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Conserved domains on  [gi|1839841780|ref|WP_169901432|]
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penicillin-binding protein 2 [Pseudomonas gessardii]

Protein Classification

penicillin-binding protein 2( domain architecture ID 11496821)

penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0016020
PubMed:  18266856|18248419

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-609 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 949.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  20 RVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFSLSMTRERSGDWQ 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 100 QILDVIVEVLQLTPEDRAIFEKRMKQgRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGY 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKR-SRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 180 MGRINEKELKTLDPVNYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDPIPGKDIVLSLDIKLQEAA 259
Cdd:TIGR03423 161 VGEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 260 EMALGGRRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLD 339
Cdd:TIGR03423 241 EKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 340 AGVVTASSRVYDPGYYMLPNydHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMF 419
Cdd:TIGR03423 321 EGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 420 EESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVASKGKWIRPHLAKTIEGET----PVDENPI 495
Cdd:TIGR03423 399 GEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDPDggvvRRTEPEV 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 496 PDIVLRDPSDWAKVNHGMQQVMHGARGTARKAAVGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQERHRDHALFVGFAPAD 575
Cdd:TIGR03423 479 LRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPYD 558

                         570       580       590
                  ....*....|....*....|....*....|....
gi 1839841780 576 NPKITVAVMVENGESGSGVAAPVVRQIMDAWLLD 609
Cdd:TIGR03423 559 NPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-609 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 949.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  20 RVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFSLSMTRERSGDWQ 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 100 QILDVIVEVLQLTPEDRAIFEKRMKQgRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGY 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKR-SRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 180 MGRINEKELKTLDPVNYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDPIPGKDIVLSLDIKLQEAA 259
Cdd:TIGR03423 161 VGEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 260 EMALGGRRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLD 339
Cdd:TIGR03423 241 EKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 340 AGVVTASSRVYDPGYYMLPNydHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMF 419
Cdd:TIGR03423 321 EGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 420 EESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVASKGKWIRPHLAKTIEGET----PVDENPI 495
Cdd:TIGR03423 399 GEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDPDggvvRRTEPEV 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 496 PDIVLRDPSDWAKVNHGMQQVMHGARGTARKAAVGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQERHRDHALFVGFAPAD 575
Cdd:TIGR03423 479 LRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPYD 558

                         570       580       590
                  ....*....|....*....|....*....|....
gi 1839841780 576 NPKITVAVMVENGESGSGVAAPVVRQIMDAWLLD 609
Cdd:TIGR03423 559 NPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 12-607 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 670.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  12 KDARLVRARVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFSLSMT 91
Cdd:COG0768     5 KEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYAD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  92 RERSGDWQQILDVIVEVLQLTPEDraiFEKRMKQGRRpfEPVPILFELTEEQIARIavNQFRLPGVEVVAQLVRHYPQGA 171
Cdd:COG0768    85 PEEVKDPEETAEKLAKLLGLDPEE---LRKKLKKKSR--FPVYLKRNLSPEEAARI--RALKLPGVYVEAEYKRYYPYGE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 172 HFAHSVGYMGRINekelktldpvnysGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVL-KRTDPIPGKDIVLS 250
Cdd:COG0768   158 LAAHVLGYVGEIN-------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGKDLVLT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 251 LDIKLQEAAEMALGG-------RRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGisfkayaelrdsIDRPLFNRVLRGLY 323
Cdd:COG0768   225 IDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGG------------PDEPLRNRAVQGTY 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 324 PPGSTIKPAVAIAGLDAGVVTASSRVYDPGYYMLPnyDHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLST 403
Cdd:COG0768   293 EPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVG--GRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYD 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 404 YMGKFGLGQKVSLDMFEESPGLMPSREwkratrrqAWFPGETLILGIGQGyMQATPLQLAQATALVASKGKWIRPHLAKT 483
Cdd:COG0768   371 YLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKE 441

