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Conserved domains on  [gi|1836287288|gb|QJI05912|]
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22 kDa protein [Human adenovirus E4]

Protein Classification

splicing factor family protein( domain architecture ID 10567434)

splicing factor family protein is a DUF2890 domain-containing protein; similar to Human adenovirus protein 33K and packaging protein 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 7-162 1.54e-24

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


:

Pssm-ID: 314108  Cd Length: 168  Bit Score: 93.53  E-value: 1.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288   7 KKLKVELPPVKDLEENWeSSQA------EEEEMEDWDSTQAEEDSLQDSLEDEEVEEAVAARPSSLAEKASSTDTISAPG 80
Cdd:pfam11081   5 KKLQLPPPPPTDEEEYW-DSQAeevldeEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288  81 RGPA----RPHSRWDETGRFPN-----PTTQTGKKERQGYKSWRGHKNAIVSCLQacggnisftrRYLLFHRGVNFPRNV 151
Cdd:pfam11081  84 APPAlpvrRPNRRWDTTGTRAGkskqpPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQY 153

                         170
                  ....*....|.
gi 1836287288 152 LHYYRHLHSPY 162
Cdd:pfam11081 154 LEDAKKLYSKY 164
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 7-162 1.54e-24

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 93.53  E-value: 1.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288   7 KKLKVELPPVKDLEENWeSSQA------EEEEMEDWDSTQAEEDSLQDSLEDEEVEEAVAARPSSLAEKASSTDTISAPG 80
Cdd:pfam11081   5 KKLQLPPPPPTDEEEYW-DSQAeevldeEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288  81 RGPA----RPHSRWDETGRFPN-----PTTQTGKKERQGYKSWRGHKNAIVSCLQacggnisftrRYLLFHRGVNFPRNV 151
Cdd:pfam11081  84 APPAlpvrRPNRRWDTTGTRAGkskqpPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQY 153

                         170
                  ....*....|.
gi 1836287288 152 LHYYRHLHSPY 162
Cdd:pfam11081 154 LEDAKKLYSKY 164
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 7-162 1.54e-24

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 93.53  E-value: 1.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288   7 KKLKVELPPVKDLEENWeSSQA------EEEEMEDWDSTQAEEDSLQDSLEDEEVEEAVAARPSSLAEKASSTDTISAPG 80
Cdd:pfam11081   5 KKLQLPPPPPTDEEEYW-DSQAeevldeEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836287288  81 RGPA----RPHSRWDETGRFPN-----PTTQTGKKERQGYKSWRGHKNAIVSCLQacggnisftrRYLLFHRGVNFPRNV 151
Cdd:pfam11081  84 APPAlpvrRPNRRWDTTGTRAGkskqpPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQY 153

                         170
                  ....*....|.
gi 1836287288 152 LHYYRHLHSPY 162
Cdd:pfam11081 154 LEDAKKLYSKY 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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