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Conserved domains on  [gi|186885957|gb|ACC93386|]
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RNA polymerase beta subunit, partial (chloroplast) [Stokesia laevis]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11413981)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
1-1024 0e+00

RNA polymerase beta subunit


:

Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 2240.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    1 NQEIDFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLIWKNDRRryIQEQTILIGKIPLMTSLGAFIVNGIYRIV 80
Cdd:CHL00001   45 DQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKKSRD--MQEQTVFIGNIPLMNSLGTFIINGIYRVV 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   81 INQILQSPGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVCYPE 160
Cdd:CHL00001  123 INQILRSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILDNVCYPE 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  161 LFLSFLNDK--KKIGSKENAILEFYQQFACVEGDPVFSESLSKDLQKKFFQQRCELGGIGRRNMNRRLNLDIPQNNTFLL 238
Cdd:CHL00001  203 IFLSFLNDKekKKIGSKENAILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRKLNLDIPENNTFLL 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  239 PRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIYAALKHNWTPTPQNLVNSTPLT 318
Cdd:CHL00001  283 PQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLT 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  319 DTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHA 398
Cdd:CHL00001  363 TTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHA 442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  399 RVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQ 478
Cdd:CHL00001  443 RIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQ 522
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  479 YFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSGNGD 558
Cdd:CHL00001  523 YFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNGD 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  559 TLRIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 638
Cdd:CHL00001  603 TLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 682
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  639 YTSFHIRKYEIQI---NQGPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSYAPEDRLLRTI 715
Cdd:CHL00001  683 YTSFHIRKYEIQThvtSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAI 762
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  716 LGMRVYTSKETCLKLPIGGRGRVIDVRWVQsSKTDETEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPY 795
Cdd:CHL00001  763 FGIQVSTSKETCLKLPIGGRGRVIDVRWIQ-KKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPY 841
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  796 LQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWIFEPES 875
Cdd:CHL00001  842 LQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEY 921
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  876 PGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYI 955
Cdd:CHL00001  922 PGKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYI 1001
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186885957  956 LQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEDAPESFRLFVRELRSLALELNHFLVSEKTFQLNRKEA 1024
Cdd:CHL00001 1002 LQEMLTYKSDHIRARQEVLGAIITGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV 1070
 
Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
1-1024 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 2240.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    1 NQEIDFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLIWKNDRRryIQEQTILIGKIPLMTSLGAFIVNGIYRIV 80
Cdd:CHL00001   45 DQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKKSRD--MQEQTVFIGNIPLMNSLGTFIINGIYRVV 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   81 INQILQSPGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVCYPE 160
Cdd:CHL00001  123 INQILRSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILDNVCYPE 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  161 LFLSFLNDK--KKIGSKENAILEFYQQFACVEGDPVFSESLSKDLQKKFFQQRCELGGIGRRNMNRRLNLDIPQNNTFLL 238
Cdd:CHL00001  203 IFLSFLNDKekKKIGSKENAILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRKLNLDIPENNTFLL 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  239 PRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIYAALKHNWTPTPQNLVNSTPLT 318
Cdd:CHL00001  283 PQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLT 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  319 DTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHA 398
Cdd:CHL00001  363 TTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHA 442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  399 RVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQ 478
Cdd:CHL00001  443 RIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQ 522
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  479 YFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSGNGD 558
Cdd:CHL00001  523 YFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNGD 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  559 TLRIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 638
Cdd:CHL00001  603 TLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 682
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  639 YTSFHIRKYEIQI---NQGPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSYAPEDRLLRTI 715
Cdd:CHL00001  683 YTSFHIRKYEIQThvtSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAI 762
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  716 LGMRVYTSKETCLKLPIGGRGRVIDVRWVQsSKTDETEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPY 795
Cdd:CHL00001  763 FGIQVSTSKETCLKLPIGGRGRVIDVRWIQ-KKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPY 841
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  796 LQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWIFEPES 875
Cdd:CHL00001  842 LQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEY 921
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  876 PGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYI 955
Cdd:CHL00001  922 PGKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYI 1001
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186885957  956 LQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEDAPESFRLFVRELRSLALELNHFLVSEKTFQLNRKEA 1024
Cdd:CHL00001 1002 LQEMLTYKSDHIRARQEVLGAIITGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV 1070
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
5-1008 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1068.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957     5 DFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLI-WKNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQ 83
Cdd:TIGR02013   62 NIELEYLSYRLGEPKYSVEECKERGLTYSAPLKVKLRLInKEEDGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQ 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    84 ILQSPGFYYQSELN--DNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVC--YP 159
Cdd:TIGR02013  142 LHRSPGVFFSSEKDttKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLgsGE 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   160 ELFLSFLNDKKKigSKENAILEFYQQFAcvEGDPVFSESLSKDLQKKFF-QQRCELGGIGRRNMNRRLNLDIPQNNTFLL 238
Cdd:TIGR02013  222 YIRNTLRKDPTN--SEEEALVEIYRKLR--PGEPPTVEAARSLLENLFFdPKRYDLGRVGRYKLNKKLGLDVPESIGVLT 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   239 PRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIyaALKHNWTPTPQNLVNSTPLT 318
Cdd:TIGR02013  298 KEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERM--STQDTDTLTPQDLINAKPIS 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   319 DTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHA 398
Cdd:TIGR02013  376 AAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYA 455
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   399 RVGRWGSLESPFYKIS--ERSKGARMLYLSPGRDEYYMVAAGNS-LALNQGIQEEqVVPARYRQEFLTIAWEQVHLRSIF 475
Cdd:TIGR02013  456 RVNEYGFIETPYRKVKdgKVVVTDEIDYLTADEEDNYVIAQANApLDENGRFVED-LVVARYRGEITLVSPDQVDYMDVS 534
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   476 SFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSG 555
Cdd:TIGR02013  535 PKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRY 614
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   556 NGDTL-------RIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVL 628
Cdd:TIGR02013  615 DEDEEepdggidIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAIL 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   629 ISERLVYEDIYTSFHIRKYEIQINQ---GPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvKESSY 705
Cdd:TIGR02013  695 ISERLVKDDVFTSIHIEEYEVEARDtklGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPK--GETEL 772
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   706 APEDRLLRTILGMRVYTSKETCLKLPIGGRGRVIDVRWVQSSKTDETEK--TESIRVYILQKREIKVGDKVAGRHGNKGI 783
Cdd:TIGR02013  773 TPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQGDELPPgvNKLVKVYIAQKRKIQVGDKMAGRHGNKGV 852
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   784 ISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHyriapfderyEQEASRKLVFSELYEASK 863
Cdd:TIGR02013  853 VSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRK----------GVPIATPVFDGASEEEIK 922
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   864 QTANPWIFEPEspGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEME 943
Cdd:TIGR02013  923 EYLEKAGLPRD--GKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEME 1000
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186885957   944 VWALEGFGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRIPTPeDAPESFRLFVRELRSLALELN 1008
Cdd:TIGR02013 1001 VWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEP-GIPESFNVLIKELQSLGLDIE 1064
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
5-1005 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1023.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    5 DFELFLERYQLVEPLI-----KERDavyesLTYSSELYVSARLIwkNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRI 79
Cdd:COG0085    48 NLSLEFGDYRLGEPKYtpeecKERD-----LTYAAPLYVKVRLV--NKETGEIKEQEVFMGDFPLMTDSGTFIINGTERV 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   80 VINQILQSPGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLN----IREILEN 155
Cdd:COG0085   121 IVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLEtdeeILEAFGD 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  156 VCYPELFLSFLnDKKKIGSKENAILEFYQQFAcvEGDPVFSESLSKDLQKKFFQ-QRCELGGIGRRNMNRRLNLDIPQNN 234
Cdd:COG0085   201 DPIQEYILATL-EKDNTKTQEEALLEIYRKLR--PGEPPTIERAEQLLDNLFFDpKRYDLAHVGRYKINKKLGLDVPPED 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  235 TFLLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIyaALKHNWTPTPQNLVNS 314
Cdd:COG0085   278 RVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERM--TTQDVEAITPQSLINI 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  315 TPLTDTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSL 394
Cdd:COG0085   356 RPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSL 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  395 AIHARVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSI 474
Cdd:COG0085   436 ALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDV 515
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  475 FSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEkcivgtglegqAALDsgalaiaehegkiIYtntdkills 554
Cdd:COG0085   516 SPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE-----------APLL-------------HY--------- 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  555 gngdtlriPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLV 634
Cdd:COG0085   563 --------PLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLV 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  635 YEDIYTSFHIRKYEIQINQ---GPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSyaPEDRL 711
Cdd:COG0085   635 KDDVLTSIHIEEYEIEARDtklGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELT--PEERL 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  712 LRTILGMRVYTSKETCLKLPIGGRGRVIDVRWVQSSKTDETEK--TESIRVYILQKREIKVGDKVAGRHGNKGIISKILP 789
Cdd:COG0085   713 LRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEGDELPPgvNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILP 792
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  790 RQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEasrklVFSELYEASkqtanpw 869
Cdd:COG0085   793 QEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEE-----IRELLEKAG------- 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  870 ifePESPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEG 949
Cdd:COG0085   861 ---LPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEA 937
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 186885957  950 FGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEdAPESFRLFVRELRSLAL 1005
Cdd:COG0085   938 YGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPG-IPESFKVLLKELQSLGL 992
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
1-1010 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 800.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    1 NQEIDFELFLERYQLVEPLIKE---------RDAVYESLTYSSELYVSARLIWKNDRRryIQEQTILIGKIPLMTSL--- 68
Cdd:cd00653    31 DDDGRLKLKFGDIYLGKPKVEEggvtrkltpNECRLRDLTYSAPLYVDIRLTVNDKGK--IKEQEVFIGEIPIMLRSklc 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   69 ---------------------GAFIVNGIYRIVINQILQSPGFYYQSElnDNGISVYTGTIISDWGGRlelgidRKSRIW 127
Cdd:cd00653   109 nlngltpeeliklgecpldpgGYFIINGTEKVIINQEQRSPNVIIVED--SKGKRIYTKTSIPSYSPY------RGSWLE 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  128 VRVSRQQKLsilvllsamglnireilenvcypelfLSFLNDKKKigsKENAILEFYQQFacvegdpvfseslskdlqkkf 207
Cdd:cd00653   181 VKSDKKKDR--------------------------IYVRIDLKR---QEEALKYIGKRF--------------------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  208 fqqrcelggigrrnmnrrlnldipqnntfllpRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVR 287
Cdd:cd00653   211 --------------------------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKR 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  288 LENMARGNIYAALKHNWTPTPQNLVNSTPLTDTYKVFFRLHP------------LSQVLDRTNPLTQIVHGRKLSylgPG 355
Cdd:cd00653   259 LEREVKEKLQKQLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRIS---SL 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  356 GLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGrwGSLESPFYKISErskgarmlylspgrdeyymv 435
Cdd:cd00653   336 GLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEK-------------------- 393
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  436 aagnslalnqgiqeeqvvparyrqefltiaweQVHLRSIFSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVP----- 510
Cdd:cd00653   394 --------------------------------EVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGtpaln 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  511 -----------LSQSEKCIVGTGLEGQAALDsgalaiaehegkiiytntdkillsgngdtlriplvmyersnkntcihqk 579
Cdd:cd00653   442 qqyrmdtklylLLYPQKPLVGTGIEEYIAFG------------------------------------------------- 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  580 phvqrgkcikkgqilaygaatvggELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQINQGP---- 655
Cdd:cd00653   473 ------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKngpe 528
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  656 ERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSYapedrllrtILGMRVYTSKETCLKLPIGGR 735
Cdd:cd00653   529 EITRGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP---------IFGEKARDVRDTSLKYPGGEK 599
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  736 GRVIDVRWvqSSKTDETEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRM 815
Cdd:cd00653   600 GIVDDVKI--FSRELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRM 677
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  816 NVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELyeaskqtanpwifepESPGKSRIFDGRTGDPFEQPVI 895
Cdd:cd00653   678 TIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGL---------------NYYGKEVLYDGRTGEPLEAPIF 742
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  896 IGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLG 975
Cdd:cd00653   743 VGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKC 822
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*
gi 186885957  976 TIIF----------GGRIPTPEdAPESFRLFVRELRSLALELNHF 1010
Cdd:cd00653   823 GIILsanlcrlckkGTNISKVG-IPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
484-933 9.61e-130

