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Conserved domains on  [gi|1850067555|ref|WP_172874420|]
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MarR family winged helix-turn-helix transcriptional regulator [Lentilactobacillus buchneri]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-145 8.74e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 80.01  E-value: 8.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555   5 MSKTNQDLLKEAIDVYLSSLKYLDNFVSEPATKYGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHD 84
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1850067555  85 YIFQKPAESDRRRLYLHLTPTGEQTEKHVNDLITKRFDSWISRYGDDKVRAILKFIKEFAA 145
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-145 8.74e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 80.01  E-value: 8.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555   5 MSKTNQDLLKEAIDVYLSSLKYLDNFVSEPATKYGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHD 84
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1850067555  85 YIFQKPAESDRRRLYLHLTPTGEQTEKHVNDLITKRFDSWISRYGDDKVRAILKFIKEFAA 145
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-133 4.50e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 71.86  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555   37 KYGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAESDRRRLYLHLTPTGEQTEKHVNDL 116
Cdd:smart00347   5 PLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEA 84

                           90
                   ....*....|....*..
gi 1850067555  117 ITKRFDSWISRYGDDKV 133
Cdd:smart00347  85 RSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-97 1.77e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 58.75  E-value: 1.77e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555  38 YGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAESDRRR 97
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-145 8.74e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 80.01  E-value: 8.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555   5 MSKTNQDLLKEAIDVYLSSLKYLDNFVSEPATKYGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHD 84
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1850067555  85 YIFQKPAESDRRRLYLHLTPTGEQTEKHVNDLITKRFDSWISRYGDDKVRAILKFIKEFAA 145
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-133 4.50e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 71.86  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555   37 KYGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAESDRRRLYLHLTPTGEQTEKHVNDL 116
Cdd:smart00347   5 PLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEA 84

                           90
                   ....*....|....*..
gi 1850067555  117 ITKRFDSWISRYGDDKV 133
Cdd:smart00347  85 RSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-97 1.77e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 58.75  E-value: 1.77e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850067555  38 YGLSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAESDRRR 97
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 40-96 1.03e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 43.69  E-value: 1.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1850067555  40 LSFEQYLILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAESDRR 96
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
43-112 1.54e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.72  E-value: 1.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1850067555  43 EQYL--ILHTIAEKQNVSLMDIASERRVTRSAISRQIKVLLQHDYIFQKPAEsdrrrlYLHLTPTGEQT-----EKH 112
Cdd:COG1321     9 EDYLkaIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG------GITLTEEGRELalrivRRH 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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