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Conserved domains on  [gi|1877233836|ref|NP_001372532|]
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LRP2-binding protein isoform 5 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 7.61e-33

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 120.03  E-value: 7.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1877233836 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 7.61e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 120.03  E-value: 7.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1877233836 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 208-242 5.06e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 5.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877233836  208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 242
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 208-241 1.75e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877233836 208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 241
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 36-240 5.49e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  36 DYTHANLVDKALQLLKERILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQ----EGNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 111 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPK 189
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1877233836 190 E----LEKAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALQCLREAAER 240
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL----AAGDLNKAVSSFKKLLAL 630
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 7.61e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 120.03  E-value: 7.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1877233836 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
44-240 1.79e-27

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 106.17  E-value: 1.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  44 DKALQLLKERILKGDTLAYFLRGQLYfEEGW-----YEEALEQFEEIKEKDH-QATYQLGVMYYDGLGTTLDAEKGVDYM 117
Cdd:COG0790    48 AAAAAAAAAAAAAGGAEAQYNLGLMY-AEGRgvpkdYEKALEWFEKAAEQGDaEAQYNLGLMYEEGLGVPQDYAKALEWY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 118 KKildspcpKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAF 195
Cdd:COG0790   127 EK-------AAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA----QYNLGVLYENGRgvPKDPAKAL 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1877233836 196 YWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAER 240
Cdd:COG0790   196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
71-255 4.92e-25

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 99.62  E-value: 4.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  71 EEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVK 150
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 151 RSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTE 228
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA 156

                         170       180
                  ....*....|....*....|....*..
gi 1877233836 229 AALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790   157 KAAEWYRKAAEQGDADAQYNLGVLYEN 183
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 36-240 7.53e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 7.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  36 DYTHANLVDKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:COG2956    85 DYLKAGLLDRAEELLEKllELDPDDAEALRLLAEIYEQEGDWEKAIEVLErllKLGPENAHAYCELAELYLE----QGDY 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 111 EKGVDYMKKILdspcpKARHLKFAAAYNLGRAYYEGKgvkrSNEEAERLWLIAADNgNPKASVKAQSMLGLYYSTKEPKE 190
Cdd:COG2956   161 DEAIEALEKAL-----KLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQ-DPDYLPALPRLAELYEKLGDPEE 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1877233836 191 LEKAFywhsEACGNGNLESQGALGLMYLYGQgiRQDTEAALQCLREAAER 240
Cdd:COG2956   231 ALELL----RKALELDPSDDLLLALADLLER--KEGLEAALALLERQLRR 274
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-256 3.85e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 3.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  44 DKALQLLKErILKGD---TLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQ---ATYQLGVMYYDglgtTLDAEKGVDYM 117
Cdd:COG2956    25 DKAIDLLEE-ALELDpetVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeALLELAQDYLK----AGLLDRAEELL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 118 KKILDSPcPKARhlkfAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNgnpkasVKAQSMLGLYYSTKepKELEKAFYW 197
Cdd:COG2956   100 EKLLELD-PDDA----EALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN------AHAYCELAELYLEQ--GDYDEAIEA 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1877233836 198 HSEACG--NGNLESQGALGLMYLygqgIRQDTEAALQCLREAAER--GNVYAQGNLVEYYYKM 256
Cdd:COG2956   167 LEKALKldPDCARALLLLAELYL----EQGDYEEAIAALERALEQdpDYLPALPRLAELYEKL 225
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 208-242 5.06e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 5.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877233836  208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 242
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 135-168 1.06e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 38.69  E-value: 1.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1877233836  135 AAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGN 168
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 208-241 1.75e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877233836 208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 241
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 134-167 4.07e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.12  E-value: 4.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877233836 134 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNG 167
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 37-140 1.95e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  37 YTHANLVDKALQLLkERILK---GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDA 110
Cdd:COG3914   122 LLALGRLEEALAAL-RRALAlnpDFAEAYLNLGEALRRLGRLEEAIAALRralELDPDNAEALNNLGNALQD-LG---RL 196

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1877233836 111 EKGVDYMKKI--LDSPCPKARHLKFAAAYNLG 140
Cdd:COG3914   197 EEAIAAYRRAleLDPDNADAHSNLLFALRQAC 228
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-165 1.96e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  37 YTHANLVDKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDAE 111
Cdd:COG0457    52 YLRLGRYEEALADYEQalELDPDDAEALNNLGLALQALGRYEEALEDYDkalELDPDDAEALYNLGLALLE-LG---RYD 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1877233836 112 KGVDYMKKILdspcpkARHLKFAAAY-NLGRAYYEGKGVKRSNEEAERLWLIAAD 165
Cdd:COG0457   128 EAIEAYERAL------ELDPDDADALyNLGIALEKLGRYEEALELLEKLEAAALA 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 59-257 3.10e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  59 TLAYFLRGQLYFEEGWYEEALEQFEEIKEKDH---QATYQLGVMYYDgLGttlDAEKGVDYMKKILdspcpKARHLKFAA 135
Cdd:COG2956     8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPetvEAHLALGNLYRR-RG---EYDRAIRIHQKLL-----ERDPDRAEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 136 AYNLGRAYYEGKGVKRSNEEAERLWLIAADNgnpkasVKAQSMLGLYYSTKepKELEKAFYWHSEACGNGNLESQGALGL 215
Cdd:COG2956    79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD------AEALRLLAEIYEQE--GDWEKAIEVLERLLKLGPENAHAYCEL 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1877233836 216 MYLYGQgiRQDTEAALQCLREA--AERGNVYAQGNLVEYYYKMK 257
Cdd:COG2956   151 AELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLEQG 192
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 44-252 3.42e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.44  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  44 DKALQLLkERILK---GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDAEKGVDYM 117
Cdd:COG3914    95 EEALALY-RRALAlnpDNAEALFNLGNLLLALGRLEEALAALRralALNPDFAEAYLNLGEALRR-LG---RLEEAIAAL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 118 KKILdspcpkARHLKFAAAY-NLGRAYYEGKGVKRSNEEAERLWLIAADNgnpkasVKAQSMLgLYYSTKEPKELEKAFY 196
Cdd:COG3914   170 RRAL------ELDPDNAEALnNLGNALQDLGRLEEAIAAYRRALELDPDN------ADAHSNL-LFALRQACDWEVYDRF 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1877233836 197 WHSEACGNGNLESQGALGLMYLygqgiRQDTEAALqcLREAAERGNVYAQGNLVEY 252
Cdd:COG3914   237 EELLAALARGPSELSPFALLYL-----PDDDPAEL--LALARAWAQLVAAAAAPEL 285
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 36-240 5.49e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836  36 DYTHANLVDKALQLLKERILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQ----EGNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877233836 111 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPK 189
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1877233836 190 E----LEKAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALQCLREAAER 240
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL----AAGDLNKAVSSFKKLLAL 630
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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