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Conserved domains on  [gi|1856631304|ref|NP_001371211|]
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nesprin-3 isoform 3 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
156-427 1.40e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  156 AQVLLHNVDNQAVLLDRLLEEAASLFNRIGDpsvDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW 235
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEE---AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  236 LKAVVEKVNGCLGRncklpitqrlstLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGA--EKITGELEEMRKVLEKLR 313
Cdd:TIGR02168  819 AANLRERLESLERR------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEEliEELESELEALLNERASLE 886
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  314 ALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE-------FRMVLQRLAQE--GLQPAAKAGTEDELVAHWRRYSATRAA 384
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEElreklaqLELRLEGLEVRidNLQERLSEEYSLTLEEAEALENKIEDD 966
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1856631304  385 LASEEPRVDRLQAQLKELivFPHNLkplsdsviATIQEYQSLK 427
Cdd:TIGR02168  967 EEEARRRLKRLENKIKEL--GPVNL--------AAIEEYEELK 999
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
156-427 1.40e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  156 AQVLLHNVDNQAVLLDRLLEEAASLFNRIGDpsvDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW 235
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEE---AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  236 LKAVVEKVNGCLGRncklpitqrlstLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGA--EKITGELEEMRKVLEKLR 313
Cdd:TIGR02168  819 AANLRERLESLERR------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEEliEELESELEALLNERASLE 886
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  314 ALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE-------FRMVLQRLAQE--GLQPAAKAGTEDELVAHWRRYSATRAA 384
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEElreklaqLELRLEGLEVRidNLQERLSEEYSLTLEEAEALENKIEDD 966
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1856631304  385 LASEEPRVDRLQAQLKELivFPHNLkplsdsviATIQEYQSLK 427
Cdd:TIGR02168  967 EEEARRRLKRLENKIKEL--GPVNL--------AAIEEYEELK 999
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
156-427 1.40e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  156 AQVLLHNVDNQAVLLDRLLEEAASLFNRIGDpsvDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW 235
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEE---AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  236 LKAVVEKVNGCLGRncklpitqrlstLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGA--EKITGELEEMRKVLEKLR 313
Cdd:TIGR02168  819 AANLRERLESLERR------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEEliEELESELEALLNERASLE 886
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856631304  314 ALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE-------FRMVLQRLAQE--GLQPAAKAGTEDELVAHWRRYSATRAA 384
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEElreklaqLELRLEGLEVRidNLQERLSEEYSLTLEEAEALENKIEDD 966
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1856631304  385 LASEEPRVDRLQAQLKELivFPHNLkplsdsviATIQEYQSLK 427
Cdd:TIGR02168  967 EEEARRRLKRLENKIKEL--GPVNL--------AAIEEYEELK 999
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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