|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
11-853 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1075.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 11 EISVFWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEV 90
Cdd:COG0060 24 EILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCHGLPIELKV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 91 EKKIGIKgKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGH 170
Cdd:COG0060 104 EKELGIK-KKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 171 KVTPYCTHDQTALSSHEVaqGYKNVKDLSAVVKFQLTNS------KDTYFLSWTTTPWTLPANVALAINKDLNYSKIRVE 244
Cdd:COG0060 183 KPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVHPDIDYVLVEVT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 245 N-EYYILATDLINSIITEK----YEIIDTFSGSNLINLKYIPPF-ESDGLVNAYYVVDGEFVTNSEGTGIVHIAPAHGED 318
Cdd:COG0060 261 GgERLILAEALVEAVLKELgiedYEVLATFKGAELEGLRYEHPFyYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGED 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 319 DYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWF 398
Cdd:COG0060 341 DFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTPLIYRATPQWF 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 399 IKTTNFKNEIINNNNNIEWFPSHiKEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAP----SSIKDLQNNSI 474
Cdd:COG0060 421 ISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGELHRTeeviGSVAELLEEEG 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 475 NKIDEDIELHRPYVDNiTLSCPKCNGKMSRVEEVIDVWFDSGSMPFAQHhypfDNQKifNQHFPADFIAEGVDQTRGWFY 554
Cdd:COG0060 500 ADAWFELDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENRE--ELHFPADFYLEGSDQTRGWFY 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 555 SLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISdSAPWNNKRFSENIVAQTkS 634
Cdd:COG0060 573 SSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVAS-SDYWGDLRFSDEILKEV-R 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 635 KFIDTLDNIYKFYNMyNkIDHYNPNNEI--TKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEY-TNTISNWY 711
Cdd:COG0060 651 DVYRRLRNTYRFLLA-N-LDDFDPAEDAvpYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFcVEDLSNWY 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 712 IRRSRGRFW-EQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTGK---SVHLQDYPQYKESFINQALEDEM 787
Cdd:COG0060 729 LDISKDRLYtEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEaeeSVHLADWPEVDEELIDEELEAKW 808
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 788 HTVIKIVELSR----QARKNAdlKIKQPLSKMVIKPNSQLNLSFLPNYYSIIKDELNIKNIELTDNINDY 853
Cdd:COG0060 809 DLVREVRSAVLkaleAARKEK--LIRQPLEAAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDL 876
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
11-825 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 877.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 11 EISVFWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEV 90
Cdd:TIGR00392 14 KILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHKV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 91 EKKIGIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGH 170
Cdd:TIGR00392 94 EKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHEKGLLYRGL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 171 KVTPYCTHDQTALSSHEVAQ--GYKNVKDLSAVVKFQLTNSKDTY-------FLSWTTTPWTLPANVALAINKDLNYSKI 241
Cdd:TIGR00392 174 KPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKTYlkvklssLLIWTTTPWTLPSNLAIAVHPDFEYALV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 242 RVEN--EYYILATDLINSIIT---EKYEIIDTFSGSNLINLKYIPPF---ESDGLVNAYYVVDGEFVTNSEGTGIVHIAP 313
Cdd:TIGR00392 254 QDNTkvEYFILAKKLVEKLYNkagSDYEIIKTFKGSDLEGLEYEHPLydfVSQLKEGAPVVIGGDHVTTEDGTGIVHTAP 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 314 AHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKL-------LSKKQLLYKKQKYEHNYPHCWRCG 386
Cdd:TIGR00392 334 GHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKGLLLKAEKITHSYPHCWRTK 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 387 NPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPSHIkEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAPSSI 466
Cdd:TIGR00392 414 TPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGSI 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 467 KDLQNNSINK-IDEDIE-LHRPYVDNITLSCPKCnGKMSRVEEVIDVWFDSGSMPFAQHHYPFDNQKiFNQHFPADFIAE 544
Cdd:TIGR00392 493 EELIELIELKgIDAWFEdLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFENEK-FKEVFPADFILE 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 545 GVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISdSAPWNNKRF 624
Cdd:TIGR00392 571 GSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVAS-SDPWEDLRF 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 625 SENIVAQTKSKFIDTLDNIYKFYNMYNKIDHYNP--NNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINE 702
Cdd:TIGR00392 650 SDEILKQVVEKYRKIRWNTYRFLLTYANLDKFDPlfNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQD 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 703 Y-TNTISNWYIRRSRGRFWEQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTG----KSVHLQDYPQYKES 777
Cdd:TIGR00392 730 FiVEELSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGgeeeESVHLNLWPEVDEE 809
|
810 820 830 840
....*....|....*....|....*....|....*....|....*...
gi 1848617803 778 FINQALEDEMHTVIKIVELSRQARKNADLKIKQPLSKMVIKPNSQLNL 825
Cdd:TIGR00392 810 FIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVL 857
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-983 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 746.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 7 NTQNEISVFWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPV 86
Cdd:PLN02882 12 KQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 87 ELEVEKKIGIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLL 166
Cdd:PLN02882 92 EYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 167 YKGHKVTPYCTHDQTALSSHEVAQGYKNVKDLSAVVKFQLTNSKD-TYFLSWTTTPWTLPANVALAINKDLNYSKIR--V 243
Cdd:PLN02882 172 YKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNFTYVKVRnkY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 244 ENEYYILATDLINSIITEK---------------YEIIDTFSGSNLINLKYIP--PFESDGLVNAYYVVDGEFVTNSEGT 306
Cdd:PLN02882 252 TGKVYIVAESRLSALPTAKpkskkgskpenaaegYEVLAKVPGSSLVGKKYEPlfDYFSEFSDTAFRVVADDYVTDDSGT 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 307 GIVHIAPAHGEDDYQL-----VLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPH 381
Cdd:PLN02882 332 GVVHCAPAFGEDDYRVclangIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPF 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 382 CWRCGNPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPSHIKEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEY 461
Cdd:PLN02882 412 CWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGEEVV 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 462 APSSIKDLQNNSINKIDediELHRPYVDNITLscPKCNGK----MSRVEEVIDVWFDSGSMPFAQHHYPFDNQKIFNQHF 537
Cdd:PLN02882 492 VIGSIAELEKLSGVKVT---DLHRHFIDHITI--PSSRGPefgvLRRVDDVFDCWFESGSMPYAYIHYPFENKELFEKNF 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 538 PADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALI-SDS 616
Cdd:PLN02882 567 PADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLInSPV 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 617 APWNNKRF-SENIVAQTKSKFIdTLDNIYKFYNMYNK------IDHYNPNN--EITKSRNTLDNWALSRLNTLIKESNIY 687
Cdd:PLN02882 647 VRAEPLRFkEEGVFGVVKDVFL-PWYNAYRFLVQNAKrlevegGAPFVPLDlaKLQNSANVLDRWINSATQSLVKFVREE 725
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 688 VNNYD-FTSAARLInEYTNTISNWYIRRSRGRFWEQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNL----T 762
Cdd:PLN02882 726 MGAYRlYTVVPYLV-KFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrkvlP 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 763 GK--SVHLQDYPQYKESFINQALEDEMHTVIKIVELSRQARKNADLKIKQPLSKM-VIKPNSQLNLSFLPNYYSIIKDEL 839
Cdd:PLN02882 805 GSeeSIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMvVVHPDAEFLDDITGKLKEYVLEEL 884
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 840 NIKNIELTDNINDYITYELKLNFSSVGPKLGNKTKNIQTLIDSLS-----EYDKKSLIESNNFKSLSSDAELTKDDFIIK 914
Cdd:PLN02882 885 NVRSLVPCNDPLKYASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSqddilEFEKAGEVTIAGHTLKAGDIKVVRDFKRPE 964
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1848617803 915 TLPKDSYQLSEDNDCVILLDKNLSPELIREGHARELIRLIQQLRKKKNLPINQRIDIYIGVTGELLESI 983
Cdd:PLN02882 965 GVSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLDEVDESA 1033
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
15-616 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 591.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 15 FWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKI 94
Cdd:pfam00133 5 FWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 95 GIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKVTP 174
Cdd:pfam00133 85 GIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 175 YCTHDQTALSSHEVAqgYKNVKDLSAVVKFQLTNSKDTYFLSWTTTPWTLPANVALAINKDLNYSkirVENEYYILATDL 254
Cdd:pfam00133 165 WSPALNTALSNLEVE--YKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYV---ITGEGYILAEAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 255 INSIITE--KYEIIDTFSGSNLINLKYIPPFESdglvNAYYVVDGEFVTNSEGTGIVHIAPAHGEDDYQLVLERDLDFLN 332
Cdd:pfam00133 240 LKSLYKKgtDKKILEDFRGKELEGKEAIHPFVN----REIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 333 VITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIINNN 412
