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Conserved domains on  [gi|1841183788|ref|WP_170829781|]
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MULTISPECIES: RodZ family helix-turn-helix domain-containing protein [Lysinibacillus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11444431)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 5-72 1.84e-26

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 99.11  E-value: 1.84e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1841183788   5 AELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYVRAFIKQYAEAVGLNAEEIL 72
Cdd:COG1426     4 ETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 5-72 1.84e-26

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 99.11  E-value: 1.84e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1841183788   5 AELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYVRAFIKQYAEAVGLNAEEIL 72
Cdd:COG1426     4 ETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 10-71 1.28e-22

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 88.71  E-value: 1.28e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788  10 RLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYVRAFIKQYAEAVGLNAEEI 71
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 8-71 4.40e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 40.61  E-value: 4.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1841183788   8 GTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPgsfyvrAFIKQYAEAVGLNAEEI 71
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSL------ETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-71 6.43e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.81  E-value: 6.43e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788   10 RLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPgsfyvrAFIKQYAEAVGLNAEEI 71
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSL------ETLKKLAKALGVSLDEL 56
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 3-72 7.30e-04

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 40.71  E-value: 7.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788   3 LVAELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIE--EGNYSIMpgsfyvraFIKQYAEAVGLNAEEIL 72
Cdd:PRK08154   25 FLAALGERVRTLRARRGMSRKVLAQASGVSERYLAQLEsgQGNVSIL--------LLRRVARALGCSLADLL 88
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 5-72 1.84e-26

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 99.11  E-value: 1.84e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1841183788   5 AELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYVRAFIKQYAEAVGLNAEEIL 72
Cdd:COG1426     4 ETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 10-71 1.28e-22

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 88.71  E-value: 1.28e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788  10 RLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYVRAFIKQYAEAVGLNAEEI 71
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 8-75 8.53e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 48.44  E-value: 8.53e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1841183788   8 GTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPGSFYvrafikQYAEAVGLNAEEILETY 75
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLY------KIAELLGVPANWLLQGE 62
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-86 4.44e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.22  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841183788   5 AELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPgsfyvrAFIKQYAEAVGLNAEEILETYKKELPSTPN 84
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSL------ETLLKLAKALGVSLDELLGGADEELPEALL 79


                  ..
gi 1841183788  85 DQ 86
Cdd:COG1396    80 SE 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 8-71 4.40e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 40.61  E-value: 4.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1841183788   8 GTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPgsfyvrAFIKQYAEAVGLNAEEI 71
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSL------ETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-71 6.43e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.81  E-value: 6.43e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788   10 RLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSIMPgsfyvrAFIKQYAEAVGLNAEEI 71
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSL------ETLKKLAKALGVSLDEL 56
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 3-72 7.30e-04

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 40.71  E-value: 7.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1841183788   3 LVAELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIE--EGNYSIMpgsfyvraFIKQYAEAVGLNAEEIL 72
Cdd:PRK08154   25 FLAALGERVRTLRARRGMSRKVLAQASGVSERYLAQLEsgQGNVSIL--------LLRRVARALGCSLADLL 88
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
6-73 3.39e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 35.59  E-value: 3.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1841183788   6 ELGTRLKEARLSKGYSLDDLQEITKIQKRYLVGIEEGNYSImpgSFYVrafIKQYAEAVGLNAEEILE 73
Cdd:COG1476     4 KLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNP---SLEL---ALKIARALGVSLEELFS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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