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Conserved domains on  [gi|187371951|gb|ACD02846|]
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vpu protein [Human immunodeficiency virus 1]

Protein Classification

Vpu( domain architecture ID 10456474)

Vpu (viral protein U), a membrane protein of HIV-1, enhances virion budding by targeting host CD4 and tetherin/BST2 to proteasome degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 1-78 2.02e-28

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


:

Pssm-ID: 109608  Cd Length: 81  Bit Score: 97.03  E-value: 2.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187371951   1 MQPLAILAIVALVVAIILAIVVWSIVIIEYRKILRQRKIDRLIEKIRERAEDSGNESEGDAEE-LSALVE-MGHHAPWDI 78
Cdd:pfam00558  1 MLLLEIIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVHsHGFDNPMFE 80
 
Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 1-78 2.02e-28

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


Pssm-ID: 109608  Cd Length: 81  Bit Score: 97.03  E-value: 2.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187371951   1 MQPLAILAIVALVVAIILAIVVWSIVIIEYRKILRQRKIDRLIEKIRERAEDSGNESEGDAEE-LSALVE-MGHHAPWDI 78
Cdd:pfam00558  1 MLLLEIIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVHsHGFDNPMFE 80
 
Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 1-78 2.02e-28

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


Pssm-ID: 109608  Cd Length: 81  Bit Score: 97.03  E-value: 2.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187371951   1 MQPLAILAIVALVVAIILAIVVWSIVIIEYRKILRQRKIDRLIEKIRERAEDSGNESEGDAEE-LSALVE-MGHHAPWDI 78
Cdd:pfam00558  1 MLLLEIIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVHsHGFDNPMFE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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