Cdd:pfam00133 316 PVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 413 NNIEWFPSHiKEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAPSSIKDLQNNSINKIDEDIELHRPYVDNIT 492
Cdd:pfam00133 396 EKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLG 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 493 lscpKCNGKMSRVEEVIDVWFDSGSMPFAQHHYPFDNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRA 572
Cdd:pfam00133 475 ----YGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNV 550
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 1848617803 573 LSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDS 616
Cdd:pfam00133 551 LVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSD 594
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
9-1009 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 567.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 9 QNEISVFWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVEL 88
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 89 EVEKKIGIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYK 168
Cdd:PTZ00427 158 EIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 169 GHKVTPYCTHDQTALSSHEVAQGYKNVKDLSAVVKFQLT---------------------------NSK----------- 210
Cdd:PTZ00427 238 SFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFVLCsdfpkveeecnieedkqllgekysvlyNNKrensnngnnns 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 211 --------DTYFLSWTTTPWTLPANVALAINKDLNYSKIR--VENEYYILATDLINSII------TEKYEIIDTFSGSNL 274
Cdd:PTZ00427 318 tnnvcyaqHSEILAWTTTPWTLPSNLALCVNEHFTYLRIHhvKSNRVVIVGECRLEWIMkelkwnVEDLKIVNRFKGKEL 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 275 INLKYIPPF-----ESDGLVNAYYVVDGEFVTNSEGTGIVHIAPAHGEDDYQLVLERDLD------FLNVITREGVYNDR 343
Cdd:PTZ00427 398 KGLRYKPLFtnfyeKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIdpekniFIDPLDANGYFTNE 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 344 FPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPSHIK 423
Cdd:PTZ00427 478 VEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIK 557
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 424 EGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAPSSIKDLQNNSINKIDEDieLHRPYVDNITLSCPKCNG--K 501
Cdd:PTZ00427 558 EKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKNIND--LHRHFIDHIEIKNPKGKTypK 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 502 MSRVEEVIDVWFDSGSMPFAQHHYPFDNQK-IFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILD 580
Cdd:PTZ00427 636 LKRIPEVFDCWFESGSMPYAKVHYPFSTEKeDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLA 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 581 SNGKKMSKSKGNVINPTELINKYGADSLRWALISDSA-PWNNKRFSENIVAQTKSKFIDTLDNIYKF-------YNMYNK 652
Cdd:PTZ00427 716 SDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAvRAENLKFQEKGVNEVVKSFILPFYHSFRFfsqevtrYECLNK 795
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 653 IDHYNPNNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYTNTISNWYIRRSRGRFWEQGISNDKKDAY 732
Cdd:PTZ00427 796 KQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGSLGEENCLQSL 875
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 733 NTLYEILTTLSRLVAPFVPFISEKIHYNL---------------------------TGKSVHLQDYPQYKESFINQ---- 781
Cdd:PTZ00427 876 CTTYRTLHLFTVLMAPFTPFITEYIYQQLrrvkstnehnennetgntkegdlnrgvIHKSVHFIMLPQVDEKYIIDyeii 955
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 782 ALEDEMHTVIKIVELSRQARKNADlkiKQPLSKMVIKPNSQlnlSFLPNYYSI---IKDELNIKNIELTDNINdYITYEL 858
Cdd:PTZ00427 956 ELIEKMKDVILLGRVLRERRKVAS---KKPLKSITILHPNE---SYFKNFDQIsnyIKEELNVLNVECSNDTS-CLDFSA 1028
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 859 KLNFSSVGPKLGNKTKNIQTLIDSLSEYDKKSLieSNNFKSLSSDAELTKDDFIIKTLP---KDSYQLSEDNDCVILLDK 935
Cdd:PTZ00427 1029 IPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLY--QQEGKITLDNVTLEGDDIIIQMKPnfqNDNTDIISNNYVTILMDF 1106
|
1050 1060 1070 1080 1090 1100 1110
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848617803 936 NLSPELIREGHARELIRLIQQLRKKKNLPINQRIDIYIGVTGELLESiktnkNMFKENLLIKNI---HLNVIDEYEN 1009
Cdd:PTZ00427 1107 TTDQQLENMASARELCNHIQKMRKNLSLNQNSPVKMHVYIADDTLRN-----NMVSEMEYIKKClrrELNVIPSQED 1178
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
16-848 |
9.45e-122 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 391.48 E-value: 9.45e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 16 WNTQKIFKKSIDNRKgqESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIG 95
Cdd:PRK13208 23 WEEEGTYKFDPDERK--PVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTERKVEKYYG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 96 IKgKQDIEKygiENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIEsvwniLS--TF---HKKGLLYKGH 170
Cdd:PRK13208 101 IR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRR-----ISqkSFldlYKKGLIYRAE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 171 KVTPYCTHDQTALSSHEVaqGYKNVKDLSAVVKFQLTNskDTYFLSWTTTPWTLPANVALAINKDlnyskirveNEYYil 250
Cdd:PRK13208 172 APVLWCPRCETAIAQAEV--EYREREGKLNYIKFPVED--GEEIEIATTRPELLPACVAVVVHPD---------DERY-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 251 aTDLINSIITekyeiidtfsgsnlinlkyIPPFESDGLVNAYYVVDGEFvtnseGTGIVHIAPAHGEDDYQLVLERDLDF 330
Cdd:PRK13208 237 -KHLVGKTAI-------------------VPLFGVEVPILADPLVDPDF-----GTGAVMICTFGDKTDVTWWRELNLPT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 331 LNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIIN 410
Cdd:PRK13208 292 RIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 411 NNNNIEWFPSHIKEgRMGNFLENM-VDWNIGRNRYWGTPLNVWICNDCNHEYAPSsIKDLqnnsinKIDEDIELhrPYVD 489
Cdd:PRK13208 372 RGKEINWYPEHMRV-RLENWIEGLnWDWCISRQRYFGTPIPVWYCKDCGHPILPD-EEDL------PVDPTKDE--PPGY 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 490 nitlSCPKCN-GKMSRVEEVIDVWFDSGSMPFAQHHYPfDNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSS 568
Cdd:PRK13208 442 ----KCPQCGsPGFEGETDVMDTWATSSITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLP 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 569 YKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLR-WAliSDSAPWNNKRFSENIVaQTKSKFIDTLDNIYKFy 647
Cdd:PRK13208 517 WKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRyWA--ASARLGSDTPFDEKQV-KIGRRLLTKLWNASRF- 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 648 nmynkIDHYNPNNEITKSR--NTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYT-NTISNWYIRRSRGRFWEQGI 724
Cdd:PRK13208 593 -----VLHFSADPEPDKAEvlEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDE 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 725 SNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTGKSVHLQDYPQYKESFINQALEDEMHTVIKIVELSRQARKNA 804
Cdd:PRK13208 668 EEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEA 747
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 1848617803 805 DLKIKQPLSKMVIKPNSQLNLsfLPNYYSIIKDELNIKNIELTD 848
Cdd:PRK13208 748 GLSLNAPLKKVEVYGPADLEL--LEAAEEDLKAAGNIEELELVE 789
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-897 |
2.07e-120 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 389.42 E-value: 2.07e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 1 MTKKYLNTQNE--ISVFWNTQKIFKksIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAG 78
Cdd:TIGR00422 1 MPKDYDPHEVEkkWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 79 WDTHGLPVELEVEKKIGIKGKQDiEKYGIENFINECkksvFNYEKEWRDFSKD----LGYWVDMDSPYITLENNYIESVW 154
Cdd:TIGR00422 79 TDHAGIATQVKVEKKLGAEGKTK-HDLGREEFREKI----WEWKEESGGTIKNqikrLGASLDWSRERFTMDEGLSKAVK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 155 NILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEVAqgYKNVKDLSAVVKFQLTNSKDTYFLSWTTTPWTLPANVALAINK 234
Cdd:TIGR00422 154 EAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 235 DlnyskirveNEYYilaTDLINsiiteKYEIIDTFSgsnlinlKYIPpfesdglVNAYYVVDGEFvtnseGTGIVHIAPA 314
Cdd:TIGR00422 232 E---------DERY---KHLIG-----KKVILPLTG-------RKIP-------IIADEYVDMEF-----GTGAVKVTPA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 315 HGEDDYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAM 394
Cdd:TIGR00422 276 HDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLS 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 395 EGWFIKTTNFKNEIINNNNNIE--WFPSHIkEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAPssikdlqnn 472
Cdd:TIGR00422 356 KQWFVKVEKLADKALEAAEEGEikFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYVA--------- 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 473 sinkiDEDIELHRPYVDNitlscPKCNGKMSrvEEVIDVWFDSGSMPFAQHHYPfDNQKIFNQHFPADFIAEGVDQTRGW 552
Cdd:TIGR00422 426 -----KEEPLPDDKTNTG-----PSVELEQD--TDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDIIFFW 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 553 FYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQT 632
Cdd:TIGR00422 493 VARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESA 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 633 KsKFIDTLDNIYKFYNMYNKIDHYNPNNEITKSrnTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYT-NTISNWY 711
Cdd:TIGR00422 573 R-NFLNKLWNASRFVLMNLSDDLELSGGEEKLS--LADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIwNDFCDWY 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 712 IRRSRGRFWEqGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKI--HYNLTGKSVHLQDYPQYKESFINQALEDEMHT 789
Cdd:TIGR00422 650 IELVKYRLYN-GNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIwqHFKEGADSIMLQSYPVVDAEFVDEEAEKAFEL 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 790 VIKIVELSRQARKNADLKIKQPLsKMVIKPNSQLNLSFLPNYYSIIKDELNIKNIELTDNIN--DYITYELKLNFSSVGP 867
Cdd:TIGR00422 729 LKEIIVSIRNLKAESNIPPNAPL-KVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPevTEAVVELVPGFEIIIP 807
|
890 900 910
....*....|....*....|....*....|....*..
