene neighborhood, and its function is unknown.


Pssm-ID: 274982  Cd Length: 94  Bit Score: 36.19  E-value: 7.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1884012929 454 ICSECGKSFSWWSALTihqRIHTGERPYPCPECG 487
Cdd:TIGR04104   2 ICKNCNEKFSYKELLK---SLWFLYRPIKCPNCG 32
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-531 6.49e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 310 RPYPCPECGRRFSQKPNLTRHLRNHTGERPHPCPHCGRSFRQK--QHLLKHQRTHLPGAQAarcPTCGQSCPSRAALRAH 387
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD---LNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 388 QRAHDGTTTA-QLLSPGSTVPGKEPRAQVtagrsTPPCSSPAARGSRDVRWGGARVDLSGSGEQRPFICSEC-GKSFSWW 465
Cdd:COG5048   109 SLSSSSSNSNdNNLLSSHSLPPSSRDPQL-----PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSlSKDPSSN 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1884012929 466 SALTIHQRIHTGERPYPCPECGRRFSQKPNLTRHRRNHTGERPYLCAACgrGFSQKQHLLKHQRVH 531
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSS 247
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-522 4.08e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 281 QRQFICSECGKSFTWWSSLNIHRRIHTGERPYPCPECGR--RFSQKPNLTRHLRNHTGERPHPCPHCGRSFRQK------ 352
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 353 --------------QHLLKHQ-----------RTHLPGAQAARCPTCGQSCPSRAALRA-------------------HQ 388
Cdd:COG5048   111 sssssnsndnnllsSHSLPPSsrdpqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnlslliSS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 389 RAHDGTTTAQLLSPGS----------------------------TVPGKEPRAQVTAGRSTPPCSSPAARGSR---DVRW 437
Cdd:COG5048   191 NVSTSIPSSSENSPLSssysipssssdqnlensssslplttnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSslpTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 438 GGARVDLSGSGEQR----PFICSECGKSFSWWSALTIHQR--IHTGE--RPYPCPE--CGRRFSQKPNLTRHRRNHTGER 507
Cdd:COG5048   271 QSSSPNESDSSSEKgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330
                  ....*....|....*
gi 1884012929 508 PYLCAACGRGFSQKQ 522
Cdd:COG5048   351 PAKEKLLNSSSKFSP 365
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-533 4.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 291 KSFTWWSSLNIHRRIHTGERPYPCPECGRRFSQKPNLTRHLRNHTGERPHPCPHCgrSFRQKQHLLKHQRTHL-PGAQAA 369
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLsSSDSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 370 RCPTCGQSC-PSRAALRAHQRAHDGTTTAQLLSPGSTVPGKEPRAQvtagrstppcSSPAARGSRDVrwggarvdLSGSG 448
Cdd:COG5048   256 SASESPRSSlPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSR----------SSPLTRHLRSV--------NHSGE 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 449 EQRPFICSE--CGKSFSWWSALTIHQRIHTGERPYPCPECGRRFSQKPNLT-------RHRRNHTGERPYLCA--ACGRG 517
Cdd:COG5048   318 SLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETLsnSCIRN 397

                         250
                  ....*....|....*.
gi 1884012929 518 FSQKQHLLKHQRVHRG 533
Cdd:COG5048   398 FKRDSNLSLHIITHLS 413
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-351 1.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.44e-05
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 326 NLTRHLRNHTGERPHPCPHCGRSFRQ 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
479-536 6.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1884012929 479 RPYPCPECGRRFSQKPNLTRHRRNHTGERPYLCAACGRGFSQ------KQHLLKHQRVHRGTLA 536
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-323 9.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.16e-05
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 298 SLNIHRRIHTGERPYPCPECGRRFSQ 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 9.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.53e-05
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 467 ALTIHQRIHTGERPYPCPECGRRFSQ 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-144 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 1884012929 119 SLKIHQRTHTGEKPYLCGKCGKSFSQ 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
447-516 1.40e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1884012929 447 SGEQRPFICSECGKSFSWWSALTIHQRIHTGERPYPCPECGR--RFSQKPNLTRHRRNHTGERPYLCAACGR 516
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-362 1.68e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.68e-04
                          10        20
                  ....*....|....*....|...
gi 1884012929 340 HPCPHCGRSFRQKQHLLKHQRTH 362
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 312-334 5.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 5.40e-04
                          10        20
                  ....*....|....*....|...
gi 1884012929 312 YPCPECGRRFSQKPNLTRHLRNH 334
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 481-503 6.97e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.97e-04
                          10        20
                  ....*....|....*....|...
gi 1884012929 481 YPCPECGRRFSQKPNLTRHRRNH 503
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-186 1.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1884012929 105 FVCLDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLARHQQQHLGARPFCCP--ECARRFSQKQHL 176
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                          90
                  ....*....|
gi 1884012929 177 LKHQKTHSRP 186
Cdd:COG5048   370 EPPQSLQQYK 379
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-195 1.10e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1884012929 131 KPYLCGKCGKSFSQKPNLARHQQQHL----GARPFCCPE--CARRFSQKQHLLKHQKTH--SRPAATYSCPEC 195
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHtsISPAKEKLLNSS 360
PHA00733 PHA00733
hypothetical protein
 311-358 2.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1884012929 311 PYPCPECGRRFSQKPNLTRHLRnhTGERPHPCPHCGRSFRQKQHLLKH 358
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 451-499 6.74e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1884012929 451 RPFiCSECGKSFSWWSALTIHQRIHTgerpYPCPECGRRFSQKPNLTRH 499
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
cxxc_20_cxxc TIGR04104
cxxc_20_cxxc protein; This small, uncommon, poorly conserved protein is found primarily in the ...
 454-487 7.53e-03

cxxc_20_cxxc protein; This small, uncommon, poorly conserved protein is found primarily in the Firmicutes. It features are pair of CxxC motifs separated by about 20 amino acids, followed by a highly hydrophobic region of about 45 amino acids. It has no conserved gene neighborhood, and its function is unknown.


Pssm-ID: 274982  Cd Length: 94  Bit Score: 36.19  E-value: 7.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1884012929 454 ICSECGKSFSWWSALTihqRIHTGERPYPCPECG 487
Cdd:TIGR04104   2 ICKNCNEKFSYKELLK---SLWFLYRPIKCPNCG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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