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Conserved domains on  [gi|1871406036|gb|QLI57762|]
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ankyrin/F-box protein [Orf virus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11476134)

ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03095 PHA03095
ankyrin-like protein; Provisional
 11-515 0e+00

ankyrin-like protein; Provisional


:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 558.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  11 NEHPHVREFKEASLYGFLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEI 90
Cdd:PHA03095    2 EEDESVDIIMEAALYDYLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  91 CGLTPVHLYASYADVdvefmrgliergasvcgessatgclysylythsvdggarLDVVELLVQAGADVNVRGEARKTPLH 170
Cdd:PHA03095   82 CGFTPLHLYLYNATT---------------------------------------LDVIKLLIKAGADVNAKDKVGRTPLH 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 171 VHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVSMATsRDVRGRTPLHHHADSFRAS 250
Cdd:PHA03095  123 VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYA-VDDRFRSLLHHHLQSFKPR 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 251 AGIVRELLAAGCDAAAADDLGNTPLHSLATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIY-NPSVCSRLIAAGA 329
Cdd:PHA03095  202 ARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFnNPRACRRLIALGA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 330 DVTARTPDGRTPLSGMIMRKHTRAVRAALATQPPADAVAASLDVAVQPE---PTDATRACVRYVVLCGG--TLSARVRSR 404
Cdd:PHA03095  282 DINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLNTASVAGgdiPSDATRLCVAKVVLRGAfsLLPEPIRAY 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 405 HADFVRECESEVVVLRTTVVGLPgTSLLDIVRAAQPPPVLLSPRVHHVLQKLRVYTDLVGARLREMRHKTNLVDAVSRLV 484
Cdd:PHA03095  362 HADFIRECEAEIAVMRTTRIGTG-VSLLDILFARNPDILLVSNASLRKKARLTVYGKALRARIEEMRKRSKLVERIIKLI 440

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1871406036 485 CPCALPPEVVRGILVHVPTDSLRHTLTLGVA 515
Cdd:PHA03095  441 CPCALPPEIVMRILDFLPDDDLRNLLRCLKL 471
 
Name Accession Description Interval E-value
PHA03095 PHA03095
ankyrin-like protein; Provisional
 11-515 0e+00

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 558.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  11 NEHPHVREFKEASLYGFLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEI 90
Cdd:PHA03095    2 EEDESVDIIMEAALYDYLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  91 CGLTPVHLYASYADVdvefmrgliergasvcgessatgclysylythsvdggarLDVVELLVQAGADVNVRGEARKTPLH 170
Cdd:PHA03095   82 CGFTPLHLYLYNATT---------------------------------------LDVIKLLIKAGADVNAKDKVGRTPLH 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 171 VHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVSMATsRDVRGRTPLHHHADSFRAS 250
Cdd:PHA03095  123 VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYA-VDDRFRSLLHHHLQSFKPR 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 251 AGIVRELLAAGCDAAAADDLGNTPLHSLATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIY-NPSVCSRLIAAGA 329
Cdd:PHA03095  202 ARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFnNPRACRRLIALGA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 330 DVTARTPDGRTPLSGMIMRKHTRAVRAALATQPPADAVAASLDVAVQPE---PTDATRACVRYVVLCGG--TLSARVRSR 404
Cdd:PHA03095  282 DINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLNTASVAGgdiPSDATRLCVAKVVLRGAfsLLPEPIRAY 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 405 HADFVRECESEVVVLRTTVVGLPgTSLLDIVRAAQPPPVLLSPRVHHVLQKLRVYTDLVGARLREMRHKTNLVDAVSRLV 484
Cdd:PHA03095  362 HADFIRECEAEIAVMRTTRIGTG-VSLLDILFARNPDILLVSNASLRKKARLTVYGKALRARIEEMRKRSKLVERIIKLI 440

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1871406036 485 CPCALPPEVVRGILVHVPTDSLRHTLTLGVA 515
Cdd:PHA03095  441 CPCALPPEIVMRILDFLPDDDLRNLLRCLKL 471
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-249 4.35e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  27 FLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHLYASYADVD 106
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG---DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 107 VefMRGLIERGASVcgesSATGCLYSYLYTHSVDGGaRLDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELL 186
Cdd:COG0666   135 I--VKLLLEAGADV----NAQDNDGNTPLHLAAANG-NLEIVKLLLEAGADVNARDNDGETPLHL--AAENGHLEIVKLL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1871406036 187 LRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVsmaTSRDVRGRTPLHHHADSFRA 249
Cdd:COG0666   206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL---NAKDKDGLTALLLAAAAGAA 265
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-161 5.31e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  72 LDVVDALLDAGADINAKEICGLTPVHlYASYADvDVEFMRGLIERGASVCGESSATgCLYsylytHSVDGGaRLDVVELL 151
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALH-LAAKNG-HLEIVKLLLEHADVNLKDNGRT-ALH-----YAARSG-HLEIVKLL 80

                          90
                  ....*....|
gi 1871406036 152 VQAGADVNVR 161
Cdd:pfam12796  81 LEKGADINVK 90
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 28-171 1.22e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  28 LVAAADVTVEDVRRYLQF-GADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEIC-----GLTPVHLYAs 101
Cdd:cd22192    22 LLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYD---NLEAAVVLMEAAPELVNEPMTsdlyqGETALHIAV- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 102 yADVDVEFMRGLIERGASVCgESSATGCLYS-------YLYTHSVDGGARL---DVVELLVQAGADVNVRGEARKTPLHV 171
Cdd:cd22192    98 -VNQNLNLVRELIARGADVV-SPRATGTFFRpgpknliYYGEHPLSFAACVgneEIVRLLIEHGADIRAQDSLGNTVLHI 175
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 55-87 7.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 7.11e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1871406036   55 YLCTPLHAYLQSGcekRLDVVDALLDAGADINA 87
Cdd:smart00248   1 DGRTPLHLAAENG---NLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
PHA03095 PHA03095
ankyrin-like protein; Provisional
 11-515 0e+00

