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Conserved domains on  [gi|1836287302|gb|QJI05926|]
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14.1 kDa protein [Human adenovirus E4]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_E4 super family cl05114
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
 1-108 1.82e-34

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


The actual alignment was detected with superfamily member pfam05385:

Pssm-ID: 283128  Cd Length: 108  Bit Score: 115.17  E-value: 1.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287302   1 MVLPVLPSPAVIETQQNCIIWLGLAHSTVVDVIRAIRANGIFITQEAEEILHVLREWLFYNFNIERSKRRDRRRRAVCSA 80
Cdd:pfam05385   1 MVLPALPAPPVCDSQNECVGWLGVAYSAVVDVIRAAAHEGVYIEPEARGRLDALREWIYYNYYTERAKRRDRRRRSVCHA 80

                          90       100
                  ....*....|....*....|....*...
gi 1836287302  81 RTRFCFVKYENVRKQLHHDTIQNTISVI 108
Cdd:pfam05385  81 RTWFCFRKYDYVRRSIWHDTTTNTISVV 108
 
Name Accession Description Interval E-value
Adeno_E4 pfam05385
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
 1-108 1.82e-34

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


Pssm-ID: 283128  Cd Length: 108  Bit Score: 115.17  E-value: 1.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287302   1 MVLPVLPSPAVIETQQNCIIWLGLAHSTVVDVIRAIRANGIFITQEAEEILHVLREWLFYNFNIERSKRRDRRRRAVCSA 80
Cdd:pfam05385   1 MVLPALPAPPVCDSQNECVGWLGVAYSAVVDVIRAAAHEGVYIEPEARGRLDALREWIYYNYYTERAKRRDRRRRSVCHA 80

                          90       100
                  ....*....|....*....|....*...
gi 1836287302  81 RTRFCFVKYENVRKQLHHDTIQNTISVI 108
Cdd:pfam05385  81 RTWFCFRKYDYVRRSIWHDTTTNTISVV 108
 
Name Accession Description Interval E-value
Adeno_E4 pfam05385
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
 1-108 1.82e-34

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


Pssm-ID: 283128  Cd Length: 108  Bit Score: 115.17  E-value: 1.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287302   1 MVLPVLPSPAVIETQQNCIIWLGLAHSTVVDVIRAIRANGIFITQEAEEILHVLREWLFYNFNIERSKRRDRRRRAVCSA 80
Cdd:pfam05385   1 MVLPALPAPPVCDSQNECVGWLGVAYSAVVDVIRAAAHEGVYIEPEARGRLDALREWIYYNYYTERAKRRDRRRRSVCHA 80

                          90       100
                  ....*....|....*....|....*...
gi 1836287302  81 RTRFCFVKYENVRKQLHHDTIQNTISVI 108
Cdd:pfam05385  81 RTWFCFRKYDYVRRSIWHDTTTNTISVV 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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