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 397.67  E-value: 9.61e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   484 ASLIPFIEHNDANRALMSSNMQRQAVPLsqsekcivgtglegqaaldsgalaiaehegkiiytntdkillsgngdtlrIP 563
Cdd:pfam00562    2 ASLIPFVDHNQSPRNTYQCAMGKQAMGI--------------------------------------------------YT 31
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   564 LVMYERSNKNT---CIHQKPHVQRGKcIKKGQIlaygaatvgGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYT 640
Cdd:pfam00562   32 LNKFYRSDQNTyvlCYPQKPLVKTGA-VEAGGF---------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFT 101
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   641 SFHIRKYEIQINQG--PERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvkessyaPEDRLLRTILGM 718
Cdd:pfam00562  102 SIHIKEIEARKTKLgpIEEITRDIPNVSEEALKKLDEDGIVRVGAEVKPGDILVGKVGPT--------ELTKLLRAIFGE 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   719 RVYTSKETCLKLPIGGRGRVIDVRWVQSSKtdetEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQD 798
Cdd:pfam00562  174 KARDVKDTSLKVPPGEEGVVDDVIVFELPP----GGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTED 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   799 GRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDeryEQEASRKLVFSELYEASKqtaNPWifepespGK 878
Cdd:pfam00562  250 GIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD---GASTEVEDIGELLEKAGY---NYY-------GK 316
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 186885957   879 SRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAK 933
Cdd:pfam00562  317 EVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
1-1024 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 2240.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    1 NQEIDFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLIWKNDRRryIQEQTILIGKIPLMTSLGAFIVNGIYRIV 80
Cdd:CHL00001   45 DQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKKSRD--MQEQTVFIGNIPLMNSLGTFIINGIYRVV 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   81 INQILQSPGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVCYPE 160
Cdd:CHL00001  123 INQILRSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILDNVCYPE 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  161 LFLSFLNDK--KKIGSKENAILEFYQQFACVEGDPVFSESLSKDLQKKFFQQRCELGGIGRRNMNRRLNLDIPQNNTFLL 238
Cdd:CHL00001  203 IFLSFLNDKekKKIGSKENAILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRKLNLDIPENNTFLL 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  239 PRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIYAALKHNWTPTPQNLVNSTPLT 318
Cdd:CHL00001  283 PQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLT 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  319 DTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHA 398
Cdd:CHL00001  363 TTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHA 442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  399 RVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQ 478
Cdd:CHL00001  443 RIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQ 522
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  479 YFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSGNGD 558
Cdd:CHL00001  523 YFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNGD 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  559 TLRIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 638
Cdd:CHL00001  603 TLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 682
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  639 YTSFHIRKYEIQI---NQGPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSYAPEDRLLRTI 715
Cdd:CHL00001  683 YTSFHIRKYEIQThvtSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAI 762
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  716 LGMRVYTSKETCLKLPIGGRGRVIDVRWVQsSKTDETEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPY 795
Cdd:CHL00001  763 FGIQVSTSKETCLKLPIGGRGRVIDVRWIQ-KKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPY 841
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  796 LQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWIFEPES 875
Cdd:CHL00001  842 LQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEY 921
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  876 PGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYI 955
Cdd:CHL00001  922 PGKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYI 1001
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186885957  956 LQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEDAPESFRLFVRELRSLALELNHFLVSEKTFQLNRKEA 1024
Cdd:CHL00001 1002 LQEMLTYKSDHIRARQEVLGAIITGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV 1070
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
5-1007 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 1088.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    5 DFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLIWKNDRrrYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQI 84
Cdd:PRK00405   66 NLSLEFVSYELGEPKYDVEECKERGLTYSAPLRVKLRLINKETG--EIKEQEVYMGDIPLMTENGTFIINGTERVIVSQL 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   85 LQSPGFYYQSELND--NGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILE-------- 154
Cdd:PRK00405  144 HRSPGVYFDHDKDKtsSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDlfyekeef 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  155 ---------------------------------NVCYPELFLSFLND---KKKIGSKENAILEFYQQFAcvEGDPVFSES 198
Cdd:PRK00405  224 gkeievpveyllgkvlaedivdeetgevlaeanDEITEELDGPYIRNtleKDPTSSREEALVEIYRRLR--PGEPPTVEA 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  199 LSKDLQKKFF-QQRCELGGIGRRNMNRRLNLDIPQNNTFLLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLL 277
Cdd:PRK00405  302 ARSLLENLFFdPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELL 381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  278 QEQFGLALVRLENMARGNIyaALKHNWTPTPQNLVNSTPLTDTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGL 357
Cdd:PRK00405  382 QNQFRIGLSRMERAVRERM--SLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGL 459
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  358 TARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAA 437
Cdd:PRK00405  460 TRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQ 539
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  438 GNSlALNQ--GIQEEQVVpARYRQEFLTIAWEQVHLRSIFSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSE 515
Cdd:PRK00405  540 ANA-PLDEdgRFVDELVT-ARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPE 617
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  516 KCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKI------LLSGNGDTLRIPLVMYERSNKNTCIHQKPHVQRGKCIK 589
Cdd:PRK00405  618 APLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIvvrveeLDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVE 697
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  590 KGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQINQ---GPERVTNEIPHLE 666
Cdd:PRK00405  698 KGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDtklGPEEITRDIPNVS 777
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  667 VHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvKESSYAPEDRLLRTILGMRVYTSKETCLKLPIGGRGRVIDVRwVQS 746
Cdd:PRK00405  778 EEALRNLDESGIVRIGAEVKPGDILVGKVTPK--GETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVK-VFT 854
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  747 SKTDETEKT----ESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFE 822
Cdd:PRK00405  855 RIEQGDELPpgvnKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILE 934
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  823 SSLGLAGGLLDRHYRIAPFDERYEQEasrklVFSELYEASkqtanpwifePESPGKSRIFDGRTGDPFEQPVIIGNPYIL 902
Cdd:PRK00405  935 THLGWAAKGLGIKFATPVFDGAKEEE-----IKELLEEAG----------LPEDGKTTLYDGRTGEPFDRPVTVGYMYML 999
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  903 KLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGTIIFGGR 982
Cdd:PRK00405 1000 KLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGEN 1079
                        1050      1060
                  ....*....|....*....|....*
gi 186885957  983 IPTPeDAPESFRLFVRELRSLALEL 1007
Cdd:PRK00405 1080 IPEP-GIPESFNVLVKELQSLGLDV 1103
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
5-1008 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1068.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957     5 DFELFLERYQLVEPLIKERDAVYESLTYSSELYVSARLI-WKNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQ 83
Cdd:TIGR02013   62 NIELEYLSYRLGEPKYSVEECKERGLTYSAPLKVKLRLInKEEDGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQ 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    84 ILQSPGFYYQSELN--DNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVC--YP 159
Cdd:TIGR02013  142 LHRSPGVFFSSEKDttKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLgsGE 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   160 ELFLSFLNDKKKigSKENAILEFYQQFAcvEGDPVFSESLSKDLQKKFF-QQRCELGGIGRRNMNRRLNLDIPQNNTFLL 238
Cdd:TIGR02013  222 YIRNTLRKDPTN--SEEEALVEIYRKLR--PGEPPTVEAARSLLENLFFdPKRYDLGRVGRYKLNKKLGLDVPESIGVLT 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   239 PRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIyaALKHNWTPTPQNLVNSTPLT 318
Cdd:TIGR02013  298 KEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERM--STQDTDTLTPQDLINAKPIS 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   319 DTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHA 398
Cdd:TIGR02013  376 AAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYA 455
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   399 RVGRWGSLESPFYKIS--ERSKGARMLYLSPGRDEYYMVAAGNS-LALNQGIQEEqVVPARYRQEFLTIAWEQVHLRSIF 475
Cdd:TIGR02013  456 RVNEYGFIETPYRKVKdgKVVVTDEIDYLTADEEDNYVIAQANApLDENGRFVED-LVVARYRGEITLVSPDQVDYMDVS 534
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   476 SFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSG 555
Cdd:TIGR02013  535 PKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRY 614
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   556 NGDTL-------RIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVL 628
Cdd:TIGR02013  615 DEDEEepdggidIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAIL 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   629 ISERLVYEDIYTSFHIRKYEIQINQ---GPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvKESSY 705
Cdd:TIGR02013  695 ISERLVKDDVFTSIHIEEYEVEARDtklGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPK--GETEL 772
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   706 APEDRLLRTILGMRVYTSKETCLKLPIGGRGRVIDVRWVQSSKTDETEK--TESIRVYILQKREIKVGDKVAGRHGNKGI 783
Cdd:TIGR02013  773 TPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQGDELPPgvNKLVKVYIAQKRKIQVGDKMAGRHGNKGV 852
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   784 ISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHyriapfderyEQEASRKLVFSELYEASK 863
Cdd:TIGR02013  853 VSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRK----------GVPIATPVFDGASEEEIK 922
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   864 QTANPWIFEPEspGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEME 943
Cdd:TIGR02013  923 EYLEKAGLPRD--GKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEME 1000
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186885957   944 VWALEGFGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRIPTPeDAPESFRLFVRELRSLALELN 1008
Cdd:TIGR02013 1001 VWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEP-GIPESFNVLIKELQSLGLDIE 1064
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
5-1005 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1023.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    5 DFELFLERYQLVEPLI-----KERDavyesLTYSSELYVSARLIwkNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRI 79
Cdd:COG0085    48 NLSLEFGDYRLGEPKYtpeecKERD-----LTYAAPLYVKVRLV--NKETGEIKEQEVFMGDFPLMTDSGTFIINGTERV 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   80 VINQILQSPGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLN----IREILEN 155
Cdd:COG0085   121 IVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLEtdeeILEAFGD 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  156 VCYPELFLSFLnDKKKIGSKENAILEFYQQFAcvEGDPVFSESLSKDLQKKFFQ-QRCELGGIGRRNMNRRLNLDIPQNN 234
Cdd:COG0085   201 DPIQEYILATL-EKDNTKTQEEALLEIYRKLR--PGEPPTIERAEQLLDNLFFDpKRYDLAHVGRYKINKKLGLDVPPED 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  235 TFLLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIyaALKHNWTPTPQNLVNS 314
Cdd:COG0085   278 RVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERM--TTQDVEAITPQSLINI 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  315 TPLTDTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSL 394
Cdd:COG0085   356 RPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSL 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  395 AIHARVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSI 474
Cdd:COG0085   436 ALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDV 515
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  475 FSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEkcivgtglegqAALDsgalaiaehegkiIYtntdkills 554
Cdd:COG0085   516 SPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE-----------APLL-------------HY--------- 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  555 gngdtlriPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLV 634
Cdd:COG0085   563 --------PLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLV 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  635 YEDIYTSFHIRKYEIQINQ---GPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSyaPEDRL 711
Cdd:COG0085   635 KDDVLTSIHIEEYEIEARDtklGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELT--PEERL 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  712 LRTILGMRVYTSKETCLKLPIGGRGRVIDVRWVQSSKTDETEK--TESIRVYILQKREIKVGDKVAGRHGNKGIISKILP 789
Cdd:COG0085   713 LRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEGDELPPgvNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILP 792
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  790 RQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEasrklVFSELYEASkqtanpw 869
Cdd:COG0085   793 QEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEE-----IRELLEKAG------- 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  870 ifePESPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEG 949
Cdd:COG0085   861 ---LPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEA 937
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 186885957  950 FGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEdAPESFRLFVRELRSLAL 1005
Cdd:COG0085   938 YGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPG-IPESFKVLLKELQSLGL 992
rpoB CHL00207
RNA polymerase beta subunit; Provisional
8-1011 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1009.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    8 LFLERYQLVEPLIKERDAVYESLTYSSELYVSARLIwkNDRRRYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQILQS 87
Cdd:CHL00207   47 LFGKNYKLKYPKYNLLSAKSYDSNYSIQIYLPLKFI--NLKTNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRS 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   88 PGFYYQSELNDNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILENVCYPELFLSFLN 167
Cdd:CHL00207  125 PGIYFKKEIKKNSNKIYSATLIPNRGSWIKFELDKNKEIWIRIDKNRKKPLIIFLKALGLTDQDIYSRLTKSEFLKKLKP 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  168 DKKKIGS--KENAILEFYQQFAcvEGDPVFSESLSKDLQKKFFQ-QRCELGGIGRRNMNRRLNLDIPQNNTFLLPRDILA 244
Cdd:CHL00207  205 ILLNSNSytNEEILLEIYKNLS--PIEPATVNDANQNLFSRFFDpKNYDLGKVGRYKINNKLNLNIPERVRNLTYEDILS 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  245 AADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVRLENMARGNIyaaLKHNWTP-TPQNLVNSTPLTDTYKV 323
Cdd:CHL00207  283 IIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRIGLKRLERILRNRM---TICDIDSlSKFNLINPKPLIALIRE 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  324 FFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGRW 403
Cdd:CHL00207  360 FFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRDIHPSHYGRICPIETPEGPNCGLIGSLATNARINKF 439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  404 GSLESPFYKISERS--KGARMLYLSPGRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQYFS 481
Cdd:CHL00207  440 GFIETPFYKVINGKvkKFGNPIYLTADSEDLYRIAPNDINLNKNNYFKKNIIPVRYKQEFKTVNPSKVDFIAISPIQVFS 519
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  482 IGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKI-LLSGNGDTL 560
Cdd:CHL00207  520 IAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQIALDSGMTIISLTEGIVVSVSAYKIiIQDDNNRYI 599
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  561 RIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYT 640
Cdd:CHL00207  600 HYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILADGSDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFT 679
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  641 SFHIRKYEIQINQ---GPERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvKESSYAPEDRLLRTILG 717
Cdd:CHL00207  680 SIHIEKYEIELRQtklGSEEITRNIPNVSEYSLKNLDENGIISIGSKVLAGDILVGKITPK--GESDQLPEGKLLRAIFG 757
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  718 MRVYTSKETCLKLPIGGRGRVIDVRWVQSSKTDE--TEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPY 795
Cdd:CHL00207  758 EKAKDVKDTSLRMPNGGYGRVIKVEIFSRSKGDElkFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPY 837
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  796 LQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWIFEPES 875
Cdd:CHL00207  838 LPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKILPFDEMYGSEYSRILINNKLNQASIKNNEYWLFNSYH 917
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  876 PGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYI 955
Cdd:CHL00207  918 PGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYT 997
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 186885957  956 LQEMLTYKSDHIRARQEVLGTIIFGGRIPTPeDAPESFRLFVRELRSLALELNHFL 1011
Cdd:CHL00207  998 LKELLTIKSDDMQGRNETLNAIVKGQPIPKP-GTPESFKVLMRELQSLGLDIEAYK 1052
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
1-1010 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 800.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    1 NQEIDFELFLERYQLVEPLIKE---------RDAVYESLTYSSELYVSARLIWKNDRRryIQEQTILIGKIPLMTSL--- 68
Cdd:cd00653    31 DDDGRLKLKFGDIYLGKPKVEEggvtrkltpNECRLRDLTYSAPLYVDIRLTVNDKGK--IKEQEVFIGEIPIMLRSklc 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   69 ---------------------GAFIVNGIYRIVINQILQSPGFYYQSElnDNGISVYTGTIISDWGGRlelgidRKSRIW 127
Cdd:cd00653   109 nlngltpeeliklgecpldpgGYFIINGTEKVIINQEQRSPNVIIVED--SKGKRIYTKTSIPSYSPY------RGSWLE 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  128 VRVSRQQKLsilvllsamglnireilenvcypelfLSFLNDKKKigsKENAILEFYQQFacvegdpvfseslskdlqkkf 207
Cdd:cd00653   181 VKSDKKKDR--------------------------IYVRIDLKR---QEEALKYIGKRF--------------------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  208 fqqrcelggigrrnmnrrlnldipqnntfllpRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALVR 287
Cdd:cd00653   211 --------------------------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKR 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  288 LENMARGNIYAALKHNWTPTPQNLVNSTPLTDTYKVFFRLHP------------LSQVLDRTNPLTQIVHGRKLSylgPG 355
Cdd:cd00653   259 LEREVKEKLQKQLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRIS---SL 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  356 GLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGrwGSLESPFYKISErskgarmlylspgrdeyymv 435
Cdd:cd00653   336 GLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEK-------------------- 393
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  436 aagnslalnqgiqeeqvvparyrqefltiaweQVHLRSIFSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVP----- 510
Cdd:cd00653   394 --------------------------------EVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGtpaln 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  511 -----------LSQSEKCIVGTGLEGQAALDsgalaiaehegkiiytntdkillsgngdtlriplvmyersnkntcihqk 579
Cdd:cd00653   442 qqyrmdtklylLLYPQKPLVGTGIEEYIAFG------------------------------------------------- 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  580 phvqrgkcikkgqilaygaatvggELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQINQGP---- 655
Cdd:cd00653   473 ------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKngpe 528
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  656 ERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKESSYapedrllrtILGMRVYTSKETCLKLPIGGR 735
Cdd:cd00653   529 EITRGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP---------IFGEKARDVRDTSLKYPGGEK 599
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  736 GRVIDVRWvqSSKTDETEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRM 815
Cdd:cd00653   600 GIVDDVKI--FSRELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRM 677
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  816 NVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEASRKLVFSELyeaskqtanpwifepESPGKSRIFDGRTGDPFEQPVI 895
Cdd:cd00653   678 TIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGL---------------NYYGKEVLYDGRTGEPLEAPIF 742
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  896 IGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLG 975
Cdd:cd00653   743 VGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKC 822
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*
gi 186885957  976 TIIF----------GGRIPTPEdAPESFRLFVRELRSLALELNHF 1010
Cdd:cd00653   823 GIILsanlcrlckkGTNISKVG-IPYAFKLLFQELQSMNIDPRLK 866
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
23-1010 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 669.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   23 RDAVYESLTYSSELYVSARLI-WKNDRR-------RYIQEQTILIGKIPLMTSLGAFIVNGIYRIVINQILQSPGFYYQS 94
Cdd:PRK09603   83 REAMERGITYSIPLKIKVRLIlWEKDTKsgekngiKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKE 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   95 ELNDNGIS--VYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREILEnVCYPELFLSFLNDK--- 169
Cdd:PRK09603  163 EESSTSLNklIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIK-MFYPLVKVRYENDKyli 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  170 ---------------------------KKIGSK----------------------------------------------- 175
Cdd:PRK09603  242 pfasldanqrmefdlkdpqgkiillagKKLTSRkikelkenhlewveypmdillnrhlaepvmvgkevlldmltqldknk 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  176 -----ENAILEFY------------------------------------QQFACVE-------GDPVFSESLSKDLQKKF 207
Cdd:PRK09603  322 lekihDLGVQEFViindlalghdasiihsfsadseslkllkqtekiddeNALAAIRihkvmkpGDPVTTEVAKQFVKKLF 401
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  208 FQ-QRCELGGIGRRNMNRRLNLDIPQNNTFLLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFGLALV 286
Cdd:PRK09603  402 FDpERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLV 481
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  287 RLENMARGNIYAALKHNWTPTPQNLVNSTPLTDTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTARTATFPI 366
Cdd:PRK09603  482 KMQKTIKDKLTTMSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEA 561
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  367 RDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVAAGNSLALNQG 446
Cdd:PRK09603  562 RDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPASTPIDEEG 641
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  447 IQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLEGQ 526
Cdd:PRK09603  642 NILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKI 721
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  527 AALDSGALAIAEHEGKIIYTNTDKILLSGNGDTL----RIPLVMYERSNKNTCIHQKPHVQRGKCIKKGQILAYGAATVG 602
Cdd:PRK09603  722 IARDSWGAIKANRAGVVEKIDSKNIYILGEGKEEayidAYSLQKNLRTNQNTSFNQVPIVKVGDKVEAGQIIADGPSMDR 801
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  603 GELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEI---QINQGPERVTNEIPHLEVHLLRNLDKNGIV 679
Cdd:PRK09603  802 GELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVdarELKHGVEEFTADIPDVKEEALAHLDESGIV 881
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  680 MLGSWVETGDILIGKLTPQmvKESSYAPEDRLLRTILGMRVYTSKETCLKLPIGGRGRVIDVR----------------- 742
Cdd:PRK09603  882 KVGTYVSAGMILVGKTSPK--GEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKvftkkgyekdarvlsay 959
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957      --------------------------------------------------------------------------------
Cdd:PRK09603  960 eeekakldmehfdrltmlnreellrvssllsqaileepfshngkdykegdqipkeeiasinrftlaslvkkyskevqnhy 1039
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  743 ------WVQSSKT--DETEKTESI---------------RVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDG 799
Cdd:PRK09603 1040 eitknnFLEQKKVlgEEHEEKLSIlekddilpngvikkvKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADG 1119
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  800 RPVDMVFNPLGVPSRMNVGQIFESSLGLAG------------------------------------GLLDRHYRIAPFDE 843
Cdd:PRK09603 1120 EPVDIVLNPLGVPSRMNIGQILEMHLGLVGkefgkqiasmledktkdfakelrakmleianainekDPLTIHALENCSDE 1199
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  844 R---YEQEASRKLVFS-ELYEASKQTANPWIFE---PESPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRS 916
Cdd:PRK09603 1200 ElleYAKDWSKGVKMAiPVFEGISQEKFYKLFElakIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARS 1279
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  917 SGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRIPTPEdAPESFRLF 996
Cdd:PRK09603 1280 TGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESE-IPETFYVL 1358
                        1290
                  ....*....|....
gi 186885957  997 VRELRSLALELNHF 1010
Cdd:PRK09603 1359 TKELQSLALDINIF 1372
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
17-1008 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 621.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   17 EPLIKERDAVYESLTYSSELYVSARLIWKNDRR---------------------RYIQEQTILIGKIPLMTSLGAFIVNG 75
Cdd:PRK14844   81 DPKYDESECIKRGITFSAQVIASIRLVIMQDGIsldeyksikesgdhsklatviKSIEEQEVHFCELPMMTDKGTFIING 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   76 IYRIVINQILQSPGFYYQSELN---DNGISVYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGLNIREI 152
Cdd:PRK14844  161 VEKVIVSQMHRSPGVFFDSDKGktyNSGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNDI 240
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  153 L----ENVCY------------PELF----LSF----------LNDKKKIGSK------ENAILEFYQQFACVEG----- 191
Cdd:PRK14844  241 LdrfyEKIKYikhkdgwkvpfvPDKFkgvrLPFdlmdvegnvlLKANVRITSRlakklyDNELKEYLVPFDSICGlflae 320
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  192 DPVFSESLSK-----------DLQK------------------------------------------------------- 205
Cdd:PRK14844  321 DLIDSASSTKilsagesikleDIKKlellsideisvlnidnlsvgpyilntlfldenmsyqdalyeiykvlrpgevpvle 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  206 ---KFFQ------QRCELGGIGRRNMNRRLNLDIPQNNTFLLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIRSVADL 276
Cdd:PRK14844  401 iveEFFRnlffspEYYDLSNIGRLKLNSYLGLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEF 480
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  277 LQEQFGLALVRLENMARGNIYAALKHNWTPTpqNLVNSTPLTDTYKVFFRLHPLSQVLDRTNPLTQIVHGRKLSYLGPGG 356
Cdd:PRK14844  481 IENQFRTGLLKLERAVVDSMSTSSLDKVSPS--DFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGG 558
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  357 LTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGRWGSLESPFYKISERSKGARMLYLSPGRDEYYMVA 436
Cdd:PRK14844  559 LTRERAGFEVRDVHPTHYGRICPIETPEGQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIA 638
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  437 AGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFSFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEK 516
Cdd:PRK14844  639 DTSAKLDENNCFVDDMLYCRYAGSFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTA 718
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  517 CIVGTGLEGQAALDSGALAIAEHEGKIIYTNTDKILLSGNgDTLRIP--------LVMYERSNKNTCIHQKPHVQRGKCI 588
Cdd:PRK14844  719 PLVATGMESFVASGSGAVVLAKRDGIVDSSDSNSIVIRAF-DKERVNyldvdiyhLRKFQRSNHNTCINQKPLVCVGDYV 797
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  589 KKGQILAYGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQINQGP---ERVTNEIPHL 665
Cdd:PRK14844  798 KEGDVIADGPAINSGELALGQNLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPlgsEKITRAIPGV 877
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  666 EVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvKESSYAPEDRLLRTILGMRVYTSKETCLKLPIGGRGRVIDVR--- 742
Cdd:PRK14844  878 NEENLYHLDDSGIVKIGTRVGPGYILVGKVTPK--PSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQvft 955
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  743 --------------------------------------------------------------W-------------VQSS 747
Cdd:PRK14844  956 rrgveenerallikqkeindfekerdyiinvtseyfydelkkllinsgsqdrekfdsiereqWwgiglknqsiseqVKSL 1035
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  748 KTDETEKTE-------------------------SIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPV 802
Cdd:PRK14844 1036 KKDFDEKVShaiaqfkrkveklhegydlpqgvsmSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPV 1115
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  803 DMVFNPLGVPSRMNVGQIFESSLGLA--------GGLLDRHYRI-APF--------DERYEQ------------------ 847
Cdd:PRK14844 1116 DIILNPLGVPSRMNVGQILETHVGWAckklgekvGNILDEINKIkSAFckgirslnDDNFTKfaaayldnkkieniddde 1195
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  848 -----------------------------------------------------------------EASRKL-----VFSE 857
Cdd:PRK14844 1196 itasvlntpnknalndelnelvenylnscksaysnlrnflievyscgsnvsicnnirdisdnnliEFARKLrdgipVAAP 1275
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  858 LYEASKQTANPWIFE---PESPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKK 934
Cdd:PRK14844 1276 VFEGPKDEQIAKLFElagLDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHF 1355
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186885957  935 GGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGTIIFGGRiPTPEDAPESFRLFVRELRSLALELN 1008
Cdd:PRK14844 1356 GGQRFGEMECWALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDS-NFECGIPESFNVMIKELRSLCLNVD 1428
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
484-933 9.61e-130

