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Conserved domains on  [gi|1846261936|gb|QKE44354|]
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Dual-ORK [Cloning vector pLeo1286]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11086 super family cl35987
sensory histidine kinase DcuS; Provisional
 134-353 2.79e-154

sensory histidine kinase DcuS; Provisional


The actual alignment was detected with superfamily member PRK11086:

Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 450.13  E-value: 2.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:PRK11086  323 KTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLG 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPD 293
Cdd:PRK11086  403 KISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPD 482

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 294 KIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 353
Cdd:PRK11086  483 EIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 369-484 1.07e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 176.35  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 369 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 448
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1846261936 449 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTVS 484
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTVS 118
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 8-122 8.09e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 174.03  E-value: 8.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   8 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 87
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1846261936  88 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTV 122
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTV 117
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 134-353 2.79e-154

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 450.13  E-value: 2.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:PRK11086  323 KTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLG 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPD 293
Cdd:PRK11086  403 KISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPD 482

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 294 KIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 353
Cdd:PRK11086  483 EIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 134-349 1.77e-84

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 265.94  E-value: 1.77e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:COG3290   173 RTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQLPDSGSEDQVatLITTLGNLIENALEAL--GPEPGGEISVTLHYRHGWLHCEVNDDGPGIA 291
Cdd:COG3290   253 KAARARERGIDLTIDIDSDLPDLPLSDTD--LVTILGNLLDNAIEAVekLPEEERRVELSIRDDGDELVIEVEDSGPGIP 330

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261936 292 PDKIDHIFDKGVSTKGSE-RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGE 349
Cdd:COG3290   331 EELLEKIFERGFSTKLGEgRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 369-484 1.07e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 176.35  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 369 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 448
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1846261936 449 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTVS 484
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTVS 118
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 8-122 8.09e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 174.03  E-value: 8.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   8 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 87
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1846261936  88 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTV 122
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTV 117
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 4.19e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 153.21  E-value: 4.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALG--PEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKG-SERGVGLALVKQQV 321
Cdd:cd16915     1 LITIVGNLIDNALDALAatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
IGv smart00406
Immunoglobulin V-Type;
22-101 3.18e-28

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.08  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   22 SLRLSCTASGRTGTIYSMAWFRQAPGKEREFLAtVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYC 101
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IGv smart00406
Immunoglobulin V-Type;
383-462 3.18e-28

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.08  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  383 SLRLSCTASGRTGTIYSMAWFRQAPGKEREFLAtVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYC 462
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 245-345 1.05e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 103.88  E-value: 1.05e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  245 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 319
Cdd:smart00387   6 LRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 1846261936  320 QVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 245-345 4.54e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 4.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALGPepGGEISVTLHyRHGWLHCEVNDDGPGIAPDKIDHIFDK---GVSTKGSERGVGLALVKQQV 321
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAK--AGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPfstADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 377-483 1.30e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 377 LVQAGGSLRLSCTASGR-TGTIYSMAWFRQAPGKEREFLATVgWSSGITYYMDsvKGRFTISRDKGKNTVYLQMDSLKPE 455
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAY-YSNGSEEGVK--KGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*...
gi 1846261936 456 DTAVYYCtatRAYSVGYDYWGQGTQVTV 483
Cdd:pfam07686  84 DSGTYTC---AVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 16-122 1.30e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  16 LVQAGGSLRLSCTASGR-TGTIYSMAWFRQAPGKEREFLATVgWSSGITYYMDsvKGRFTISRDKGKNTVYLQMDSLKPE 94
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAY-YSNGSEEGVK--KGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*...
gi 1846261936  95 DTAVYYCtatRAYSVGYDYWGQGTQVTV 122
Cdd:pfam07686  84 DSGTYTC---AVIPSGEGVFGKGTRLTV 108
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 134-353 2.79e-154

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 450.13  E-value: 2.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:PRK11086  323 KTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLG 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPD 293
Cdd:PRK11086  403 KISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPD 482

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 294 KIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 353
Cdd:PRK11086  483 EIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 134-349 1.77e-84

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 265.94  E-value: 1.77e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:COG3290   173 RTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQLPDSGSEDQVatLITTLGNLIENALEAL--GPEPGGEISVTLHYRHGWLHCEVNDDGPGIA 291
Cdd:COG3290   253 KAARARERGIDLTIDIDSDLPDLPLSDTD--LVTILGNLLDNAIEAVekLPEEERRVELSIRDDGDELVIEVEDSGPGIP 330

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261936 292 PDKIDHIFDKGVSTKGSE-RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGE 349
Cdd:COG3290   331 EELLEKIFERGFSTKLGEgRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 369-484 1.07e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 176.35  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 369 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 448
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1846261936 449 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTVS 484
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTVS 118
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 8-122 8.09e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 174.03  E-value: 8.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   8 QLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQ 87
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1846261936  88 MDSLKPEDTAVYYCTA-TRAYSVGY-DYWGQGTQVTV 122
Cdd:cd04981    81 LNSLTSEDTAVYYCARgLGGYGYSYfDYWGQGTTVTV 117
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 4.19e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 153.21  E-value: 4.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALG--PEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKG-SERGVGLALVKQQV 321
Cdd:cd16915     1 LITIVGNLIDNALDALAatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
158-345 2.20e-28

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 115.01  E-value: 2.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 158 SHEFMNKLHVILGLLHL------KSYKQLEDYILKTANNYQEEIGSLL-------GKIK--------SPVIAGFLISKIN 216
Cdd:COG0642   118 SHELRTPLTAIRGYLELlleeldEEQREYLETILRSADRLLRLINDLLdlsrleaGKLElepepvdlAELLEEVVELFRP 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 217 RATDLGHTLILNSESQLPD-SGSEDQVATLittLGNLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI 295
Cdd:COG0642   198 LAEEKGIELELDLPDDLPTvRGDPDRLRQV---LLNLLSNAIKYT--PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDL 272

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1846261936 296 DHIFDKGVSTKGSER----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG0642   273 ERIFEPFFRTDPSRRgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
IGv smart00406
Immunoglobulin V-Type;
22-101 3.18e-28

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.08  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   22 SLRLSCTASGRTGTIYSMAWFRQAPGKEREFLAtVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYC 101
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IGv smart00406
Immunoglobulin V-Type;
383-462 3.18e-28

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.08  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  383 SLRLSCTASGRTGTIYSMAWFRQAPGKEREFLAtVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYC 462
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
151-345 8.77e-27