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 558.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  11 NEHPHVREFKEASLYGFLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEI 90
Cdd:PHA03095    2 EEDESVDIIMEAALYDYLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  91 CGLTPVHLYASYADVdvefmrgliergasvcgessatgclysylythsvdggarLDVVELLVQAGADVNVRGEARKTPLH 170
Cdd:PHA03095   82 CGFTPLHLYLYNATT---------------------------------------LDVIKLLIKAGADVNAKDKVGRTPLH 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 171 VHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVSMATsRDVRGRTPLHHHADSFRAS 250
Cdd:PHA03095  123 VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYA-VDDRFRSLLHHHLQSFKPR 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 251 AGIVRELLAAGCDAAAADDLGNTPLHSLATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIY-NPSVCSRLIAAGA 329
Cdd:PHA03095  202 ARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFnNPRACRRLIALGA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 330 DVTARTPDGRTPLSGMIMRKHTRAVRAALATQPPADAVAASLDVAVQPE---PTDATRACVRYVVLCGG--TLSARVRSR 404
Cdd:PHA03095  282 DINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLNTASVAGgdiPSDATRLCVAKVVLRGAfsLLPEPIRAY 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 405 HADFVRECESEVVVLRTTVVGLPgTSLLDIVRAAQPPPVLLSPRVHHVLQKLRVYTDLVGARLREMRHKTNLVDAVSRLV 484
Cdd:PHA03095  362 HADFIRECEAEIAVMRTTRIGTG-VSLLDILFARNPDILLVSNASLRKKARLTVYGKALRARIEEMRKRSKLVERIIKLI 440

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1871406036 485 CPCALPPEVVRGILVHVPTDSLRHTLTLGVA 515
Cdd:PHA03095  441 CPCALPPEIVMRILDFLPDDDLRNLLRCLKL 471
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-249 4.35e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  27 FLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHLYASYADVD 106
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG---DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 107 VefMRGLIERGASVcgesSATGCLYSYLYTHSVDGGaRLDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELL 186
Cdd:COG0666   135 I--VKLLLEAGADV----NAQDNDGNTPLHLAAANG-NLEIVKLLLEAGADVNARDNDGETPLHL--AAENGHLEIVKLL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1871406036 187 LRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVsmaTSRDVRGRTPLHHHADSFRA 249
Cdd:COG0666   206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL---NAKDKDGLTALLLAAAAGAA 265
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
137-359 1.02e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 137 HSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSvgANVA 216
Cdd:COG0666    59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA--AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN--GNLE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 217 TLRLFIDAGVSMaTSRDVRGRTPLHHHAdsFRASAGIVRellaagcdaaaaddlgntplhslatfcscrrsvldQLIAGG 296
Cdd:COG0666   135 IVKLLLEAGADV-NAQDNDGNTPLHLAA--ANGNLEIVK-----------------------------------LLLEAG 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1871406036 297 ADINARNHYGHTCLYYASIY-NPSVCSRLIAAGADVTARTPDGRTPLSGMIMRKHTRAVRAALA 359
Cdd:COG0666   177 ADVNARDNDGETPLHLAAENgHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-226 1.12e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  36 VEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHLYASYadvdvefmrglie 115
Cdd:COG0666   133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---NLEIVKLLLEAGADVNARDNDGETPLHLAAEN------------- 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 116 rgasvcgessatgclysylythsvdggARLDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGADPEA 195
Cdd:COG0666   197 ---------------------------GHLEIVKLLLEAGADVNAKDNDGKTALDL--AAENGNLEIVKLLLEAGADLNA 247