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 397.67  E-value: 9.61e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   484 ASLIPFIEHNDANRALMSSNMQRQAVPLsqsekcivgtglegqaaldsgalaiaehegkiiytntdkillsgngdtlrIP 563
Cdd:pfam00562    2 ASLIPFVDHNQSPRNTYQCAMGKQAMGI--------------------------------------------------YT 31
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   564 LVMYERSNKNT---CIHQKPHVQRGKcIKKGQIlaygaatvgGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYT 640
Cdd:pfam00562   32 LNKFYRSDQNTyvlCYPQKPLVKTGA-VEAGGF---------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFT 101
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   641 SFHIRKYEIQINQG--PERVTNEIPHLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPQmvkessyaPEDRLLRTILGM 718
Cdd:pfam00562  102 SIHIKEIEARKTKLgpIEEITRDIPNVSEEALKKLDEDGIVRVGAEVKPGDILVGKVGPT--------ELTKLLRAIFGE 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   719 RVYTSKETCLKLPIGGRGRVIDVRWVQSSKtdetEKTESIRVYILQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQD 798
Cdd:pfam00562  174 KARDVKDTSLKVPPGEEGVVDDVIVFELPP----GGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTED 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   799 GRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDeryEQEASRKLVFSELYEASKqtaNPWifepespGK 878
Cdd:pfam00562  250 GIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD---GASTEVEDIGELLEKAGY---NYY-------GK 316
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 186885957   879 SRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAK 933
Cdd:pfam00562  317 EVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
5-1003 1.39e-81