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 108.07  E-value: 8.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 151 ADALRER-----SHEFMNKLHVILGLLH-LKSYKQLED--------YILKTANNYQEEIGSLL-------GKIK------ 203
Cdd:COG2205    12 LERLKSEflanvSHELRTPLTSILGAAElLLDEEDLSPeerrelleIIRESAERLLRLIEDLLdlsrlesGKLSlelepv 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 204 --SPVIAGFLISKINRATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEAlGPePGGEISVTLHYRHGWLH 280
Cdd:COG2205    92 dlAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLA---NLLDNAIKY-SP-PGGTITISARREGDGVR 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261936 281 CEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG2205   167 ISVSDNGPGIPEEELERIFERFYRGDNSRGeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 245-345 1.05e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 103.88  E-value: 1.05e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  245 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 319
Cdd:smart00387   6 LRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 1846261936  320 QVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 16-122 2.75e-25

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 100.10  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  16 LVQAGGSLRLSCTASGRTGTiYSMAWFRQAPGKEREFLATvgWSSGITYYMDSVKGRFTISRDKGKnTVYLQMDSLKPED 95
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSS-TYIYWYRQKPGQGPEFLIY--LSSSKGKTKGGVPGRFSGSRDGTS-SFSLTISNLQPED 84

                          90       100
                  ....*....|....*....|....*..
gi 1846261936  96 TAVYYCTATRAYSVGYDYWGQGTQVTV 122
Cdd:cd00099    85 SGTYYCAVSESGGTDKLTFGSGTRLTV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 377-483 2.75e-25

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 100.10  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 377 LVQAGGSLRLSCTASGRTGTiYSMAWFRQAPGKEREFLATvgWSSGITYYMDSVKGRFTISRDKGKnTVYLQMDSLKPED 456
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSS-TYIYWYRQKPGQGPEFLIY--LSSSKGKTKGGVPGRFSGSRDGTS-SFSLTISNLQPED 84

                          90       100
                  ....*....|....*....|....*..
gi 1846261936 457 TAVYYCTATRAYSVGYDYWGQGTQVTV 483
Cdd:cd00099    85 SGTYYCAVSESGGTDKLTFGSGTRLTV 111
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
135-345 3.74e-25

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 106.95  E-value: 3.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 135 TEVRKLMQRLDGLVnyADAlrerSHEFMNKLHVILGLLHLksykqLEDYILKTANNYQEEIGSLLGKI------------ 202
Cdd:COG5002   156 TELERLEQMRREFV--ANV----SHELRTPLTSIRGYLEL-----LLDGAADDPEERREYLEIILEEAerlsrlvndlld 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 203 ------------KSPVIAGFLISKI-----NRATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEAlGPEp 264
Cdd:COG5002   225 lsrlesgelkleKEPVDLAELLEEVveelrPLAEEKGIELELDLPEDPLLvLGDPDRLEQVLT---NLLDNAIKY-TPE- 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 265 GGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK--------GVSTKGSerGVGLALVKQQVENLGGSIAVESEPGI 336
Cdd:COG5002   300 GGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERfyrvdksrSRETGGT--GLGLAIVKHIVEAHGGRIWVESEPGK 377


                  ....*....
gi 1846261936 337 FTQFFVQIP 345
Cdd:COG5002   378 GTTFTITLP 386
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 249-344 1.74e-24

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 97.29  E-value: 1.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENL 324
Cdd:cd00075     5 LSNLLDNALKYSPP--GGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREgggtGLGLAIVRRIVEAH 82

                          90       100
                  ....*....|....*....|
gi 1846261936 325 GGSIAVESEPGIFTQFFVQI 344
Cdd:cd00075    83 GGRITVESEPGGGTTFTVTL 102
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 134-345 4.24e-24

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 105.30  E-value: 4.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 134 KTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLIS 213
Cdd:PRK15053  322 KDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFG 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 214 KINRATDLGHTLILNSESQ---LPDSGSEDQVATLittLGNLIENALEA--LGPEPGGEISVTLHYRHGWLHCEVNDDGP 288
Cdd:PRK15053  402 KVQRARELGLKMVIVPGSQlsqLPPGLDSTEFAAI---VGNLLDNAFEAslRSDEGNKIVELFLSDEGDDVVIEVADQGC 478

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 289 GIAPDKIDHIFDKGVSTKGS---ERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK15053  479 GVPESLRDKIFEQGVSTRADepgEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 158-345 4.40e-24

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 104.27  E-value: 4.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 158 SHEFMNKLHVILGLLHLksykqLEDYILKTANNYQEEIGSLLGKIKSPV------IAGFL----ISKIN-RATDLgHTLI 226
Cdd:COG5000   209 AHEIKNPLTPIQLSAER-----LRRKLADKLEEDREDLERALDTIIRQVdrlkriVDEFLdfarLPEPQlEPVDL-NELL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 227 LNSESQLPDSGSEDQVATLITT-----------------LGNLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPG 289
Cdd:COG5000   283 REVLALYEPALKEKDIRLELDLdpdlpevladrdqleqvLINLLKNAIEAI--EEGGEIEVSTRREDGRVRIEVSDNGPG 360

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1846261936 290 IAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG5000   361 IPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 159-345 1.86e-23

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 101.41  E-value: 1.86e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 159 HEFMNKLHVILGLLHLksykqLEDYILKTANnyQEEIGSLLGKIK------SPVIAGFL--------------ISKI--- 215
Cdd:COG4191   151 HEINNPLAAILGNAEL-----LRRRLEDEPD--PEELREALERILegaeraAEIVRSLRafsrrdeeerepvdLNELide 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 216 ------NRATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGP 288
Cdd:COG4191   224 alellrPRLKARGIEVELDLPPDLPPvLGDPGQLEQVLL---NLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGP 300

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261936 289 GIAPDKIDHIFDKGVSTKGSERGVG--LALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG4191   301 GIPPEVLERIFEPFFTTKPVGKGTGlgLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 245-345 4.54e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 4.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALGPepGGEISVTLHyRHGWLHCEVNDDGPGIAPDKIDHIFDK---GVSTKGSERGVGLALVKQQV 321
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAK--AGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPfstADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
222-345 4.75e-23

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 100.31  E-value: 4.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 222 GHTLILNSESQLPD-SGSEDQvatLITTLGNLIENALEALGPepGGEISVTLHYRHG----------WLHCEVNDDGPGI 290
Cdd:COG3852   224 NIRIVRDYDPSLPEvLGDPDQ---LIQVLLNLVRNAAEAMPE--GGTITIRTRVERQvtlgglrprlYVRIEVIDNGPGI 298

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1846261936 291 APDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG3852   299 PEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 251-345 8.70e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 82.91  E-value: 8.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFD-----KGVST-KGSerGVGLALVKQQVENL 324
Cdd:COG4251   401 NLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifqrlHSRDEyEGT--GIGLAIVKKIVERH 478