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 484 IE---GETPVDENPIPDIVLrDPSDWAKVNHGMQQVMHGARGTARKAAVgAQYRIAGKSGTAQVVAIKQGEKYDRskvqe 560
Cdd:COG0768   442 IVdpdGEVVKEEPEVLRRVI-SPETAETVREGMEGVVNEPGGTARRAAI-PGYRVAGKTGTAQVVDIGNGGYYKG----- 514

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 1839841780 561 RHRdhALFVGFAPADNPKITVAVMVENGES---GSGVAAPVVRQIMDAWL 607
Cdd:COG0768   515 RHI--ASFVGFAPADNPRYAVAVVVENPGGgayGGTVAAPVFREIMEAYL 562
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 8-622 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 609.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780   8 KDHEKDARLVRARVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFS 87
Cdd:PRK10795    9 RDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPLALNRTIYQ 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  88 LSMTRERSGDWQQILDVIVEVLQLTPEDRAIFEKRMKQGRRpFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHY 167
Cdd:PRK10795   89 LEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRR-FTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYQRRYY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 168 PQGAHFAHSVGYMGRINEKELKTLDPV----NYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDPIP 243
Cdd:PRK10795  168 PYGSALTHVIGYVSKINDKDVERLDKEgklaNYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQLHEQPPQA 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 244 GKDIVLSLDIKLQEAAEMALGGRRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRGLY 323
Cdd:PRK10795  248 GHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLINRATQGVY 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 324 PPGSTIKPAVAIAGLDAGVVTASSRVYDPGYYMLPNYDHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLST 403
Cdd:PRK10795  328 PPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDMGIDRLSE 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 404 YMGKFGLGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVASKGKWIRPH-LAK 482
Cdd:PRK10795  408 WMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVKVPHlLMS 487

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 483 TIEGETPV-----DENPIPDIvlrDPSDWAKVNHGMQQVMHGARGTARKAAVGAQYRIAGKSGTAQVVAIKQGEKYDRSK 557
Cdd:PRK10795  488 TAEDGKQVpwvqpHEPPVGDI---HSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYNAHK 564

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839841780 558 VQERHRDHALFVGFAPADNPKITVAVMVENGESGSGVAApVVRQIMDAWLLDQDGRLKPEfANPS 622
Cdd:PRK10795  565 IAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDHIMLGDNNTDLPA-ENPA 627
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 268-604 1.17e-81

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 259.27  E-value: 1.17e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 268 GAVVALDPNTGEVLAMVSQPSFDPNLFVTgisfkayaelrdsidrPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASS 347
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG----------------PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 348 RVYDPGYYMLPNYDhkYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMFEESPGLMP 427
Cdd:pfam00905  65 TIFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 428 SRewkratrrqaWFPGETLILGIGqgyMQATPLQLAQATALVASKGKWIRPHLAKTIEGETPVDENPIPDIvlrDPSDWA 507
Cdd:pfam00905 143 PY----------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNKLPI---SKSTAE 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 508 KVNHGMQQVMHGARGTARKAAVGaqYRIAGKSGTAQVVAIKQGEKYDrskvqerHRDHALFVGFAPADNPKITVAVMVEN 587
Cdd:pfam00905 207 KVKDMLRLVVNDGTGTGTAAVPG--YKVAGKTGTAQVAGPKGGGYYD-------GAQIGWFVGYAPADNPKYAFAVLIDD 277

                         330
                  ....*....|....*....
gi 1839841780 588 GE--SGSGVAAPVVRQIMD 604
Cdd:pfam00905 278 PKryYGGKVAAPIFKDILE 296
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-609 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 949.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  20 RVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFSLSMTRERSGDWQ 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 100 QILDVIVEVLQLTPEDRAIFEKRMKQgRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGY 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKR-SRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 180 MGRINEKELKTLDPVNYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDPIPGKDIVLSLDIKLQEAA 259
Cdd:TIGR03423 161 VGEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 260 EMALGGRRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLD 339
Cdd:TIGR03423 241 EKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 340 AGVVTASSRVYDPGYYMLPNydHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMF 419
Cdd:TIGR03423 321 EGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 420 EESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVASKGKWIRPHLAKTIEGET----PVDENPI 495
Cdd:TIGR03423 399 GEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDPDggvvRRTEPEV 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 496 PDIVLRDPSDWAKVNHGMQQVMHGARGTARKAAVGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQERHRDHALFVGFAPAD 575
Cdd:TIGR03423 479 LRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPYD 558