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 288.01  E-value: 1.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    5 DFELFLERYQLVEPLIKERD----------AVYESLTYSSELYVSARLIWKNDRRRyiqEQTILIGKIPLM--------T 66
Cdd:PRK08565   46 GLKIVLGKIRVGEPEIKEADgserpitpmeARLRNLTYAAPLYLTMIPVENGIEYE---PEEVKIGDLPIMvkskicplS 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   67 SL----------------GAFIVNGIYRIVINQILQSPG--FYYQSELNDNgiSVYTGTIISDWGG-RLELGIDRKSR-- 125
Cdd:PRK08565  123 GLspdelieigedpkdpgGYFIINGSERVIVSQEDLAPNrvLVDKGEAGSS--ITHTAKVISSRAGyRAQVTVERRKDgt 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  126 IWVRVSR-QQKLSILVLLSAMGLNI-REILENVCY-----PELFLSFLNDKKKIGSKENAILEFYQQFAcvEGDPvfses 198
Cdd:PRK08565  201 IYVSFPAvPGKIPFVILMRALGLETdRDIVYAVSLdpeiqQELLPSLEQASSIAATVEDALDYIGKRVA--IGQP----- 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  199 lskdlqKKFFQQRCE-------LGGIGRRNMNRRlnldipqNNTFLLPRdilaAADRLIRIKFGMGTLDDMNHLQNKRIR 271
Cdd:PRK08565  274 ------REYRIERAEqildkylLPHLGTSPEDRI-------KKAYFLGQ----MASKLLELYLGRREPDDKDHYANKRLR 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  272 SVADLLQEQFGLALVRLENMARGNIYAALKHNWTPTPQNLVNSTPLTDtykvffRL-HPL------------SQVLDRTN 338
Cdd:PRK08565  337 LAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDLRAIVRPDIITE------RIrHALatgnwvggrtgvSQLLDRTN 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  339 PLTQIVHGRKLsyLGPggLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARVGRwGSLESPFYKI----- 413
Cdd:PRK08565  411 YLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISV-GVDEEEVEEIlyelg 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  414 ---------SERSKGARmLYLSpGR-------------------------DE----YYMVAAGNSLALN----------- 444
Cdd:PRK08565  486 vvpveeareEEYISWSR-VYLN-GRligyhpdgeelaekirelrrsgkisDEvnvaYIETGEINEVYVNcdsgrvrrpli 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  445 -----------------------------QGI-------QEEQVVPARYRQEFLTiawEQVHLrSIFSFQYFSIGASLIP 488
Cdd:PRK08565  564 vvengkpkltrehveklkkgeltfddlvkMGVieyldaeEEENAYVALDPEDLTP---EHTHL-EIWPPAILGITASIIP 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  489 FIEHNDANRALMSSNMQRQAVPLSQSEKcivgtglegQAALDSgalaiaehegkiiytntdkillsgngdtlRIPLVMYE 568
Cdd:PRK08565  640 YPEHNQSPRNTYQAAMAKQSLGLYAANF---------RIRTDT-----------------------------RGHLLHYP 681
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  569 rsnkntcihQKPHVQrgkcIKKGQILAYGaatvggELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYE 648
Cdd:PRK08565  682 ---------QRPLVQ----TRALEIIGYN------DRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYE 742
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  649 IQINQ--GPERVTNEIP------HLEVHLLRNLDKNGIVMLGSWVETGDILIGKLTPqmvkeSSYAPEDRLLRTILGMRv 720
Cdd:PRK08565  743 TEERKypGGQEDKIEIPepnvrgYRGEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSP-----PRFLEELEELSLGLQER- 816
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  721 ytsKETCLKLPIGGRGRVIDVRWVQSSktdETEKTESIRVYILQKREIkvGDKVAGRHGNKGIISKILPRQDMPYLQDGR 800
Cdd:PRK08565  817 ---RDTSVTVRHGEKGIVDTVLITESP---EGNKLVKVRVRDLRIPEL--GDKFASRHGQKGVIGMLVPQEDMPFTEDGI 888
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  801 PVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEAsRKLVFSELYEASkqtanpwifepespGKSR 880
Cdd:PRK08565  889 VPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYGEPEEEL-RKELLKLGYKPD--------------GTEV 953
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  881 IFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFGVAYILQEML 960
Cdd:PRK08565  954 MYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAMLLKERL 1033
                        1130      1140      1150      1160      1170
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 186885957  961 TYKSD-----------HI---RARQEVLGTIIFG--GRIpTPEDAPESFRLFVRELRSL 1003
Cdd:PRK08565 1034 LDSSDkttiyvcelcgHIawyDRRKNKYVCPIHGdkGNI-SPVEVSYAFKLLLQELMSM 1091
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
480-1003 5.54e-62