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1871406036 196 LDEHGLTPADVLVKSVGANVATLRLFIDAGV 226
Cdd:COG0666   248 KDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-331 1.97e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.25  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  33 DVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSgceKRLDVVDALLDAGADINAKEICGLTPVHLYASYADV---DVEF 109
Cdd:PHA03100   12 IIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEA---RNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdVKEI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 110 MRGLIERGASV-CGESSATGCLYSYLYTHSvdggARLDVVELLVQAGADVNVRGEARKTPLHVHCASFEVDSDIVELLLR 188
Cdd:PHA03100   89 VKLLLEYGANVnAPDNNGITPLLYAISKKS----NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 189 AGADPEALDEhgltpadvlVKsvganvatlrLFIDAGVSMaTSRDVRGRTPLHHHADSFRASagIVRellaagcdaaaad 268
Cdd:PHA03100  165 KGVDINAKNR---------VN----------YLLSYGVPI-NIKDVYGFTPLHYAVYNNNPE--FVK------------- 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1871406036 269 dlgntplhslatfcscrrsvldQLIAGGADINARNHYGHTCLYYA-SIYNPSVCSRLIAAGADV 331
Cdd:PHA03100  210 ----------------------YLLDLGANPNLVNKYGDTPLHIAiLNNNKEIFKLLLNNGPSI 251
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 9-227 2.32e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.25  E-value: 2.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036   9 RNNEHPHVREFKEASLYGFLVAAADV---TVEDVRRYLQFGADVNYKGAYLCTPLHaYLQSGCEKRLDVVDALLDAGADI 85
Cdd:PHA03100   56 DNGADINSSTKNNSTPLHYLSNIKYNltdVKEIVKLLLEYGANVNAPDNNGITPLL-YAISKKSNSYSIVEYLLDNGANV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  86 NAKEICGLTPVHLYASYADVDVEFMRGLIERGASVCGEssatgclysylythsvdggarlDVVELLVQAGADVNVRGEAR 165
Cdd:PHA03100  135 NIKNSDGENLLHLYLESNKIDLKILKLLIDKGVDINAK----------------------NRVNYLLSYGVPINIKDVYG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1871406036 166 KTPLHVhcASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSvgANVATLRLFIDAGVS 227
Cdd:PHA03100  193 FTPLHY--AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN--NNKEIFKLLLNNGPS 250
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
143-359 2.76e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 2.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 143 ARLDVVELLVQAGADVNVRGEARKTPLHVHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSvgANVATLRLFI 222
Cdd:COG0666    30 LLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN--GDLEIVKLLL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 223 DAGVSMATsRDVRGRTPLHHHAdsFRASAGIVRellaagcdaaaaddlgntplhslatfcscrrsvldQLIAGGADINAR 302
Cdd:COG0666   108 EAGADVNA-RDKDGETPLHLAA--YNGNLEIVK-----------------------------------LLLEAGADVNAQ 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1871406036 303 NHYGHTCLYYASIY-NPSVCSRLIAAGADVTARTPDGRTPLSGMIMRKHTRAVRAALA 359
Cdd:COG0666   150 DNDGNTPLHLAAANgNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-256 3.06e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 81.65  E-value: 3.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  21 EASLYgfLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAylQSGCEKRLDVVDALLDAGADINAKEICGLTPVHlYA 100
Cdd:PHA02876  308 ETPLY--LMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQ--ASTLDRNKDIVITLLELGANVNARDYCDKTPIH-YA 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 101 SYADvDVEFMRGLIERGASVCGESSATGCLYSYlythSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVHCASfEVDS 180
Cdd:PHA02876  383 AVRN-NVVIINTLLDYGADIEALSQKIGTALHF----ALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKK-NCKL 456

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 181 DIVELLLRAGADPE------------ALDEHG-----------LTPADVLVKSVGANVATLRlFIDAGVSMA--TSRDVR 235
Cdd:PHA02876  457 DVIEMLLDNGADVNainiqnqyplliALEYHGivnillhygaeLRDSRVLHKSLNDNMFSFR-YIIAHICIQdfIRHDIR 535

                         250       260
                  ....*....|....*....|..
gi 1871406036 236 -GRTPLHHHADSFRASAGIVRE 256
Cdd:PHA02876  536 nEVNPLKRVPTRFTSLRESFKE 557
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 43-342 1.49e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 76.64  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  43 LQFGADVNYKGAYLCTPLHAYLQSGCEKrldVVDALLDAGADINAKEICGLT---------------------------P 95
Cdd:PHA02876  165 LEGGADVNAKDIYCITPIHYAAERGNAK---MVNLLLSYGADVNIIALDDLSvlecavdsknidtikaiidnrsninknD 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  96 VHLYASYADVDVEFMRGLIERGASVcgeSSATGCLYSYLYtHSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVhCAS 175
Cdd:PHA02876  242 LSLLKAIRNEDLETSLLLYDAGFSV---NSIDDCKNTPLH-HASQAPSLSRLVPKLLERGADVNAKNIKGETPLYL-MAK 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 176 FEVDSDIVELLLRAGADPEALDEHGLTPADvLVKSVGANVATLRLFIDAGVSMaTSRDVRGRTPLHHHAdsFRASAGIVR 255
Cdd:PHA02876  317 NGYDTENIRTLIMLGADVNAADRLYITPLH-QASTLDRNKDIVITLLELGANV-NARDYCDKTPIHYAA--VRNNVVIIN 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 256 ELLAAGCDAAAADDLGNTPLHsLATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIYN--PSVCSRLIAAGADVTA 333
Cdd:PHA02876  393 TLLDYGADIEALSQKIGTALH-FALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNckLDVIEMLLDNGADVNA 471


                  ....*....
gi 1871406036 334 RTPDGRTPL 342
Cdd:PHA02876  472 INIQNQYPL 480
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-343 3.31e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  35 TVEDVRRYLQ-FGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEICGLTPVHLYASYADVDV--EFMR 111
Cdd:PHA02878   12 NYETILKYIEyIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGmkEMIR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 112 GLIERGASVCGESSATGCLYS----------------------YLYTHSVDGGARLDVVELLVQAGADVNVRGEAR-KTP 168
Cdd:PHA02878   92 SINKCSVFYTLVAIKDAFNNRnveifkiiltnrykniqtidlvYIDKKSKDDIIEAEITKLLLSYGADINMKDRHKgNTA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 169 LHVhcASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSvgANVATLRLFIDAGVSMaTSRDVRGRTPLHHhadsfr 248
Cdd:PHA02878  172 LHY--ATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKH--YNKPIVHILLENGAST-DARDKCGNTPLHI------ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 249 aSAGIVRELlaagcdaaaaddlgntplhslatfcscrrSVLDQLIAGGADINARNHYGHTCLYYASIYNPSVCSRLIAAG 328
Cdd:PHA02878  241 -SVGYCKDY-----------------------------DILKLLLEHGVDVNAKSYILGLTALHSSIKSERKLKLLLEYG 290

