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Conserved domains on  [gi|187953471|gb|AAI37172|]
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Sortilin-related receptor, L(DLR class) A repeats-containing [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 765.03  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    124 SLALARPKSSDVYVSYDYGKSFKKIsdKLNFGLGNrsEAVIAQFYHSPADNKRYIFadaYAQYLWITFDFCNTLQGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKI--DEIEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDKPNTIYIERHEPSGYSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhllgSEQQSSVQLWVSFGRKPMRAAQFVTRHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    357 DQVFVCVSHS--NNRTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    591 GEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKSYspPVPCPVGSTYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 187953471    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 9.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1651 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGSKMW---ASQRAASNFTEIKNLLVNTLYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 187953471 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.59e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 66.12  E-value: 1.59e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 187953471  1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 8.20e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.15  E-value: 8.20e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 187953471 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.64e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.64e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.12e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 63.04  E-value: 2.12e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 6.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 6.19e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 6.96e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.96e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 187953471 1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.27e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 2.27e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1419 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1628 1.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187953471 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTNTVLKVLKPDTTYQVKVQ 1628
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVR 75
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1120-1153 2.62e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.62e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 187953471 1120 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1934-2021 3.47e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1934 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTvEYTLNKLEPGGKYHIIVQLGNMSK 2013
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 187953471 2014 DS----SIKITT 2021
Cdd:cd00063    82 ESppseSVTVTT 93
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 2.37e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 187953471 1471 CDRFEFECHQpKTCIPNWKRCDGHQDCQDGRDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1513-1546 5.79e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 5.79e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1513 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDE 1546
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 6.43e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 6.43e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    913 YHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1703-2099 1.28e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1703 AASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSY--GENYLSFTLTMESDIKVNGYVV 1780
Cdd:COG3401     6 LTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVAAVAVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1781 NLFWAFD-----THKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQ 1855
Cdd:COG3401    86 AAPPTATglttlTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1856 TavecTWTGPRNVVYGIFYATSFLdlyrnpKSLTTSLHNKTVIVSKDEQYLFLVRVVVP-YQGPSSDYVVVKMIPDSRLP 1934
Cdd:COG3401   166 A----GVVVSPDTSATAAVATTSL------TVTSTTLVDGGGDIEPGTTYYYRVAATDTgGESAPSNEVSVTTPTTPPSA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1935 PRHLHVVHTGKTSVVIKWEspyDSPDQDLL-YAIAVKDlirKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQL----G 2009
Cdd:COG3401   236 PTGLTATADTPGSVTLSWD---PVTESDATgYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAvdaaG 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 2010 NMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFW-KSLALKEKhfnesrGYEIHMFDSAMNITAYLGNT-TDNFFK 2083
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWtASSDADVT------GYNVYRSTSGGGTYTKIAETvTTTSYT 383

                         410
                  ....*....|....*.
gi 187953471 2084 ISNLKMGHNYTFTVQA 2099
Cdd:COG3401   384 DTGLTPGTTYYYKVTA 399
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 8.11e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 8.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 187953471   890 MFWTDWGdLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 5.10e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 5.10e-05
                            10        20
                    ....*....|....*....|....*...
gi 187953471   1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 6.29e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 6.29e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 187953471    780 EQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-993 4.37e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 4.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAsKYSGSQ 993
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA-NLDGTN 42
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 765.03  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    124 SLALARPKSSDVYVSYDYGKSFKKIsdKLNFGLGNrsEAVIAQFYHSPADNKRYIFadaYAQYLWITFDFCNTLQGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKI--DEIEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDKPNTIYIERHEPSGYSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhllgSEQQSSVQLWVSFGRKPMRAAQFVTRHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    357 DQVFVCVSHS--NNRTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    591 GEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKSYspPVPCPVGSTYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 187953471    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 6.94e-133