                          90       100
                  ....*....|....*....|.
gi 1846261936 325 GGSIAVESEPGIFTQFFVQIP 345
Cdd:COG4251   479 GGRIWVESEPGEGATFYFTLP 499
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 249-345 1.26e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 75.61  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENAL---EAlgpepgGEISVTLHYR-----HGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGL 314
Cdd:cd16922     5 LLNLLGNAIkftEE------GEVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTrkyggtGLGL 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 315 ALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16922    79 AISKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 2.14e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 74.74  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALGPEpGGEI--------SVTL-HYRHGW-LHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGL 314
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGS-GGEIilrtrtqrQVTLgHPRHRLaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 315 ALVKQQVENLGGSIAVESEPGiFTQFFVQIP 345
Cdd:cd16918    80 AIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
249-353 2.78e-16

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 80.99  E-value: 2.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSI 328
Cdd:PRK10364  353 LLNLYLNAIQAIGQ--HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTI 430

                          90       100
                  ....*....|....*....|....*
gi 1846261936 329 AVESEPGIFTQFFVQIPWDGERSNR 353
Cdd:PRK10364  431 QVASQEGKGATFTLWLPVNITRRDP 455
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 17-122 1.20e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 72.69  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  17 VQAGGSLRLSCTASgrTGTIYSMAWFRQAPGKEREFLATVGWSSGityymDSVKGRFTISRDKGKNTVYLQMDSLKPEDT 96
Cdd:cd04983    10 VQEGENVTLNCNYS--TSTFYYLFWYRQYPGQGPQFLIYISSDSG-----NKKKGRFSATLDKSRKSSSLHISAAQLSDS 82

                          90       100
                  ....*....|....*....|....*.
gi 1846261936  97 AVYYCTATRAYSVGYDYWGQGTQVTV 122
Cdd:cd04983    83 AVYFCALSESGGTGKLTFGKGTRLTV 108
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 378-483 1.20e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 72.69  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 378 VQAGGSLRLSCTASgrTGTIYSMAWFRQAPGKEREFLATVGWSSGityymDSVKGRFTISRDKGKNTVYLQMDSLKPEDT 457
Cdd:cd04983    10 VQEGENVTLNCNYS--TSTFYYLFWYRQYPGQGPQFLIYISSDSG-----NKKKGRFSATLDKSRKSSSLHISAAQLSDS 82

                          90       100
                  ....*....|....*....|....*.
gi 1846261936 458 AVYYCTATRAYSVGYDYWGQGTQVTV 483
Cdd:cd04983    83 AVYFCALSESGGTGKLTFGKGTRLTV 108
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
224-345 1.45e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 79.24  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 224 TLILNSESQLP----DSGSEDQVatlittLGNLIENALEALgpEPGGEISVTLHY-RHGWLHCEVNDDGPGIAPDKIDHI 298
Cdd:PRK11360  482 DFETELDNELPpiwaDPELLKQV------LLNILINAVQAI--SARGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKI 553

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1846261936 299 FDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK11360  554 FDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 245-345 1.07e-14

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 72.23  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENAL----------EALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI------------------- 295
Cdd:cd16916    39 LADPLTHLLRNAVdhgieapeerLAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaatls 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 296 -----DHIFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16916   119 ddevlNLIFAPGFSTAEqvtdvSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 377-483 1.30e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 377 LVQAGGSLRLSCTASGR-TGTIYSMAWFRQAPGKEREFLATVgWSSGITYYMDsvKGRFTISRDKGKNTVYLQMDSLKPE 455
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAY-YSNGSEEGVK--KGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*...
gi 1846261936 456 DTAVYYCtatRAYSVGYDYWGQGTQVTV 483
Cdd:pfam07686  84 DSGTYTC---AVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 16-122 1.30e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  16 LVQAGGSLRLSCTASGR-TGTIYSMAWFRQAPGKEREFLATVgWSSGITYYMDsvKGRFTISRDKGKNTVYLQMDSLKPE 94
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAY-YSNGSEEGVK--KGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*...
gi 1846261936  95 DTAVYYCtatRAYSVGYDYWGQGTQVTV 122
Cdd:pfam07686  84 DSGTYTC---AVIPSGEGVFGKGTRLTV 108
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-345 8.10e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 67.42  E-value: 8.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEAL--GPEPGGEISVTLHYR-HGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGS 327
Cdd:cd16920     7 NLVRNGIEAMseGGCERRELTIRTSPAdDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86

                          90
                  ....*....|....*...
gi 1846261936 328 IAVESEPGIFTQFFVQIP 345
Cdd:cd16920    87 LSVESPAGGGATFQFTLP 104
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
248-349 1.86e-13

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 72.36  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 248 TLGNLIENALE-ALGP-EPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFdKGVSTKGSERGVGLALVKQQVENL- 324
Cdd:COG2972   340 ILQPLVENAIEhGIEPkEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLL-EELSSKGEGRGIGLRNVRERLKLYy 418

                          90       100
                  ....*....|....*....|....*..
gi 1846261936 325 --GGSIAVESEPGIFTQFFVQIPWDGE 349
Cdd:COG2972   419 geEYGLEIESEPGEGTTVTIRIPLEEE 445
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
252-345 7.50e-13

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 70.60  E-value: 7.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 252 LIENAL----------EALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI-------------------DH----- 297
Cdd:COG0643   285 LVRNAVdhgietpeerLAAGKPETGTITLSAYHEGGRVVIEVSDDGRGLDLEKIrakaiekglitaeeaaalsDEellel 364

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261936 298 IFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG0643   365 IFAPGFSTAEevtdlSGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-345 7.73e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 64.75  E-value: 7.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEALGPEpgGEISV--TLHYRHGWLhcEVNDDGPGIAPDKIDHIFDKGVSTK--GSERGVGLALVKQQVENLGG 326
Cdd:cd16943    10 NLLVNAAQAMEGR--GRITIrtWAHVDQVLI--EVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQKHGG 85

                          90
                  ....*....|....*....
gi 1846261936 327 SIAVESEPGIFTQFFVQIP 345
Cdd:cd16943    86 TIRVASVPGGGTRFTIILP 104
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-334 8.01e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 65.35  E-value: 8.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALE-ALGpepggEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKG--VSTKGSERGVGLALVKQQV 321
Cdd:cd16954    38 LMELLGNLLDNACKwCLE-----FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGqrLDEQRPGQGLGLAIAKEIV 112

                          90
                  ....*....|...
gi 1846261936 322 ENLGGSIAVESEP 334
Cdd:cd16954   113 EQYGGELSLSDSP 125
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 37-122 8.70e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 64.61  E-value: 8.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  37 YSMAWFRQAPGKEREFLATVgWSSGITYYMDSVKGRFTISRDKGKNTVyLQMDSLKPEDTAVYYCTATRAYSVGYDYWGQ 116
Cdd:cd05899    27 DNMYWYRQDPGKGLQLLFYS-YGGGLNEEGDLPGDRFSASRPSLTRSS-LTIKSAEPEDSAVYLCASSLGGGADEAYFGP 104


