|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1-440 |
1.82e-30 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 124.57 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 1 MTLVLRDAQRVALE---RLTEPGRHfAALWAEPRSGKTAVALLWLQHIRPRV----AVVVGPKVAEATWRTEAAKWLSTE 73
Cdd:COG0553 238 LKATLRPYQLEGAAwllFLRRLGLG-GLLADDMGLGKTIQALALLLELKERGlarpVLIVAPTSLVGNWQRELAKFAPGL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 74 yRFFPLTAGNE-YPDPKSFKGITILFVNYEQFtkapfQRLKPFLSEMSRlcggqGAMLLDESHIIKTPSSITGRNIRPLA 152
Cdd:COG0553 317 -RVLVLDGTRErAKGANPFEDADLVITSYGLL-----RRDIELLAAVDW-----DLVILDEAQHIKNPATKRAKAVRALK 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 153 dhWHYRLLMTGTPVtnPNQIDAVYGQWTFLDPsirDHWPSARDFREHFgewtnvKGFPELVRPRNQAELNQYLQPNVITM 232
Cdd:COG0553 386 --ARHRLALTGTPV--ENRLEELWSLLDFLNP---GLLGSLKAFRERF------ARPIEKGDEEALERLRRLLRPFLLRR 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 233 T---GAGDPVPirKVVYPVPSEVLEQHQALLKDGLVEMHGHIVLGLNP------LTRLLRMRTLVAGWA-KDEDGTSFTV 302
Cdd:COG0553 453 TkedVLKDLPE--KTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIrrrgliLAALTRLRQICSHPAlLLEEGAELSG 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 303 PTAarrRLTVLGRVLGRAKG---KVIIACTHLHEVKLVARYLRHKGLGYLIITGATPNKN--HVIEDFQRDEDARVLLVQ 377
Cdd:COG0553 531 RSA---KLEALLELLEELLAegeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEErdELVDRFQEGPEAPVFLIS 607
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1842031919 378 PRTVSMAVDISVANDLIWYTSDFNYVTFKQASDRI------KlspaSPTVWFLCGKGTVDEDVWVTLQE 440
Cdd:COG0553 608 LKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAhrigqtR----DVQVYKLVAEGTIEEKILELLEE 672
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
5-184 |
2.81e-13 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 67.98 E-value: 2.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALE---RLTEPGRHfAALWAEPRSGKTAVAL-----LWLQHIRPRVAVVVGPKVAEATWRTEAAKWLSTeYRF 76
Cdd:cd17919 1 LRPYQLEGLNfllELYENGPG-GILADEMGLGKTLQAIaflayLLKEGKERGPVLVVCPLSVLENWEREFEKWTPD-LRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 77 FPLTAGNE-------YPDPKSFKgitILFVNYEQFTK--APFQRLKPFLsemsrlcggqgaMLLDESHIIKTPSSITGRN 147
Cdd:cd17919 79 VVYHGSQReraqiraKEKLDKFD---VVLTTYETLRRdkASLRKFRWDL------------VVVDEAHRLKNPKSQLSKA 143
|
170 180 190
....*....|....*....|....*....|....*..
gi 1842031919 148 IRPLADhwHYRLLMTGTPVtnPNQIDAVYGQWTFLDP 184
Cdd:cd17919 144 LKALRA--KRRLLLTGTPL--QNNLEELWALLDFLDP 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
5-165 |
2.97e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 47.87 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALERLTEpGRHFAALWAEPRSGKTAVALLWL-----QHIRPRVAVVVGPKVAEATWRTEAAKWL-STEYRFFP 78
Cdd:smart00487 9 LRPYQKEAIEALLS-GLRDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLGpSLGLKVVG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 79 LTAGNEYPDPKS--FKGIT-ILFVNYEQFTKApFQRLKPFLSEMSRLcggqgamLLDESHIIKTPS--SITGRNIRPLAD 153
Cdd:smart00487 88 LYGGDSKREQLRklESGKTdILVTTPGRLLDL-LENDKLSLSNVDLV-------ILDEAHRLLDGGfgDQLEKLLKLLPK 159
|
170
....*....|..
