Chain A, Non-structural protein 4A,Serine protease NS3
NS3 protease( domain architecture ID 10502700)
NS3 (non-structural protein 3) proease is a peptidase family S29 member; the hepatitis C virus NS3/4A protease cleaves at least 4 sites on the viral polyprotein and is essential for virus maturation, making it an attractive target for drug development
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Peptidase_S29 | pfam02907 | Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a ... |
52-199 | 1.90e-85 | |||
Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold. The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3. The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins. The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A. : Pssm-ID: 427049 Cd Length: 149 Bit Score: 248.88 E-value: 1.90e-85
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Name | Accession | Description | Interval | E-value | |||
Peptidase_S29 | pfam02907 | Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a ... |
52-199 | 1.90e-85 | |||
Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold. The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3. The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins. The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A. Pssm-ID: 427049 Cd Length: 149 Bit Score: 248.88 E-value: 1.90e-85
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Name | Accession | Description | Interval | E-value | |||
Peptidase_S29 | pfam02907 | Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a ... |
52-199 | 1.90e-85 | |||
Hepatitis C virus NS3 protease; Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold. The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3. The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins. The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A. Pssm-ID: 427049 Cd Length: 149 Bit Score: 248.88 E-value: 1.90e-85
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Blast search parameters | ||||
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