                  ....*.
gi 1846261936 117 GTQVTV 122
Cdd:cd05899   105 GTRLTV 110
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 398-483 8.70e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 64.61  E-value: 8.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 398 YSMAWFRQAPGKEREFLATVgWSSGITYYMDSVKGRFTISRDKGKNTVyLQMDSLKPEDTAVYYCTATRAYSVGYDYWGQ 477
Cdd:cd05899    27 DNMYWYRQDPGKGLQLLFYS-YGGGLNEEGDLPGDRFSASRPSLTRSS-LTIKSAEPEDSAVYLCASSLGGGADEAYFGP 104


                  ....*.
gi 1846261936 478 GTQVTV 483
Cdd:cd05899   105 GTRLTV 110
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 1.45e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 64.13  E-value: 1.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALeALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTK------GSERGVGLALVK 318
Cdd:cd16953     1 LGQVLRNLIGNAI-SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSISR 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 319 QQVENLGGSIAVE--SEPGIFT--QFFVQIP 345
Cdd:cd16953    80 QIIEAHGGISVAEnhNQPGQVIgaRFTVQLP 110
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 159-345 1.91e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 69.38  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 159 HEFMNKLHVILGLLHLKSYKQlEDYilktaNNYQEEIGSLLGKIKSpVIAGFL-ISK---INRATDLGHTLI------LN 228
Cdd:COG5805   296 HEIRNPLTSIKGFLQLLQPGI-EDK-----EEYFDIMLSELDRIES-IISEFLaLAKpqaVNKEKENINELIqdvvtlLE 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 229 SESQLPD--------------SGSEDQVATLITtlgNLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDK 294
Cdd:COG5805   369 TEAILHNiqirlelldedpfiYCDENQIKQVFI---NLIKNAIEAM--PNGGTITIHTEEEDNSVIIRVIDEGIGIPEER 443

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1846261936 295 IDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:COG5805   444 LKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 373-483 1.96e-12

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.91  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  373 SGGGLVQAGGSLRLSCTASGRTGtiYSMAWFRQAPgkerEFLATvgwssgityymdsvKGRFTISRDKgkNTVYLQMDSL 452
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP--PEVTWYKQGG----KLLAE--------------SGRFSVSRSG--STSTLTISNV 58

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1846261936  453 KPEDTAVYYCTATRAYsvgYDYWGqGTQVTV 483
Cdd:smart00410  59 TPEDSGTYTCAATNSS---GSASS-GTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 12-122 1.96e-12

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.91  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   12 SGGGLVQAGGSLRLSCTASGRTGtiYSMAWFRQAPgkerEFLATvgwssgityymdsvKGRFTISRDKgkNTVYLQMDSL 91
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP--PEVTWYKQGG----KLLAE--------------SGRFSVSRSG--STSTLTISNV 58

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1846261936   92 KPEDTAVYYCTATRAYsvgYDYWGqGTQVTV 122
Cdd:smart00410  59 TPEDSGTYTCAATNSS---GSASS-GTTLTV 85
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 251-345 4.89e-12

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 68.08  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEALGPepGGEISVTLHY-RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKgsERG--VGLALVKQQVENLGGS 327
Cdd:COG5809   386 NLLKNAIEAMPE--GGNITIETKAeDDDKVVISVTDEGCGIPEERLKKLGEPFYTTK--EKGtgLGLMVSYKIIEEHGGK 461

                          90
                  ....*....|....*...
gi 1846261936 328 IAVESEPGIFTQFFVQIP 345
Cdd:COG5809   462 ITVESEVGKGTTFSITLP 479
PRK09303 PRK09303
histidine kinase;
251-335 8.88e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 66.51  E-value: 8.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEaLGPEpGGEISVT-LHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENLG 325
Cdd:PRK09303  279 NLLDNAIK-YTPE-GGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGtegyGIGLSVCRRIVRVHY 356

                          90
                  ....*....|
gi 1846261936 326 GSIAVESEPG 335
Cdd:PRK09303  357 GQIWVDSEPG 366
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-328 1.12e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 61.31  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEalgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSerGVGLALVKQQVE 322
Cdd:cd16950     5 LSNLVDNALR----YGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFqpfyrgDNARGTSGT--GLGLAIVQRISD 78


                  ....*.
gi 1846261936 323 NLGGSI 328
Cdd:cd16950    79 AHGGSL 84
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 6-122 1.38e-11

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 61.42  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   6 QVQLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGityymDSVKGRFTISRDKGKNTVY 85
Cdd:cd16095     1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLTSLDHIST-----KVSEDRITSSREDTNSQIF 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1846261936  86 LQMDSLKPEDTAVYYCTATRAYSVGYD--YWGQGTQVTV 122
Cdd:cd16095    76 LQIKGLGLRDSGQYHCARRVGYGDDTDklIFGPGTDVIV 114
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 367-483 1.38e-11

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 61.42  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 367 QVQLVESGGGLVQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGWSSGityymDSVKGRFTISRDKGKNTVY 446
Cdd:cd16095     1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLTSLDHIST-----KVSEDRITSSREDTNSQIF 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1846261936 447 LQMDSLKPEDTAVYYCTATRAYSVGYD--YWGQGTQVTV 483
Cdd:cd16095    76 LQIKGLGLRDSGQYHCARRVGYGDDTDklIFGPGTDVIV 114
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 379-484 1.45e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 61.23  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 379 QAGGSLRLSCTASG---RTGTIYsmaWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPE 455
Cdd:cd04982    11 EESKSVTISCKVSGidfSTTYIH---WYRQKPGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTSTLTITNLEKE 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 456 DTAVYYCtATRAYSVGYDY--WGQGTQVTVS 484
Cdd:cd04982    88 DSATYYC-AYWESGSGYYIkvFGSGTKLIVT 117
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 18-122 2.49e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 60.84  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  18 QAGGSLRLSCTASG---RTGTIYsmaWFRQAPGKEREFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSLKPE 94
Cdd:cd04982    11 EESKSVTISCKVSGidfSTTYIH---WYRQKPGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTSTLTITNLEKE 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 1846261936  95 DTAVYYCtATRAYSVGYDY--WGQGTQVTV 122
Cdd:cd04982    88 DSATYYC-AYWESGSGYYIkvFGSGTKLIV 116
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-340 2.82e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 60.16  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTK--GSERGVGLALVKQQVE 322
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVE 80

                          90
                  ....*....|....*...
gi 1846261936 323 NLGGSIAVESEPGIFTQF 340
Cdd:cd16976    81 EHGGRLSVANEEGAGARF 98
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 16-122 3.48e-11

