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Conserved domains on  [gi|187611420|sp|Q8IVN8|]
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RecName: Full=Somatomedin-B and thrombospondin type-1 domain-containing protein; AltName: Full=RPE-spondin; Flags: Precursor

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 16075017)

thrombospondin type-1 (TSP1) domain-containing protein; the TSP1 domain mediates cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 75-121 1.01e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 61.14  E-value: 1.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 187611420   75 CFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGC 121
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPC 47
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 75-121 1.01e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 61.14  E-value: 1.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 187611420   75 CFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGC 121
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPC 47
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 75-121 1.01e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 61.14  E-value: 1.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 187611420   75 CFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGC 121
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPC 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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