                         570       580       590
                  ....*....|....*....|....*....|....
gi 1839841780 576 NPKITVAVMVENGESGSGVAAPVVRQIMDAWLLD 609
Cdd:TIGR03423 559 NPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 12-607 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 670.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  12 KDARLVRARVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFSLSMT 91
Cdd:COG0768     5 KEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYAD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  92 RERSGDWQQILDVIVEVLQLTPEDraiFEKRMKQGRRpfEPVPILFELTEEQIARIavNQFRLPGVEVVAQLVRHYPQGA 171
Cdd:COG0768    85 PEEVKDPEETAEKLAKLLGLDPEE---LRKKLKKKSR--FPVYLKRNLSPEEAARI--RALKLPGVYVEAEYKRYYPYGE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 172 HFAHSVGYMGRINekelktldpvnysGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVL-KRTDPIPGKDIVLS 250
Cdd:COG0768   158 LAAHVLGYVGEIN-------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGKDLVLT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 251 LDIKLQEAAEMALGG-------RRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGisfkayaelrdsIDRPLFNRVLRGLY 323
Cdd:COG0768   225 IDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGG------------PDEPLRNRAVQGTY 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 324 PPGSTIKPAVAIAGLDAGVVTASSRVYDPGYYMLPnyDHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLST 403
Cdd:COG0768   293 EPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVG--GRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYD 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 404 YMGKFGLGQKVSLDMFEESPGLMPSREwkratrrqAWFPGETLILGIGQGyMQATPLQLAQATALVASKGKWIRPHLAKT 483
Cdd:COG0768   371 YLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKE 441

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 484 IE---GETPVDENPIPDIVLrDPSDWAKVNHGMQQVMHGARGTARKAAVgAQYRIAGKSGTAQVVAIKQGEKYDRskvqe 560
Cdd:COG0768   442 IVdpdGEVVKEEPEVLRRVI-SPETAETVREGMEGVVNEPGGTARRAAI-PGYRVAGKTGTAQVVDIGNGGYYKG----- 514

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 1839841780 561 RHRdhALFVGFAPADNPKITVAVMVENGES---GSGVAAPVVRQIMDAWL 607
Cdd:COG0768   515 RHI--ASFVGFAPADNPRYAVAVVVENPGGgayGGTVAAPVFREIMEAYL 562
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 8-622 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 609.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780   8 KDHEKDARLVRARVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIADNRPSFS 87
Cdd:PRK10795    9 RDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPLALNRTIYQ 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  88 LSMTRERSGDWQQILDVIVEVLQLTPEDRAIFEKRMKQGRRpFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHY 167
Cdd:PRK10795   89 LEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRR-FTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYQRRYY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 168 PQGAHFAHSVGYMGRINEKELKTLDPV----NYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDPIP 243
Cdd:PRK10795  168 PYGSALTHVIGYVSKINDKDVERLDKEgklaNYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQLHEQPPQA 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 244 GKDIVLSLDIKLQEAAEMALGGRRGAVVALDPNTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRGLY 323
Cdd:PRK10795  248 GHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLINRATQGVY 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 324 PPGSTIKPAVAIAGLDAGVVTASSRVYDPGYYMLPNYDHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLST 403
Cdd:PRK10795  328 PPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDMGIDRLSE 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 404 YMGKFGLGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVASKGKWIRPH-LAK 482
Cdd:PRK10795  408 WMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVKVPHlLMS 487

