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Conserved domains on  [gi|18490910|gb|AAH22500|]
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Leucine-rich, glioma inactivated 1 [Homo sapiens]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
91-151 3.59e-16

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 3.59e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18490910    91 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 510-550 1.55e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 56.32  E-value: 1.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   510 KFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKH 550
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 146-221 1.95e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18490910    146 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 221
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 420-460 8.09e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   420 FTNQTDIPNMeDVYAVKHFSVKGDVYICLTRFIGDSKVMKW 460
Cdd:pfam03736   2 FVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 272-310 4.62e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 49.00  E-value: 4.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18490910   272 FRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYK 310
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-362 9.63e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18490910   317 KFIKIQDIEIlkiRKPNDIETFKIENNWYFVVADSSkaGFTTIYKW 362
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 465-504 1.39e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18490910   465 FQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNW 504
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 225-265 1.83e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18490910   225 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 265
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 366-413 8.14e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 8.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18490910   366 GFYSHQSLHAWyRDTDVEYLEIvrtpqtLRTPHLILSSSSQRPVIYQW 413
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSI------GGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
91-151 3.59e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 3.59e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18490910    91 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-175 2.09e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910  91 PSLQLLLFTSNSFDVISDdAFIGLPHLEYLFIENNNIKSISrHTFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDL 170
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDL 235


                ....*
gi 18490910 171 RGNSF 175
Cdd:COG4886 236 SNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 510-550 1.55e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 56.32  E-value: 1.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   510 KFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKH 550
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 146-221 1.95e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18490910    146 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 221
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 420-460 8.09e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   420 FTNQTDIPNMeDVYAVKHFSVKGDVYICLTRFIGDSKVMKW 460
Cdd:pfam03736   2 FVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 272-310 4.62e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 49.00  E-value: 4.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18490910   272 FRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYK 310
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRRCT smart00082
Leucine rich repeat C-terminal domain;
173-221 6.97e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 6.97e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 18490910    173 NSFNCDCKLKWLVEWL---GHTNaTVEDIYCEGPPEYKKRKINSLSSkDFDC 221
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQ-DPVDLRCASPSSLRGPLLELLHS-EFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-362 9.63e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18490910   317 KFIKIQDIEIlkiRKPNDIETFKIENNWYFVVADSSkaGFTTIYKW 362
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-173 7.44e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 7.44e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18490910 103 FDVISDDAFigLPHLEYLFIENNNIKSISrhTFRGLKSLIHLSLANNNLQTLP--KDIFKGLDSLTNVDLRGN 173
Cdd:cd21340 110 FDPRSLAAL--SNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-177 2.18e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 2.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910   57 NARSIPRTVPPDVISLSFVRSGFTEISEgsflFTPS-LQLLLFTSNSFDVISDDafigLPH-LEYLFIENNNIKSISRHT 134
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELPE----RLPSaLQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTLPAHL 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 18490910  135 frgLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDlrgNSFNC 177
Cdd:PRK15370 303 ---PSGITHLNVQSNSLTALPETLPPGLKTLEAGE---NALTS 339
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 465-504 1.39e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18490910   465 FQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNW 504
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 225-265 1.83e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18490910   225 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 265
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 366-413 8.14e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 8.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18490910   366 GFYSHQSLHAWyRDTDVEYLEIvrtpqtLRTPHLILSSSSQRPVIYQW 413
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSI------GGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
138-161 1.08e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....
gi 18490910    138 LKSLIHLSLANNNLQTLPKDIFKG 161
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 139-173 1.80e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 18490910   139 KSLIHLSLANNNLQTLPkdIFKGLDSLTNVDLRGN 173
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
91-151 3.59e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 3.59e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18490910    91 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
115-175 8.90e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 71.79  E-value: 8.90e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18490910   115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-175 2.09e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910  91 PSLQLLLFTSNSFDVISDdAFIGLPHLEYLFIENNNIKSISrHTFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDL 170
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDL 235


                ....*
gi 18490910 171 RGNSF 175
Cdd:COG4886 236 SNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 510-550 1.55e-10