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 60.15  E-value: 3.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  16 LVQAGGSLRLSCTASG--RTGTIYSMAWfRQAPGKER--EFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSL 91
Cdd:cd07700     9 LVQTNQTVKMSCEAKTspKNTRIYWLRQ-RQAPSKDShfEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRYILSLMSV 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936  92 KPEDTAVYYCTATRAYSVGYdywGQGTQVTV 122
Cdd:cd07700    88 KPEDSGTYFCMTVGSPELIF---GTGTKLSV 115
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 377-483 3.48e-11

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 60.15  E-value: 3.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 377 LVQAGGSLRLSCTASG--RTGTIYSMAWfRQAPGKER--EFLATVGWSSGITYYMDSVKGRFTISRDKGKNTVYLQMDSL 452
Cdd:cd07700     9 LVQTNQTVKMSCEAKTspKNTRIYWLRQ-RQAPSKDShfEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRYILSLMSV 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 453 KPEDTAVYYCTATRAYSVGYdywGQGTQVTV 483
Cdd:cd07700    88 KPEDSGTYFCMTVGSPELIF---GTGTKLSV 115
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 135-351 5.16e-11

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 64.93  E-value: 5.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 135 TEVRKLMQRLDGLVNYADAL-RERSHEFMNKLHVILGLLHLKSyKQLEDY----ILKTANN------------YQEE--- 194
Cdd:COG3920   279 TERKRAEEELEASLEEKELLlRELHHRVKNNLQVVSSLLRLQA-RRADDPeareALEESQNriqalalvhellYQSEdwe 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 195 ---IGSLLGKIKSPVIAGFLISKI-------------NRATDLGhtLILNsesqlpdsgsEdqvatLITtlgnlieNALE 258
Cdd:COG3920   358 gvdLRDYLRELLEPLRDSYGGRGIrieldgpdvelpaDAAVPLG--LILN----------E-----LVT-------NALK 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 259 -ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDkidhiFDKGVStkgseRGVGLALVKQQVENLGGSIAVESEPGif 337
Cdd:COG3920   414 hAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPAR-----KGLGLRLIRALVRQLGGTLELDRPEG-- 481

                         250
                  ....*....|....
gi 1846261936 338 TQFFVQIPWDGERS 351
Cdd:COG3920   482 TRVRITFPLAELAA 495
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
251-345 5.52e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 65.08  E-value: 5.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEALgpEPGGEISVTLHYR---------HGWL------HCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLA 315
Cdd:PRK13837  567 NLCSNAAQAM--DGAGRVDISLSRAklrapkvlsHGVLppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLA 644

                          90       100       110
                  ....*....|....*....|....*....|
gi 1846261936 316 LVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK13837  645 TVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 206-339 1.80e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 58.74  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 206 VIAGFLISKINRATDLG--HTLILNSESQLPDSgsedqVATLITTLGNLIENALEALGPEPGGE--ISVTLHYRHGWL-- 279
Cdd:cd16935     1 ALDSLLSEKLELAREKGieFTIEIDIPILLPIS-----PLDLCIIFGNLLDNAIEACAKIDKENrfIHLKIRQKKGFLii 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1846261936 280 HCEVNDDGpgiapdKIDHIFDKGVSTKG-SERGVGLALVKQQVENLGGSIAVESEPGIFTQ 339
Cdd:cd16935    76 SIENSYEG------ELKKKNGLFLSTKKdKNHGIGLKSIREIVKKYNGNLSIEYENGIFTL 130
envZ PRK09467
osmolarity sensor protein; Provisional
 249-330 2.96e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 62.24  E-value: 2.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEaLGpepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSerGVGLALVKQQVE 322
Cdd:PRK09467  336 LANLVVNAAR-YG---NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFqpftrgDSARGSSGT--GLGLAIVKRIVD 409


                  ....*...
gi 1846261936 323 NLGGSIAV 330
Cdd:PRK09467  410 QHNGKVEL 417
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
264-349 6.05e-10

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 59.63  E-value: 6.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 264 PGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIdhifdkgvstkgSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQ 343
Cdd:COG4585   179 GATRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRAT 246


                  ....*.
gi 1846261936 344 IPWDGE 349
Cdd:COG4585   247 LPLAAA 252
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
249-334 9.85e-10

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 60.80  E-value: 9.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENA----LEALgpepggEISVTLHYRHgwLHCEVNDDGPGIAPDKIDHIFDKG--VSTKGSERGVGLALVKQQVE 322
Cdd:PRK10815  383 MGNVLDNAckycLEFV------EISARQTDEH--LHIVVEDDGPGIPESKRELIFDRGqrADTLRPGQGLGLSVAREITE 454

                          90
                  ....*....|..
gi 1846261936 323 NLGGSIAVESEP 334
Cdd:PRK10815  455 QYEGKISAGDSP 466
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 17-122 1.49e-09

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 55.16  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  17 VQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLatvgwssgitYYMDSVKG-----RFTISRDkgKNTVYLQMDSL 91
Cdd:cd04984    10 VSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYL----------IYEDKHRPsgipdRFSGSKS--GNTASLTISGA 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936  92 KPEDTAVYYCTATRAYSVGYdywGQGTQVTV 122
Cdd:cd04984    78 QTEDEADYYCQVWDSNSYVF---GGGTKLTV 105
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 378-483 1.49e-09

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 55.16  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 378 VQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLatvgwssgitYYMDSVKG-----RFTISRDkgKNTVYLQMDSL 452
Cdd:cd04984    10 VSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYL----------IYEDKHRPsgipdRFSGSKS--GNTASLTISGA 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261936 453 KPEDTAVYYCTATRAYSVGYdywGQGTQVTV 483
Cdd:cd04984    78 QTEDEADYYCQVWDSNSYVF---GGGTKLTV 105
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 249-335 1.65e-09

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 59.86  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEaLGPePGGEISVTLHYRHGWLHCEVNDDGPGIaPD-KIDHIFDKGVST-------KGSerGVGLALVKQQ 320
Cdd:PRK11100  373 LGNLLDNAID-FSP-EGGTITLSAEVDGEQVALSVEDQGPGI-PDyALPRIFERFYSLprpangrKST--GLGLAFVREV 447

                          90
                  ....*....|....*
gi 1846261936 321 VENLGGSIAVESEPG 335
Cdd:PRK11100  448 ARLHGGEVTLRNRPE 462
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
238-335 1.67e-09

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 55.69  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 238 SEDQVATLITTLGNLIENALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHifdkGVSTkGSERGVGLAL 316
Cdd:COG2172    28 DEDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD----PYST-LAEGGRGLFL 102

                          90
                  ....*....|....*....
gi 1846261936 317 VKQQVENLGgsiaVESEPG 335
Cdd:COG2172   103 IRRLMDEVE----YESDPG 117
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 245-339 2.51e-09