                         330
                  ....*....|....*
gi 1871406036 329 ADVTARTPDGRTPLS 343
Cdd:PHA02878  291 ADINSLNSYKLTPLS 305
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 31-171 3.91e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.37  E-value: 3.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  31 AADVTVEDVRRYL-QFGADVNYKGAYLCTPLHAYLQsgcEKRLDVVDALLDAGADINAKEICGLTPVHLYASYAdVDVEF 109
Cdd:PHA02878  175 ATENKDQRLTELLlSYGANVNIPDKTNNSPLHHAVK---HYNKPIVHILLENGASTDARDKCGNTPLHISVGYC-KDYDI 250

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1871406036 110 MRGLIERGASVCGESSATGCLYSYLYTHSVdggarlDVVELLVQAGADVNVRGEARKTPLHV 171
Cdd:PHA02878  251 LKLLLEHGVDVNAKSYILGLTALHSSIKSE------RKLKLLLEYGADINSLNSYKLTPLSS 306
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 33-230 4.95e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 68.23  E-value: 4.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  33 DVTVEDVRRYLQFGADVNYKGaYLCTPLHAYLQS---GCEKRLDVVDALLDAGADINAKEICGLTPVhlyasyadvdvef 109
Cdd:PHA02989   47 DVKIKIVKLLIDNGADVNYKG-YIETPLCAVLRNreiTSNKIKKIVKLLLKFGADINLKTFNGVSPI------------- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 110 mrgliergasVCgessatgclysYLYTHSVDggaRLDVVELLVQAGADVN-VRGEARKTPLHVHCASFEVDSDIVELLLR 188
Cdd:PHA02989  113 ----------VC-----------FIYNSNIN---NCDMLRFLLSKGINVNdVKNSRGYNLLHMYLESFSVKKDVIKILLS 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1871406036 189 AGADP-EALDEHGLTPADVLVKSVGANVA--TLRLFIDAGVSMAT 230
Cdd:PHA02989  169 FGVNLfEKTSLYGLTPMNIYLRNDIDVISikVIKYLIKKGVNIET 213
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 39-209 6.19e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 6.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  39 VRRYLQFGADVNYKGAY-LCTPLHaYLQSgcEKRLDVVDALLDAGADINAKEICGLTPVHLYASYADVDVefMRGLIERG 117
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALH-YATE--NKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPI--VHILLENG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 118 ASV-----CGESS---ATGCLYSYlythsvdggarlDVVELLVQAGADVNVRGEARK-TPLHVHCASfevdSDIVELLLR 188
Cdd:PHA02878  225 ASTdardkCGNTPlhiSVGYCKDY------------DILKLLLEHGVDVNAKSYILGlTALHSSIKS----ERKLKLLLE 288

                         170       180
                  ....*....|....*....|.
gi 1871406036 189 AGADPEALDEHGLTPADVLVK 209
Cdd:PHA02878  289 YGADINSLNSYKLTPLSSAVK 309
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 46-203 1.71e-10

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 63.78  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  46 GADVNYKGAYLCTPLHAYLQSGcEKRLDVVDALLDAGADINAKEICGLTPV----------------------------- 96
Cdd:PHA02716  202 GVNVNLQNNHLITPLHTYLITG-NVCASVIKKIIELGGDMDMKCVNGMSPImtyiinidninpeitniyiesldgnkvkn 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  97 -----HLYASYA-DVDVEFMRGLIERGASV-CGESSATGCLYSYLYTHSVDggarLDVVELLVQAGADVNVRGEARKTPL 169
Cdd:PHA02716  281 ipmilHSYITLArNIDISVVYSFLQPGVKLhYKDSAGRTCLHQYILRHNIS----TDIIKLLHEYGNDLNEPDNIGNTVL 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1871406036 170 H--------VHCASFEVDSDI----VELLLRAGADPEALDEHGLTP 203
Cdd:PHA02716  357 HtylsmlsvVNILDPETDNDIrldvIQCLISLGADITAVNCLGYTP 402
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-326 6.89e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 6.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  39 VRRYLQFGADVNYKGAYLCTPLHAYLQSGCEkrlDVVDALLDAGADINakeicgLTPVhlyasyADVDVEFMRGLIERGA 118
Cdd:PHA02874   51 VELFIKHGADINHINTKIPHPLLTAIKIGAH---DIIKLLIDNGVDTS------ILPI------PCIEKDMIKTILDCGI 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 119 SVcgeSSATGCLYSYLYtHSVDGGaRLDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGADPEALDE 198
Cdd:PHA02874  116 DV---NIKDAELKTFLH-YAIKKG-DLESIKMLFEYGADVNIEDDNGCYPIHI--AIKHNFFDIIKLLLEKGAYANVKDN 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 199 HGLTPADVLVKSvgANVATLRLFIDAGvSMATSRDVRGRTPLHHHADSFRAsagiVRELLAAGCDAAAADDLGNTPLHSl 278
Cdd:PHA02874  189 NGESPLHNAAEY--GDYACIKLLIDHG-NHIMNKCKNGFTPLHNAIIHNRS----AIELLINNASINDQDIDGSTPLHH- 260

