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Conserved domains on  [gi|1835638659|ref|XP_033788432|]
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oocyte zinc finger protein XlCOF6-like isoform X2 [Geotrypetes seraphini]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-50 4.37e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


:

Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.37e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1835638659  11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISL 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-671 2.91e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 212 CPECDKNFNRQSNLKRHKRIHTGEKPYAC--PECEKSFSQQSILRRHKRIHTGEKayicsecgkrfncqSNLKKHQRIHT 289
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP--------------SDLNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 290 GEKLYTC--PECGKNFNRQSNLKSHKRIHTGEKPYTCPECGKSFSQQSVLRRHKRIHTGEKpytcpecgKSFRQQSILRT 367
Cdd:COG5048   102 NSKASSSslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP--------QSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 368 HKRIHTGEKPyicpecgkcynhkAHLKLHYSIHTGEKPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTCPECGKSFSQQS 447
Cdd:COG5048   174 NSLSKDPSSN-------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 448 ILRRHKRIHTGEKAYICSECGKRFNCQSNLKKHQRIHTGE-------KLYTCPECGKSFNRQSNLKSHKR--IHTGE--K 516
Cdd:COG5048   241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 517 PYTCPE--CGKSFSQQSVLRRHKRIHTGEKPYTCP--ECGKSFRQQSILRTHKRIHtgekpnicpecgkcynhkahlklH 592
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ-----------------------Q 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 593 YSIHTGEKPYTC--PECGKSFNGQSHLKRHRRIHTGEKP--YTCPECGKSFSQQSILQRHNRIHTGEKAYICSECGKSFN 668
Cdd:COG5048   378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                  ...
gi 1835638659 669 CQS 671
Cdd:COG5048   458 DLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
672-697 5.63e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 672 NLKIHERIHTGEKPYTCPECGKNFNR 697
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-221 6.07e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 196 NLRKHEKIHTTEKRYTCPECDKNFNR 221
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-50 4.37e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.37e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1835638659  11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISL 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-51 1.51e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1835638659  11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISLD 51
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
11-67 1.58e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.58e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659   11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISLDTEAMHE---TKREENEEKC 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPdliSQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-671 2.91e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 212 CPECDKNFNRQSNLKRHKRIHTGEKPYAC--PECEKSFSQQSILRRHKRIHTGEKayicsecgkrfncqSNLKKHQRIHT 289
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP--------------SDLNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 290 GEKLYTC--PECGKNFNRQSNLKSHKRIHTGEKPYTCPECGKSFSQQSVLRRHKRIHTGEKpytcpecgKSFRQQSILRT 367
Cdd:COG5048   102 NSKASSSslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP--------QSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 368 HKRIHTGEKPyicpecgkcynhkAHLKLHYSIHTGEKPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTCPECGKSFSQQS 447
Cdd:COG5048   174 NSLSKDPSSN-------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 448 ILRRHKRIHTGEKAYICSECGKRFNCQSNLKKHQRIHTGE-------KLYTCPECGKSFNRQSNLKSHKR--IHTGE--K 516
Cdd:COG5048   241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 517 PYTCPE--CGKSFSQQSVLRRHKRIHTGEKPYTCP--ECGKSFRQQSILRTHKRIHtgekpnicpecgkcynhkahlklH 592
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ-----------------------Q 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 593 YSIHTGEKPYTC--PECGKSFNGQSHLKRHRRIHTGEKP--YTCPECGKSFSQQSILQRHNRIHTGEKAYICSECGKSFN 668
Cdd:COG5048   378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                  ...