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 222.21  E-value: 5.54e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   480 FSIGASLIPFIEHNDANRALMSSNMQRQAVPLsqsekcivgtglegqaaldsgalaiaehegkiiYTNTDKILLSGNGDT 559
Cdd:TIGR03670  127 LGIIASTIPYPEHNQSPRNTMGAAMAKQSLGL---------------------------------YAANYRIRLDTRGHL 173
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   560 LRIPlvmyersnkntcihQKPHVQrgkcIKKGQILAYGaatvggELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIY 639
Cdd:TIGR03670  174 LHYP--------------QKPLVK----TRVLELIGYD------DRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLA 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   640 TSFHIRKYEIQINQGP--ERVTNEIPHLEVH------LLRNLDKNGIVMLGSWVETGDILIGKLTPQMVKEssyapEDRL 711
Cdd:TIGR03670  230 RSTFFRTYEAEERRYPggQEDRFEIPEPDVRgyrgeeAYKHLDEDGIVYPEVEVKGGDVLIGKTSPPRFLE-----ELRE 304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   712 LRTILGMRvytsKETCLKLPIGGRGrVIDVrwVQSSKTDETEKTESIRVYILQKREIkvGDKVAGRHGNKGIISKILPRQ 791
Cdd:TIGR03670  305 FGLVTERR----RDTSVTVRHGEKG-IVDK--VIITETEEGNKLVKVRVRDLRIPEL--GDKFASRHGQKGVIGMIVPQE 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   792 DMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPFDERYEQEAsRKLVFSELYEASkqtanpwif 871
Cdd:TIGR03670  376 DMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEEL-RKELLKLGFKPD--------- 445
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   872 epespGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGEMEVWALEGFG 951
Cdd:TIGR03670  446 -----GKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHG 520
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186885957   952 VAYILQEMLTYKSD-----------HI---RARQEVLGTIIFG--GRIpTPEDAPESFRLFVRELRSL 1003
Cdd:TIGR03670  521 AAMLLKERLLDESDkyvvyvcencgHIaweDKRKGTAYCPVCGetGDI-SPVEMSYAFKLLLDELKSL 587
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
480-965 2.13e-56