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 54.53  E-value: 2.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEALGPEPGG-EISVTLHYRHGWL--HCEvNDDGPGIapDKIDHIFDKgvSTKGSERGVGLALVKQQV 321
Cdd:pfam14501   6 LCVIFGNLLDNAIEACSKIDDNrFIRLKIREKQNFLiiRIE-NTYEGEL--KFEGKLPST--KTKGDGHGIGLKSIRRIV 80

                          90
                  ....*....|....*...
gi 1846261936 322 ENLGGSIAVESEPGIFTQ 339
Cdd:pfam14501  81 KKYGGNLSTEIENGIFTL 98
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 251-345 4.84e-09

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 54.04  E-value: 4.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEAlGPEpGGEISVTLH-YRHGWLHCEVNDDGPGIAPDKIDHIF--------DKGVSTKGSerGVGLALVKQQV 321
Cdd:cd16925    11 NLLSNAFKF-TPD-GGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFerfrqgdgSSTRAHGGT--GLGLSIVKEFV 86

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16925    87 ELHGGTVTVSDAPGGGALFQVELP 110
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-345 5.78e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 53.48  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPEPGGEISVtlHYR---HGWLHCeVNDDGPGIAPD---KIDHIFDKGVSTKGSE-RGVGLALVKQQV 321
Cdd:cd16921     5 LTNLLGNAIKFRRPRRPPRIEV--GAEdvgEEWTFY-VRDNGIGIDPEyaeKVFGIFQRLHSREEYEgTGVGLAIVRKII 81

                          90       100
                  ....*....|....*....|....
gi 1846261936 322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16921    82 ERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 252-345 8.49e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 53.20  E-value: 8.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 252 LIENALEALGPE--PGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVStkgSERGVGLALV--KQQVENLGGS 327
Cdd:cd16957     9 LVENAIRHAFPKrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVT---SEKGTGTALEnlNRRLIGLFGS 85

                          90       100
                  ....*....|....*....|.
gi 1846261936 328 IA---VESEPGIFTQFFVQIP 345
Cdd:cd16957    86 EAclhIESEVHGGTEVWFVIP 106
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 5-122 8.58e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 53.29  E-value: 8.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   5 SQVQLVESggglVQAGGSLRLSCTASGRTgTIYSMAWFRQAPGKEREFLAtvgwsSGITYYMDSVKGRFTISRDKGKNTV 84
Cdd:cd07706     3 TQAQPDVS----VQVGEEVTLNCRYETSW-TNYYLFWYKQLPSGEMTFLI-----RQDSSEQNAKSGRYSVNFQKAQKSI 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1846261936  85 YLQMDSLKPEDTAVYYCtatrAYSVGYD----YWGQGTQVTV 122
Cdd:cd07706    73 SLTISALQLEDSAKYFC----ALSLPYDtdklIFGKGTRLTV 110
PRK10490 PRK10490
sensor protein KdpD; Provisional
 249-345 8.78e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 58.12  E-value: 8.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK-----------GVstkgserGVGLALV 317
Cdd:PRK10490  783 LINLLENAVKYAGA--QAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKfargnkesaipGV-------GLGLAIC 853

                          90       100
                  ....*....|....*....|....*...
gi 1846261936 318 KQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK10490  854 RAIVEVHGGTIWAENRPEGGACFRVTLP 881
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-335 1.01e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 52.92  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPEPGGEISVTLHY---RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLG 325
Cdd:cd16944     9 LTNILKNAAEAIEGRPSDVGEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEHG 88

                          90
                  ....*....|
gi 1846261936 326 GSIAVESEPG 335
Cdd:cd16944    89 GRISLSNREA 98
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 367-483 1.05e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 52.91  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 367 QVQLVESggglVQAGGSLRLSCTASGRTgTIYSMAWFRQAPGKEREFLAtvgwsSGITYYMDSVKGRFTISRDKGKNTVY 446
Cdd:cd07706     4 QAQPDVS----VQVGEEVTLNCRYETSW-TNYYLFWYKQLPSGEMTFLI-----RQDSSEQNAKSGRYSVNFQKAQKSIS 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1846261936 447 LQMDSLKPEDTAVYYCtatrAYSVGYD----YWGQGTQVTV 483
Cdd:cd07706    74 LTISALQLEDSAKYFC----ALSLPYDtdklIFGKGTRLTV 110
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
223-345 1.27e-08

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 56.94  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 223 HTLILNSESQLPDSGSEDQVATLITtlgNLIENALEAlgPEPGGEISVTlhyrhgWLHC------EVNDDGPGIAPDKID 296
Cdd:PRK11006  299 HTITFEVDNSLKVFGNEDQLRSAIS---NLVYNAVNH--TPEGTHITVR------WQRVpqgaefSVEDNGPGIAPEHIP 367

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1846261936 297 HI------FDKGVS--TKGSerGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK11006  368 RLterfyrVDKARSrqTGGS--GLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-344 1.54e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.90  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGLALVKQQVE 322
Cdd:cd16947    25 LKNLISNAIKYGSD--GKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqgnGLGLTITKRLAE 102

                          90       100
                  ....*....|....*....|..
gi 1846261936 323 NLGGSIAVESEPGIFTQFFVQI 344
Cdd:cd16947   103 SMGGSIYVNSKPYEKTVFTVTL 124
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-335 2.41e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 51.94  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEaLGPEpggEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSERGVGLALVKQQVENL 324
Cdd:cd16949     7 NVLRNALR-YSPS---KILLDISQDGDQWTITITDDGPGVPEDQLEQIFlpfyrvDSARDRESGGTGLGLAIAERAIEQH 82

                          90
                  ....*....|..
gi 1846261936 325 GGSI-AVESEPG 335
Cdd:cd16949    83 GGKIkASNRKPG 94
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 7-122 2.82e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 51.62  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936   7 VQLVESGGGL-VQAGGSLRLSCTASGRTGTIYsMAWFRQAPGKEREFLAtvgwsSGITYYMDSVKGRFTISrdkGKNTVY 85
Cdd:cd04980     1 IVMTQSPASLsVSPGERVTISCKASQSISSNY-LAWYQQKPGQAPKLLI-----YYASTLHSGVPSRFSGS---GSGTDF 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1846261936  86 -LQMDSLKPEDTAVYYCtaTRAYSVGYDYwGQGTQVTV 122
Cdd:cd04980    72 tLTISSVEPEDAAVYYC--QQGYTFPYTF-GGGTKLEI 106
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 368-483 2.82e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 51.62  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 368 VQLVESGGGL-VQAGGSLRLSCTASGRTGTIYsMAWFRQAPGKEREFLAtvgwsSGITYYMDSVKGRFTISrdkGKNTVY 446
Cdd:cd04980     1 IVMTQSPASLsVSPGERVTISCKASQSISSNY-LAWYQQKPGQAPKLLI-----YYASTLHSGVPSRFSGS---GSGTDF 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1846261936 447 -LQMDSLKPEDTAVYYCtaTRAYSVGYDYwGQGTQVTV 483
Cdd:cd04980    72 tLTISSVEPEDAAVYYC--QQGYTFPYTF-GGGTKLEI 106
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 249-345 2.95e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 56.49  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEAlgpEPGGEISVTLHYRHG-WLHCEVNDDGPGIAPDKIDHIFD---------KGVSTKGSerGVGLALVK 318
Cdd:PRK11091  403 LWNLISNAVKF---TQQGGVTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAmyyqvkdshGGKPATGT--GIGLAVSK 477

