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Conserved domains on  [gi|1859470901|ref|NP_001371366|]
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protein LSM14 homolog A isoform r [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FDF super family cl09757
FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an ...
 149-232 2.20e-12

FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops. It is found at the C terminus of Scd6p-like SM domains. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain.


The actual alignment was detected with superfamily member pfam09532:

Pssm-ID: 430668  Cd Length: 104  Bit Score: 62.09  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470901 149 NKRQVEDKLEKQEKPvnGEDKGDsgVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPT--------WAEE 220
Cdd:pfam09532  17 NKQEVFAELRKNDKL--DEEKRL--VNENNATRVATNEQPNEEVKGVYKKDDFFDNISSEANDRGIQSgpspsgrdWREE 92

                          90
                  ....*....|..
gi 1859470901 221 RRLNAETFGIPL 232
Cdd:pfam09532  93 RSLNTETFGVDS 104
 
Name Accession Description Interval E-value
FDF pfam09532
FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an ...
 149-232 2.20e-12

FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops. It is found at the C terminus of Scd6p-like SM domains. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain.


Pssm-ID: 430668  Cd Length: 104  Bit Score: 62.09  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470901 149 NKRQVEDKLEKQEKPvnGEDKGDsgVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPT--------WAEE 220
Cdd:pfam09532  17 NKQEVFAELRKNDKL--DEEKRL--VNENNATRVATNEQPNEEVKGVYKKDDFFDNISSEANDRGIQSgpspsgrdWREE 92

                          90
                  ....*....|..
gi 1859470901 221 RRLNAETFGIPL 232
Cdd:pfam09532  93 RSLNTETFGVDS 104
 
Name Accession Description Interval E-value
FDF pfam09532
FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an ...
 149-232 2.20e-12

FDF domain; The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops. It is found at the C terminus of Scd6p-like SM domains. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain.


Pssm-ID: 430668  Cd Length: 104  Bit Score: 62.09  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470901 149 NKRQVEDKLEKQEKPvnGEDKGDsgVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPT--------WAEE 220
Cdd:pfam09532  17 NKQEVFAELRKNDKL--DEEKRL--VNENNATRVATNEQPNEEVKGVYKKDDFFDNISSEANDRGIQSgpspsgrdWREE 92

                          90
                  ....*....|..
gi 1859470901 221 RRLNAETFGIPL 232
Cdd:pfam09532  93 RSLNTETFGVDS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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