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 206.35  E-value: 2.13e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  480 FSIGASLIPFIEHNDANRALMSSNMQRQAVPLsqsekcivgtglegqaaldsgalaiaehegkiiYTNTDKILLSGNGDT 559
Cdd:PRK07225  133 LGIGAGMIPYPEHNASPRITMGAGMIKQSLGL---------------------------------PAANYKLRPDTRGHL 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  560 LRIPlvmyersnkntcihQKPHVQrgkcIKKGQILAYGaatvggELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIY 639
Cdd:PRK07225  180 LHYP--------------QVPLVK----TQTQEIIGFD------ERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLG 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  640 TSFHIRKYEiqinqGPERVTN-------EIPHLEVH------LLRNLDKNGIVMLGSWVETGDILIGKLTPqmvkessya 706
Cdd:PRK07225  236 RSHFFRTYE-----GEERRYPggqedrfEIPDKDVRgyrgeeAYRHLDEDGLVNPETEVKEGDVLIGKTSP--------- 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  707 PedRLLR--TILGMRVYTSKETCLKLPIGGRGrVIDVrwVQSSKTDETEKTESIRVYILQKREIkvGDKVAGRHGNKGII 784
Cdd:PRK07225  302 P--RFLEepDDFGISPEKRRETSVTMRSGEEG-IVDT--VILTETEEGSRLVKVRVRDLRIPEL--GDKFASRHGQKGVI 374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  785 SKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFESSLGLAGGLLDRHYRIAPF-DERYE--QEASRKLVFselyea 861
Cdd:PRK07225  375 GLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFsGEDEEdlREALEKLGF------ 448
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  862 skqtanpwifepESPGKSRIFDGRTGDPFEQPVIIGNPYILKLIHQVDDKIHGRSSGRYSRLTQQPLKGRAKKGGQRVGE 941
Cdd:PRK07225  449 ------------EHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGE 516
                         490       500
                  ....*....|....*....|....
gi 186885957  942 MEVWALEGFGVAYILQEMLTYKSD 965
Cdd:PRK07225  517 MERDVLIGHGAAMLLKERLLDESD 540
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
86-271 3.68e-47