gi 1842031919 154 HwHYRLLMTGTP 165
Cdd:smart00487 160 N-VQLLLLSATP 170
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
129-434 |
9.28e-06 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 48.26 E-value: 9.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPLADHwhYRLLMTGTPVTnpNQIDAVYGQWTFLDPSIrdhWPSArdfrEHFGEWTNVKG 208
Cdd:PLN03142 295 IIIDEAHRIKNENSLLSKTMRLFSTN--YRLLITGTPLQ--NNLHELWALLNFLLPEI---FSSA----ETFDEWFQISG 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 209 fpelvrPRNQAELNQYLQpNVITmtgagdPVPIRKVVYPVPSEVLEQHQALLKDGLVEMHGH-----------IVLGLNP 277
Cdd:PLN03142 364 ------ENDQQEVVQQLH-KVLR------PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQyykallqkdldVVNAGGE 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 278 LTRLLRMRT----------LVAGwakDEDGTSFT-----VPTAArrRLTVLGRVLGRAK---GKVIIACTHLHEVKLVAR 339
Cdd:PLN03142 431 RKRLLNIAMqlrkccnhpyLFQG---AEPGPPYTtgehlVENSG--KMVLLDKLLPKLKerdSRVLIFSQMTRLLDILED 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 340 YLRHKGLGYLIITGAT--PNKNHVIEDFQRDEDAR-VLLVQPRTVSMAVDISVANDLIWYTSDFNYVTFKQASDRIKL-- 414
Cdd:PLN03142 506 YLMYRGYQYCRIDGNTggEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRig 585
|
330 340
....*....|....*....|
gi 1842031919 415 SPASPTVWFLCGKGTVDEDV 434
Cdd:PLN03142 586 QKKEVQVFRFCTEYTIEEKV 605
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
33-227 |
3.08e-04 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 42.67 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 33 GKT--AVALLW-LQHIRP---RVAVVVGPKVAEATWRTEAAKWLSTEyrffPLTA----GNEYP------DPKSFKGITI 96
Cdd:pfam00176 29 GKTlqTISLLLyLKHVDKnwgGPTLIVVPLSLLHNWMNEFERWVSPP----ALRVvvlhGNKRPqerwknDPNFLADFDV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 97 LFVNYEqftkapfqrlkpFLSEMSRLCGGQG--AMLLDESHIIKTPSSITGRNIRPLADHwhYRLLMTGTPVtnPNQIDA 174
Cdd:pfam00176 105 VITTYE------------TLRKHKELLKKVHwhRIVLDEGHRLKNSKSKLSKALKSLKTR--NRWILTGTPL--QNNLEE 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1842031919 175 VYGQWTFLDPSIrdhWPSARDFREHFGewtnvKGFPELVRPRNQAELNQYLQP 227
Cdd:pfam00176 169 LWALLNFLRPGP---FGSLSTFRNWFD-----RPIERGGGKKGVSRLHKLLKP 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1-440 |
1.82e-30 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 124.57 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 1 MTLVLRDAQRVALE---RLTEPGRHfAALWAEPRSGKTAVALLWLQHIRPRV----AVVVGPKVAEATWRTEAAKWLSTE 73
Cdd:COG0553 238 LKATLRPYQLEGAAwllFLRRLGLG-GLLADDMGLGKTIQALALLLELKERGlarpVLIVAPTSLVGNWQRELAKFAPGL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 74 yRFFPLTAGNE-YPDPKSFKGITILFVNYEQFtkapfQRLKPFLSEMSRlcggqGAMLLDESHIIKTPSSITGRNIRPLA 152
Cdd:COG0553 317 -RVLVLDGTRErAKGANPFEDADLVITSYGLL-----RRDIELLAAVDW-----DLVILDEAQHIKNPATKRAKAVRALK 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 153 dhWHYRLLMTGTPVtnPNQIDAVYGQWTFLDPsirDHWPSARDFREHFgewtnvKGFPELVRPRNQAELNQYLQPNVITM 232
Cdd:COG0553 386 --ARHRLALTGTPV--ENRLEELWSLLDFLNP---GLLGSLKAFRERF------ARPIEKGDEEALERLRRLLRPFLLRR 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 233 T---GAGDPVPirKVVYPVPSEVLEQHQALLKDGLVEMHGHIVLGLNP------LTRLLRMRTLVAGWA-KDEDGTSFTV 302
Cdd:COG0553 453 TkedVLKDLPE--KTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIrrrgliLAALTRLRQICSHPAlLLEEGAELSG 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 303 PTAarrRLTVLGRVLGRAKG---KVIIACTHLHEVKLVARYLRHKGLGYLIITGATPNKN--HVIEDFQRDEDARVLLVQ 377
Cdd:COG0553 531 RSA---KLEALLELLEELLAegeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEErdELVDRFQEGPEAPVFLIS 607
