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Conserved domains on  [gi|187984902|gb|EDU50390|]
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WD domain containing protein [Pyrenophora tritici-repentis Pt-1C-BFP]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-659 1.51e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCaGSVDVFVSCGADGSVRMFDLRSLEH 537
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKC 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 538 STIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPHDSHLLAtfAADSNLIRILDVRQpGQALLELRGH 617
Cdd:cd00200  170 VATLTGHTG----------------------------EVNSVAFSPDGEKLLS--SSSDGTIKLWDLST-GKCLGTLRGH 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187984902 618 SAAVNSIEWNPSRRgMLASGGDDSLVLIWDLLHANNGATISG 659
Cdd:cd00200  219 ENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSG 259
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-659 1.51e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCaGSVDVFVSCGADGSVRMFDLRSLEH 537
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKC 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 538 STIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPHDSHLLAtfAADSNLIRILDVRQpGQALLELRGH 617
Cdd:cd00200  170 VATLTGHTG----------------------------EVNSVAFSPDGEKLLS--SSSDGTIKLWDLST-GKCLGTLRGH 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187984902 618 SAAVNSIEWNPSRRgMLASGGDDSLVLIWDLLHANNGATISG 659
Cdd:cd00200  219 ENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
458-648 1.34e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWntmSP--KLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCAGSvDVFVSCGADGSVRMFDL--- 532
Cdd:COG2319  161 HSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLatg 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 533 ---RSLEHST-----IIYEPSDK---GGDRDKG----SPTGGRMSPTKAQQTmsyaPPLLRLAASPhDSHLLATfAADSN 597
Cdd:COG2319  237 kllRTLTGHSgsvrsVAFSPDGRllaSGSADGTvrlwDLATGELLRTLTGHS----GGVNSVAFSP-DGKLLAS-GSDDG 310

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 187984902 598 LIRILDVrQPGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDL 648
Cdd:COG2319  311 TVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDL 359
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 607-647 3.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 187984902   607 PGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWD 647
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
608-647 3.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 187984902  608 GQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWD 647
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 571-648 4.60e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.95  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 571 SYAPPLLRLAASPHDSHLLATFAADSNlIRILDVRQPGQALLE-------LRGHSAAVNSIEWNPSRRGMLASGGDDSLV 643
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLT-IRVWEIPHNDESVKEikdpqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....*
gi 187984902 644 LIWDL 648
Cdd:PTZ00420 151 NIWDI 155
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-659 1.51e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCaGSVDVFVSCGADGSVRMFDLRSLEH 537
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKC 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 538 STIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPHDSHLLAtfAADSNLIRILDVRQpGQALLELRGH 617
Cdd:cd00200  170 VATLTGHTG----------------------------EVNSVAFSPDGEKLLS--SSSDGTIKLWDLST-GKCLGTLRGH 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187984902 618 SAAVNSIEWNPSRRgMLASGGDDSLVLIWDLLHANNGATISG 659
Cdd:cd00200  219 ENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-659 3.80e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCAGSvDVFVSCGADGSVRMFDLRSLE- 536
Cdd:cd00200    8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEc 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 537 ------H----STIIYEPSDK---GGDRDK-----GSPTGgrmsptKAQQTMSYAPPLLRLAASPHDSHLLATFAADsNL 598
Cdd:cd00200   86 vrtltgHtsyvSSVAFSPDGRilsSSSRDKtikvwDVETG------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQD-GT 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187984902 599 IRILDVRQpGQALLELRGHSAAVNSIEWNPSRRGMLASGGDDSlVLIWDLLHANNGATISG 659
Cdd:cd00200  159 IKLWDLRT-GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-647 2.80e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 2.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCAGSVDvFVSCGADGSVRMFDLRSLEH 537
Cdd:cd00200  134 HTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKC 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 538 STIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPHDshLLATFAADSNLIRILDVRqPGQALLELRGH 617
Cdd:cd00200  212 LGTLRGHEN----------------------------GVNSVAFSPDG--YLLASGSEDGTIRVWDLR-TGECVQTLSGH 260

                        170       180       190
                 ....*....|....*....|....*....|
gi 187984902 618 SAAVNSIEWNPSrRGMLASGGDDSLVLIWD 647
Cdd:cd00200  261 TNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
458-648 1.34e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWntmSP--KLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCAGSvDVFVSCGADGSVRMFDL--- 532
Cdd:COG2319  161 HSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLatg 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 533 ---RSLEHST-----IIYEPSDK---GGDRDKG----SPTGGRMSPTKAQQTmsyaPPLLRLAASPhDSHLLATfAADSN 597
Cdd:COG2319  237 kllRTLTGHSgsvrsVAFSPDGRllaSGSADGTvrlwDLATGELLRTLTGHS----GGVNSVAFSP-DGKLLAS-GSDDG 310