gi 1848617803 868 KLG--NKTKNIQTLIDSLSEYDKKSL-----IESNNF 897
Cdd:TIGR00422 808 VKGliNKAKELARLQKQLDKEKKEVIriegkLENEGF 844
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
33-624 |
2.02e-107 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 337.67 E-value: 2.02e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 33 ESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIGIKGKQDIEKYGIENfin 112
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAE--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 113 eckksvfnYEKEWRDFSKDlgywvdmdspyitlennYIEsVWniLSTFHKKGllykghkvtpycthdqtalsshevaqgy 192
Cdd:cd00818 78 --------FNAKCREFALR-----------------YVD-EQ--EEQFQRLG---------------------------- 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 193 knvkdlsavvkfqltnskdtYFLSWtttpwtlpanvalainkdlnyskirvENEYYILATDLINSIITEKYEIIDTfsgs 272
Cdd:cd00818 102 --------------------VWVDW--------------------------ENPYKTMDPEYMESVWWVFKQLHEK---- 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 273 nlinlkyippfesdGLVnayYvvdgefvtnsEGTGIVHiapahgeddyqlvlerdldflnvitregvyndrfpelvgnka 352
Cdd:cd00818 132 --------------GLL---Y----------RGYKVVP------------------------------------------ 142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 353 knsdieiikllskkqllykkqkyehnyphcWrcgnPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPSHIKEgRMGNFLE 432
Cdd:cd00818 143 ------------------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLE 187
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 433 NMVDWNIGRNRYWGTPLNVWICNDCNHEYapssikdlqnnsinkidedielhrpyvdnitlscpkcngkMSRVEEVIDVW 512
Cdd:cd00818 188 NRRDWCISRQRYWGTPIPVWYCEDCGEVL----------------------------------------VRRVPDVLDVW 227
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 513 FDSGSMPFAQHHYPFDNqKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGN 592
Cdd:cd00818 228 FDSGSMPYAQLHYPFEN-EDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGN 306
|
570 580 590
....*....|....*....|....*....|..
gi 1848617803 593 VINPTELINKYGADSLRWALISDSAPWNNKRF 624
Cdd:cd00818 307 YVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-761 |
6.40e-106 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 353.31 E-value: 6.40e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 11 EISVFWNTQKIFKKSIDNRKGqESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEV 90
Cdd:PLN02843 11 EIQKLWEENQVYKRVSDRNNG-ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 91 EKKIGIKGKQDIE----KYGIENFineCKKSVfnyeKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLL 166
Cdd:PLN02843 90 LQSLDQEARKELTpiklRAKAAKF---AKKTV----DTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 167 YKGHKVTPYCTHDQTALSSHEV--AQGYKNVkdlSAVVKFQLTNSKDT------YFLS------WTTTPWTLPANVALAI 232
Cdd:PLN02843 163 YRGRKPVHWSPSSRTALAEAELeyPEGHVSK---SIYVAFPVVSPSETspeeleEFLPglslaiWTTTPWTMPANAAVAV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 233 NKDLNYSKIRVE-------------------------NEYYILATDLINSIITE---KYEIIDTFSGSNLINLKYIPPF- 283
Cdd:PLN02843 240 NDKLQYSVVEVQsfsedestsggnkkkrpgnvlkeqqKLFLIVATDLVPALEAKwgvKLVVLKTFPGSDLEGCRYIHPLy 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 284 ESDGLVnayyVVDGEFVTNSEGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVG-NKAKNSDIEIIKL 362
Cdd:PLN02843 320 NRESPV----VIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGlSVLGEGNAAVVEA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 363 LSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPsHIKEGRMGNFLENMVDWNIGRN 442
Cdd:PLN02843 396 LDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIP-AQGENRIRAMVSGRSDWCISRQ 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 443 RYWGTPLNVWicndcnheYAPSSIKDLQNNS-INKIDEDIELHRP----YVDNITLSCPKCNGKMSRVE---EVIDVWFD 514
Cdd:PLN02843 475 RTWGVPIPVF--------YHVETKEPLMNEEtIAHVKSIVAQKGSdawwYMDVEDLLPEKYRDKASDYEkgtDTMDVWFD 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 515 SGSMPFAQhhypfdNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVI 594
Cdd:PLN02843 547 SGSSWAGV------LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVV 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 595 NPTELI----NK-----YGADSLR-WALISDSApwNNKRFSENIVAQTKS---KFIDTLDniykfYNMYNkIDHYNPNNE 661
Cdd:PLN02843 621 DPRLVIeggkNQkqepaYGADVLRlWVASVDYT--GDVLIGPQILKQMSDiyrKLRGTLR-----YLLGN-LHDWKPDNA 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 662 IT-KSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYTN-TISNWYIRRSRGRFWEQGISNDKKDAYNT-LYEI 738
Cdd:PLN02843 693 VPyEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIvDLSNFYLDVAKDRLYVGGTTSFTRRSCQTvLAAH 772
|
810 820
....*....|....*....|...
gi 1848617803 739 LTTLSRLVAPFVPFISEKIHYNL 761
Cdd:PLN02843 773 LLSLLRAIAPILPHLAEDAWQNL 795
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
624-798 |
2.92e-72 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 237.06 E-value: 2.92e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 624 FSENIVAQTKSKFIDTLDNIYKFYNMYNKIDHYNPN--NEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLIN 701
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGkdDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 702 EYTNTISNWYIRRSRGRFWEQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTGK------SVHLQDYPQYK 775
Cdd:cd07961 81 EFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRElgdapeSVHLLDWPEVD 160
|
170 180
....*....|....*....|...
gi 1848617803 776 ESFINQALEDEMHTVIKIVELSR 798
Cdd:cd07961 161 ESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-852 |
4.04e-66 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 239.62 E-value: 4.04e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 1 MTKKY--LNTQNEISVFWNTQKIFKKSIDNRKgqeSFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFyverKAG 78
Cdd:PRK05729 5 LPKTYdpKEVEAKWYQKWEEKGYFKPDDNSKK---PFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGY----NTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 79 W----DTHGLPVELEVEKKIGIKG--KQDIekyGIENFINECKksvfnyekEWRDFS--------KDLGYWVDMDSPYIT 144
Cdd:PRK05729 78 WlpgtDHAGIATQMVVERQLAAEGksRHDL---GREKFLEKVW--------EWKEESggtitnqlRRLGASCDWSRERFT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 145 LENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEVAqgYKNVKDLSAVVKFQLTNSKDtyFLSWTTT-PWT 223
Cdd:PRK05729 147 MDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--YKEVKGKLWHIRYPLADGSD--YLVVATTrPET 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 224 LPANVALAIN-KDLNYskirveneyyilaTDLINsiiteKYEIIDtfsgsnLINlKYIPPFESDglvnayYVvDGEFvtn 302
Cdd:PRK05729 223 MLGDTAVAVNpEDERY-------------KHLIG-----KTVILP------LVG-REIPIIADE------YV-DPEF--- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 303 seGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVG------NKAknsdieIIKLLSKKQLLYKKQKYE 376
Cdd:PRK05729 268 --GTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGldrfeaRKA------IVADLEELGLLVKIEPHT 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 377 HNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIInnnnniewfpSHIKEGRMgNF------------LENMVDWNIGRNRY 444
Cdd:PRK05729 340 HSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPAL----------EAVENGEI-KFvperwektyfhwMENIQDWCISRQLW 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 445 WGTPLNVWICNDCNHEYAPSSIKDLQNNSINKiDEDielhrpyvdnitlscpkcngkmsrveeVIDVWFDSGSMPFAqhh 524
Cdd:PRK05729 409 WGHRIPAWYDEDGEVYVGREEPEAREKALLTQ-DED---------------------------VLDTWFSSALWPFS--- 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 525 ypfdnqkifnqhfpadfiaegvdqTRGW---------FY--SLLV----I-----------STILKGKSSYKRALSLGHI 578
Cdd:PRK05729 458 ------------------------TLGWpektedlkrFYptSVLVtgfdIiffwvarmimmGLHFTGQVPFKDVYIHGLV 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 579 LDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQTKsKFIDTLDNIYKFYNMyNKIDHYNP 658
Cdd:PRK05729 514 RDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYR-NFANKLWNASRFVLM-NLEGADVG 591
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 659 NNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYT-NTISNWYIRRSRGRFWEQgisnDKKDAYNTLYE 737
Cdd:PRK05729 592 ELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLELAKPVLQEA----AKRATRATLAY 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 738 ILTTLSRLVAPFVPFISEKIHYNLTGKSVH----LQDYPQYKESFINQAlEDEMHTVIKIVELSRQARKNADLKIKQPLs 813
Cdd:PRK05729 668 VLEQILRLLHPFMPFITEELWQKLAPLGIEesimLAPWPEADEAIDEAA-EAEFEWLKELITAIRNIRAEMNIPPSKKL- 745
|
890 900 910
....*....|....*....|....*....|....*....