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 483 TIEGETPV-----DENPIPDIvlrDPSDWAKVNHGMQQVMHGARGTARKAAVGAQYRIAGKSGTAQVVAIKQGEKYDRSK 557
Cdd:PRK10795  488 TAEDGKQVpwvqpHEPPVGDI---HSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYNAHK 564

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839841780 558 VQERHRDHALFVGFAPADNPKITVAVMVENGESGSGVAApVVRQIMDAWLLDQDGRLKPEfANPS 622
Cdd:PRK10795  565 IAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDHIMLGDNNTDLPA-ENPA 627
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 268-604 1.17e-81

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 259.27  E-value: 1.17e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 268 GAVVALDPNTGEVLAMVSQPSFDPNLFVTgisfkayaelrdsidrPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASS 347
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG----------------PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 348 RVYDPGYYMLPNYDhkYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMFEESPGLMP 427
Cdd:pfam00905  65 TIFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 428 SRewkratrrqaWFPGETLILGIGqgyMQATPLQLAQATALVASKGKWIRPHLAKTIEGETPVDENPIPDIvlrDPSDWA 507
Cdd:pfam00905 143 PY----------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNKLPI---SKSTAE 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 508 KVNHGMQQVMHGARGTARKAAVGaqYRIAGKSGTAQVVAIKQGEKYDrskvqerHRDHALFVGFAPADNPKITVAVMVEN 587
Cdd:pfam00905 207 KVKDMLRLVVNDGTGTGTAAVPG--YKVAGKTGTAQVAGPKGGGYYD-------GAQIGWFVGYAPADNPKYAFAVLIDD 277

                         330
                  ....*....|....*....
gi 1839841780 588 GE--SGSGVAAPVVRQIMD 604
Cdd:pfam00905 278 PKryYGGKVAAPIFKDILE 296
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 63-235 9.83e-52

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 175.97  E-value: 9.83e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  63 PIPPTRGLIFDRNGVVIADNRPSFSLSMTRERSGDwQQILDVIVEVLQLTPEDRAIFEKRMK------QGRRPFEPVPIL 136
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVYSLTITPSKLKK-ADALKTALKLAKLLSNYEDLDDEDLTerflkmNSYKSYYPVVIK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 137 FELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGYMGRINEKELKTLDPVNYSGTHHIGKTGIERFYEPELH 216
Cdd:pfam03717  80 KNLSEEEVARIEENLLELPGVSIETDPVRYYPYGELAAHLLGYVGEITEEELEKYLDKGYSRGDLVGKSGLEKQYESVLR 159

                         170
                  ....*....|....*....
gi 1839841780 217 GQVGYEEVETNARGRVLRV 235
Cdd:pfam03717 160 GKDGVRQVEVDALGRVIRE 178
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 247-623 3.10e-44

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 167.40  E-value: 3.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 247 IVLSLDIKLQEAAEMAL---------GGRRGAVVALDPNTGEVLAMVSqpsfdpnlfvtGISFKAYAelrdsidrplFNR 317
Cdd:COG0744   297 IYTTLDPKLQKAAEKAVknvlpegkpGGLQAALVVVDPKTGEVLAMVG-----------GRDYGKSQ----------FNR 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 318 VLRGLYPPGSTIKPAVAIAGLDAG-----VVTASSRVYDPGYYMLPNYDHKYRnwnrtgdGYVDLDTAIMRSNDTYFYDL 392
Cdd:COG0744   356 ATQAKRQPGSTFKPFVYAAALEQGytpatTVDDEPVTFPGGGWSPKNYDGRYR-------GPVTLREALANSLNTPAVRL 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 393 AHKLGIDRLSTYMGKFGLGQKVSldmfeespglmpsrewkratrrqawfPGETLILGIGQgymqATPLQLAQATALVASK 472
Cdd:COG0744   429 AQEVGLDKVVDTARRLGITSPLD--------------------------PNPSLALGTSE----VSPLEMASAYATFANG 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 473 GKWIRPHLAKTIE---GETPVDENPIPDIVLrDPSDWAKVNHGMQQVMhgARGTARKAAVGaQYRIAGKSGTAQvvaikq 549
Cdd:COG0744   479 GVYVEPHAITKVTdadGKVLYEAKPKCEQVI-SPEVAYLMTDMLQDVV--TSGTGRAARLP-GRPVAGKTGTTN------ 548

