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FLJ00254 protein, partial [Homo sapiens]
trimeric_dUTPase domain-containing protein( domain architecture ID 10165877)
trimeric_dUTPase domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
trimeric_dUTPase | cd07557 | Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common ... |
92-166 | 3.45e-13 | ||
Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common family of dUTPase, found in bacteria, eukaryotes, and archaea. They catalyze the hydrolysis of the dUTP-Mg complex (dUTP-Mg) into dUMP and pyrophosphate. This reaction is crucial for the preservation of chromosomal integrity as it removes dUTP and therefore reduces the cellular dUTP/dTTP ratio, and prevents dUTP from being incorporated into DNA. It also provides dUMP as the precursor for dTTP synthesis via the thymidylate synthase pathway. dUTPases are homotrimeric, except some monomeric viral dUTPases, which have been shown to mimic a trimer. Active sites are located at the subunit interface. : Pssm-ID: 143638 [Multi-domain] Cd Length: 92 Bit Score: 62.90 E-value: 3.45e-13
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Name | Accession | Description | Interval | E-value | |||
trimeric_dUTPase | cd07557 | Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common ... |
92-166 | 3.45e-13 | |||
Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common family of dUTPase, found in bacteria, eukaryotes, and archaea. They catalyze the hydrolysis of the dUTP-Mg complex (dUTP-Mg) into dUMP and pyrophosphate. This reaction is crucial for the preservation of chromosomal integrity as it removes dUTP and therefore reduces the cellular dUTP/dTTP ratio, and prevents dUTP from being incorporated into DNA. It also provides dUMP as the precursor for dTTP synthesis via the thymidylate synthase pathway. dUTPases are homotrimeric, except some monomeric viral dUTPases, which have been shown to mimic a trimer. Active sites are located at the subunit interface. Pssm-ID: 143638 [Multi-domain] Cd Length: 92 Bit Score: 62.90 E-value: 3.45e-13
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dUTPase | pfam00692 | dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. |
71-195 | 4.02e-13 | |||
dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. Pssm-ID: 395562 [Multi-domain] Cd Length: 129 Bit Score: 63.85 E-value: 4.02e-13
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dut | TIGR00576 | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); The main function of these proteins is ... |
72-163 | 2.33e-12 | |||
deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); The main function of these proteins is in maintaining the levels of dUTP in the cell to prevent dUTP incorporation into DNA during DNA replication. Pol proteins in viruses are very similar to this protein family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Changed role from 132 to 123. RTD [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism] Pssm-ID: 273149 [Multi-domain] Cd Length: 142 Bit Score: 62.25 E-value: 2.33e-12
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Dut | COG0756 | dUTP pyrophosphatase (dUTPase) [Nucleotide transport and metabolism, Defense mechanisms]; dUTP ... |
75-163 | 1.02e-09 | |||
dUTP pyrophosphatase (dUTPase) [Nucleotide transport and metabolism, Defense mechanisms]; dUTP pyrophosphatase (dUTPase) is part of the Pathway/BioSystem: Thymidylate biosynthesis Pssm-ID: 440519 [Multi-domain] Cd Length: 143 Bit Score: 55.02 E-value: 1.02e-09
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dut | PRK00601 | dUTP diphosphatase; |
75-163 | 4.21e-07 | |||
dUTP diphosphatase; Pssm-ID: 234802 [Multi-domain] Cd Length: 150 Bit Score: 47.85 E-value: 4.21e-07
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Name | Accession | Description | Interval | E-value | |||
trimeric_dUTPase | cd07557 | Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common ... |
92-166 | 3.45e-13 | |||
Trimeric dUTP diphosphatases; Trimeric dUTP diphosphatases, or dUTPases, are the most common family of dUTPase, found in bacteria, eukaryotes, and archaea. They catalyze the hydrolysis of the dUTP-Mg complex (dUTP-Mg) into dUMP and pyrophosphate. This reaction is crucial for the preservation of chromosomal integrity as it removes dUTP and therefore reduces the cellular dUTP/dTTP ratio, and prevents dUTP from being incorporated into DNA. It also provides dUMP as the precursor for dTTP synthesis via the thymidylate synthase pathway. dUTPases are homotrimeric, except some monomeric viral dUTPases, which have been shown to mimic a trimer. Active sites are located at the subunit interface. Pssm-ID: 143638 [Multi-domain] Cd Length: 92 Bit Score: 62.90 E-value: 3.45e-13
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dUTPase | pfam00692 | dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. |
71-195 | 4.02e-13 | |||
dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. Pssm-ID: 395562 [Multi-domain] Cd Length: 129 Bit Score: 63.85 E-value: 4.02e-13
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dut | TIGR00576 | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); The main function of these proteins is ... |
72-163 | 2.33e-12 | |||
deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); The main function of these proteins is in maintaining the levels of dUTP in the cell to prevent dUTP incorporation into DNA during DNA replication. Pol proteins in viruses are very similar to this protein family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Changed role from 132 to 123. RTD [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism] Pssm-ID: 273149 [Multi-domain] Cd Length: 142 Bit Score: 62.25 E-value: 2.33e-12
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Dut | COG0756 | dUTP pyrophosphatase (dUTPase) [Nucleotide transport and metabolism, Defense mechanisms]; dUTP ... |
75-163 | 1.02e-09 | |||
dUTP pyrophosphatase (dUTPase) [Nucleotide transport and metabolism, Defense mechanisms]; dUTP pyrophosphatase (dUTPase) is part of the Pathway/BioSystem: Thymidylate biosynthesis Pssm-ID: 440519 [Multi-domain] Cd Length: 143 Bit Score: 55.02 E-value: 1.02e-09
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dut | PRK00601 | dUTP diphosphatase; |
75-163 | 4.21e-07 | |||
dUTP diphosphatase; Pssm-ID: 234802 [Multi-domain] Cd Length: 150 Bit Score: 47.85 E-value: 4.21e-07
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PLN02547 | PLN02547 | dUTP pyrophosphatase |
83-163 | 1.03e-05 | |||
dUTP pyrophosphatase Pssm-ID: 215302 Cd Length: 157 Bit Score: 44.01 E-value: 1.03e-05
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PHA02703 | PHA02703 | ORF007 dUTPase; Provisional |
75-202 | 2.02e-05 | |||
ORF007 dUTPase; Provisional Pssm-ID: 165079 Cd Length: 165 Bit Score: 43.43 E-value: 2.02e-05
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PHA03094 | PHA03094 | dUTPase; Provisional |
75-163 | 1.62e-03 | |||
dUTPase; Provisional Pssm-ID: 165376 [Multi-domain] Cd Length: 144 Bit Score: 37.44 E-value: 1.62e-03
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Blast search parameters | ||||
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