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 424.31  E-value: 6.94e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   133 SDVYVSYDYGKSFKKISDKLNfglgnrsEAVIAQFYHSPADNKRYIFADAyAQYLWITFDFCNTLQGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   209 LLLHSKASNLLLGFDR----SHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEP------SGYSTVF 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGGkcfsGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   279 RSTDFFQSREnqEVILEEVRDFQLRDKYMFATKVvhllgSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   359 VFVCVSHSNNR--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   432 SMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187953471   512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQ-GMETNELKYSTNEGETWKTFIFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 9.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1651 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGSKMW---ASQRAASNFTEIKNLLVNTLYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 187953471 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.59e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 66.12  E-value: 1.59e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 187953471  1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 8.20e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.15  E-value: 8.20e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 187953471 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.64e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.64e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 2.11e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.99  E-value: 2.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.12e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 63.04  E-value: 2.12e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1235 2.70e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.65  E-value: 2.70e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 187953471  1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEdpVNC 1235
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 6.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 6.19e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 6.96e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.96e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 187953471 1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1235 9.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 9.06e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 187953471 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDpvNC 1235
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE--NC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.27e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 2.27e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1419 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 4.97e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 4.97e-11
                            10        20
                    ....*....|....*....|....*...
gi 187953471   1373 QFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 8.83e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 8.83e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 187953471  1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1325-1356 1.12e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.12e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 187953471   1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 1.21e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 1.21e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 187953471  1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1628 1.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187953471 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTNTVLKVLKPDTTYQVKVQ 1628
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVR 75
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.28e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.28e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 1.57e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 1.57e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 187953471   1239 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 1.70e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 1.70e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1418 TCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 1.95e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.95e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
fn3 pfam00041
Fibronectin type III domain;
1652-1735 2.21e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471  1652 DAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGS-KMWASQRAASN--FTEIKNLLVNTLYTVRVAAVTS 1728
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTV-SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 187953471  1729 RGIGNWS 1735
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1542-1753 2.32e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.79  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1542 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTNTVL 1614
Cdd:COG3401   213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1615 KVLKPDTTYQVKVqvqclsKAHNTN-------DFVTLRTPEGLPDAPRNLQLSLPrEAEGVIVGhWAPPihTHGLIREYI 1687
Cdd:COG3401   290 TGLTNGTTYYYRV------TAVDAAgnesapsNVVSVTTDLTPPAAPSGLTATAV-GSSSITLS-WTAS--SDADVTGYN 359

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187953471 1688 VEYSRSGSKMW---ASQRAASNFTeIKNLLVNTLYTVRVAAVTSRgiGNWSDSKSITTIKGKVIPPPDI 1753
Cdd:COG3401   360 VYRSTSGGGTYtkiAETVTTTSYT-DTGLTPGTTYYYKVTAVDAA--GNESAPSEEVSATTASAASGES 425
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 3.47e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 3.47e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 187953471  1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1558-1629 1.24e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.24e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187953471   1558 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTNTVLKVLKPDTTYQVKVQV 1629
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1120-1153 2.62e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.62e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 187953471 1120 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1934-2021 3.47e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1934 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTvEYTLNKLEPGGKYHIIVQLGNMSK 2013
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 187953471 2014 DS----SIKITT 2021
Cdd:cd00063    82 ESppseSVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 3.56e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 3.56e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 187953471  1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 6.40e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 6.40e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1417 STCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1651-1732 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 1.04e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   1651 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGL--IREYIVEYSRSGSKmWASQRAASNFTE--IKNLLVNTLYTVRVAAV 1726
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 187953471   1727 TSRGIG 1732
Cdd:smart00060   78 NGAGEG 83
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 2.37e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 187953471 1471 CDRFEFECHQpKTCIPNWKRCDGHQDCQDGRDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1934-2007 4.71e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 4.71e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187953471   1934 PPRHLHVVHTGKTSVVIKWESPYDspDQDLLYAIAVKDLIRKTDRSYK-VKSRNSTVEYTLNKLEPGGKYHIIVQ 2007
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1513-1546 5.79e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 5.79e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1513 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDE 1546
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1514-1549 5.89e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 5.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 187953471 1514 CMSREFQCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 6.32e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 6.32e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1117 CDLDtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 6.43e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 6.43e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    913 YHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
fn3 pfam00041
Fibronectin type III domain;
1557-1628 8.03e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 8.03e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187953471  1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQ 1628
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1703-2099 1.28e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1703 AASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSY--GENYLSFTLTMESDIKVNGYVV 1780
Cdd:COG3401     6 LTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVAAVAVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1781 NLFWAFD-----THKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQ 1855
Cdd:COG3401    86 AAPPTATglttlTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1856 TavecTWTGPRNVVYGIFYATSFLdlyrnpKSLTTSLHNKTVIVSKDEQYLFLVRVVVP-YQGPSSDYVVVKMIPDSRLP 1934
Cdd:COG3401   166 A----GVVVSPDTSATAAVATTSL------TVTSTTLVDGGGDIEPGTTYYYRVAATDTgGESAPSNEVSVTTPTTPPSA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1935 PRHLHVVHTGKTSVVIKWEspyDSPDQDLL-YAIAVKDlirKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQL----G 2009
Cdd:COG3401   236 PTGLTATADTPGSVTLSWD---PVTESDATgYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAvdaaG 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 2010 NMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFW-KSLALKEKhfnesrGYEIHMFDSAMNITAYLGNT-TDNFFK 2083
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWtASSDADVT------GYNVYRSTSGGGTYTKIAETvTTTSYT 383

                         410
                  ....*....|....*.
gi 187953471 2084 ISNLKMGHNYTFTVQA 2099
Cdd:COG3401   384 DTGLTPGTTYYYKVTA 399
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 1.51e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1470 RCDRFEFECHQPKtCIPNWKRCDGHQDCQDGRDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
fn3 pfam00041
Fibronectin type III domain;
1934-2007 5.67e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 5.67e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187953471  1934 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLiRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQ 2007
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 8.11e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 8.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 187953471   890 MFWTDWGdLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 1.11e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 1.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1470 RCDRFEFECHqPKTCIPNWKRCDGHQDCQDGRDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1513-1549 1.15e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 1.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1513 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1122-1153 1.34e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 187953471  1122 QFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    7 EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1749-1829 1.65e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.65e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   1749 PPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGD 1828
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 187953471   1829 S 1829
Cdd:smart00060   83 G 83
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 5.10e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 5.10e-05
                            10        20
                    ....*....|....*....|....*...
gi 187953471   1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 6.29e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 6.29e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 1.72e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*....
gi 187953471 1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDED 1309
Cdd:cd00112     6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 187953471    780 EQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2025-2112 5.95e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 2025 SAPDALKII-TENDHVLLFWKSLALKEKHFnesRGYEIHMFDSAMN--ITAYLGNTTDNFFKISNLKMGHNYTFTVQARC 2101
Cdd:cd00063     2 SPPTNLRVTdVTSTSVTLSWTPPEDDGGPI---TGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 187953471 2102 LFGNqicGEPA 2112
Cdd:cd00063    79 GGGE---SPPS 86
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 933-969 3.30e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 3.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 187953471   933 IYWTDAYLEC-IERITFSGQQRSVIL-DNLPHPYAIAVF 969
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFtDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-993 4.37e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 4.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAsKYSGSQ 993
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA-NLDGTN 42
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 765.03  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    124 SLALARPKSSDVYVSYDYGKSFKKIsdKLNFGLGNrsEAVIAQFYHSPADNKRYIFadaYAQYLWITFDFCNTLQGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKI--DEIEGVII--ETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDKPNTIYIERHEPSGYSTVFR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhllgSEQQSSVQLWVSFGRKPMRAAQFVTRHPINE---YYIADASE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    357 DQVFVCVSHS--NNRTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    591 GEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKSYspPVPCPVGSTYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 187953471    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 6.94e-133

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 424.31  E-value: 6.94e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   133 SDVYVSYDYGKSFKKISDKLNfglgnrsEAVIAQFYHSPADNKRYIFADAyAQYLWITFDFCNTLQGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   209 LLLHSKASNLLLGFDR----SHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEP------SGYSTVF 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGGkcfsGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   279 RSTDFFQSREnqEVILEEVRDFQLRDKYMFATKVvhllgSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   359 VFVCVSHSNNR--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   432 SMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187953471   512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQ-GMETNELKYSTNEGETWKTFIFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
Sortilin_C pfam15901
Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of ...
 588-752 4.24e-58

Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.


Pssm-ID: 464928 [Multi-domain]  Cd Length: 164  Bit Score: 198.31  E-value: 4.24e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   588 TEPGEKSTVFTIFGSNKENVHSWLIL-QVNATDALGVPCTENDYKLWSPS-DERGNECLLGHKTVFKRRTPHATCFNGED 665
Cdd:pfam15901    1 TEPDDTSLKFLLFGSSSSSRSDWEVVyTIDFSGLFDRKCTDDDYELWSPRhDQDGPKCLLGHKQKYRRRKPDADCFNGKD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   666 FDRPVVVSNCSCTREDYECDFGFKMSEDLSleVCVPDPEFSGKSYsPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARL 745
Cdd:pfam15901   81 FKDPKIEENCECTREDFECDYGFERSANDG--KCVLVPGLLPPDG-PKEDCKPGTYYLGSSGYRKIPGNTCEGGLELDKD 157


