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Conserved domains on  [gi|1877090400|ref|NP_001364370|]
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LRP2-binding protein isoform 3 [Homo sapiens]

Protein Classification

SEL1-like repeat protein( domain architecture ID 11434924)

SEL1-like repeat family protein may function as an adaptor protein for the assembly of macromolecular complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  16870393
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
1-157 1.82e-30

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 113.48  E-value: 1.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400   1 MYYDGLGTTLDAEKGVDYMKKIldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSM 80
Cdd:COG0790    72 MYAEGRGVPKDYEKALEWFEKA-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYN 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1877090400  81 LGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 157
Cdd:COG0790   141 LGLLYLNGEgvPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 199-233 4.81e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.07  E-value: 4.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877090400  199 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 233
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
1-157 1.82e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 113.48  E-value: 1.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400   1 MYYDGLGTTLDAEKGVDYMKKIldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSM 80
Cdd:COG0790    72 MYAEGRGVPKDYEKALEWFEKA-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYN 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1877090400  81 LGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 157
Cdd:COG0790   141 LGLLYLNGEgvPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 110-144 1.61e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.01  E-value: 1.61e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877090400  110 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 144
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 110-143 9.27e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 9.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877090400 110 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 143
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 199-233 4.81e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.07  E-value: 4.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877090400  199 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 233
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 199-233 9.19e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 33.26  E-value: 9.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1877090400 199 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 233
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
1-157 1.82e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 113.48  E-value: 1.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400   1 MYYDGLGTTLDAEKGVDYMKKIldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSM 80
Cdd:COG0790    72 MYAEGRGVPKDYEKALEWFEKA-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYN 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1877090400  81 LGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 157
Cdd:COG0790   141 LGLLYLNGEgvPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
36-232 6.50e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 109.25  E-value: 6.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400  36 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQG 113
Cdd:COG0790    64 EAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQY 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400 114 ALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdc 189
Cdd:COG0790   140 NLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE---------------- 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1877090400 190 lpefigRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRL 232
Cdd:COG0790   204 ------QGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
1-142 3.44e-23

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 94.22  E-value: 3.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400   1 MYYDGLGTTLDAEKGVDYMKKildspcpKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSM 80
Cdd:COG0790   108 MYEEGLGVPQDYAKALEWYEK-------AAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA----QYN 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1877090400  81 LGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAER 142
Cdd:COG0790   177 LGVLYENGRgvPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
36-237 5.32e-18

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 80.36  E-value: 5.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400  36 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQG 113
Cdd:COG0790    28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEA----QYNLGLMYAEGRgvPKDYEKALEWFEKAAEQGDAEAQY 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400 114 ALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdc 189
Cdd:COG0790   104 NLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGvpkdPAKAAEWYRKAAE---------------- 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1877090400 190 lpefigRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALA 237
Cdd:COG0790   168 ------QGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADA 209
TPR COG0790
TPR repeat [General function prediction only];
58-237 3.39e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 61.48  E-value: 3.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400  58 AERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLR 137
Cdd:COG0790    12 AAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877090400 138 EAAERGNVYAQGNLVEYYYK----MKFFTKCVAFSKRIADydevhdipmiaqvtdclpefigRGMAMASFYHARCLQLGL 213
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEglgvPQDYAKALEWYEKAAE----------------------QGDADAQYNLGLLYLNGE 149

                         170       180
                  ....*....|....*....|....
gi 1877090400 214 GITRDETTAKHYYSKACRLNPALA 237
Cdd:COG0790   150 GVPKDPAKAAEWYRKAAEQGDADA 173
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 110-144 1.61e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.01  E-value: 1.61e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877090400  110 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 144
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 37-70 3.49e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 3.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1877090400   37 AAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGN 70
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 110-143 9.27e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 9.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877090400 110 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 143
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 36-69 2.23e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.50  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1877090400  36 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNG 69
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 199-233 4.81e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.07  E-value: 4.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1877090400  199 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 233
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 199-233 9.19e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 33.26  E-value: 9.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1877090400 199 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 233
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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