gi 1848617803 814 KMVIKPNSQLNLSFLPNYYSIIKDELNIKNIELTDNIND 852
Cdd:PRK05729 746 PLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
15-849 |
2.95e-60 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 222.62 E-value: 2.95e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 15 FWNTQKIFKKSIDnrKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFyverKAGW----DtH-GLPVELE 89
Cdd:COG0525 19 YWEENGYFKADPD--SDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGY----NTLWqpgtD-HaGIATQAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 90 VEKKI---GIKgKQDIekyGIENFIneckksvfnyEK--EWRDFS--------KDLGYWVDMDSPYITLENNYIESVwni 156
Cdd:COG0525 92 VERQLaeeGKS-RHDL---GREKFL----------ERvwEWKEESggtitnqlRRLGASCDWSRERFTMDEGLSKAV--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 157 LSTF---HKKGLLYKGHKVTPYCTHDQTALSSHEVAqgYKNVKDLSAVVKFQLTNSKDtyFLSWTTT-PWTLPANVALAI 232
Cdd:COG0525 155 REVFvrlYEKGLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKGHLWHIRYPLADGSG--YIVVATTrPETMLGDTAVAV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 233 N-KDLNYskirveneyyilaTDLInsiitekyeiidtfsGSNLInlkyIPpfesdgLVN--------AYyvVDGEFvtns 303
Cdd:COG0525 231 HpEDERY-------------KHLI---------------GKTVI----LP------LVGreipiiadEY--VDPEF---- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 304 eGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVG------NKAknsdieIIKLLSKKQLLYKKQKYEH 377
Cdd:COG0525 267 -GTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGldrfeaRKA------IVADLEELGLLVKVEPHKH 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 378 NYPHCWRCGNPLIYYAMEGWFIKTTNFKNeiinnnnniewfPS--HIKEGRMgNF------------LENMVDWNIGRNR 443
Cdd:COG0525 340 SVGHSDRSGTVIEPYLSDQWFVKMKPLAK------------PAieAVEDGEI-KFvperwektyfhwMENIRDWCISRQL 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 444 YWGTPLNVWICNDcNHEYAPSSikdlqnnsinkiDEDielhrpyvdnitlSCPKCNGK-MSRVEEVIDVWFDSGSMPFAq 522
Cdd:COG0525 407 WWGHRIPAWYCPD-GEVYVART------------EPE-------------ACAKAGSVnLTQDEDVLDTWFSSALWPFS- 459
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 523 hhypfdnqkifnqhfpadfiaegvdqTRGW---------FY--SLLVisT---IL--------------KGKSSYKRALS 574
Cdd:COG0525 460 --------------------------TLGWpektedlkyFYptSVLV--TgfdIIffwvarmimmglhfTGEVPFKDVYI 511
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 575 LGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQTKsKFIDTLDNIYKFYNMyNKID 654
Cdd:COG0525 512 HGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYR-NFANKLWNASRFVLM-NLEG 589
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 655 HYNPNNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYT-NTISNWYIRRSRGRFWeQGISNDKKDAYN 733
Cdd:COG0525 590 FDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYLELAKPRLY-GGDEAAKRETRA 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 734 TLYEILTTLSRLVAPFVPFISEKIHYNL----TGKSVHLQDYPQYKESFINQALEDEMHTVIKIVELSRQARKNADLKIK 809
Cdd:COG0525 669 TLVYVLEQILRLLHPFMPFITEEIWQKLpprkEGESIMLAPWPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPS 748
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 1848617803 810 QPLsKMVIKPNSQLNLSFLPNYYSIIKDELNIKNIELTDN 849
Cdd:COG0525 749 KKL-PLLLKGADEADRARLEENAAYIKRLARLEEITILVD 787
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
41-618 |
3.65e-52 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 187.84 E-value: 3.65e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 41 PPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIGIKGKQDiEKYGIENFINECKKSVFN 120
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 121 YEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALSshevaqgyknvkdlsa 200
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAIS---------------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 201 vvkfqltnskdtyflswtttpwtlpanvalainkdlnyskirveneyyilatdlinsiitekyeiidtfsgsnlinlkyi 280
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 281 ppfesdglvnayyvvdgefvtnsegtgivhiapahgeddyqlvlerdldflnvitregvyndrfpelvgnkaknsDIEIi 360
Cdd:cd00817 152 ---------------------------------------------------------------------------DIEV- 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 361 kllskkqllykkqkyehnyphCWRCGNPLIYYAMEGWFIKTTNFKNE--IINNNNNIEWFPSHIKEgRMGNFLENMVDWN 438
Cdd:cd00817 156 ---------------------CSRSGDVIEPLLKPQWFVKVKDLAKKalEAVKEGDIKFVPERMEK-RYENWLENIRDWC 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 439 IGRNRYWGTPLNVWICNDCNHEYAPSSIkdlqnnsinkiDEDIELHRPYvdnitlSCPKCNGK-MSRVEEVIDVWFDSGS 517
Cdd:cd00817 214 ISRQLWWGHRIPAWYCKDGGHWVVAREE-----------DEAIDKAAPE------ACVPCGGEeLKQDEDVLDTWFSSSL 276
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 518 MPFAQHHYPfDNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPT 597
Cdd:cd00817 277 WPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPL 355
|
570 580
....*....|....*....|.
gi 1848617803 598 ELINKYGADSLRWALISDSAP 618
Cdd:cd00817 356 DVIDGYGADALRFTLASAATQ 376
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-898 |
1.44e-51 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 197.15 E-value: 1.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 15 FWNTQKIFKKSID--NRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEK 92
Cdd:PTZ00419 40 WWEKSGFFKPAEDakSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 93 KIGIKGKQDIEKYGIENFIneckKSVFnyekEWRDFS--------KDLGYWVDMDSPYITLENNYIESVWNILSTFHKKG 164
Cdd:PTZ00419 120 KLMKEENKTRHDLGREEFL----KKVW----EWKDKHgnnicnqlRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 165 LLYKGHKVTPYCTHDQTALSSHEV------------AQGYKNVKDLSAVVKF--QLTNSKDTYFLSWTTTPWTLPANVAL 230
Cdd:PTZ00419 192 LIYRDTRLVNWCCYLKTAISDIEVefeeiekptkitIPGYDKKVEVGVLWHFayPLEDSGQEEIVVATTRIETMLGDVAV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 231 AIN-KDLNYskirveneyyilaTDLINSiitekyEIIDTFsgsnlINLKYIPPFESDGLVnayyvvDGEFvtnseGTGIV 309
Cdd:PTZ00419 272 AVHpKDERY-------------KKLHGK------ELIHPF-----IPDRKIPIIADDELV------DMEF-----GTGAV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 310 HIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPL 389
Cdd:PTZ00419 317 KITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIV 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 390 IYYAMEGWFIKTTNF--KNEIINNNNNIEWFPSHiKEGRMGNFLENMVDWNIGRNRYWGTPLNVWIC------NDCNHE- 460
Cdd:PTZ00419 397 EPMLIPQWYVNCKDMakRAVEAVRNGELKIIPSS-HENVWYHWLENIQDWCISRQLWWGHRIPAYRViskgpeTDPSDEe 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 461 --YAPSSIKDLQNNSINKI---DEDIELhrpyvdnitlscpkcngkmSRVEEVIDVWFDSGSMPFAQHHYPFDNQKiFNQ 535
Cdd:PTZ00419 476 pwVVARSEEEALEKAKKKFglsEEDFEL-------------------EQDEDVLDTWFSSGLFPFSTLGWPDQTDD-LQR 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 536 HFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISD 615
Cdd:PTZ00419 536 FFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEG 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 616 SAP---------WNNKRFSENI------------VAQTKS---------------KFIDTLDNIYKFYNMYNKIDHYNPN 659
Cdd:PTZ00419 616 NLPekeikraieLQKKEFPNGIpecgtdalrfglLAYTQQgrninldinrvvgyrHFCNKLWNAVKFALMKLLKDFNLPN 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 660 NEITKSRNT-----LDNWALSRLNTLIKESNIYVNNYDFTSAARLI-NEYTNTISNWYIRRSRGRFWEQGISNDKKDAYN 733
Cdd:PTZ00419 696 STLFKPNNVeslpwEDKWILHRLNVAIKEVTEGFKEYDFSEATQATyNFWLYELCDVYLELIKPRLSKQSDGERKQHAQD 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 734 TLYEILTTLSRLVAPFVPFISEKIH-----YNLTGKSVHLQDYPQYKESFINQALEDEMHTVIKIVELSRQARKNADLKI 808
Cdd:PTZ00419 776 VLHTVLDIGLRLLHPMMPFITEELYqrlpnYLRKSESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPN 855
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 809 KQPLSKMVIKPNSQLnLSFLPNYYSIIKDELNIKNIELTDNI----------------NDYITYELKLNFSSVGPKLGNK 872
Cdd:PTZ00419 856 KTKPDCYVTAKDAEL-IELIESAENLISTLAKIGSVSVIPPIeeeaevpkgcgfdvvdNKVIIYLNLDEFIDLKKELAKL 934
|
970 980
....*....|....*....|....*.