                          90       100
                  ....*....|....*....|....*..
gi 1846261936 319 QQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK11091  478 RLAQAMGGDITVTSEEGKGSCFTLTIH 504
glnL PRK11073
nitrogen regulation protein NR(II);
224-345 4.03e-08

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 55.09  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 224 TLILNSESQLPD-SGSEDQVATLITtlgNLIENALEALGPEpGGEIsvTLHYR-------HGWLH-----CEVNDDGPGI 290
Cdd:PRK11073  219 RLIRDYDPSLPElAHDPDQIEQVLL---NIVRNALQALGPE-GGTI--TLRTRtafqltlHGERYrlaarIDIEDNGPGI 292

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1846261936 291 APDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGiFTQFFVQIP 345
Cdd:PRK11073  293 PPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLP 346
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-334 6.34e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 50.92  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGLALVKQQVE 322
Cdd:cd16946     9 FVNLLENSLRY--TDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasggsGLGLAICHNIAL 86

                          90
                  ....*....|..
gi 1846261936 323 NLGGSIAVESEP 334
Cdd:cd16946    87 AHGGTISAEHSP 98
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-335 3.88e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 48.56  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEaLGPEpGGEISVTLHYRHGWLhCEVNDDGPGIAPDKIDHIFDK-----GVSTKGSerGVGLALVKQQVEN 323
Cdd:cd16940    18 LRNLVDNAVR-YSPQ-GSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERfyrsdGQNYGGS--GLGLSIVKRIVEL 92

                          90
                  ....*....|..
gi 1846261936 324 LGGSIAVESEPG 335
Cdd:cd16940    93 HGGQIFLGNAQG 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 251-345 4.10e-07

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 48.53  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEALGPepGGEISVT-----------LHYRH----GWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLA 315
Cdd:cd16919     7 NLAVNARDAMPE--GGRLTIEtsnqrvdadyaLNYRDlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLG 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1846261936 316 L--VKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16919    85 LsmVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-334 4.67e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.20  E-value: 4.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEalgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSERGVGLALVKQQVE 322
Cdd:cd16939     5 LDNLLRNALR----YAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFepfvrlDPSRDRATGGFGLGLAIVHRVAL 80

                          90
                  ....*....|..
gi 1846261936 323 NLGGSIAVESEP 334
Cdd:cd16939    81 WHGGHVECDDSE 92
PRK10604 PRK10604
sensor protein RstB; Provisional
 249-334 6.99e-07

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 51.53  E-value: 6.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEALGPEPggEISVTLHYRHGWLHceVNDDGPGIAPDKIDHIFDKGV--------STKGSerGVGLALVKQQ 320
Cdd:PRK10604  324 LDNLLNNALRYAHSRV--RVSLLLDGNQACLI--VEDDGPGIPPEERERVFEPFVrldpsrdrATGGC--GLGLAIVHSI 397

                          90
                  ....*....|....
gi 1846261936 321 VENLGGSIAVESEP 334
Cdd:PRK10604  398 ALAMGGSVNCDESE 411
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 8.64e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 47.58  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHI------FDKGVSTKGSERGVGLALVK 318
Cdd:cd16952     1 LRSAFSNLVSNAVKY--TPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLterfyrVDIERCRNTGGTGLGLAIVK 78

                          90       100
                  ....*....|....*....|....*..
gi 1846261936 319 QQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16952    79 HVMSRHDARLLIASELGKGSRFTCLFP 105
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 152-194 8.73e-07

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 46.09  E-value: 8.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1846261936 152 DALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEE 194
Cdd:pfam14689  14 KALRHQRHDFLNHLQVISGYLQLGRYDRAEEYIKEVVKDLKEE 56
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-345 1.15e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 47.28  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 319
Cdd:cd16948     6 LSFIIGQIVSNALKY--SKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfqestGMGLYLVKK 83

                          90       100
                  ....*....|....*....|....*.
gi 1846261936 320 QVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16948    84 LCDKLGHKIDVESEVGEGTTFTITFP 109
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
230-345 1.27e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 51.13  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 230 ESQLPDSGSEDQVaTLITTLGNLIENALEALGPepgGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK--GVSTkG 307
Cdd:PRK10841  549 EPDVPVALNGDPM-RLQQVISNLLSNAIKFTDT---GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPffQVGT-G 623

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1846261936 308 SER-----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK10841  624 VQRnfqgtGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
249-345 1.76e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.89  E-value: 1.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  249 LGNLIENALEaLGPEPGGEISVTLHY---RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQV 321
Cdd:PRK09959   833 LSNLLSNALK-FTTEGAVKITTSLGHiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtgsGLGLMICKELI 911

                           90       100
                   ....*....|....*....|....
gi 1846261936  322 ENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK09959   912 KNMQGDLSLESHPGIGTTFTITIP 935
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
255-319 6.56e-06

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 45.36  E-value: 6.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1846261936 255 NALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQ 319
Cdd:pfam13581  42 NAVEhAYREGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEGGRGLALIRG 107
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-345 7.47e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 44.08  E-value: 7.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 264 PGGEISVTLHYRHGWLHCEVNDDGPGIAPDkidhifdkgvsTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQ 343
Cdd:cd16917    17 GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTAR 85


                  ..
gi 1846261936 344 IP 345
Cdd:cd16917    86 LP 87
PRK15347 PRK15347
two component system sensor kinase;
245-345 7.55e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 48.48  E-value: 7.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 245 LITTLGNlienaleALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLAL-VKQQVEN 323
Cdd:PRK15347  518 LVNLLGN-------AVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLtIASSLAK 590

                          90       100
                  ....*....|....*....|...
gi 1846261936 324 L-GGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK15347  591 MmGGELTLFSTPGVGSCFSLVLP 613
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 252-319 8.37e-06

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 44.18  E-value: 8.37e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261936 252 LIENALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKidhifDKGVSTKGSERGVGLALVKQ 319
Cdd:cd16936     8 AVTNAVRhAYRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLR-----PADPDAGLREGGRGLALIRA 71
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-335 2.90e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.22  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALeALGPEpGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVS-----TKGSERGVGLALVKQQVEN 323
Cdd:cd16945     9 INNLLDNAI-DFSPE-GGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQL 86

