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Conserved domains on  [gi|1842013461|ref|YP_009800576|]
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acetyltransferase [Pseudomonas phage Nerthus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 12226222)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 34-150 2.86e-16

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


:

Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 70.47  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  34 ELDYSLQQAAATImmDDGCFLIVFDDNEPVGFLWGFccalpwnpaKLAMDTL----LYVEPHYRGSRAGYKLVKAWEAWA 109
Cdd:COG0454    19 ALDAELKAMEGSL--AGAEFIAVDDKGEPIGFAGLR---------RLDDKVLelkrLYVLPEYRGKGIGKALLEALLEWA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1842013461 110 AERGATSVQLSVasGIHEDKTAEFYQRMGYQHI-------GTEYRKEL 150
Cdd:COG0454    88 RERGCTALELDT--LDGNPAAIRFYERLGFKEIeryvayvGGEFEKEL 133
 
Name Accession Description Interval E-value
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 34-150 2.86e-16

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 70.47  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  34 ELDYSLQQAAATImmDDGCFLIVFDDNEPVGFLWGFccalpwnpaKLAMDTL----LYVEPHYRGSRAGYKLVKAWEAWA 109
Cdd:COG0454    19 ALDAELKAMEGSL--AGAEFIAVDDKGEPIGFAGLR---------RLDDKVLelkrLYVLPEYRGKGIGKALLEALLEWA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1842013461 110 AERGATSVQLSVasGIHEDKTAEFYQRMGYQHI-------GTEYRKEL 150
Cdd:COG0454    88 RERGCTALELDT--LDGNPAAIRFYERLGFKEIeryvayvGGEFEKEL 133
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 49-140 9.81e-13

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 59.78  E-value: 9.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  49 DDGCFLIVFDDNEPVGFLWGFCCALPWNPAKLAMdtllYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVasgihED 128
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRL----AVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET-----TN 71

                          90
                  ....*....|..
gi 1842013461 129 KTAEFYQRMGYQ 140
Cdd:pfam13508  72 RAAAFYEKLGFE 83
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-120 9.17e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 49.20  E-value: 9.17e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1842013461  53 FLIVFDDNEPVGFLWGFCCALPWNPAKLAMdtlLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLS 120
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGD---LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 58-141 8.38e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 8.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  58 DDNEPVGFLWGFCCAL-PWN-P-----AKLAMDTLLY----------------------------VEPHYRGSRAGYKLV 102
Cdd:PRK03624   11 ADFEAVIALWERCDLTrPWNdPemdieRKLNHDPSLFlvaevggevvgtvmggydghrgwayylaVHPDFRGRGIGRALV 90

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1842013461 103 KAWEAWAAERGATSVQLSVASGihEDKTAEFYQRMGYQH 141
Cdd:PRK03624   91 ARLEKKLIARGCPKINLQVRED--NDAVLGFYEALGYEE 127
 
Name Accession Description Interval E-value
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 34-150 2.86e-16

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 70.47  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  34 ELDYSLQQAAATImmDDGCFLIVFDDNEPVGFLWGFccalpwnpaKLAMDTL----LYVEPHYRGSRAGYKLVKAWEAWA 109
Cdd:COG0454    19 ALDAELKAMEGSL--AGAEFIAVDDKGEPIGFAGLR---------RLDDKVLelkrLYVLPEYRGKGIGKALLEALLEWA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1842013461 110 AERGATSVQLSVasGIHEDKTAEFYQRMGYQHI-------GTEYRKEL 150
Cdd:COG0454    88 RERGCTALELDT--LDGNPAAIRFYERLGFKEIeryvayvGGEFEKEL 133
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 49-140 9.81e-13

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 59.78  E-value: 9.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  49 DDGCFLIVFDDNEPVGFLWGFCCALPWNPAKLAMdtllYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVasgihED 128
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRL----AVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET-----TN 71

                          90
                  ....*....|..
gi 1842013461 129 KTAEFYQRMGYQ 140
Cdd:pfam13508  72 RAAAFYEKLGFE 83
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 42-145 1.04e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 61.16  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  42 AAATIMMDDGCFLIVFDDNEPVGflwgfCCALPWNPAKLAMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSV 121
Cdd:COG1246    19 RPYALEEEIGEFWVAEEDGEIVG-----CAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT 93

                          90       100
                  ....*....|....*....|....
gi 1842013461 122 ASgihedKTAEFYQRMGYQHIGTE 145
Cdd:COG1246    94 TS-----AAIHFYEKLGFEEIDKE 112
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
49-151 1.21e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 61.25  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  49 DDGCFLIVFDDNEPVGFLWGFCCALPWNPAKLAMDtLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVASGIHed 128
Cdd:COG3153    37 AAGLSLVAEDDGEIVGHVALSPVDIDGEGPALLLG-PLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLL-- 113

                          90       100
                  ....*....|....*....|...
gi 1842013461 129 ktaEFYQRMGYQHIGTEYRKELP 151
Cdd:COG3153   114 ---PFYERFGFRPAGELGLTLGP 133
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 49-139 2.80e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.14  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  49 DDGCFLIVFDDNEPVGFLwgfCCALPWNPAKLAMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVASgiHED 128
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFA---SLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAA--DNL 105