gi 1848617803 873 TKNIQTLIDSLSEYDKKslIESNNFK 898
Cdd:PTZ00419 935 EKKLAKLQKSLESYLKK--ISIPNYE 958
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
41-809 |
2.39e-50 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 193.67 E-value: 2.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 41 PPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIGIKGKQDIEKYGIENFINECKKSVFN 120
Cdd:PRK14900 56 PPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQ 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 121 YEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEVAQGYKNVKDLSA 200
Cdd:PRK14900 136 YGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQGELWS 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 201 VvKFQLTNSKDTYFLSwTTTPWTLPANVALAINKDlnyskirveneyyilatdlinsiiTEKYEiidtfsgsNLINLKYI 280
Cdd:PRK14900 216 F-AYPLADGSGEIVVA-TTRPETMLGDTAVAVHPL------------------------DPRYM--------ALHGKKVR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 281 PPFESDGLVnayYVVDGEFVTNSEGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEII 360
Cdd:PRK14900 262 HPITGRTFP---IVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVK 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 361 KLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIINNNNN--IEWFPSHIKEGRMGnFLENMVDWN 438
Cdd:PRK14900 339 RLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMA-WMRNIHDWC 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 439 IGRNRYWGTPLNVWICNDCNHEYA---PSSikdlqnnsinkidedielhrpyvdnitlsCPKCNGKMSRVEE-VIDVWFD 514
Cdd:PRK14900 418 ISRQLWWGHQIPAWYCPDGHVTVAretPEA-----------------------------CSTCGKAELRQDEdVLDTWFS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 515 SGSMPFAQHHYPfDNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVI 594
Cdd:PRK14900 469 SGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVI 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 595 NPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQTKSkFIDTLDNIYKFYNMyNKIDHYNPNNEITKSRNTL-DNWA 673
Cdd:PRK14900 548 DPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRA-FANKLWNASRFALM-NLSGYQERGEDPARLARTPaDRWI 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 674 LSRLNTLIKESNIYVNNYDFTSAARLINEYT-NTISNWYIRRSRGRFWeqGISNDKKDAYN-TLYEILTTLSRLVAPFVP 751
Cdd:PRK14900 626 LARLQRAVNETVEALEAFRFNDAANAVYAFVwHELCDWYIELAKEALA--SEDPEARRSVQaVLVHCLQTSYRLLHPFMP 703
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848617803 752 FISEKIHYNLTGK--------SVHLQDYPQYKEsfINQALEDEMHTVIKIVELSRQARKNADLKIK 809
Cdd:PRK14900 704 FITEELWHVLRAQvgasawadSVLAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWK 767
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
8-780 |
1.68e-49 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 190.54 E-value: 1.68e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 8 TQNEISVFWNTQKIFKKSIDnrKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVE 87
Cdd:PLN02943 65 SEERIYNWWESQGYFKPNFD--RGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQ 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 88 LEVEKKIGIKGKQDIEkYGIENFIneckKSVFNYEKEW----RDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKK 163
Cdd:PLN02943 143 LVVEKMLASEGIKRTD-LGRDEFT----KRVWEWKEKYggtiTNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEK 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 164 GLLYKGHKVTPYCTHDQTALSSHEVAqgYKNVKDLSAVVKFQLTNSKDTYFLSWTTTPWTLPANVALAIN-KDLNYSKir 242
Cdd:PLN02943 218 GLIYQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNpEDDRYSK-- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 243 veneyYIlatdlinsiitEKYEIIDTFSGsnlinlKYIPpfesdglvnayyVVDGEFVTNSEGTGIVHIAPAHGEDDYQL 322
Cdd:PLN02943 294 -----YI-----------GKMAIVPMTYG------RHVP------------IIADRYVDKDFGTGVLKISPGHDHNDYLL 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 323 VLERDLDFLNVITREGVYND-----RFPelvGNKAKNSDIEIIKLLSKKQLLYKkqkyehNYPHCWRCGN---PLIyyaM 394
Cdd:PLN02943 340 ARKLGLPILNVMNKDGTLNEvaglyWFE---AREKLWSDLEETGLAVKKEPHTL------RVPRSQRGGEviePLV---S 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 395 EGWFIKTTNF--KNEIINNNNNIEWFPSHIkEGRMGNFLENMVDWNIGRNRYWGTPLNVW--ICNDCNHEY-APSSIKDL 469
Cdd:PLN02943 408 KQWFVTMEPLaeKALKAVENGELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEEDYiVARSAEEA 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 470 QNNSINKIDEDIELHRPyvdnitlscpkcngkmsrvEEVIDVWFDSGSMPFAQHHYPFDNQKIFNQHFPADFIAEGVDQT 549
Cdd:PLN02943 487 LEKAREKYGKDVEIYQD-------------------PDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDIL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 550 RGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIV 629
Cdd:PLN02943 548 FFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLT 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 630 AQtkSKFIDTLDNIYKF--YNMYNKID----HYNPNNEITKSRNTL-----DNWALSRLNTLIKESNIYVNNYDFTSAAR 698
Cdd:PLN02943 628 SN--KAFTNKLWNAGKFvlQNLPSQSDtsawEHILACKFDKEESLLslplpECWVVSKLHELIDSVTTSYDKYFFGDVGR 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 699 LINEYT-NTISNWYIRRSRGRFWEQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIhynltgksvhLQDYPQYKES 777
Cdd:PLN02943 706 EIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEEL----------WQALPYRKEA 775
|
...
gi 1848617803 778 FIN 780
Cdd:PLN02943 776 LIV 778
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
389-614 |
4.34e-42 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 156.81 E-value: 4.34e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 389 LIYY------AMEGWFIKTTNFKNEIINNNNNIEWFPSHIKEgRMGNFLENMVDWNIGRNRYWGTPLnvwicndcnheya 462
Cdd:cd00668 128 LIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPL------------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 463 pssikdlqnnsinkidedielhrpyvdnitlscPkcngkmsrvEEVIDVWFDSGSMPFAQHHYPFDNqKIFNQHFPADFI 542
Cdd:cd00668 194 ---------------------------------P---------EDVFDVWFDSGIGPLGSLGYPEEK-EWFKDSYPADWH 230
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848617803 543 AEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALIS 614
Cdd:cd00668 231 LIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTS 302
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
35-172 |
6.15e-40 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 150.26 E-value: 6.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 35 FVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIGIKGKQDIekygIENFINEC 114
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFREDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1848617803 115 KKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKV 172
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-795 |
7.56e-38 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 153.49 E-value: 7.56e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 48 PHAGHvlGR--VIKDLVARLKTMQGFYVERKAGWDTHGLPVeLEVEKKIGIKGKQDIEKYG---------IENFINECKK 116
Cdd:PRK12300 1 LHVGH--GRtyTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAERIARGDPETIELYKslygipeeeLEKFKDPEYI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 117 SVFnYEKEWRDFSKDLGYWVD-------MDSPYitleNNYIEsvWNilstFHK---KGLLYKG-HKVTpYCTHDQTALSS 185
Cdd:PRK12300 78 VEY-FSEEAKEDMKRIGYSIDwrrefttTDPEY----SKFIE--WQ----FRKlkeKGLIVKGsHPVR-YCPNDNNPVGD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 186 HEVAQGY-KNVKDLSaVVKFqlTNSKDTYFLSWTTTPWTLPANVALAINKDLNYSKIRVENEYYILATDLINSIITEKY- 263
Cdd:PRK12300 146 HDLLDGEePEIVEYT-LIKF--EESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSFQDRd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 264 -EIIDTFSGSNLINLKYIPPFESDGLVnayyVVDGEFVTNSEGTGIVHIAPAHGEDDY--------QLVLERDLDFLNVI 334
Cdd:PRK12300 223 vEIIEEIKGSELIGKKVKNPVTGKEVP----ILPADFVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVIEPIPLI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 335 TREG-----------------------------VYNDRF---------PELVGNKAKNSDIEIIKLLSKKQLLYKKQKYE 376
Cdd:PRK12300 299 EVEGygefpakevveklgiksqedpeleeatkeVYRAEFhkgvlkentGEYAGKPVREAREKITKDLIEKGIADIMYEFS 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 377 HNYPHCwRCGNPLIYYAMEG-WFIKTTN--FKNEIINNNNNIEWFPSHIKEgRMGNFLENMVDWNIGRNRYWGTPL---N 450