                          90
                  ....*....|..
gi 1846261936 324 LGGSIAVESEPG 335
Cdd:cd16945    87 HGGRITLRNRPD 98
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
233-334 8.05e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 45.01  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 233 LPDS----GSEDQVATLITtlgNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGS 308
Cdd:PRK10549  340 LPDSatvfGDPDRLMQLFN---NLLENSLRY--TDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGS 414

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1846261936 309 ER------GVGLALVKQQVENLGGSIAVESEP 334
Cdd:PRK10549  415 RNrasggsGLGLAICLNIVEAHNGRIIAAHSP 446
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
249-345 1.63e-04

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 43.99  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEAlgpEPGGEiSVTLHYRHGWLHCEVNDDGPG--IAPDKIDHIFDK------GVSTKGSERGVGLALVKQQ 320
Cdd:PRK09835  380 ISNLLSNALRY---TPAGE-AITVRCQEVDHQVQLVVENPGtpIAPEHLPRLFDRfyrvdpSRQRKGEGSGIGLAIVKSI 455

                          90       100
                  ....*....|....*....|....*
gi 1846261936 321 VENLGGSIAVESEPgIFTQFFVQIP 345
Cdd:PRK09835  456 VVAHKGTVAVTSDA-RGTRFVISLP 479
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 158-345 1.80e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 44.13  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 158 SHEFMNKLHVILGLLHLKSYKQL----EDYiLKTANNYQEEIGSLLGKI--KSPVIAGfliskinratdlGHTLILNSE- 230
Cdd:PRK11466  452 SHEIRTPLYGILGTAQLLADNPAlnaqRDD-LRAITDSGESLLTILNDIldYSAIEAG------------GKNVSVSDEp 518

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 231 ---SQLPDSG---------------SEDQVATLITTLG-----------NLIENALEAlgPEPGGEISVTLHYRHGWLhC 281
Cdd:PRK11466  519 fepRPLLESTlqlmsgrvkgrpirlATDIADDLPTALMgdprrirqvitNLLSNALRF--TDEGSIVLRSRTDGEQWL-V 595

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1846261936 282 EVNDDGPGIAPDKIDHIFDKGVSTKGSE--RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:PRK11466  596 EVEDSGCGIDPAKLAEIFQPFVQVSGKRggTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
PRK13557 PRK13557
histidine kinase; Provisional
 283-353 2.08e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 43.89  E-value: 2.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1846261936 283 VNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLAL------VKQQvenlGGSIAVESEPGIFTQFFVQIPWDGERSNR 353
Cdd:PRK13557  329 VTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLsmvygfAKQS----GGAVRIYSEVGEGTTVRLYFPASDQAENP 401
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 211-335 9.03e-04

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 42.02  E-value: 9.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 211 LISKINRATDLghTLiLNSESQLPDSGSEdqvaTLITTLGNLIENALE----------ALGPEPGGEISVTLHYRHGWLH 280
Cdd:PRK10547  359 LAGKLGKQVEL--TL-VGSSTELDKSLIE----RIIDPLTHLVRNSLDhgielpekrlAAGKNSVGNLILSAEHQGGNIC 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 281 CEVNDDGPGIAPDKI------------DH---------IFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEP 334
Cdd:PRK10547  432 IEVTDDGAGLNRERIlakaasqglavsENmsdeevgmlIFAPGFSTAEqvtdvSGRGVGMDVVKRNIQEMGGHVEIQSKQ 511


                  .
gi 1846261936 335 G 335
Cdd:PRK10547  512 G 512
PRK10337 PRK10337
sensor protein QseC; Provisional
 232-319 1.21e-03

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 41.17  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 232 QLPDSGSEDQVATLITTL--GNLIENALEAlgPEPGGEISVTLHYRHgwlhCEVNDDGPGIAPDKIDHIFDK-----GVS 304
Cdd:PRK10337  338 TLNAHPVIRTGQPLLLSLlvRNLLDNAIRY--SPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERfyrppGQE 411

                          90
                  ....*....|....*
gi 1846261936 305 TKGSerGVGLALVKQ 319
Cdd:PRK10337  412 ATGS--GLGLSIVRR 424
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-331 1.99e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 37.83  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 251 NLIENALEaLGPEpGGEISVTLHYRHGWLHCEVNDDGPGIAPD---KIDHIF--DKGVSTKGSERGVGLALVKQQVENLG 325
Cdd:cd16975    11 NIISNACQ-YAPE-GGTVSISIYDEEEYLYFEIWDNGHGFSEQdlkKALELFyrDDTSRRSGGHYGMGLYIAKNLVEKHG 88


                  ....*.
gi 1846261936 326 GSIAVE 331
Cdd:cd16975    89 GSLIIE 94
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 17-122 4.99e-03

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 36.77  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936  17 VQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGwssGItyYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDT 96
Cdd:cd20988    10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFIYREG---GI--YGPGFKDNFRGDIDSSNNLAVLKILEASERDE 84

                          90       100
                  ....*....|....*....|....*....
gi 1846261936  97 AVYYCTATRAYSVGYD---YWGQGTQVTV 122
Cdd:cd20988    85 GSYYCASDTPGGGREYdplIFGKGTYLTV 113
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 378-483 4.99e-03

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 36.77  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 378 VQAGGSLRLSCTASGRTGTIYSMAWFRQAPGKEREFLATVGwssGItyYMDSVKGRFTISRDKGKNTVYLQMDSLKPEDT 457
Cdd:cd20988    10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFIYREG---GI--YGPGFKDNFRGDIDSSNNLAVLKILEASERDE 84

                          90       100
                  ....*....|....*....|....*....
gi 1846261936 458 AVYYCTATRAYSVGYD---YWGQGTQVTV 483
Cdd:cd20988    85 GSYYCASDTPGGGREYdplIFGKGTYLTV 113
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 249-345 6.54e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 37.71  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261936 249 LGNLIENALEA---------LGPEPggeISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER--------- 310
Cdd:cd16929    48 LFELLKNAMRAtveshgddsDDLPP---IKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdlis 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1846261936 311 ----------GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 345
Cdd:cd16929   125 gtqpsplagfGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
232-290 9.22e-03

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 38.41  E-value: 9.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1846261936 232 QLPDSGSEDQV---ATLIT-TLGNLIENAlEALGPEpGGEISVTLHYRHGWLHCEVNDDGPGI 290
Cdd:PRK10755  231 LLPESAADITVqgdATLLRlLLRNLVENA-HRYSPE-GSTITIKLSQEDGGAVLAVEDEGPGI 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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