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 550 gekydrskvqeRHRDhALFVGFapadNPKITVAVMVEN-------GESGSGVAAPVVRQIMDAWLldqDGRLKPEFANPS 622
Cdd:COG0744   549 -----------DNRD-AWFVGY----TPQLVTAVWVGNddnspmgYVTGGSLPAPIWRDFMEAAL---EGLPVEDFPKPS 609


                  .
gi 1839841780 623 S 623
Cdd:COG0744   610 G 610
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 2-607 2.09e-42

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 161.53  E-value: 2.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780   2 TQPIRIKDHEKDARLVRARVIFGAIAVVVLMCVLIARLYFLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVIAD 81
Cdd:PRK15105    4 AKTQKLKRQEEQANFISWRFALLCGCILLALVFLLGRVAWLQVINPDMLVREGDMRSLRVQEVSTSRGMITDRSGRPLAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780  82 NRPSFSL----SMTRERSGD-----WQQILDVI-VEVLQLT------PEDRAIFEKRMKQgrrpfepvPILFELteeqia 145
Cdd:PRK15105   84 SVPVKAIwadpKEVHDAGGIsvddrWKALADALnIPLDQLSarinanPKGRFIYLARQVN--------PDMADY------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 146 riaVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGYmgrinekelktldpVNYSGThhiGKTGIERFYEPELHGQVGYEEVE 225
Cdd:PRK15105  150 ---IKKLKLPGIHLREESRRYYPSGEVTAHLIGF--------------TNVDSQ---GIEGVEKSFDKWLTGQPGERIVR 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 226 TNARGRVLRVLKRTDPIPGKDIVLSLDIKLQEAAEMALG-------GRRGAVVALDPNTGEVLAMVSQPSFDPNlfvtgi 298
Cdd:PRK15105  210 KDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNnavafnkAESGSAVLVDVNTGEVLAMANSPSYNPN------ 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 299 sfkayaELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASSRVYDPGYYMlpnYDHKYRNWNRtgdgYVDLD 378
Cdd:PRK15105  284 ------NLSGTPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNTVPYRI---NGHEIKDVAR----YSELT 350

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 379 -TAIM-RSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKVSLDMFEESPGLMPsrewkratRRQAWFPGETLILGIGQGYMq 456
Cdd:PRK15105  351 lTGVLqKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYP--------QKQRWSDIERATFSFGYGLM- 421

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 457 ATPLQLAQATALVASKGKWiRPHLAKTIEGETPvDENPIPDIVLRdpsdwaKVNHGMQQV-MHGARGTarKAAVGAqYRI 535
Cdd:PRK15105  422 VTPLQLARVYATIGSYGIY-RPLSITKVDPPVP-GERVFPESIVR------TVVHMMESVaLPGGGGV--KAAIKG-YRI 490

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1839841780 536 AGKSGTAQVVAikQGEKYDRSKVqerhrdhALFVGFAPADNPKITVAVMVENGESGS----GVAAPVVRQIMDAWL 607
Cdd:PRK15105  491 AIKTGTAKKVG--PDGRYINKYI-------AYTAGVAPASQPRFALVVVINDPQAGKyyggAVSAPVFGAIMGGVL 557
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 243-603 7.25e-30