Cdd:PRK12300 379 NRPVYC-RCGTECVVKVVKDqWFIDYSDpeWKELAHKALDNMEIIPEEYRK-EFENTIDWLKDRACARRRGLGTRLpwdE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 451 VWIC---NDcnheyapSSI--------KDLQNNSINKIDEDIELhrpyVDNITLScpkcNGKMSRVEEVIDV-------- 511
Cdd:PRK12300 457 EWIIeslSD-------STIymayytiaHKIREYGIKPEQLTPEF----FDYVFLG----KGDPEEVSKKTGIpkeileem 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 512 ------WF--D---SGSmPFAQHHYPFdnqKIFNqH---FPADFiaegvdQTRGwfyslLVIStilkgkssykralslGH 577
Cdd:PRK12300 522 reeflyWYpvDwrhSGK-DLIPNHLTF---FIFN-HvaiFPEEK------WPRG-----IVVN---------------GF 570
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 578 ILdSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQTKskfidtlDNIYKFYNMYNKIDHYN 657
Cdd:PRK12300 571 VL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVR-------RQLERFYELAKELIEIG 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 658 PNNEITksrnTLDNWALSRLNTLIKESNIYVNNYDFTSAA-RLINEYTNTIsNWYIRRSrgrfweqGISNDKkdaynTLY 736
Cdd:PRK12300 643 GEEELR----FIDKWLLSRLNRIIKETTEAMESFQTRDAVqEAFYELLNDL-RWYLRRV-------GEANNK-----VLR 705
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 737 EILTTLSRLVAPFVPFISEKIHYNLTGKS-VHLQDYPQYKESFINQALEDEMHTVIKIVE 795
Cdd:PRK12300 706 EVLEIWIRLLAPFTPHLAEELWHKLGGEGfVSLEKWPEPDESKIDEEAELAEEYVKRLIE 765
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-885 |
1.46e-37 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 153.13 E-value: 1.46e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 1 MTKKYLNTQNEIS--VFWNTQKIFKKsiDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAG 78
Cdd:PLN02381 96 MAKQYSPSAVEKSwyAWWEKSGYFGA--DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPG 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 79 WDTHGLPVELEVEKKIGIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILS 158
Cdd:PLN02381 174 VDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFV 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 159 TFHKKGLLYKGHKVTPY-CTHdQTALSSHEV------------AQGYKNVKDLSAVVKFQLTNSKDT-YFLSWTTTPWTL 224
Cdd:PLN02381 254 RLYKEGLIYRDIRLVNWdCTL-RTAISDVEVdyidikertllkVPGYDKPVEFGVLTSFAYPLEGGLgEIVVATTRIETM 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 225 PANVALAINKDlnyskirveneyyilatdlinsiiTEKYeiidtfsgSNLINLKYIPPFESDGLVnayYVVDGEFVTNSE 304
Cdd:PLN02381 333 LGDTAIAIHPD------------------------DERY--------KHLHGKFAVHPFNGRKLP---IICDAILVDPNF 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 305 GTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRF-PELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCW 383
Cdd:PLN02381 378 GTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGgSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCS 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 384 RCGN---PLIyyaMEGWFIKTTN-----FKNEIINNNNNIEWFPSHIkEGRMGNFLENMVDWNIGRNRYWGTPLNVWicn 455
Cdd:PLN02381 458 RTNDvvePMI---KPQWFVNCSSmakqaLDAAIDGENKKLEFIPKQY-LAEWKRWLENIRDWCISRQLWWGHRIPAW--- 530
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 456 dcnheYApsSIKDLQNNSINKIDEDIELHRPYVDNITLSCPKCNGK---MSRVEEVIDVWFDSGSMPFAQHHYPfDNQKI 532
Cdd:PLN02381 531 -----YV--TLEDDQLKELGSYNDHWVVARNESDALLEASQKFPGKkfeLSQDPDVLDTWFSSGLFPLSVLGWP-DDTDD 602
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 533 FNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELIN----------- 601
Cdd:PLN02381 603 LKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrl 682
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 602 --------------------------KYGADSLRWALISDSAPwnnkrfSENIVAQTKS-----KFIDTLDNIYKFyNMY 650
Cdd:PLN02381 683 eegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQ------SDKINLDILRvvgyrQWCNKLWNAVRF-AMS 755
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 651 NKIDHYNPnnEITKSRNTLD---NWALSRLNTLIKESNIYVNNYDFTSAArlineytNTISNW--------YIRRSRGRF 719
Cdd:PLN02381 756 KLGDDYTP--PATLSVETMPfscKWILSVLNKAISKTVSSLDAYEFSDAA-------STVYSWwqyqfcdvFIEAIKPYF 826
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 720 W--EQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTG-------KSVHLQDYPQYKESFINQALEDEMHTV 790
Cdd:PLN02381 827 AgdNPEFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQpkdhtrkDSIMISEYPSAVEAWTNEKVEYEMDLV 906
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 791 IKIVELSRQARKNADLKIKQPLSKMVIKPNSQLNLSFLPNYYSIIKDELNIKNIEL-------------TDNIND----Y 853
Cdd:PLN02381 907 LSTVKCLRSLRAEVLEKQKNERLPAFALCRNQEIAAIIKSHQLEILTLANLSSLKVllsendappagcaFENVNEnlkvY 986
|
970 980 990
....*....|....*....|....*....|..
gi 1848617803 854 ITYELKLNFSSVGPKLGNKTKNIQTLIDSLSE 885
Cdd:PLN02381 987 LQAQGAVNAEAELEKLRNKMDEIQKQQEKLEK 1018
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
834-1022 |
3.66e-32 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 124.12 E-value: 3.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 834 IIKDELNIKNIELTDNINDYITYELKLNFSSVGPKLGNKTKNIQTLIDSLSEYDKKSLIESnnfKSLSSDA-----ELTK 908
Cdd:pfam19302 3 IIKEELNVKEVEFGADESELVEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDG---GTLTIDVdgeeiELTS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 909 DDFIIKTLPKDSYQLSEDNDCVILLDKNLSPELIREGHARELIRLIQQLRKKKNLPINQRIDIYIGVTGELLESIKTNKN 988
Cdd:pfam19302 80 EDLLVTRQGKEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEMLEAAIEKFED 159
|
170 180 190
....*....|....*....|....*....|....
gi 1848617803 989 MFKENLLIKNIHLNVIDEYEnTIHFNNKEIKISL 1022
Cdd:pfam19302 160 YIKKETLAVEIIFNEEKEYT-EVDINGEKLKIAV 192
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
670-816 |
9.31e-30 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 115.19 E-value: 9.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 670 DNWALSRLNTLIKESNIYVNNYDFTSAARLINEY-TNTISNWYIRRSRGRFWEqgiSNDKKDAYNTLYEILTTLSRLVAP 748
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFfWNDLSDWYLELIKDRLYG---EEPDSRAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1848617803 749 FVPFISEKIHYNLtgkSVHLQDYPQyKESFINQALEDEMHTVIKIVELSRQARKNADLKIKQPLSKMV 816
Cdd:pfam08264 78 FMPFITEELWQKE---SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
624-761 |
5.33e-20 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 87.23 E-value: 5.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 624 FSENIVAQTKsKFIDTLDNIYKFYNMYnkIDHYNPNNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEY 703
Cdd:cd07962 1 FDEKRVEGGR-NFCNKLWNAARFVLMN--LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1848617803 704 T-NTISNWYIRRSRGRFWEqGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNL 761
Cdd:cd07962 78 FwNDFCDWYLELVKPRLYG-EDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
436-791 |
8.33e-20 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 95.50 E-value: 8.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 436 DWNIGRNRYWGTPLNVWICNDCnheyapssikdlqnnSINKIDED---IELhrPYVDNIT------L---------SCPK 497
Cdd:COG0495 421 DWLISRQRYWGEPIPIIHCEDC---------------GVVPVPEDqlpVEL--PEDVDFDptggspLarapewvnvTCPK 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 498 CNGKMSRVEEVIDVWFDSgS---MPFAQHHY---PFDNQKIfNQHFPadfiaegVDQ--------------TRGW---FY 554
Cdd:COG0495 484 CGGPARRETDTMDTFVDS-SwyyLRYTDPHNdeaPFDPEAA-NYWLP-------VDQyiggiehailhllyARFFtkvLR 554
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 555 SLLVISTilkgKSSYKRALSLGHILD--SNGK------KMSKSKGNVINPTELINKYGADSLRWALISD-----SAPWNN 621
Cdd:COG0495 555 DLGLVSF----DEPFKRLLTQGMVLEvgKDGVviggieKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAgpperDLEWSD 630
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 622 K------RFsenivaqtkskfidtLDNIYKFYNMYNKIDHYNPNNEITKSRntldnwALSR-LNTLIKESNIYVNNYDF- 693
Cdd:COG0495 631 SgvegayRF---------------LNRVWRLVVDEAEALKLDVADLSEADK------ELRRaLHKTIKKVTEDIERLRFn 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 694 TSAARLInEYTNTISNWYIRRSRGRFweqgisndkkdaynTLYEILTTLSRLVAPFVPFISEKIHYNLTGK-SVHLQDYP 772
Cdd:COG0495 690 TAIAALM-ELVNALYKAKDSGEADRA--------------VLREALETLVLLLAPFAPHIAEELWERLGHEgSVADAPWP 754
|
410
....*....|....*....
