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Conserved domains on  [gi|1836287292|gb|QJI05916|]
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19 kDa protein [Human adenovirus E4]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_GP19K super family cl04819
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 2.76e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


The actual alignment was detected with superfamily member pfam04881:

Pssm-ID: 461465  Cd Length: 132  Bit Score: 58.20  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287292  41 CQLSFQPDGNRCAVLIKCGWECDSVVIHYKNKTRNNTLASTWQPGDPEWYTVSVPGADgSLRTVNNTFIFKHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGD-KIGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 1836287292 121 SRQYDMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
 
Name Accession Description Interval E-value
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 2.76e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 58.20  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287292  41 CQLSFQPDGNRCAVLIKCGWECDSVVIHYKNKTRNNTLASTWQPGDPEWYTVSVPGADgSLRTVNNTFIFKHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGD-KIGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 1836287292 121 SRQYDMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
 
Name Accession Description Interval E-value
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 2.76e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 58.20  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287292  41 CQLSFQPDGNRCAVLIKCGWECDSVVIHYKNKTRNNTLASTWQPGDPEWYTVSVPGADgSLRTVNNTFIFKHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGD-KIGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 1836287292 121 SRQYDMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 16-131 1.22e-09

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 53.58  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287292  16 LILGLGSTAVVTEKADPcLTFNPDKCQLSFQPDGNRCAVLIKCGWECDSVVIHYKNKTRNNTLASTWQPGDPEWYTVSV- 94
Cdd:pfam04881   4 MFKGEAAEAATCIAAKK-EEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGDKIGKFAVKAIFQEGCDIDMNMSKf 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1836287292  95 PGADGSLRTVNNTFIFkhMCNTAMFMSRQYDMWPPRK 131
Cdd:pfam04881  83 QGENPKQFCLEFPFTE--CCDALLIMAKALKCTLLQK 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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