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 166.75  E-value: 3.68e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    86 QSPGFYYQSELNDNGIS-VYTGTIISDWGGRLELGIDRKSRIWVRVSRQQKLSILVLLSAMGL-NIREILENVCYP---- 159
Cdd:pfam04561    1 RSNGIYVEKELDKNGIIaTYTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLvSDREILDRLCYDfndp 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   160 ---ELFLSFLNDKKKIGSKENAILEFYQQFACVEGDPVFSESLSKDLQKKFfqqrcelggiGRRNMNRRLNLDIPQNNTF 236
Cdd:pfam04561   81 qmlELLKPELEEAENIYTQEEALDYIGKGFALRRGEEPRLQRAREILYSRD----------PKYNLNKHLGLNEPFENER 150
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 186885957   237 LLPRDILAAADRLIRIKFGMGTLDDMNHLQNKRIR 271
Cdd:pfam04561  151 LKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
332-399 3.33e-28

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 108.00  E-value: 3.33e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186885957   332 QVLDRTNPLTQIVHGRKLSYlGPGGLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHAR 399
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
935-1012 1.05e-26

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 104.59  E-value: 1.05e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   935 GGQRVGEMEVWALEGFGVAYILQEMLTYKSD----HIRARQEVLG-----TIIFGGRIPTPEDAPESFRLFVRELRSLAL 1005
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAaynkcPICKGETDISPGYIPESFKLLFQELQSLGI 80

                   ....*..
gi 186885957  1006 ELNHFLV 1012
Cdd:pfam04560   81 DPRLLLE 87
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
10-400 1.51e-19

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 93.09  E-value: 1.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   10 LERYQLVEPLIKERD----------AVYESLTYSSELYVSARLIWKNDRRryiQEQTILIGKIPLMTS------------ 67
Cdd:PRK09606   56 LGKIRVGKPVVKEADgsereiypmeARLRNLTYSAPLYLEMSPVEGGEEE---EPEEVYIGELPVMVGskicnlyglsee 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   68 ------------LGAFIVNGIYRIVINQILQSPGFYYQSELNDNGISVYTGTIISDWGG---RLELGIDRKSRIWV---R 129
Cdd:PRK09606  133 elievgedpldpGGYFIVNGSERVLMTLEDLAPNKILVEKDERYGDRIEVAKVFSQRRGyraLVTVERNRDGLLEVsfpS 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  130 VSRqqKLSILVLLSAMGL-NIREILENVC-YPELFLSFLND--KKKIGSKENAIlEFYqqfacveGDPVFSESlSKDLQK 205
Cdd:PRK09606  213 VPG--SIPFVILMRALGLeTDEEIVEAVSdDPEIVKFMLENleEAEVDTQEEAL-EYI-------GKRVAPGQ-TKEYRI 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  206 KFFQQ---RCELGGIGRRNMNRRlnldipqNNTFLLPRdilaAADRLIRIKFGMGTLDDMNHLQNKRIRSVADLLQEQFG 282
Cdd:PRK09606  282 KRAEYvidRYLLPHLGVEPEVRR-------AKAHYLGR----MAEACFELALGRREEDDKDHYANKRLKLAGDLMEDLFR 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957  283 LALVRLenmARGNIYA---ALKHNWTPTPQNLVNSTPLTDtykvffRL-HPL------------SQVLDRTNPLTQIVHG 346
Cdd:PRK09606  351 VAFNRL---ARDVKYQlerANMRNRELSIKTAVRSDVLTE------RLeHAMatgnwvggrtgvSQLLDRTDYMATLSHL 421
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 186885957  347 RKLsyLGPggLTARTATFPIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARV 400
Cdd:PRK09606  422 RRV--VSP--LSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVEI 471
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
6-318 7.76e-16

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 80.89  E-value: 7.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957     6 FELFLERYQLVEPLIKERDAVYES----------LTYSSELYVsaRLIWKNDRRRYIQEQTILIGKIPLMT--------- 66
Cdd:pfam04563   44 LSLKFGQIRLGKPMFDETDGSTREiypqecrlrnLTYSAPLYV--DLELSVYNGEDIKPIEVFIGRLPIMLrsnacilsg 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957    67 ---------------SLGAFIVNGIYRIVINQILQS---PGFYYQSELNDNGI--SVYTGTIIS---DWGGRLE-LGIDR 122
Cdd:pfam04563  122 ateselvklgecpldPGGYFIINGSEKVIVAQEHRSrnhPIVFKKADPKKRGSvaSVRSSAEISvrpDSTSWVNvLEYLS 201
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   123 KSRIWVRVS-RQQKLSILVLLSAMGLNI-REILENVCYpELFLSFLNDKKKIGSKENAILEFYQQFACVE-----GDPVF 195
Cdd:pfam04563  202 NGTIYFKFPyIKKEIPIVIILRALGFTSdREIFELICY-DVNDQQLQEELLPSLEEGFKIRIQTQEQALDyiggrGRAIF 280
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186885957   196 SESLSKD---------LQKKFFQQRCELGGIGRRNMnrrlnldipqnntfllpRDILAAADRLIRIKFGMGTLDDMNHLQ 266
Cdd:pfam04563  281 RMGRPREprikyaeeiLQKEVLPHLGTYELDETKKA-----------------YFIGYMIRRLLLLALGRREVDDRDHLG 343
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 186885957   267 NKRIRSVADLLQEQFGLALVRLENMARGNIYAALKHNWTPTPQNLVNSTPLT 318
Cdd:pfam04563  344 NKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVLGSPDDLMLQLLVNAKPIT 395
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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