gi 1848617803 773 QYKESfinqALEDEMHTVI 791
Cdd:COG0495 755 EADEA----ALVEDEVTIV 769
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
669-793 |
2.41e-16 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 77.95 E-value: 2.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 669 LDNWALSRLNTLIKESNIYVNNYDFTSAARLINEY-TNTISNWY----------------IRRSrgrfweqgisndkkdA 731
Cdd:cd07960 45 LDRYALHRLNELIKEVREAYENYEFHKVYQALNNFcTVDLSAFYldiikdrlycdakdslERRS---------------A 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848617803 732 YNTLYEILTTLSRLVAPFVPFISEKIHYNLTG----KSVHLQDYPQYKESFINQALEDEMHTVIKI 793
Cdd:cd07960 110 QTVLYHILDALLKLLAPILPFTAEEVWEHLPGekkeESVFLEDWPELPEEWKDEELEEKWEKLLAL 175
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
42-779 |
5.57e-14 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 76.79 E-value: 5.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 42 PTANGLpHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVelevekkigikgkqdiEKYGIENFINECKKSVFNY 121
Cdd:PLN02563 121 PSGAGL-HVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPA----------------EQYAIETGTHPKITTLKNI 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 122 EKeWRDFSKDLGYWVDMDSPYITLENNYIE-SVWNILSTFhKKGLLYKGHKVTPYCTHDQTALSSHEVAQGY-------- 192
Cdd:PLN02563 184 AR-FRSQLKSLGFSYDWDREISTTEPEYYKwTQWIFLQLL-KRGLAYQAEVPVNWCPALGTVLANEEVVDGLsergghpv 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 193 -----------------------------KNVKDLS---------AVVKFQLTN----SKDTYFLSWTTTPWTL--PANV 228
Cdd:PLN02563 262 irkpmrqwmlkitayadrlledlddldwpESIKEMQrnwigrsegAELDFSVLDgegkERDEKITVYTTRPDTLfgATYL 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 229 ALAINKDLNYSKIRVE-----NEYYILA---TDL-INSIITEKYEIidtFSGSNLINlkyipPFESDGLvnAYYVVDgeF 299
Cdd:PLN02563 342 VVAPEHPLLSSLTTAEqkeavEEYVDAAsrkSDLeRTELQKEKTGV---FTGSYAIN-----PATGEAI--PIWVAD--Y 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 300 VTNSEGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDR----FPEL-VGNKAKNSDIEIIKLLSKKQLLYKKQK 374
Cdd:PLN02563 410 VLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDaekaYTGEgVIVNSSSSGLDINGLSSKEAAKKVIEW 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 375 YEHNyphcwrcgnpliyyameGWFIKTTNFKneiinnnnniewfpshikegrmgnflenMVDWNIGRNRYWGTPLNVWIC 454
Cdd:PLN02563 490 LEET-----------------GNGKKKVNYK----------------------------LRDWLFARQRYWGEPIPVVFL 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 455 NDCNHEYAPSsikdlqnnsinkiDEDIELHRPYVDNITlscPKCNGK--MSRVEEVIDVWFDSGSMPFAQ---------- 522
Cdd:PLN02563 525 EDSGEPVPVP-------------ESDLPLTLPELDDFT---PTGTGEppLAKAVSWVNTVDPSSGKPARRetntmpqwag 588
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 523 ---HHYPFDNQKIFNQHF---------PADFIAEGVDQ-------TRGW---FYSLLVISTilkgKSSYKRALSLGHIL- 579
Cdd:PLN02563 589 scwYYLRFMDPKNSNALVdkekekywmPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILg 664
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 580 --------DSNGK---------------------------------------------KMSKSKGNVINPTELINKYGAD 606
Cdd:PLN02563 665 eveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGAD 744
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 607 SLR-----WALISDSAPWNNK------RFseniVAQTkSKFIDTLDNIYKFYNMYNKIDHYNPNNEITKSrntldnwals 675
Cdd:PLN02563 745 SLRlyemfMGPLRDSKTWSTSgvegvhRF----LGRT-WRLVVGAPLPDGSFRDGTVVTDEEPSLEQLRL---------- 809
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 676 rLNTLIKESNIYVNNYDFTSAARLINEYTNTISNWyirrsrgrfweqgisnDKKDAyntlyEILTTLSRLVAPFVPFISE 755
Cdd:PLN02563 810 -LHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKW----------------DKVPR-----EAIEPFVLLLSPYAPHLAE 867
|
890 900
....*....|....*....|....*
gi 1848617803 756 KIHYNLTGK-SVHLQDYPQYKESFI 779
Cdd:PLN02563 868 ELWFRLGHSnSLAYEPWPEANPSYL 892
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
582-758 |
1.02e-13 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 75.15 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 582 NGKKMSKSKGNVINPTELINKYGADSLRWALISDSApwNNKR--FS-ENIVAQTKSKFIDTLDN--------IYKFYNmy 650
Cdd:COG0143 324 EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVP--FGQDgdFSwEDFVARVNSDLANDLGNlasrtlsmIHKYFD-- 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 651 NKIDHYNPNNEItksrntlDNWALSRLNTLIKESNIYVNNYDFTSAARLINEytntisnwYIRRSRGRF-----WEQGIS 725
Cdd:COG0143 400 GKVPEPGELTEA-------DEELLAEAEAALEEVAEAMEAFEFRKALEEIMA--------LARAANKYIdetapWKLAKD 464
|
170 180 190
....*....|....*....|....*....|....*.
gi 1848617803 726 NDKKDAYNTLY---EILTTLSRLVAPFVPFISEKIH 758
Cdd:COG0143 465 EDPERLATVLYtllEALRILAILLKPFLPETAEKIL 500
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
570-621 |
1.80e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.58 E-value: 1.80e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1848617803 570 KRALSLGHILdSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNN 621
Cdd:cd00812 261 KGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDAD 311
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
508-757 |
4.13e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 67.13 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 508 VIDVWFDS--------GsmpfaqhhYPFDNQKIFNQHFPADFIAEGVDQTRgwFYSllVI-STILK--GKSSYKRALSLG 576
Cdd:PRK12267 224 VVYVWIDAllnyitalG--------YGSDDDELFKKFWPADVHLVGKDILR--FHA--IYwPIMLMalGLPLPKKVFAHG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 577 HILdSNGKKMSKSKGNVINPTELINKYGADSLRWALI------SDSApwnnkrFS-ENIVAQTKSKFIDTLDNiykFYN- 648
Cdd:PRK12267 292 WWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYLLrevpfgSDGD------FSpEALVERINSDLANDLGN---LLNr 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 649 ---MYNKidhYNpNNEITKSRN--TLDNWALSRLNTLIKESNIYVNNYDFTSAA----RLIneytnTISNWYIRRSRGrf 719
Cdd:PRK12267 362 tvaMINK---YF-DGEIPAPGNvtEFDEELIALAEETLKNYEELMEELQFSRALeevwKLI-----SRANKYIDETAP-- 430
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1848617803 720 WEQGISNDKKDAYNT-LY---EILTTLSRLVAPFVPFISEKI 757
Cdd:PRK12267 431 WVLAKDEGKKERLATvMYhlaESLRKVAVLLSPFMPETSKKI 472
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
582-757 |
1.03e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 65.29 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 582 NGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFS-ENIVAQTKSKFIDTLDN-IYKFYNMYNK-IDHYNP 658
Cdd:PRK11893 296 DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSrEAFINRINADLANDLGNlAQRTLSMIAKnFDGKVP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 659 NNEITksrNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYTNtISNWYIRRSRGRFWEQGISNDKKDAYNTLYEI 738
Cdd:PRK11893 376 EPGAL---TEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVR-AANKYIDEQAPWSLAKTDPERLATVLYTLLEV 451
|
170
....*....|....*....
gi 1848617803 739 LTTLSRLVAPFVPFISEKI 757
Cdd:PRK11893 452 LRGIAVLLQPVMPELAAKI 470
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
42-188 |
4.32e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 62.69 E-value: 4.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 42 PTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKiGIKGKQDIEKYGIEnfineckksvfnY 121
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKE-GITPEELVDRYHEI------------H 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848617803 122 EKEWRDFSkdlgywVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEV 188
Cdd:pfam09334 75 REDFKKFN------ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV 135
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
639-757 |
1.15e-09 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 56.83 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 639 TLDNIYKFYNMYNKIDHYNPNNEITKsrnTLDNWALSRLNTLIKESNIYVNNYDFTSAARLI-NEYTNTIsNWYIRRSRG 717
Cdd:cd07959 9 AILRLERFYELAEELIETEGELEELT---FIDRWLLSRLNRLIKETTEAYENMQFREALKEGlYELQNDL-DWYRERGGA 84
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1848617803 718 RfweqgisnDKKDaynTLYEILTTLSRLVAPFVPFISEKI 757
Cdd:cd07959 85 G--------MNKD---LLRRFIEVWTRLLAPFAPHLAEEI 113
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
639-749 |
7.05e-09 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 54.82 E-value: 7.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 639 TLDNIYKFYNMYNKIDHY-NPNNEITKS--RNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYTNTIsNWYIRRS 715
Cdd:cd07375 7 ARAFLNRLYRLLSFFRKAlGGTQPKWDNelLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLDEL 85
|
90 100 110
....*....|....*....|....*....|....
gi 1848617803 716 RGRFWeqgISNDKKDAYNTLYEILTTLSRLVAPF 749
Cdd:cd07375 86 KPALQ---TEELREAVLAVLRAALVVLTKLLAPF 116
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
508-616 |
4.40e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.00 E-value: 4.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 508 VIDVWFDS--GSMPFAQhhYPFDNQK---IFNQHFPAD--FIaeGVDQTRgwFYSLLVISTILK-GKSSYKRALSLGHIL 579
Cdd:cd00814 202 VIYVWFDAliGYISATG--YYNEEWGnswWWKDGWPELvhFI--GKDIIR--FHAIYWPAMLLGaGLPLPTRIVAHGYLT 275
|
90 100 110
....*....|....*....|....*....|....*..