                   ....*..
gi 187953471   746 EGELVPC 752
Cdd:pfam15901  158 EPVEHPC 164
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 9.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1651 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGSKMW---ASQRAASNFTEIKNLLVNTLYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 187953471 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.59e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 66.12  E-value: 1.59e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 187953471  1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 8.20e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.15  E-value: 8.20e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 187953471 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.64e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.64e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 2.11e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.99  E-value: 2.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.12e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 63.04  E-value: 2.12e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1235 2.70e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.65  E-value: 2.70e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 187953471  1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEdpVNC 1235
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 6.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 6.19e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 6.96e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.96e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 187953471 1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1235 9.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 9.06e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 187953471 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDpvNC 1235
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE--NC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.27e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 2.27e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187953471 1419 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 4.97e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 4.97e-11
                            10        20
                    ....*....|....*....|....*...
gi 187953471   1373 QFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 8.83e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 8.83e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 187953471  1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1325-1356 1.12e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.12e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 187953471   1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 1.21e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 1.21e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 187953471  1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1628 1.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187953471 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTNTVLKVLKPDTTYQVKVQ 1628
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVR 75
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.28e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.28e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 1.57e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 1.57e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 187953471   1239 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 1.70e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 1.70e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1418 TCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 1.95e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.95e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 187953471   1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
fn3 pfam00041
Fibronectin type III domain;
1652-1735 2.21e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471  1652 DAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGS-KMWASQRAASN--FTEIKNLLVNTLYTVRVAAVTS 1728
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTV-SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 187953471  1729 RGIGNWS 1735
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1542-1753 2.32e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.79  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1542 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTNTVL 1614
Cdd:COG3401   213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1615 KVLKPDTTYQVKVqvqclsKAHNTN-------DFVTLRTPEGLPDAPRNLQLSLPrEAEGVIVGhWAPPihTHGLIREYI 1687
Cdd:COG3401   290 TGLTNGTTYYYRV------TAVDAAgnesapsNVVSVTTDLTPPAAPSGLTATAV-GSSSITLS-WTAS--SDADVTGYN 359

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187953471 1688 VEYSRSGSKMW---ASQRAASNFTeIKNLLVNTLYTVRVAAVTSRgiGNWSDSKSITTIKGKVIPPPDI 1753
Cdd:COG3401   360 VYRSTSGGGTYtkiAETVTTTSYT-DTGLTPGTTYYYKVTAVDAA--GNESAPSEEVSATTASAASGES 425
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 3.47e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 3.47e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 187953471  1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1558-1629 1.24e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.24e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187953471   1558 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTNTVLKVLKPDTTYQVKVQV 1629
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1120-1153 2.62e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.62e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 187953471 1120 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1934-2021 3.47e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1934 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTvEYTLNKLEPGGKYHIIVQLGNMSK 2013
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 187953471 2014 DS----SIKITT 2021
Cdd:cd00063    82 ESppseSVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 3.56e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 3.56e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 187953471  1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 6.40e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 6.40e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1417 STCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1651-1732 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 1.04e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   1651 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGL--IREYIVEYSRSGSKmWASQRAASNFTE--IKNLLVNTLYTVRVAAV 1726
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 187953471   1727 TSRGIG 1732
Cdd:smart00060   78 NGAGEG 83
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 2.37e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 187953471 1471 CDRFEFECHQpKTCIPNWKRCDGHQDCQDGRDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1934-2007 4.71e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 4.71e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187953471   1934 PPRHLHVVHTGKTSVVIKWESPYDspDQDLLYAIAVKDLIRKTDRSYK-VKSRNSTVEYTLNKLEPGGKYHIIVQ 2007
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1513-1546 5.79e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 5.79e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1513 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDE 1546
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1594-1780 5.89e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 5.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1594 VVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSlPREAEGVIVgHW 1673
Cdd:COG3401   176 ATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTAT-ADTPGSVTL-SW 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1674 APpiHTHGLIREYIVEYSRSGSKMWaSQRAASNFTEI--KNLLVNTLYTVRVAAVTSRGI-GNWSDSKSITTIKGKVIPP 1750
Cdd:COG3401   254 DP--VTESDATGYRVYRSNSGDGPF-TKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAP 330