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1842031919 378 PRTVSMAVDISVANDLIWYTSDFNYVTFKQASDRI------KlspaSPTVWFLCGKGTVDEDVWVTLQE 440
Cdd:COG0553 608 LKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAhrigqtR----DVQVYKLVAEGTIEEKILELLEE 672
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
5-184 |
2.81e-13 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 67.98 E-value: 2.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALE---RLTEPGRHfAALWAEPRSGKTAVAL-----LWLQHIRPRVAVVVGPKVAEATWRTEAAKWLSTeYRF 76
Cdd:cd17919 1 LRPYQLEGLNfllELYENGPG-GILADEMGLGKTLQAIaflayLLKEGKERGPVLVVCPLSVLENWEREFEKWTPD-LRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 77 FPLTAGNE-------YPDPKSFKgitILFVNYEQFTK--APFQRLKPFLsemsrlcggqgaMLLDESHIIKTPSSITGRN 147
Cdd:cd17919 79 VVYHGSQReraqiraKEKLDKFD---VVLTTYETLRRdkASLRKFRWDL------------VVVDEAHRLKNPKSQLSKA 143
|
170 180 190
....*....|....*....|....*....|....*..
gi 1842031919 148 IRPLADhwHYRLLMTGTPVtnPNQIDAVYGQWTFLDP 184
Cdd:cd17919 144 LKALRA--KRRLLLTGTPL--QNNLEELWALLDFLDP 176
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
317-412 |
2.90e-11 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 60.95 E-value: 2.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 317 LGRAKGKVIIACTHLHEVKLVARYLRHKGLGYLIITGATPNK--NHVIEDFQRDEDARVLLVQPRTVSMAVDISVANDLI 394
Cdd:cd18793 23 LREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKerQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVI 102
|
90
....*....|....*...
gi 1842031919 395 WYTSDFNYVTFKQASDRI 412
Cdd:cd18793 103 LYDPWWNPAVEEQAIDRA 120
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
5-187 |
7.07e-09 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 55.82 E-value: 7.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALERLTEpgRHFAALWAEPRSGKTAVALLWLQHIRP----RVAVVVGPK-VAEATWRTEAAKWLSTEYRFFPL 79
Cdd:cd18013 1 PHPYQKVAINFIIE--HPYCGLFLDMGLGKTVTTLTALSDLQLddftRRVLVIAPLrVARSTWPDEVEKWNHLRNLTVSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 80 TAGNEYPDPKSF-KGITILFVNYEQFTKAPFQRLKPFLSEMsrlcggqgaMLLDESHIIKTPSSITG---RNIRPLADHW 155
Cdd:cd18013 79 AVGTERQRSKAAnTPADLYVINRENLKWLVNKSGDPWPFDM---------VVIDELSSFKSPRSKRFkalRKVRPVIKRL 149
|
170 180 190
....*....|....*....|....*....|..
gi 1842031919 156 hyrLLMTGTPvtNPNQIDAVYGQWTFLDPSIR 187
Cdd:cd18013 150 ---IGLTGTP--SPNGLMDLWAQIALLDQGER 176
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
6-196 |
1.75e-07 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 51.82 E-value: 1.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 6 RDAQRVALERltePGRhfaALWA-EPRSGKTAVALLWLQHIR---PrvAVVVGPKVAEATWRTEAAKWLSTE--YRFFPL 79
Cdd:cd18010 6 REGVCFALRR---GGR---VLIAdEMGLGKTVQAIAIAAYYReewP--LLIVCPSSLRLTWADEIERWLPSLppDDIQVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 80 TAGNEYPDPKSFKgitILFVNYEQFTKAPFQRLKpflsemsrlcGGQGAMLLDESHIIKTPSSITGRNIRPLADHWHYRL 159
Cdd:cd18010 78 VKSKDGLRDGDAK---VVIVSYDLLRRLEKQLLA----------RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVI 144
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1842031919 160 LMTGTP-VTNP----NQIDAvygqwtfLDPsirDHWPSARDF 196
Cdd:cd18010 145 LLSGTPaLSRPielfTQLDA-------LDP---KLFGRFHDF 176
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
32-168 |
6.53e-07 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 50.37 E-value: 6.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 32 SGKTA-----VALLWLQHIRPRVAVVVGPKVAEATWRTEAAKWLSTEYRffPLTAGNEYPDPKSFKGIT----------- 95
Cdd:cd18007 37 LGKTLqvitfLHTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWLPPDLR--PLLVLVSLSASKRADARLrkinkwhkegg 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 96 ILFVNYEQFTK----APFQRLKPFLSEMSRLCGGQGAMLLDESHIIKTPSSITG---RNIRPladhwHYRLLMTGTPVTN 168