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1871406036 279 ATFCSCRRSVLDQLIAGGADINARNHYGHTCLYYASIY--NPSVCSRLIA 326
Cdd:PHA02874  261 AINPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYinKDPVIKDIIA 310
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-211 9.37e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.75  E-value: 9.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  33 DVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHLYASYADVDVefMRG 112
Cdd:PHA02874  101 CIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKG---DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDI--IKL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 113 LIERGA--SVCGESSATGCLYS----------YLYTHSVDGGARLD---------------VVELLVQaGADVNVRGEAR 165
Cdd:PHA02874  176 LLEKGAyaNVKDNNGESPLHNAaeygdyacikLLIDHGNHIMNKCKngftplhnaiihnrsAIELLIN-NASINDQDIDG 254

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1871406036 166 KTPLHvHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSV 211
Cdd:PHA02874  255 STPLH-HAINPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYI 299
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 49-200 2.33e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 57.52  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  49 VNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAkeicglTPVHLYASYADVDVEFMRGLIERGASVCGESSATG 128
Cdd:PHA02859   14 TDYLFYRYCNPLFYYVEKDDIEGVKKWIKFVNDCNDLYE------TPIFSCLEKDKVNVEILKFLIENGADVNFKTRDNN 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1871406036 129 --CLYSYLythSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVHCASFEVDSDIVELLLRAGADPEALDEHG 200
Cdd:PHA02859   88 lsALHHYL---SFNKNVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNVRINVIKLLIDSGVSFLNKDFDN 158
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 34-206 3.63e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 56.75  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  34 VTVEDVRRYLQFGADVNYK-GAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEICGLTPVHLYASYADVDVEFMRG 112
Cdd:PHA02859   64 VNVEILKFLIENGADVNFKtRDNNLSALHHYLSFNKNVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNVRINVIKL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 113 LIERGASVCG-ESSATGCLYSYLYTHSvdggarldvvellvqagadvnvrgearktplhvhcasfevDSDIVELLLRAGA 191
Cdd:PHA02859  144 LIDSGVSFLNkDFDNNNILYSYILFHS----------------------------------------DKKIFDFLTSLGI 183

                         170
                  ....*....|....*
gi 1871406036 192 DPEALDEHGLTPADV 206
Cdd:PHA02859  184 DINETNKSGYNCYDL 198
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 96-258 1.14e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 57.44  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  96 VHLYASYAD-VDVEFMRGLIERGASVCGESSATGCLYSYLYTHSVdggaRLDVVELLVQAGADVNVRGEArKTPLHVHCA 174
Cdd:PHA02989    4 LYEYILYSDtVDKNALEFLLRTGFDVNEEYRGNSILLLYLKRKDV----KIKIVKLLIDNGADVNYKGYI-ETPLCAVLR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 175 SFEVDSD----IVELLLRAGADPEALDEHGLTPADVLV-KSVGANVATLRLFIDAGVSMATSRDVRGRTPLHHHADSFRA 249
Cdd:PHA02989   79 NREITSNkikkIVKLLLKFGADINLKTFNGVSPIVCFIyNSNINNCDMLRFLLSKGINVNDVKNSRGYNLLHMYLESFSV 158


                  ....*....
gi 1871406036 250 SAGIVRELL 258
Cdd:PHA02989  159 KKDVIKILL 167
PHA02798 PHA02798
ankyrin-like protein; Provisional
 20-190 5.33e-08

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 55.23  E-value: 5.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  20 KEASLYGFLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQS--GCEKRLDVVDALLDAGADINAKEICGLTPVH 97
Cdd:PHA02798   35 NEYSIFQKYLQRDSPSTDIVKLFINLGANVNGLDNEYSTPLCTILSNikDYKHMLDIVKILIENGADINKKNSDGETPLY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  98 --LYASYADvDVEFMRGLIERGASVCGESS-ATGCLYSYLYT-HSVDggarLDVVELLVQAGADVNVRGEARK-TPLHVH 172
Cdd:PHA02798  115 clLSNGYIN-NLEILLFMIENGADTTLLDKdGFTMLQVYLQSnHHID----IEIIKLLLEKGVDINTHNNKEKyDTLHCY 189

                         170       180
                  ....*....|....*....|
gi 1871406036 173 CAS--FEVDSDIVELLLRAG 190
Cdd:PHA02798  190 FKYniDRIDADILKLFVDNG 209
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 143-309 1.30e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 52.13  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 143 ARLDVVELLVQAGADVN--VRGEARkTPLHvHCASFE--VDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATL 218
Cdd:PHA02859   64 VNVEILKFLIENGADVNfkTRDNNL-SALH-HYLSFNknVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNVRINVI 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 219 RLFIDAGVSmatsrdvrgrtPLHHHADSfrasagivrellaagcdaaaaddlgNTPLHSLATFCScRRSVLDQLIAGGAD 298
Cdd:PHA02859  142 KLLIDSGVS-----------FLNKDFDN-------------------------NNILYSYILFHS-DKKIFDFLTSLGID 184

                         170
                  ....*....|.
gi 1871406036 299 INARNHYGHTC 309
Cdd:PHA02859  185 INETNKSGYNC 195
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 148-218 1.02e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 1.02e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1871406036 148 VELLVQAGADVNVRGEARKTPLHVHCASFEVDsdIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATL 218
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQ--VVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
PHA02798 PHA02798
ankyrin-like protein; Provisional
 99-342 2.86e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 49.83  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  99 YASYADVDVEFMRGLIERGASVCGESSATGCLYSYLYTHSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVHCASFEV 178
Cdd:PHA02798   43 YLQRDSPSTDIVKLFINLGANVNGLDNEYSTPLCTILSNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 179 DS-DIVELLLRAGADPEALDEHGLTPADVLVKS-VGANVATLRLFIDAGVSMATSRDVRGRTPLHHH------------A 244
Cdd:PHA02798  123 NNlEILLFMIENGADTTLLDKDGFTMLQVYLQSnHHIDIEIIKLLLEKGVDINTHNNKEKYDTLHCYfkynidridadiL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 245 DSFRASAGIVREllAAGCDAAAADDLGNTPLHSLATFcscRRSVLDqLIAGGADINARNHYGHTCLYYaSIY--NPSVCS 322
Cdd:PHA02798  203 KLFVDNGFIINK--ENKSHKKKFMEYLNSLLYDNKRF---KKNILD-FIFSYIDINQVDELGFNPLYY-SVShnNRKIFE 275

