NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1883779905|gb|QMT14876|]
View 

toll-like receptor 4, partial [Poecile lugubris]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 6.08e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 6.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRITKNKrLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 142 IDLSENRLTFSSccsPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTLfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779905 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 6.08e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 6.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRITKNKrLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 142 IDLSENRLTFSSccsPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTLfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779905 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
LRR_8 pfam13855
Leucine rich repeat;
114-173 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 3.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1883779905 114 ELRVLRITKNkRLKNFRQ-NFEGLTNLEVIDLSENRLTFSsccSPQ-FQNCPNLKYLNLSFN 173
Cdd:pfam13855   2 NLRSLDLSNN-RLTSLDDgAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 135-249 1.15e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 135 GLTNLEVIDLSENRLTFSSccsPQ--FQNCPNLKYLNLSFNSnirLTGDFAN--VKNLLYLDLQHTTLFG--PGSYPVFL 208
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGPI---PDdiFTTSSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGeiPNDIGSFS 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1883779905 209 SLQkliYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEG 249
Cdd:PLN00113  165 SLK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG 202
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-173 3.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 3.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883779905 105 PALKLSLFKELRVLRITKNkRLKNFRQnFEGLTNLEVIDLSENRLTFSSCCSPQFQNCPNLKYLNLSFN 173
Cdd:cd21340   112 PRSLAALSNSLRVLNISGN-NIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 6.08e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 6.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRITKNKrLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 142 IDLSENRLTFSSccsPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTLfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779905 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-261 9.08e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 9.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905  73 RLVNLGLEEISQVPARSKVKQLECKKCSFEDVPAlKLSLFKELRVLRITKNKrLKNFRQNFEGLTNLEVIDLSENRLTfs 152
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ-LTDLPEPLGNLTNLKSLDLSNNQLT-- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 153 sCCSPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTLfgpGSYPVFLS-LQKLIYLDISHTKteVKSQCTF 231
Cdd:COG4886   173 -DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL---TDLPEPLAnLTNLETLDLSNNQ--LTDLPEL 246

                         170       180       190
                  ....*....|....*....|....*....|
gi 1883779905 232 CGLNSLQVLKMAGNSFEGNKLASNFKNLSH 261
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPPLANLTNLKT 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-261 3.43e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905  61 TLFNCIGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRITKNKrLKNFRQNFEGL 136
Cdd:COG4886   127 DLPEELANLTNLKELDLSNNQLTDLPEPlgnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ-ITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 137 TNLEVIDLSENRLTFsscCSPQFQNCPNLKYLNLSFNsNIRLTGDFANVKNLLYLDLQHTTLfgpGSYPVFLSLQKLIYL 216
Cdd:COG4886   205 TNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNN-QLTDLPELGNLTNLEELDLSNNQL---TDLPPLANLTNLKTL 277

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1883779905 217 DISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEGNKLASNFKNLSH 261
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR_8 pfam13855
Leucine rich repeat;
114-173 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 3.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1883779905 114 ELRVLRITKNkRLKNFRQ-NFEGLTNLEVIDLSENRLTFSsccSPQ-FQNCPNLKYLNLSFN 173
Cdd:pfam13855   2 NLRSLDLSNN-RLTSLDDgAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-248 1.48e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 107 LKLSLFKELRVLRITKNKRLKNFRQNFEGLTNLEVIDLSENRltfssccspQFQNCPNLKYLNLSFNSNIRLTGDFANVK 186
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANLT 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1883779905 187 NLLYLDLQHTTLfgpGSYPVFLS-LQKLIYLDISHTK-TEVKSqcTFCGLNSLQVLKMAGNSFE 248
Cdd:COG4886   137 NLKELDLSNNQL---TDLPEPLGnLTNLKSLDLSNNQlTDLPE--ELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
137-196 1.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1883779905 137 TNLEVIDLSENRLTfsSCCSPQFQNCPNLKYLNLSFNSNIRLTGD-FANVKNLLYLDLQHT 196
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 135-249 1.15e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 135 GLTNLEVIDLSENRLTFSSccsPQ--FQNCPNLKYLNLSFNSnirLTGDFAN--VKNLLYLDLQHTTLFG--PGSYPVFL 208
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGPI---PDdiFTTSSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGeiPNDIGSFS 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1883779905 209 SLQkliYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEG 249
Cdd:PLN00113  165 SLK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG 202
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-184 1.48e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1883779905 137 TNLEVIDLSENRLTFSsccsPQFQNCPNLKYLNLSFNSNIRLTGDFAN 184
Cdd:pfam12799   1 PNLEVLDLSNNQITDI----PPLAKLPNLETLDLSGNNKITDLSDLAN 44
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-173 3.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 3.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883779905 105 PALKLSLFKELRVLRITKNkRLKNFRQnFEGLTNLEVIDLSENRLTFSSCCSPQFQNCPNLKYLNLSFN 173
Cdd:cd21340   112 PRSLAALSNSLRVLNISGN-NIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 109-249 4.22e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 109 LSLFKELRVLRITKNKRLKNFRQNFEGLTNLEVIDLSENRLT----------------------FSSCCSPQFQNCPNLK 166
Cdd:PLN00113  160 IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnLSGEIPYEIGGLTSLN 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779905 167 YLNLSFNSnirLTGD----FANVKNLLYLDLQHTTLFGPGSYPVFlSLQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKM 242
Cdd:PLN00113  240 HLDLVYNN---LTGPipssLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHL 315


                  ....*..
gi 1883779905 243 AGNSFEG 249
Cdd:PLN00113  316 FSNNFTG 322
LRR_8 pfam13855
Leucine rich repeat;
187-247 6.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1883779905 187 NLLYLDLQHTTL--FGPGSypvFLSLQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSF 247
Cdd:pfam13855   2 NLRSLDLSNNRLtsLDDGA---FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH