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Conserved domains on  [gi|1878426116|gb|KAF5910255|]
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CDGSH iron-sulfur domain-containing protein 1-like [Clarias magur]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-CDGSH super family cl02748
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
54-78 3.87e-04

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


The actual alignment was detected with superfamily member smart00704:

Pssm-ID: 470664  Cd Length: 38  Bit Score: 35.40  E-value: 3.87e-04
                           10        20
                   ....*....|....*....|....*
gi 1878426116   54 KVVHAFDIEDlGDKAVYCRCWRSKK 78
Cdd:smart00704   1 KRPDEVEVEK-RKKYALCRCGRSKN 24
 
Name Accession Description Interval E-value
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
54-78 3.87e-04

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 35.40  E-value: 3.87e-04
                           10        20
                   ....*....|....*....|....*
gi 1878426116   54 KVVHAFDIEDlGDKAVYCRCWRSKK 78
Cdd:smart00704   1 KRPDEVEVEK-RKKYALCRCGRSKN 24
 
Name Accession Description Interval E-value
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
54-78 3.87e-04

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 35.40  E-value: 3.87e-04
                           10        20
                   ....*....|....*....|....*
gi 1878426116   54 KVVHAFDIEDlGDKAVYCRCWRSKK 78
Cdd:smart00704   1 KRPDEVEVEK-RKKYALCRCGRSKN 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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