gi 1848617803 580 dSNGKKMSKSKGNVINPTELINKYGADSLRWALISDS 616
Cdd:cd00814 276 -VEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-184 |
1.24e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 54.85 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 42 PTANGLPHAGHVLGRVIKDLVARLKTMQG---FYVerkAGWDTHGLPVELEVEKKiGIKGKQDIEKYGIENfineckKSV 118
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGydvLFV---TGTDEHGTKIEQKAEEE-GVTPQELCDKYHEIF------KDL 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848617803 119 FnyekEWRDFSKDLgywvdmdspYI-TLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALS 184
Cdd:cd00814 79 F----KWLNISFDY---------FIrTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP 132
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
508-642 |
1.74e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 54.60 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 508 VIDVWFDS--GSMPFAQhhYPFDNQKIFNQHFPAD-------FIaeGVDQTRgwFYSLLVISTILKGKSSYKRALSLGHI 578
Cdd:pfam09334 244 VFYVWLDApiGYISATK--ELSGNEEKWKEWWPNDpdtelvhFI--GKDIIY--FHTIFWPAMLLGAGYRLPTTVFAHGY 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848617803 579 LDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFS-ENIVAQTKSKFIDTLDN 642
Cdd:pfam09334 318 LTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSwEDFVERVNSELADDLGN 382
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
42-176 |
2.57e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 53.79 E-value: 2.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 42 PTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEkKIGIKgKQDIEKYGIENFINECKKSVFNY 121
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAI-KIGRD-PEDWTEYNIKKMKEQLKRMGFSY 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1848617803 122 EKEwRDFSkdlgywvdmdspyiTLENNYieSVWN--ILSTFHKKGLLYKG-HKVTpYC 176
Cdd:cd00812 87 DWR-REFT--------------TCDPEY--YKFTqwLFLKLYEKGLAYKKeAPVN-WC 126
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
582-700 |
5.53e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 53.18 E-value: 5.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 582 NGKKMSKSKGNVINPTELINKYGADSLRWALIS-------DsapwnnkrFSENIVAQTKSkfidTLDniyKFYNMYNKID 654
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSahyrsplD--------FSEEALEEAEK----ALE---RLYNALRRLE 326
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848617803 655 HYNPNNEITKSRntLDNW----------------ALSRLNTLIKESNIYVNNYDFTSAARLI 700
Cdd:COG0215 327 EALGAADSSAEE--IEELreefiaamdddfntpeALAVLFELVREINKALDEGEDKAALAAL 386
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
551-761 |
3.56e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.79 E-value: 3.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 551 GWFYSL-LVISTILKGKSSYKRALSL-----------GH-ILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSA 617
Cdd:PLN02224 319 GWPASLhLIGKDILRFHAVYWPAMLMsaglelpkmvfGHgFLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFLREVE 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 618 PWNNKRFSEN-IVAQTKSKFIDTLDNIykfynMYNKIDHYNPNNE---ITKSRNTLDNWALS-RLNTLIKESNIYVNNYD 692
Cdd:PLN02224 399 FGNDGDYSEDrFIKIVNAHLANTIGNL-----LNRTLGLLKKNCEstlVEDSTVAAEGVPLKdTVEKLVEKAQTNYENLS 473
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848617803 693 FTSAARLINEYTNTISNWYIRRSRGRFWEQGISNDKKDAYN--TLYEILTTLSRLVAPFVPFISEKIHYNL 761
Cdd:PLN02224 474 LSSACEAVLEIGNAGNTYMDQRAPWFLFKQGGVSAEEAAKDlvIILEVMRVIAVALSPIAPCLSLRIYSQL 544
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
42-181 |
4.35e-05 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 47.42 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 42 PTANGLPHAGHVLGRVIKDLVARLKTMQG---FYVerkAGWDTHGLPVELEVEKKiGIKGKQDIEKYgienfineckksV 118
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGhdvLFV---TGTDEHGTKIELAAEKE-GITPQELVDRI------------H 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848617803 119 FNYEKEWRDF--SKDLgywvdmdspYI-TLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQT 181
Cdd:COG0143 74 AEFKELFEKLgiSFDN---------FIrTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECER 130
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
578-680 |
7.75e-05 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 46.34 E-value: 7.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 578 ILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPwnNKRFSenivaqtkskfIDTLDNIYKFYNMYNKIdhYn 657
Cdd:PRK00750 273 FLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFARPKP--AKRLD-----------FDVIPKLVDEYDRFERK--Y- 336
|
90 100
....*....|....*....|....*
gi 1848617803 658 PNNEITKSRNTLDN--WALSRLNTL 680
Cdd:PRK00750 337 FGQEEKKEEEELANpvYHIHNGNPL 361
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
582-614 |
8.16e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 44.88 E-value: 8.16e-05
10 20 30
....*....|....*....|....*....|...
gi 1848617803 582 NGKKMSKSKGNVINPTELINKYGADSLRWALIS 614
Cdd:cd00672 171 DGEKMSKSLGNFITVRDALKKYDPEVLRLALLS 203
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
573-707 |
9.39e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 46.56 E-value: 9.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 573 LSLGHiLDSNGKKMSKSKGNVINPTELINKYGADSLRW--ALISDSAPWNnkrFSENIVAQTKSK------FIDTLDNIY 644
Cdd:PTZ00399 304 LHSGH-LHIKGLKMSKSLKNFITIRQALSKYTARQIRLlfLLHKWDKPMN---YSDESMDEAIEKdkvffnFFANVKIKL 379
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1848617803 645 KFYNMYNKIDH----YNPNNEITKSRNT-----LDNW----ALSRLNTLIKESNIYVNNYDFTSA--ARLINEYTNTI 707
Cdd:PTZ00399 380 RESELTSPQKWtqhdFELNELFEETKSAvhaalLDNFdtpeALQALQKLISATNTYLNSGEQPSAplLRSVAQYVTKI 457
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
576-612 |
1.87e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 45.45 E-value: 1.87e-04
10 20 30
....*....|....*....|....*....|....*..
gi 1848617803 576 GHILdSNGKKMSKSKGNVINPTELINKYGADSLRWAL 612
Cdd:PLN02959 710 GHLM-LNSEKMSKSTGNFLTLRQAIEEFSADATRFAL 745
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
578-610 |
3.27e-04 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 44.42 E-value: 3.27e-04
10 20 30
....*....|....*....|....*....|....
gi 1848617803 578 ILDSNGKKMSKSKGNVINPTELInKYG-ADSLRW 610
Cdd:COG1384 280 FLDENGEKISKSKGNGLTVEEWL-EYAePESLRY 312
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
41-176 |
8.83e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 42.95 E-value: 8.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 41 PPTANGLPHAGHVLGRVIKDLVARLKTMQGF-------------YVERKAgwDTHGL-PVEL--EVEKKIgikgKQDIEK 104
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYdvffltgtdehgqKIQRKA--EEAGIsPQELadRNSAAF----KRLWEA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1848617803 105 YGIEN--FINeckksvfnyekewrdfskdlgywvdmdspyiTLENNYIESVWNILSTFHKKGLLYKGHKVTPYC 176
Cdd:PRK11893 83 LNISYddFIR-------------------------------TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYC 125
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
576-634 |
9.06e-04 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 42.35 E-value: 9.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 576 GHILdSNGKKMSKSKGNVINPTELINKYGADSLRWALIsdSAPWNNK-RFSENIVAQTKS 634
Cdd:pfam01406 245 GHVM-IDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL--SVHYRSPlDFSEELLEQAKS 301
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
578-610 |
1.82e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 41.86 E-value: 1.82e-03
10 20 30
....*....|....*....|....*....|...
gi 1848617803 578 ILDSNGKKMSKSKGNVINPTELINKYGADSLRW 610
Cdd:pfam01921 272 ILLKGGGKMSSSKGNVITPEDWLEYAPPESLRF 304
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
45-181 |
1.93e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 42.09 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 45 NGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVElevekkigikgkQDIEKYGIEnfineckksvfnyEKE 124
Cdd:PRK12267 16 NGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ------------QAAEKAGKT-------------PQE 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848617803 125 WRD-----FsKDLgyWVDMDSPY---I-TLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQT 181
Cdd:PRK12267 71 YVDeisagF-KEL--WKKLDISYdkfIrTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCET 133
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
537-618 |
2.45e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 41.54 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848617803 537 FPADFIAEGVD--------QTRGWFYSL--LVISTILKGKSSYKRALSLghILDSNGKKMSKSKGNVINPTELINKYGAD 606
Cdd:cd00674 219 WPMRWAILGVDfepfgkdhASAGGSYDTgkEIAREIFGGEPPVPVMYEF--IGLKGGGKMSSSKGNVITPSDWLEVAPPE 296
|
90
....*....|..
gi 1848617803 607 SLRWALISDSAP 618
Cdd:cd00674 297 VLRYLYARRKNP 308
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-105 |
7.96e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 40.14 E-value: 7.96e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848617803 42 PTANGLPHAGHVLGRVIKDLVARLKTMQG---FYVerkAGWDTHGLPVELEVEKKiGIKGKQDIEKY 105
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGhevLFV---CADDAHGTPIMLKAEKE-GITPEELIARY 73
|
|
| |
