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Conserved domains on  [gi|18539467|gb|AAL74404|]
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nucleolar RNA-associated protein beta [Homo sapiens]

Protein Classification

nucleolar RNA-associated family protein( domain architecture ID 13691714)

nucleolar RNA-associated protein (NRAP) family protein such as nucleolar protein 6 (NOL6) that is involved in RNA binding, localization, and ribosome biogenesis; it interacts with pre-rRNA primary transcripts to facilitate ribosome assembly within the nucleolus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 641-846 1.38e-58

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465418  Cd Length: 201  Bit Score: 199.75  E-value: 1.38e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    641 LDALIQGL-KETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAfsfyetlrerss 719
Cdd:pfam17405    2 FDSLLPPSsSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA------------ 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    720 llprldkpcpAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGL-----------QCRATATHTDVLK 788
Cdd:pfam17405   70 ----------AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLY 139

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    789 D-GFVFRIRVAYQREPQILKEVQSPEGMISLRDTAAS---LRLERDTRQLPLLTSALHGLQQ 846
Cdd:pfam17405  140 PsGYVFRLRIHHDREETLLERQLKDKGLARYQREEAAealAKYKRRFIHLPRHTQAIQTLCT 201
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 6.79e-58

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


:

Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 6.79e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFG---SVCFSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 848-992 3.17e-56

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465419  Cd Length: 157  Bit Score: 191.24  E-value: 3.17e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    848 HPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTV 927
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    928 EEQVEIRSGFLAARAQLP-----VMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQL--MDPR 992
Cdd:pfam17406   81 EDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQGggLDVK 152
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.77e-55

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18539467    396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 2.78e-43

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 2.78e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404    1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                   ....
gi 18539467    625 LHAD 628
Cdd:pfam17404  156 RHLG 159
 
Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 641-846 1.38e-58

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 199.75  E-value: 1.38e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    641 LDALIQGL-KETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAfsfyetlrerss 719
Cdd:pfam17405    2 FDSLLPPSsSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA------------ 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    720 llprldkpcpAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGL-----------QCRATATHTDVLK 788
Cdd:pfam17405   70 ----------AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLY 139

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    789 D-GFVFRIRVAYQREPQILKEVQSPEGMISLRDTAAS---LRLERDTRQLPLLTSALHGLQQ 846
Cdd:pfam17405  140 PsGYVFRLRIHHDREETLLERQLKDKGLARYQREEAAealAKYKRRFIHLPRHTQAIQTLCT 201
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 6.79e-58

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 6.79e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFG---SVCFSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 848-992 3.17e-56

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 191.24  E-value: 3.17e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    848 HPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTV 927
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    928 EEQVEIRSGFLAARAQLP-----VMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQL--MDPR 992
Cdd:pfam17406   81 EDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQGggLDVK 152
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.77e-55

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18539467    396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 2.78e-43

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 2.78e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404    1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                   ....
gi 18539467    625 LHAD 628
Cdd:pfam17404  156 RHLG 159
 
Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 641-846 1.38e-58

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 199.75  E-value: 1.38e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    641 LDALIQGL-KETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAfsfyetlrerss 719
Cdd:pfam17405    2 FDSLLPPSsSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA------------ 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    720 llprldkpcpAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGL-----------QCRATATHTDVLK 788
Cdd:pfam17405   70 ----------AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLY 139

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    789 D-GFVFRIRVAYQREPQILKEVQSPEGMISLRDTAAS---LRLERDTRQLPLLTSALHGLQQ 846
Cdd:pfam17405  140 PsGYVFRLRIHHDREETLLERQLKDKGLARYQREEAAealAKYKRRFIHLPRHTQAIQTLCT 201
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 6.79e-58

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 6.79e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFG---SVCFSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 848-992 3.17e-56

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 191.24  E-value: 3.17e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    848 HPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTV 927
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18539467    928 EEQVEIRSGFLAARAQLP-----VMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQL--MDPR 992
Cdd:pfam17406   81 EDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQGggLDVK 152
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.77e-55

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18539467    396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 2.78e-43

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 2.78e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404    1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18539467    546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                   ....
gi 18539467    625 LHAD 628
Cdd:pfam17404  156 RHLG 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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