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 187984902 598 LIRILDVrQPGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDL 648
Cdd:COG2319  311 TVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
458-648 2.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 2.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWntmSP--KLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFcagSVD--VFVSCGADGSVRMFDLR 533
Cdd:COG2319  203 HTGAVRSVAF---SPdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTVRLWDLA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 534 SLEHSTIIYEPSDK--------------GGDRDKG----SPTGGRMSPTKAqqtmSYAPPLLRLAASPhDSHLLATfAAD 595
Cdd:COG2319  277 TGELLRTLTGHSGGvnsvafspdgkllaSGSDDGTvrlwDLATGKLLRTLT----GHTGAVRSVAFSP-DGKTLAS-GSD 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 187984902 596 SNLIRILDVRQpGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDL 648
Cdd:COG2319  351 DGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
456-648 2.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 2.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 456 PEHTAPLTSLDWNTmSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFcagSVD--VFVSCGADGSVRMFDLR 533
Cdd:COG2319   75 LGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 534 SLEHSTIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPhDSHLLATfAADSNLIRILDVRQpGQALLE 613
Cdd:COG2319  151 TGKLLRTLTGHSG----------------------------AVTSVAFSP-DGKLLAS-GSDDGTVRLWDLAT-GKLLRT 199

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 187984902 614 LRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDL 648
Cdd:COG2319  200 LTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
455-659 1.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 455 TPEHTAPLTSLDWNTMSPKLIITSSIDTTcTIWDIPSLTAKTQLIAHDKEVFDVRFcAGSVDVFVSCGADGSVRMFDLRS 534
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTL-LLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 535 LEHSTIIYEPSDkggdrdkgsptggrmsptkaqqtmsyapPLLRLAASPhDSHLLATfAADSNLIRILDVRQpGQALLEL 614
Cdd:COG2319  110 GLLLRTLTGHTG----------------------------AVRSVAFSP-DGKTLAS-GSADGTVRLWDLAT-GKLLRTL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 187984902 615 RGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDLLHANNGATISG 659
Cdd:COG2319  159 TGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 607-647 3.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 187984902   607 PGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWD 647
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
575-663 2.44e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 575 PLLRLAASPHDSHLLAtfAADSNLIRILDVrQPGQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDLLHANNG 654
Cdd:COG2319   80 AVLSVAFSPDGRLLAS--ASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGKLL 155


                 ....*....
gi 187984902 655 ATISGEHAS 663
Cdd:COG2319  156 RTLTGHSGA 164
WD40 pfam00400
WD domain, G-beta repeat;
608-647 3.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 187984902  608 GQALLELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWD 647
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 571-648 4.60e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.95  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 571 SYAPPLLRLAASPHDSHLLATFAADSNlIRILDVRQPGQALLE-------LRGHSAAVNSIEWNPSRRGMLASGGDDSLV 643
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLT-IRVWEIPHNDESVKEikdpqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....*
gi 187984902 644 LIWDL 648
Cdd:PTZ00420 151 NIWDI 155
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 462-664 2.23e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 462 LTSLDWNTMSPKLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFCAGSVDVFVSCGADGSVRMFDLrslehstii 541
Cdd:PLN00181 535 LSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI--------- 605

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 542 yepsdkggdrDKGSPTGgrMSPTKAQqtmsyapplLRLAASPHDSHLLATFAADSNLIRILDVRQPGQALLELRGHSAAV 621
Cdd:PLN00181 606 ----------NQGVSIG--TIKTKAN---------ICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 187984902 622 NSIEWNPSrrGMLASGGDDSLVLIWDLLHANNGATISGEHAST 664
Cdd:PLN00181 665 SYVRFVDS--STLVSSSTDNTLKLWDLSMSISGINETPLHSFM 705
WD40 COG2319
WD40 repeat [General function prediction only];
458-534 1.11e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 458 HTAPLTSLDWntmSP--KLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVFDVRFcagSVD--VFVSCGADGSVRMFDLR 533
Cdd:COG2319  329 HTGAVRSVAF---SPdgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF---SPDgrTLASGSADGTVRLWDLA 402


                 .
gi 187984902 534 S 534
Cdd:COG2319  403 T 403
PTZ00421 PTZ00421
coronin; Provisional
 575-658 6.75e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187984902 575 PLLRLAASPHDSHLLATfAADSNLIRILDVRQPG------QALLELRGHSAAVNSIEWNPSRRGMLASGGDDSLVLIWDL 648
Cdd:PTZ00421  77 PIIDVAFNPFDPQKLFT-ASEDGTIMGWGIPEEGltqnisDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV 155

                         90
                 ....*....|
gi 187984902 649 LHANNGATIS 658
Cdd:PTZ00421 156 ERGKAVEVIK 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 613-648 1.14e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 187984902 613 ELRGHSAAVNSIEWNPSRRgMLASGGDDSLVLIWDL 648
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 498-531 5.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 187984902   498 LIAHDKEVFDVRFCAGSvDVFVSCGADGSVRMFD 531
Cdd:smart00320   8 LKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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