                         250       260
                  ....*....|....*....|
gi 1871406036 323 RLIAAGADVTARTPDGRTPL 342
Cdd:PHA02798  276 YLLQLGGDINIITELGNTCL 295
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 105-310 4.59e-06

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 49.53  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 105 VDVEFMRGLIERGAS----VCGESsATGCLYSYLYTHSVDggarLDVVELLVQAGADVNVRGEARKTPLHVHCASFEVDS 180
Cdd:PHA02716  153 IDLDLIKYMVDVGIVnlnyVCKKT-GYGILHAYLGNMYVD----IDILEWLCNNGVNVNLQNNHLITPLHTYLITGNVCA 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 181 DIVELLLRAGADPEALDEHGLTP---------------ADVLVKSVGAN--------------------VATLRLFIDAG 225
Cdd:PHA02716  228 SVIKKIIELGGDMDMKCVNGMSPimtyiinidninpeiTNIYIESLDGNkvknipmilhsyitlarnidISVVYSFLQPG 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 226 VSMaTSRDVRGRTPLHHHADSFRASAGIVRELLAAGCDAAAADDLGNTPLHS-LATFC-----------SCRRSVLDQLI 293
Cdd:PHA02716  308 VKL-HYKDSAGRTCLHQYILRHNISTDIIKLLHEYGNDLNEPDNIGNTVLHTyLSMLSvvnildpetdnDIRLDVIQCLI 386

                         250
                  ....*....|....*..
gi 1871406036 294 AGGADINARNHYGHTCL 310
Cdd:PHA02716  387 SLGADITAVNCLGYTPL 403
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 141-354 1.36e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.65  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 141 GGARldVVELLVQAGADVNVRGEARKTPLhvhCASFEVDS-DIVELLLRAGADPEALdehgltPADVLVKSvganvaTLR 219
Cdd:PHA02874   46 GDAK--IVELFIKHGADINHINTKIPHPL---LTAIKIGAhDIIKLLIDNGVDTSIL------PIPCIEKD------MIK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 220 LFIDAGVSMATsRDVRGRTPLHHHADsfRASAGIVRELLAAGCDAAAADDLGNTPLHsLATFcSCRRSVLDQLIAGGADI 299
Cdd:PHA02874  109 TILDCGIDVNI-KDAELKTFLHYAIK--KGDLESIKMLFEYGADVNIEDDNGCYPIH-IAIK-HNFFDIIKLLLEKGAYA 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1871406036 300 NARNHYGHTCLYYASIYNPSVCSR-LIAAGADVTARTPDGRTPLSGMIMrkHTRAV 354
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKlLIDHGNHIMNKCKNGFTPLHNAII--HNRSA 237
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-160 2.63e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  36 VEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHLYASYADVDVefMRGLIE 115
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMG---DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI--CKMLLD 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1871406036 116 RGASVcGESSATGCLYSYLYTHSVDggaRLDVVELLVQAGADVNV 160
Cdd:PHA02875  190 SGANI-DYFGKNGCVAALCYAIENN---KIDIVRLFIKRGADCNI 230
PHA02946 PHA02946
ankyin-like protein; Provisional
 98-310 4.44e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.82  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  98 LYASYADVDVEFMRGLIErgasvCGESSATgclYSYLYTHSVDGGARLDVVELLVQAGADVNVRGEARKTPLHVhcASFE 177
Cdd:PHA02946   13 LYAKYNSKNLDVFRNMLQ-----AIEPSGN---YHILHAYCGIKGLDERFVEELLHRGYSPNETDDDGNYPLHI--ASKI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 178 VDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFIDAGVSMATSRDVRGRTPL----------------- 240
Cdd:PHA02946   83 NNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEGCGPLlactdpservfkkimsi 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 241 ---------------HHHADSFRASAGIVRELLAAGCDAAAADDLGNTPLHSLATFCSCRRSVLDQLIAgGADINARNHY 305
Cdd:PHA02946  163 gfearivdkfgknhiHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKTVKNVDIINLLLP-STDVNKQNKF 241


                  ....*
gi 1871406036 306 GHTCL 310
Cdd:PHA02946  242 GDSPL 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-161 5.31e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  72 LDVVDALLDAGADINAKEICGLTPVHlYASYADvDVEFMRGLIERGASVCGESSATgCLYsylytHSVDGGaRLDVVELL 151
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALH-LAAKNG-HLEIVKLLLEHADVNLKDNGRT-ALH-----YAARSG-HLEIVKLL 80