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 56.32  E-value: 1.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   510 KFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKH 550
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 146-221 1.95e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18490910    146 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 221
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-173 1.96e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910  92 SLQLLLFTSNSFDVIsDDAFIGLPHLEYLFIENNNIKSISRhTFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDLR 171
Cdd:COG4886 114 NLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190


                ..
gi 18490910 172 GN 173
Cdd:COG4886 191 NN 192
LRR_8 pfam13855
Leucine rich repeat;
71-127 5.31e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.31e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18490910    71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 420-460 8.09e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   420 FTNQTDIPNMeDVYAVKHFSVKGDVYICLTRFIGDSKVMKW 460
Cdd:pfam03736   2 FVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 272-310 4.62e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 49.00  E-value: 4.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18490910   272 FRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYK 310
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRRCT smart00082
Leucine rich repeat C-terminal domain;
173-221 6.97e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 6.97e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 18490910    173 NSFNCDCKLKWLVEWL---GHTNaTVEDIYCEGPPEYKKRKINSLSSkDFDC 221
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQ-DPVDLRCASPSSLRGPLLELLHS-EFKC 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-173 8.32e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 8.32e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18490910 102 SFDVISDDAFIGLPHLEYLFIENNNIKSISRHtFRGLKSLIHLSLANNNLQTLPKDIfKGLDSLTNVDLRGN 173
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNN 169
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-362 9.63e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18490910   317 KFIKIQDIEIlkiRKPNDIETFKIENNWYFVVADSSkaGFTTIYKW 362
Cdd:pfam03736   1 KFVPYQTIPT---RGARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-173 7.44e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 7.44e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18490910 103 FDVISDDAFigLPHLEYLFIENNNIKSISrhTFRGLKSLIHLSLANNNLQTLP--KDIFKGLDSLTNVDLRGN 173
Cdd:cd21340 110 FDPRSLAAL--SNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-177 2.18e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 2.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910   57 NARSIPRTVPPDVISLSFVRSGFTEISEgsflFTPS-LQLLLFTSNSFDVISDDafigLPH-LEYLFIENNNIKSISRHT 134
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELPE----RLPSaLQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTLPAHL 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 18490910  135 frgLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDlrgNSFNC 177
Cdd:PRK15370 303 ---PSGITHLNVQSNSLTALPETLPPGLKTLEAGE---NALTS 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 115-153 8.11e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 8.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18490910   115 PHLEYLFIENNNIKSISrhTFRGLKSLIHLSLANNNLQT 153
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 465-504 1.39e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18490910   465 FQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNW 504
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-167 1.44e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910  72 LSFVRSGFTEIseGSFLFTPSLQLL-LFtSNSFDVIsdDAFIGLPHLEYLFIENNNIKSISRhtFRGLKSLIHLSLANNN 150
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLyLY-DNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                        90
                ....*....|....*..
gi 18490910 151 LQTLpkdifKGLDSLTN 167
Cdd:cd21340  80 ISVV-----EGLENLTN 91
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 225-265 1.83e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18490910   225 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 265
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 366-413 8.14e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 8.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18490910   366 GFYSHQSLHAWyRDTDVEYLEIvrtpqtLRTPHLILSSSSQRPVIYQW 413
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSI------GGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
138-161 1.08e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....
gi 18490910    138 LKSLIHLSLANNNLQTLPKDIFKG 161
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
138-161 1.08e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....
gi 18490910    138 LKSLIHLSLANNNLQTLPKDIFKG 161
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-176 1.18e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18490910  91 PSLQLLLFTSNSFDVISDdaFIGLPHLEYLFIENNNIKSISrhTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170
Cdd:COG4886 228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303


                ....*.
gi 18490910 171 RGNSFN 176
Cdd:COG4886 304 LLLLLN 309
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 139-173 1.80e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 18490910   139 KSLIHLSLANNNLQTLPkdIFKGLDSLTNVDLRGN 173
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
136-176 2.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18490910   136 RGLKSLIhlsLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176
Cdd:pfam13855   1 PNLRSLD---LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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