Cdd:cd18007 115 VLLIGYELFRNlasnATTDPRLKQEFIAALLDPGPDLLVLDEGHRLKNEKSQLSkalSKVKT-----KRRILLTGTPLQN 189
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
5-165 |
2.97e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 47.87 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALERLTEpGRHFAALWAEPRSGKTAVALLWL-----QHIRPRVAVVVGPKVAEATWRTEAAKWL-STEYRFFP 78
Cdd:smart00487 9 LRPYQKEAIEALLS-GLRDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLGpSLGLKVVG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 79 LTAGNEYPDPKS--FKGIT-ILFVNYEQFTKApFQRLKPFLSEMSRLcggqgamLLDESHIIKTPS--SITGRNIRPLAD 153
Cdd:smart00487 88 LYGGDSKREQLRklESGKTdILVTTPGRLLDL-LENDKLSLSNVDLV-------ILDEAHRLLDGGfgDQLEKLLKLLPK 159
|
170
....*....|..
gi 1842031919 154 HwHYRLLMTGTP 165
Cdd:smart00487 160 N-VQLLLLSATP 170
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
5-165 |
6.74e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 45.76 E-value: 6.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 5 LRDAQRVALERLTEPGR-HFAALWAEPRSGKTAVALLWLQHIRPRVAVVVGPKVAEAT-WRTEAAKWLSTEYRFFpLTAG 82
Cdd:cd17926 1 LRPYQEEALEAWLAHKNnRRGILVLPTGSGKTLTALALIAYLKELRTLIVVPTDALLDqWKERFEDFLGDSSIGL-IGGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 83 NEypdpKSFKGITILFVNYeqftkapfQRLKPFLSEMSRLCGGQGAMLLDESHIIktpSSITGRNIRPLADHwHYRLLMT 162
Cdd:cd17926 80 KK----KDFDDANVVVATY--------QSLSNLAEEEKDLFDQFGLLIVDEAHHL---PAKTFSEILKELNA-KYRLGLT 143
|
...
gi 1842031919 163 GTP 165
Cdd:cd17926 144 ATP 146
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
129-434 |
9.28e-06 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 48.26 E-value: 9.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPLADHwhYRLLMTGTPVTnpNQIDAVYGQWTFLDPSIrdhWPSArdfrEHFGEWTNVKG 208
Cdd:PLN03142 295 IIIDEAHRIKNENSLLSKTMRLFSTN--YRLLITGTPLQ--NNLHELWALLNFLLPEI---FSSA----ETFDEWFQISG 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 209 fpelvrPRNQAELNQYLQpNVITmtgagdPVPIRKVVYPVPSEVLEQHQALLKDGLVEMHGH-----------IVLGLNP 277
Cdd:PLN03142 364 ------ENDQQEVVQQLH-KVLR------PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQyykallqkdldVVNAGGE 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 278 LTRLLRMRT----------LVAGwakDEDGTSFT-----VPTAArrRLTVLGRVLGRAK---GKVIIACTHLHEVKLVAR 339
Cdd:PLN03142 431 RKRLLNIAMqlrkccnhpyLFQG---AEPGPPYTtgehlVENSG--KMVLLDKLLPKLKerdSRVLIFSQMTRLLDILED 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 340 YLRHKGLGYLIITGAT--PNKNHVIEDFQRDEDAR-VLLVQPRTVSMAVDISVANDLIWYTSDFNYVTFKQASDRIKL-- 414
Cdd:PLN03142 506 YLMYRGYQYCRIDGNTggEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRig 585
|
330 340
....*....|....*....|
gi 1842031919 415 SPASPTVWFLCGKGTVDEDV 434
Cdd:PLN03142 586 QKKEVQVFRFCTEYTIEEKV 605
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
33-200 |
2.76e-05 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 45.35 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 33 GKT--AVALLW--LQH---IRP--RVAVVVGPKVAEATWRTEAAKWLSTEyRFFPLTA-GNEYPDPKSFKGIT------I 96
Cdd:cd18004 36 GKTlqAIALVWtlLKQgpyGKPtaKKALIVCPSSLVGNWKAEFDKWLGLR-RIKVVTAdGNAKDVKASLDFFSsastypV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 97 LFVNYEQFtkapfQRLKPFLSEMSRLcggqGAMLLDESHIIKTPSSITGRNIRPL-ADHwhyRLLMTGTPVTnpNQIDAV 175
Cdd:cd18004 115 LIISYETL-----RRHAEKLSKKISI----DLLICDEGHRLKNSESKTTKALNSLpCRR---RLLLTGTPIQ--NDLDEF 180
|
170 180
....*....|....*....|....*
gi 1842031919 176 YGQWTFLDPSIrdhWPSARDFREHF 200