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 123.91  E-value: 7.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 243 PGKDIVLSLDIKLQEAAEMAL--GGRR----------GAVVALDPNTGEVLAMVSQpsfdpnlfvtgisfkayaelRDSI 310
Cdd:TIGR02074 220 GGLKIYTTLDLDAQKAAEKVLntGLRVagrrdgddlqAALVAIDPDTGAVRALVGG--------------------RDYG 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 311 DRPlFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASSRVYDP------GYYMLPNYDHKYRnwnrtgdGYVDLDTAIMRS 384
Cdd:TIGR02074 280 KSQ-FNRATQAKRQPGSTFKPFVYAAALEKGLTPATIVNDEPityngnGPWSPKNYGGGYR-------GNVTLRQALAQS 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 385 NDTYFYDLAHKLGIDRLSTYMGKFGLgqKVSLDMfeespglmpsrewkratrrqawfpgetlILGIGQGYMQATPLQLAQ 464
Cdd:TIGR02074 352 RNIPAVRLLQEVGLDKVVALAKRFGI--TSPLDP----------------------------VLSLALGTVEVSPLEMAS 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 465 ATALVASKGKWIRPHLAKTIE---GETPVDENPIPDIVLrDPSDWAKVNHGMQQVMhgARGTARKAAVGAqYRIAGKSGT 541
Cdd:TIGR02074 402 AYAVFANGGKYVEPHGIRKIVdrdGKVIYENKPKTTQVI-SPATAYIMTDMLKGVV--ESGTGRSARLPG-RPVAGKTGT 477

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 542 AQVvaikqgekydrskvqerHRDhALFVGFapadNPKITVAVMVEN--------GESGSGVAAPVVRQIM 603
Cdd:TIGR02074 478 TQN-----------------WRD-AWFVGY----TPYYVTAVWVGYddkktlgkSGTGGGLAAPIWRDFM 525
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
268-607 2.16e-23

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 105.24  E-value: 2.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 268 GAVVALDPNTGEVLAMVSqpsfdpnlfvtGISFKAYAelrdsidrplFNRVLRGLYPPGSTIKPAVAIAGLDAGvVTASS 347
Cdd:COG5009   423 GALVALDPHTGAVLALVG-----------GFDFEQSK----------FNRATQAKRQPGSSFKPFVYAAALDNG-YTPAT 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 348 RVYD-PGYYMLPNYDHKYR--NWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKvsldmfeespg 424
Cdd:COG5009   481 IINDaPIVFDDGGGGGVWRpkNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYSK----------- 549

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 425 lMPsrewkratrrqawfPGETLILGIGqgymQATPLQLAQATALVASKGKWIRPHLAKTIE---GETPVDENPIPDIVLR 501
Cdd:COG5009   550 -LP--------------PNLSLALGSG----EVTPLEMARAYAVFANGGYRVEPYLIDRIEdrnGKVIYRADPARACEDC 610

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 502 DPSDW----AKVNHGMQQV------------MHGA--RGTARKA-AVGAQyrIAGKSGTAQvvaikqgekyDrskvqerH 562
Cdd:COG5009   611 DAAEWdgaePRLPDPAEQVidprtayqmtsmLRGVvqRGTGRRArALGRD--IAGKTGTTN----------D-------S 671

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1839841780 563 RDhALFVGFapadNPKITVAVMV--------ENGESGSGVAAPVVRQIMDAWL 607
Cdd:COG5009   672 KD-AWFVGF----TPDLVAGVWVgfddprslGRGETGGRAALPIWIDFMKAAL 719
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 233-624 1.30e-14

