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Conserved domains on  [gi|1867163231|ref|NP_001371957|]
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multiple epidermal growth factor-like domains protein 11 isoform 1 precursor [Homo sapiens]

Protein Classification

EMI and EGF_CA domain-containing protein( domain architecture ID 10540561)

EMI and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.99e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.99e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867163231   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 275-320 3.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 36.56  E-value: 3.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGSFGFQCSQHCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 362-409 8.53e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 35.41  E-value: 8.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  362 CPCD--ADNTISCHPVTGACTCQPGWSGHHCNEsCPVGYYGDGCQLPCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.99e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.99e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867163231   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 275-320 3.48e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 3.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGSFGFQCSQHCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 362-409 8.53e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  362 CPCD--ADNTISCHPVTGACTCQPGWSGHHCNEsCPVGYYGDGCQLPCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 25-94 1.99e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 60.51  E-value: 1.99e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867163231   25 PNVCS--HWESYAVTVQESYAHPFDQIYYTRCTDIlnwFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYE 94
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 275-320 3.48e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 3.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  275 CPCHHGG----QCDHVTGQCHCTAGYMGDRCqEECPFGSFGFQCSQHCDC 320
Cdd:pfam00053    1 CDCNPHGslsdTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 362-409 8.53e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1867163231  362 CPCD--ADNTISCHPVTGACTCQPGWSGHHCNEsCPVGYYGDGCQLPCTC 409
Cdd:pfam00053    1 CDCNphGSLSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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