                          90
                  ....*....|.
gi 1842013461 129 KTAEFYQRMGY 139
Cdd:pfam00583 106 AAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-144 6.73e-11

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 56.93  E-value: 6.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461   1 MIHTRQATLLDMLLIAPLADRYSKEaNTKGYPVELDYSLQQAA--ATIMMDDGCFLIVFDDNEPVGFLWgFCCALPWNPA 78
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEAIAE-GTATFETEPPSEEEREAwfAAILAPGRPVLVAEEDGEVVGFAS-LGPFRPRPAY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1842013461  79 KLAMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVASgihEDKTA-EFYQRMGYQHIGT 144
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLA---DNEASiALYEKLGFEEVGT 142
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-147 3.27e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 53.51  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  68 GFCCALPWNPAKLAMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVASgihEDKTA-EFYQRMGYQHIGTEY 146
Cdd:COG0456     1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVRE---DNEAAiALYEKLGFEEVGERP 77


                  .
gi 1842013461 147 R 147
Cdd:COG0456    78 N 78
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-120 9.17e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 49.20  E-value: 9.17e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1842013461  53 FLIVFDDNEPVGFLWGFCCALPWNPAKLAMdtlLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLS 120
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGD---LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
49-146 2.23e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 49.80  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  49 DDGCF-LIVFDDNEPVGflwgfCCAL---PWNPAKLAMdtlLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVasg 124
Cdd:COG2153    31 DEDARhLLAYDDGELVA-----TARLlppGDGEAKIGR---VAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSA--- 99

                          90       100
                  ....*....|....*....|...
gi 1842013461 125 iheDKTAE-FYQRMGYQHIGTEY 146
Cdd:COG2153   100 ---QAHAVgFYEKLGFVPVGEEF 119
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
69-144 1.14e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 46.83  E-value: 1.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1842013461  69 FCCALPWNPAKLAMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSVQLSVASGiheDKTAE-FYQRMGYQHIGT 144
Cdd:COG3393     4 AMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDAD---NPAARrLYERLGFRPVGE 77
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 35-149 2.72e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 46.50  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  35 LDYSLQQAAATIMMDDGCFLIV-FDDNEPVGFlwgfcCALPwNPAKLamdTLLYVEPHYRGSRAGYKLVKAWEAWAAERG 113
Cdd:pfam13673  14 YEFISPEALRERIDQGEYFFFVaFEGGQIVGV-----IALR-DRGHI---SLLFVDPDYQGQGIGKALLEAVEDYAEKDG 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1842013461 114 ATSVQLSVasgiHEDKTA-EFYQRMGYQHIGTEYRKE 149
Cdd:pfam13673  85 IKLSELTV----NASPYAvPFYEKLGFRATGPEQEFN 117
PRK03624 PRK03624
putative acetyltransferase; Provisional
 58-141 8.38e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 8.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  58 DDNEPVGFLWGFCCAL-PWN-P-----AKLAMDTLLY----------------------------VEPHYRGSRAGYKLV 102
Cdd:PRK03624   11 ADFEAVIALWERCDLTrPWNdPemdieRKLNHDPSLFlvaevggevvgtvmggydghrgwayylaVHPDFRGRGIGRALV 90

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1842013461 103 KAWEAWAAERGATSVQLSVASGihEDKTAEFYQRMGYQH 141
Cdd:PRK03624   91 ARLEKKLIARGCPKINLQVRED--NDAVLGFYEALGYEE 127
COG3375 COG3375
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
31-115 1.31e-06

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 442602 [Multi-domain]  Cd Length: 271  Bit Score: 46.09  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461  31 YPVELDYSLQQAAatimmddGCFLIVFDDNEPVGFLWGFCCALPWNPAklamdtlLY-----VEPHYRGSRAGYKLVKAW 105
Cdd:COG3375    35 VPVHLLRALAHAG-------GYVLGAFDGGELVGFSFGFPGFRPGGLY-------LHshmagVLPEYRGRGVGYALKLHQ 100

                          90
                  ....*....|
gi 1842013461 106 EAWAAERGAT 115
Cdd:COG3375   101 REWALERGVT 110
PRK07757 PRK07757
N-acetyltransferase;
1-146 1.78e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 36.71  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842013461   1 MIHTRQATLLDMLLIAPLADRYSKEAntkgypVELDYSLQQAAATIMmddgCFLIVFDDNEPVGflwgfCCALPWNPAKL 80
Cdd:PRK07757    1 MMEIRKARLSDVKAIHALINVYAKKG------LMLPRSLDELYENIR----DFYVAEEEGEIVG-----CCALHILWEDL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1842013461  81 AMDTLLYVEPHYRGSRAGYKLVKAWEAWAAERGATSV---QLSVasgihedktaEFYQRMGYQHIGTEY 146
Cdd:PRK07757   66 AEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVfalTYQP----------EFFEKLGFREVDKEA 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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