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 77.18  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 233 LRVLKRTDPiPGKDIVLSLDIKLQEAAE---------MALGGRR-GAVVALDPNTGEVLAMV-SQPSFDPNLF--VTGIs 299
Cdd:COG4953   261 ARRLLRQLP-GGTRIRTTLDAGLQRRLErlvrryvrrLKQNGIHnAAVLVVDNRTGEVLAYVgSADFFDASRQgqVDMV- 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 300 fkayaelrdsidrplfnRVLRGlypPGSTIKPAVAIAGLDAGVVTASSRVYD-P----GYYmlP-NYDHKYRnwnrtgdG 373
Cdd:COG4953   339 -----------------RALRS---PGSTLKPFLYGLALDQGLIHPETLLADvPtsfgGYR--PeNFDGTFQ-------G 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 374 YVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQkvsldmfeespgLMPSREWkratrrqawfPGETLILGiGQG 453
Cdd:COG4953   390 PVSAREALARSLNIPAVRLLEALGPARFYARLRRAGLRL------------LLPPAEH----------YGLSLILG-GAE 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 454 ymqATPLQLAQATALVASKGKWIRPHLAKtiegetpvDENPIPDIVLRDPSDWAKVNHGMQQVMHGARGTARKAAvGAQY 533
Cdd:COG4953   447 ---VTLEELVGLYAALARGGEARPLRLLA--------GEPASPGRRLLSPGAAWLVRDILSDVPRPDGAFGWRAL-DSPP 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 534 RIAGKSGTAqvvaikQGekydrskvqerHRDhALFVGFapadNPKITVAVMVEN-------GESGSGVAAPVVRQIMDAw 606
Cdd:COG4953   515 PIAWKTGTS------YG-----------FRD-AWAVGF----TGRYTVGVWVGNpdgtpvpGLTGAEAAAPLLFDIFDL- 571

                         410
                  ....*....|....*...
gi 1839841780 607 lLDQDGRLKPeFANPSSA 624
Cdd:COG4953   572 -LPASRWPLP-FPPPAGL 587
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 269-487 6.21e-06

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 49.36  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 269 AVVALDPNTGEVLAMVSqpSFDPNLfvtgisfkayaelrdsidrPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTAS-- 346
Cdd:PRK11636  428 ALVSINPQNGAVMALVG--GFDFNQ-------------------SKFNRATQALRQVGSNIKPFLYTAAMDKGLTLASml 486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 347 -----SRvYDPGyymlPNYDHKYRNWNRTGDGYVDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGlgqkvsldmfee 421
Cdd:PRK11636  487 ndvpiSR-WDAG----AGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFG------------ 549

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 422 spglmpsrewkratrrqawFPGETLI----LGIGQGYMqaTPLQLAQATALVASKGKWIRPHLAKTIEGE 487
Cdd:PRK11636  550 -------------------FPAQNIVhtesLALGSASF--TPMQVARGYAVMANGGFLVDPYFISKIEND 598
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 242-541 1.43e-04

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 44.84  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 242 IPGKDIVLSLDIKLQEAAEMAL--GGRR-----------GAVVALDPNTGEVLAMVSqpSFDPNLfvTGisfkayaelrd 308
Cdd:PRK14850  377 FSGTKIFTTLDYISQNAAEQAVkiGIPIlkrkkrlkdleVAMVIIDRFSGEVRALIG--SSKPEF--NG----------- 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 309 sidrplFNRVLRGLYPPGSTIKPAVAIAGLDagvvtassrvyDPGYYML----PNYDHKY----------RNWNRTGDGY 374
Cdd:PRK14850  442 ------YNRALKARRSIGSLSKPITYLTALS-----------QPEKYHLntwiSDTPISIkldngqywtpKNNNFSFSGK 504

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 375 VDLDTAIMRSNDTYFYDLAHKLGIDRLSTYMGKFGLGQKvsldmfeespglmpsrewkratrrqAWFPGETLILGIgqgy 454
Cdd:PRK14850  505 VMLIDALIHSINIPTVHLSINLGLKKLVDSWILLGISSN-------------------------YITPLPSISLGA---- 555

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839841780 455 MQATPLQLAQATALVASKG-KWIRPHLAKTIEGETPVDENPIPDIV-LRDPSDWAKVNHGMQQVMhgARGTARK-AAVGA 531
Cdd:PRK14850  556 INLTPMEVAQVFQIIGSGGyKSSLSSIRSIISDDNKVLYQNFPQSKhVESSQASYLTLYAMQQVV--KSGTAKSlGTIFK 633

                         330
                  ....*....|
gi 1839841780 532 QYRIAGKSGT 541
Cdd:PRK14850  634 EFSLAGKTGT 643
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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