Cdd:cd18004 181 FALVDFVNPGI---LGSLASFRKVF 202
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
1-166 |
9.74e-05 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 44.63 E-value: 9.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 1 MTLVLRDAQRVALERL---TEPGRHFAALWAEPRSGKTAVALLWLQHIR--PRVAVVVgP-KVAEATWRTEAAKWLSTey 74
Cdd:COG1061 77 TSFELRPYQQEALEALlaaLERGGGRGLVVAPTGTGKTVLALALAAELLrgKRVLVLV-PrRELLEQWAEELRRFLGD-- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 75 rffPLTAGNEYPDPKsfkgiTILFVNYEQFTKapfqrlKPFLSEMSRLCGgqgamLL--DESHIIKTPSsitgrnIRPLA 152
Cdd:COG1061 154 ---PLAGGGKKDSDA-----PITVATYQSLAR------RAHLDELGDRFG-----LViiDEAHHAGAPS------YRRIL 208
|
170
....*....|....*.
gi 1842031919 153 DHWH--YRLLMTGTPV 166
Cdd:COG1061 209 EAFPaaYRLGLTATPF 224
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
129-168 |
1.65e-04 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 43.13 E-value: 1.65e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPL-ADHwhyRLLMTGTPVTN 168
Cdd:cd18001 129 VILDEGHKIKNSKTKSAKSLREIpAKN---RIILTGTPIQN 166
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
33-168 |
2.40e-04 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 42.17 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 33 GKTAVALLWLQHI----RPRVAVVVGPKVAEATWRTEAAKwlsteyrFFPL-------TAGNEYPDPKSFKGITILFVNY 101
Cdd:cd18012 35 GKTLQTLALLLSRkeegRKGPSLVVAPTSLIYNWEEEAAK-------FAPElkvlvihGTKRKREKLRALEDYDLVITSY 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1842031919 102 eqftkAPFQRLKPFLSEMS-RLCggqgamLLDESHIIKTPSSITGRNIRPL-ADHwhyRLLMTGTPVTN 168
Cdd:cd18012 108 -----GLLRRDIELLKEVKfHYL------VLDEAQNIKNPQTKTAKAVKALkADH---RLALTGTPIEN 162
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
33-227 |
3.08e-04 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 42.67 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 33 GKT--AVALLW-LQHIRP---RVAVVVGPKVAEATWRTEAAKWLSTEyrffPLTA----GNEYP------DPKSFKGITI 96
Cdd:pfam00176 29 GKTlqTISLLLyLKHVDKnwgGPTLIVVPLSLLHNWMNEFERWVSPP----ALRVvvlhGNKRPqerwknDPNFLADFDV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 97 LFVNYEqftkapfqrlkpFLSEMSRLCGGQG--AMLLDESHIIKTPSSITGRNIRPLADHwhYRLLMTGTPVtnPNQIDA 174
Cdd:pfam00176 105 VITTYE------------TLRKHKELLKKVHwhRIVLDEGHRLKNSKSKLSKALKSLKTR--NRWILTGTPL--QNNLEE 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1842031919 175 VYGQWTFLDPSIrdhWPSARDFREHFGewtnvKGFPELVRPRNQAELNQYLQP 227
Cdd:pfam00176 169 LWALLNFLRPGP---FGSLSTFRNWFD-----RPIERGGGKKGVSRLHKLLKP 213
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
129-203 |
3.51e-04 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 42.11 E-value: 3.51e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1842031919 129 MLLDESHIIKTPSSITGRNIrpLADHWHYRLLMTGTPVTNPNQidavyGQWTFLdpsirdHW--PSARDFREHFGEW 203
Cdd:cd18002 132 MVLDEAQAIKSSSSSRWKTL--LSFHCRNRLLLTGTPIQNSMA-----ELWALL------HFimPTLFDSHDEFNEW 195
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
33-201 |
1.47e-03 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 39.92 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 33 GKTAVALLWLQHIRPRV-----AVVVGPKVAEATWRTEAAKW----------------LSTEYRFFPLTAGNeyPDPKSF 91
Cdd:cd17995 31 GKTIQSIAFLEHLYQVEgirgpFLVIAPLSTIPNWQREFETWtdmnvvvyhgsgesrqIIQQYEMYFKDAQG--RKKKGV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 92 KGITILFVNYEQFTKApfqrlKPFLSEMSRLCggqgaMLLDESHIIKTPSSITGRNIRPLadHWHYRLLMTGTPVTNpnq 171
Cdd:cd17995 109 YKFDVLITTYEMVIAD-----AEELRKIPWRV-----VVVDEAHRLKNRNSKLLQGLKKL--TLEHKLLLTGTPLQN--- 173
|
170 180 190
....*....|....*....|....*....|...