                         170       180       190
                  ....*....|....*....|....*....|
gi 187953471 1751 PDIHIDSYGENYLSFTLTMESDIKVNGYVV 1780
Cdd:COG3401   331 SGLTATAVGSSSITLSWTASSDADVTGYNV 360
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1514-1549 5.89e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 5.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 187953471 1514 CMSREFQCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 6.32e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 6.32e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1117 CDLDtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 6.43e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 6.43e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    913 YHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
fn3 pfam00041
Fibronectin type III domain;
1557-1628 8.03e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 8.03e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187953471  1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQ 1628
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1703-2099 1.28e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1703 AASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSY--GENYLSFTLTMESDIKVNGYVV 1780
Cdd:COG3401     6 LTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVAAVAVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1781 NLFWAFD-----THKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQ 1855
Cdd:COG3401    86 AAPPTATglttlTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1856 TavecTWTGPRNVVYGIFYATSFLdlyrnpKSLTTSLHNKTVIVSKDEQYLFLVRVVVP-YQGPSSDYVVVKMIPDSRLP 1934
Cdd:COG3401   166 A----GVVVSPDTSATAAVATTSL------TVTSTTLVDGGGDIEPGTTYYYRVAATDTgGESAPSNEVSVTTPTTPPSA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1935 PRHLHVVHTGKTSVVIKWEspyDSPDQDLL-YAIAVKDlirKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQL----G 2009
Cdd:COG3401   236 PTGLTATADTPGSVTLSWD---PVTESDATgYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAvdaaG 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 2010 NMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFW-KSLALKEKhfnesrGYEIHMFDSAMNITAYLGNT-TDNFFK 2083
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWtASSDADVT------GYNVYRSTSGGGTYTKIAETvTTTSYT 383

                         410
                  ....*....|....*.
gi 187953471 2084 ISNLKMGHNYTFTVQA 2099
Cdd:COG3401   384 DTGLTPGTTYYYKVTA 399
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 1.51e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1470 RCDRFEFECHQPKtCIPNWKRCDGHQDCQDGRDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
fn3 pfam00041
Fibronectin type III domain;
1934-2007 5.67e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 5.67e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187953471  1934 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLiRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQ 2007
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1807-2037 6.41e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.62  E-value: 6.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1807 VGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAP--SLKAKAINQTAVECTWTGPRNVV---YGIFYATSFLDL 1881
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAptGLTATADTPGSVTLSWDPVTESDatgYRVYRSNSGDGP 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1882 YRNPKSLTTSLHNKTViVSKDEQYLFLVRVVVpYQGPSSDY-VVVKMIPDSRLP--PRHLHVVHTGKTSVVIKWEspyDS 1958
Cdd:COG3401   276 FTKVATVTTTSYTDTG-LTNGTTYYYRVTAVD-AAGNESAPsNVVSVTTDLTPPaaPSGLTATAVGSSSITLSWT---AS 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1959 PDQDLL-YAIAvkdliRKTDRSY---KVKSRNSTVEYTLNKLEPGGKYHIIVQ----LGNMSkDSSIKITTVSLSAPDAL 2030
Cdd:COG3401   351 SDADVTgYNVY-----RSTSGGGtytKIAETVTTTSYTDTGLTPGTTYYYKVTavdaAGNES-APSEEVSATTASAASGE 424


                  ....*..
gi 187953471 2031 KIITEND 2037
Cdd:COG3401   425 SLTASVD 431
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 8.11e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 8.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 187953471   890 MFWTDWGdLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 1.11e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 1.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 187953471   1470 RCDRFEFECHqPKTCIPNWKRCDGHQDCQDGRDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1513-1549 1.15e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 1.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187953471  1513 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1122-1153 1.34e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 187953471  1122 QFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    7 EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1749-1829 1.65e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.65e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   1749 PPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGD 1828
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 187953471   1829 S 1829
Cdd:smart00060   83 G 83
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 5.10e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 5.10e-05
                            10        20
                    ....*....|....*....|....*...
gi 187953471   1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 6.29e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 6.29e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSNMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1546-1784 1.16e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1546 EKACSDELTVYK-------VQNLQWTADFSGDVTLTWmrpkKMPSASCV--YNVYYRVVGESIWKTLETHSNKTNTVLKV 1616
Cdd:COG3401   311 ESAPSNVVSVTTdltppaaPSGLTATAVGSSSITLSW----TASSDADVtgYNVYRSTSGGGTYTKIAETVTTTSYTDTG 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1617 LKPDTTYQVKvqVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSK 1696
Cdd:COG3401   387 LTPGTTYYYK--VTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDT 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1697 MWASQRAASNFTEIKNLLVNTLYTVRV-AAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKV 1775
Cdd:COG3401   465 GNAVPFTTTSSTVTATTTDTTTANLSVtTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGD 544