                          90
                  ....*....|
gi 1871406036 152 VQAGADVNVR 161
Cdd:pfam12796  81 LEKGADINVK 90
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 28-171 1.22e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  28 LVAAADVTVEDVRRYLQF-GADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEIC-----GLTPVHLYAs 101
Cdd:cd22192    22 LLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYD---NLEAAVVLMEAAPELVNEPMTsdlyqGETALHIAV- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 102 yADVDVEFMRGLIERGASVCgESSATGCLYS-------YLYTHSVDGGARL---DVVELLVQAGADVNVRGEARKTPLHV 171
Cdd:cd22192    98 -VNQNLNLVRELIARGADVV-SPRATGTFFRpgpknliYYGEHPLSFAACVgneEIVRLLIEHGADIRAQDSLGNTVLHI 175
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 272-435 1.50e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 272 NTPLHSLATFCSCRRSVLDQLIAGGAD---------------------------------------------------IN 300
Cdd:PHA03100  107 ITPLLYAISKKSNSYSIVEYLLDNGANvniknsdgenllhlylesnkidlkilkllidkgvdinaknrvnyllsygvpIN 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 301 ARNHYGHTCLYYASIY-NPSVCSRLIAAGADVTARTPDGRTPLSGMIMRKHTRAVRAALATQPPADAVAASLDVAVQPEP 379
Cdd:PHA03100  187 IKDVYGFTPLHYAVYNnNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLLYFKDKDL 266

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 380 -----TDATRACVRYVVlcggTLSARVRSRHA---------DFVRECESEVVVLRTTVvgLPGTSLLDIV 435
Cdd:PHA03100  267 ntitkIKMLKKSIMYMF----LLDPGFYKNRKlienskslkDVINECEKEIERMKEIK--LNKVTVYDII 330
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 145-345 1.83e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 145 LDVVELLVQAGADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSvgANVATLRLFIDa 224
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHY--AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDS--KNIDTIKAIID- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 225 gvsmatsrdvrGRTPLHHHADSFRASagivrellaagcdaaaaddLGNTPLHSlatfcscrrSVLdqLIAGGADINARNH 304
Cdd:PHA02876  233 -----------NRSNINKNDLSLLKA-------------------IRNEDLET---------SLL--LYDAGFSVNSIDD 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1871406036 305 YGHTCLYYASiYNPSV---CSRLIAAGADVTARTPDGRTPLSGM 345
Cdd:PHA02876  272 CKNTPLHHAS-QAPSLsrlVPKLLERGADVNAKNIKGETPLYLM 314
PHA02798 PHA02798
ankyrin-like protein; Provisional
 37-202 2.09e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.06  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  37 EDVRRYLQFGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINA---KEicGLTPVHLY--ASYADVDVEFMR 111
Cdd:PHA02798  126 EILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEIIKLLLEKGVDINThnnKE--KYDTLHCYfkYNIDRIDADILK 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 112 GLIERGASVCGESSAT-GCLYSYLYTHSVDG-GARLDVVELLVqAGADVNVRGEARKTPLhvHCASFEVDSDIVELLLRA 189
Cdd:PHA02798  204 LFVDNGFIINKENKSHkKKFMEYLNSLLYDNkRFKKNILDFIF-SYIDINQVDELGFNPL--YYSVSHNNRKIFEYLLQL 280

                         170
                  ....*....|...
gi 1871406036 190 GADPEALDEHGLT 202
Cdd:PHA02798  281 GGDINIITELGNT 293
Ank_4 pfam13637
Ankyrin repeats (many copies);
58-107 2.28e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 2.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1871406036  58 TPLHAYLQSGCekrLDVVDALLDAGADINAKEICGLTPVHLYASYADVDV 107
Cdd:pfam13637   3 TALHAAAASGH---LELLRLLLEKGADINAVDGNGETALHFAASNGNVEV 49
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 24-169 3.83e-04

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 43.36  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  24 LYGFLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcEKRLDVVDALLDAGADINAKEICGLTPVHLYASYA 103
Cdd:PHA02716  285 LHSYITLARNIDISVVYSFLQPGVKLHYKDSAGRTCLHQYILRH-NISTDIIKLLHEYGNDLNEPDNIGNTVLHTYLSML 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1871406036 104 DVdvefmrgliergasvcgessatgclySYLYTHSVDGGARLDVVELLVQAGADVNVRGEARKTPL 169
Cdd:PHA02716  364 SV--------------------------VNILDPETDNDIRLDVIQCLISLGADITAVNCLGYTPL 403
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-225 4.12e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  36 VEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGA---DINAKEicGLTPVHLYASYADVDVefMRG 112
Cdd:PHA02875   48 SEAIKLLMKHGAIPDVKYPDIESELHDAVEEG---DVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDI--MKL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 113 LIERGasvcgessatgclysylythsvdggarldvvellvqagADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGAD 192
Cdd:PHA02875  121 LIARG--------------------------------------ADPDIPNTDKFSPLHL--AVMMGDIKGIELLIDHKAC 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1871406036 193 PEALDEHGLTPadVLVKSVGANVATLRLFIDAG 225
Cdd:PHA02875  161 LDIEDCCGCTP--LIIAMAKGDIAICKMLLDSG 191
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 10-192 4.15e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  10 NNEHPHVR-EFKEASLYGFLVAaadvtVEDVRRYLQFGADVNYKGAYlcTPLHAYLQSgceKRLDVVDALLDAGADINAK 88
Cdd:PHA02875   62 DVKYPDIEsELHDAVEEGDVKA-----VEELLDLGKFADDVFYKDGM--TPLHLATIL---KKLDIMKLLIARGADPDIP 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  89 EICGLTPVHLYASYADVDVefMRGLIERGASVCGESsatGCLYSYLYTHSVDGGarLDVVELLVQAGADVNVRGeaRKTP 168
Cdd:PHA02875  132 NTDKFSPLHLAVMMGDIKG--IELLIDHKACLDIED---CCGCTPLIIAMAKGD--IAICKMLLDSGANIDYFG--KNGC 202