gi 1842031919 172 idAVYGQWT---FLDPSirdHWPSARDFREHFG 201
Cdd:cd17995 174 --NTEELWSllnFLEPE---KFPSSEEFLEEFG 201
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
26-164 |
1.64e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 38.92 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 26 LWAEPRSGKTAVALLW-LQHI---RPRVAVVVGPKVAEATWRTEAAKWLSTEYRFFPLTAGNEYPDPKSFKG--ITILFV 99
Cdd:cd00046 6 ITAPTGSGKTLAALLAaLLLLlkkGKKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGGSSAEEREKNKLgdADIIIA 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1842031919 100 NYEQFTKAPFQRLKPFLSEMSRLcggqgamLLDESHIIktpsSITGRNIR--PLADHWH-----YRLLMTGT 164
Cdd:cd00046 86 TPDMLLNLLLREDRLFLKDLKLI-------IVDEAHAL----LIDSRGALilDLAVRKAglknaQVILLSAT 146
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
131-168 |
2.49e-03 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 39.58 E-value: 2.49e-03
10 20 30
....*....|....*....|....*....|....*...
gi 1842031919 131 LDESHIIKTPSSITGRNIRPLadHWHYRLLMTGTPVTN 168
Cdd:cd18008 153 LDEAHNIKNRSTKTSRAVCAL--KAERRWCLTGTPIQN 188
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
131-168 |
3.53e-03 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 38.87 E-value: 3.53e-03
10 20 30
....*....|....*....|....*....|....*...
gi 1842031919 131 LDESHIIKTPSSITGRNIRPLadHWHYRLLMTGTPVTN 168
Cdd:cd17999 132 LDEGHIIKNSKTKLSKAVKQL--KANHRLILSGTPIQN 167
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
129-186 |
3.88e-03 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 38.57 E-value: 3.88e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPLADHWhyRLLMTGTPVTNPNQidAVYGQWTFLDPSI 186
Cdd:cd18006 126 LVVDEAHRLKNQNSLLHKTLSEFSVDF--RLLLTGTPIQNSLQ--ELYALLSFIEPNV 179
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
129-200 |
4.41e-03 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 38.46 E-value: 4.41e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPLadHWHYRLLMTGTPV-TNPNQIdavygqWTFLDPSIRDHWPSARDFREHF 200
Cdd:cd17997 129 IIIDEAHRIKNEKSKLSQIVRLF--NSRNRLLLTGTPLqNNLHEL------WALLNFLLPDVFTSSEDFDEWF 193
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
129-215 |
6.91e-03 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 38.10 E-value: 6.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842031919 129 MLLDESHIIKTPSSITGRNIRPLAdhWHYRLLMTGTPVTnpNQIDAVYGQWTFLDPSirdHWPSARDFREHFGEWT---N 205
Cdd:cd18058 135 VIIDEAHRLKNRNCKLLEGLKLMA--LEHKVLLTGTPLQ--NSVEELFSLLNFLEPS---QFPSETTFLEEFGDLKteeQ 207
|
90
....*....|
gi 1842031919 206 VKGFPELVRP 215
Cdd:cd18058 208 VKKLQSILKP 217
|
|
| |