                  ....*....
gi 187953471 1776 NGYVVNLFW 1784
Cdd:COG3401   545 VLITDLVSL 553
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 1162-1240 1.21e-04

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 44.78  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471  1162 EYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCTAiyhtCEASNFQCRN-GHC---IPQRWACDGDTD---CQDGSDEDP 1232
Cdd:pfam12999   37 NWKClnHSEIKLSFDQVNDDYCDCPDGSDEPGTNA----CSNGKFYCANeGFIpgyIPSFKVDDGVCDydiCCDGSDEAL 112


                   ....*...
gi 187953471  1233 VNCEKKCN 1240
Cdd:pfam12999  113 GKCPNKCG 120
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 1.72e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*....
gi 187953471 1281 FVCKNRQqCLFHSMVCDGIIQCRDGSDED 1309
Cdd:cd00112     6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 187953471    780 EQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2025-2112 5.95e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 2025 SAPDALKII-TENDHVLLFWKSLALKEKHFnesRGYEIHMFDSAMN--ITAYLGNTTDNFFKISNLKMGHNYTFTVQARC 2101
Cdd:cd00063     2 SPPTNLRVTdVTSTSVTLSWTPPEDDGGPI---TGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 187953471 2102 LFGNqicGEPA 2112
Cdd:cd00063    79 GGGE---SPPS 86
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1814-2106 6.36e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1814 TSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLK--AKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTS 1891
Cdd:COG3401    18 AANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGtlLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1892 LHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHvvhtGKTSVVIKWESPYDSPDQDLLY-AIAVK 1970
Cdd:COG3401    98 TGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGA----GLYGVDGANASGTTASSVAGAGvVVSPD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471 1971 DLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDS------SIKITTVSLSAPDALKIITENDH-VLLFW 2043
Cdd:COG3401   174 TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESapsnevSVTTPTTPPSAPTGLTATADTPGsVTLSW 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187953471 2044 kslalkEKHFNES-RGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQ 2106
Cdd:COG3401   254 ------DPVTESDaTGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNE 311
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 1223-1275 1.16e-03

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 42.08  E-value: 1.16e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187953471  1223 DCQDGSDEDPVN-CEkkcNG-FRCPN----GTCIPSSKHCDGLRD---CSDGSDEQ--HCEPLC 1275
Cdd:pfam12999   59 DCPDGSDEPGTNaCS---NGkFYCANegfiPGYIPSFKVDDGVCDydiCCDGSDEAlgKCPNKC 119
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 933-969 3.30e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 3.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 187953471   933 IYWTDAYLEC-IERITFSGQQRSVIL-DNLPHPYAIAVF 969
Cdd:pfam00058    3 LYWTDSSLRAsISSADLNGSDRKTLFtDDLQHPNAIAVD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2025-2104 3.62e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 3.62e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471   2025 SAPDALKII-TENDHVLLFWKSlALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLF 2103
Cdd:smart00060    2 SPPSNLRVTdVTSTSVTLSWEP-PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    .
gi 187953471   2104 G 2104
Cdd:smart00060   81 G 81
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-993 4.37e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 4.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 187953471    953 RSVILDNLPHPYAIAV--FKNEIYWDDWSQLSIFRAsKYSGSQ 993
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA-NLDGTN 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 798-937 9.98e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.26  E-value: 9.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187953471  798 EHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLetVEALAFEPLSQL--------LYWVDAGFKKIEVANPDGDFRLTI 869
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGR--PNGLAFDPDGRLlvadhgrgLVRFDPADGEVTVLADEYGKPLNR 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187953471  870 VNSSVLDRpralvlvpqEGVMFWTDWGDLKP--GIYRSNMDGSAayHLVSEDVKWPNGI--SVDDQWIYWTD 937
Cdd:COG3386    95 PNDGVVDP---------DGRLYFTDMGEYLPtgALYRVDPDGSL--RVLADGLTFPNGIafSPDGRTLYVAD 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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