                         170       180
                  ....*....|....*....|....*
gi 1871406036 169 LHVHCASFEVDS-DIVELLLRAGAD 192
Cdd:PHA02875  203 VAALCYAIENNKiDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
287-342 4.98e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 4.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1871406036 287 SVLDQLIAGGADINARNHYGHTCLYYASIYNPSVCSRLIAAGADVTARTpDGRTPL 342
Cdd:pfam12796  11 ELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTAL 65
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 292-428 5.07e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 292 LIAGGADINARNHYGHTCLYYASIY-NPSVCSRLIAAGADVTARTPDGRTPLSgMIMRKHTRAVRAALATQPPADavaAS 370
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANgHVQVVRVLLEFGADPTLLDKDGKTPLE-LAEENGFREVVQLLSRHSQCH---FE 176

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1871406036 371 LDVAVQPEPTDATRacvryvvlcGGTLSARVRSRHADFVRECESEVVVLRTTVVGLPG 428
Cdd:PTZ00322  177 LGANAKPDSFTGKP---------PSLEDSPISSHHPDFSAVPQPMMGSLIVIMVGLPG 225
Ank_5 pfam13857
Ankyrin repeats (many copies);
151-206 9.98e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 9.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1871406036 151 LVQAG-ADVNVRGEARKTPLHVhcASFEVDSDIVELLLRAGADPEALDEHGLTPADV 206
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHV--AAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-120 1.20e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  27 FLVAAADVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDaGADINAKEIcGLTPVHlYASYADvD 106
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG---HLEIVKLLLE-HADVNLKDN-GRTALH-YAARSG-H 73

                          90
                  ....*....|....
gi 1871406036 107 VEFMRGLIERGASV 120
Cdd:pfam12796  74 LEIVKLLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
172-242 2.05e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 2.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1871406036 172 HCASFEVDSDIVELLLRAGADPEALDEHGLTPadvLVKSVGANVA-TLRLFIDagvSMATSRDVRGRTPLHH 242
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTA---LHLAAKNGHLeIVKLLLE---HADVNLKDNGRTALHY 67
Ank_5 pfam13857
Ankyrin repeats (many copies);
45-98 2.98e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 2.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1871406036  45 FGADVNYKGAYLCTPLHAYLQSGcekRLDVVDALLDAGADINAKEICGLTPVHL 98
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYG---ALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PHA02917 PHA02917
ankyrin-like protein; Provisional
 33-222 3.54e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 39.98  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  33 DVTVEDVRRYLQFGADVNYKGAYLCTPLHAYLQSGCEKRLDVVDALLDAGADINAKEICGLTPVHLYAS--YADVDVEFM 110
Cdd:PHA02917    9 EVALDELKQMLRDRDPNDTRNQFKNNALHAYLFNEHCNNVEVVKLLLDSGTNPLHKNWRQLTPLEEYTNsrHVKVNKDIA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036 111 RGLIErgasVCGESSATGC-LYSYLYTHSVDggarLDVVELLVQAGADVNVRGEARKTPLHVHCASFEVDSDIVELLLRA 189
Cdd:PHA02917   89 MALLE----ATGYSNINDFnIFSYMKSKNVD----VDLIKVLVEHGFDLSVKCENHRSVIENYVMTDDPVPEIIDLFIEN 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1871406036 190 GAD---PEALDEHGLTPADVLVKSVGanvATLRLFI 222
Cdd:PHA02917  161 GCSvlyEDEDDEYGYAYDDYQPRNCG---TVLHLYI 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
145-203 4.15e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 4.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1871406036 145 LDVVELLVQAGADVNVRGEARKTPLHvHCASFEvDSDIVELLLrAGADPEaLDEHGLTP 203
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALH-LAAKNG-HLEIVKLLL-EHADVN-LKDNGRTA 64
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-88 4.24e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 4.24e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1871406036  57 CTPLHAYlqSGCEKRLDVVDALLDAGADINAK 88
Cdd:pfam00023   3 NTPLHLA--AGRRGNLEIVKLLLSKGADVNAR 32
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 273-342 4.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 38.65  E-value: 4.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1871406036 273 TPLHSLATFCSCRRSVLDQLIAGGADINAR-NHYGHTCL-YYASI---YNPSVCSRLIAAGADVTARTPDGRTPL 342
Cdd:PHA02859   53 TPIFSCLEKDKVNVEILKFLIENGADVNFKtRDNNLSALhHYLSFnknVEPEILKILIDSGSSITEEDEDGKNLL 127
PHA02946 PHA02946
ankyin-like protein; Provisional
 74-222 5.97e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871406036  74 VVDALLDAGADINAKEICGLTPVHLYASYADVDVEFMRGLIERGASVCGESSATGCLYSYLYThsvDGGARldVVELLVQ 153
Cdd:PHA02946   87 IVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEGCGPLLACT---DPSER--VFKKIMS 161

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1871406036 154 AGADVNVRGEARKTPLHVHCASFEVDSDIVELLLRAGADPEALDEHGLTPADVLVKSVGANVATLRLFI 222
Cdd:PHA02946  162 IGFEARIVDKFGKNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKTVKNVDIINLLL 230
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 55-87 7.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 7.11e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1871406036   55 YLCTPLHAYLQSGcekRLDVVDALLDAGADINA 87
Cdd:smart00248   1 DGRTPLHLAAENG---NLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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