gi 1835638659 669 CQS 671
Cdd:COG5048   458 DLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-249 2.26e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 224 NLKRHKRIHTGEKPYACPECEKSFSQ 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
672-697 5.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 672 NLKIHERIHTGEKPYTCPECGKNFNR 697
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
transpos_ISL3 NF033550
ISL3 family transposase;
396-455 1.51e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 41.42  E-value: 1.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835638659 396 HYSIHTGEKPYTCPECGKSfNGQSHLKRHRRIH---TGEKP---------YTCPECGKSFSQQ-SILRRHKRI 455
Cdd:NF033550    1 VVEAELTRGDATCPECGKP-SRRVHDTGKRRIRhlpIFGRPvylelrvrrFKCPECGKTFTEElPWARKRSRI 72
PHA00733 PHA00733
hypothetical protein
 517-576 2.16e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 2.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 517 PYTCPECGKSFSQQSVLRRHKRIHTGEKpyTCPECGKSFRQQSILRThkriHTGEKPNIC 576
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLD----HVCKKHNIC 126
transpos_ISL3 NF033550
ISL3 family transposase;
592-651 5.56e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.49  E-value: 5.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835638659 592 HYSIHTGEKPYTCPECGKSfNGQSHLKRHRRIH---TGEKP---------YTCPECGKSFSQQ-SILQRHNRI 651
Cdd:NF033550    1 VVEAELTRGDATCPECGKP-SRRVHDTGKRRIRhlpIFGRPvylelrvrrFKCPECGKTFTEElPWARKRSRI 72
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-221 6.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 196 NLRKHEKIHTTEKRYTCPECDKNFNR 221
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-50 4.37e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.37e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1835638659  11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISL 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-51 1.51e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1835638659  11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISLD 51
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
11-67 1.58e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.58e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659   11 VTFEDIAVSFSQEEWEYLDEEQKELYREVMKENYETLISLDTEAMHE---TKREENEEKC 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPdliSQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-671 2.91e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 212 CPECDKNFNRQSNLKRHKRIHTGEKPYAC--PECEKSFSQQSILRRHKRIHTGEKayicsecgkrfncqSNLKKHQRIHT 289
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP--------------SDLNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 290 GEKLYTC--PECGKNFNRQSNLKSHKRIHTGEKPYTCPECGKSFSQQSVLRRHKRIHTGEKpytcpecgKSFRQQSILRT 367
Cdd:COG5048   102 NSKASSSslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP--------QSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 368 HKRIHTGEKPyicpecgkcynhkAHLKLHYSIHTGEKPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTCPECGKSFSQQS 447
Cdd:COG5048   174 NSLSKDPSSN-------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 448 ILRRHKRIHTGEKAYICSECGKRFNCQSNLKKHQRIHTGE-------KLYTCPECGKSFNRQSNLKSHKR--IHTGE--K 516
Cdd:COG5048   241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 517 PYTCPE--CGKSFSQQSVLRRHKRIHTGEKPYTCP--ECGKSFRQQSILRTHKRIHtgekpnicpecgkcynhkahlklH 592
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ-----------------------Q 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 593 YSIHTGEKPYTC--PECGKSFNGQSHLKRHRRIHTGEKP--YTCPECGKSFSQQSILQRHNRIHTGEKAYICSECGKSFN 668
Cdd:COG5048   378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                  ...
gi 1835638659 669 CQS 671
Cdd:COG5048   458 DLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-706 5.50e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 84.36  E-value: 5.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 296 CPECGKNFNRQSNLKSHKRIHTGEKPYTC--PECGKSFSQQSVLRRHKRIHTGEKPYTCpeCGKSFRQQSILRTHKRIHT 373
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 374 GEKPYICPecgKCYNHKAHLKLHYSIHtgEKPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTCP--ECGKSFSQQSILRR 451
Cdd:COG5048   114 SSNSNDNN---LLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 452 HKRIHTGEKAYICSECGKRFNCQSNLKKHQRIHTGEKLYTCPECG----KSFNRQSNLKSHKRIHTGEKPYTCPECG--K 525
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSASESPRSSLptA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 526 SFSQQSVLRRHKRIHTG-EKPYTCPECGKSFRQQSILRTHKR--IHTGE--KPNICPE--CGKCYNHKAHLKLHYSIHTG 598
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 599 EKPYTCP--ECGKSFNGQSHLKRH-----RRIHTGEKPYTC--PECGKSFSQQSILQRHNRIHT--GEKAYICSECGKSF 667
Cdd:COG5048   349 ISPAKEKllNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1835638659 668 NCQSNLKIHERIHTgEKPYTCPECGKNFNRQSHLKSHKR 706
Cdd:COG5048   429 NRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-592 7.07e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 7.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 177 ESERPFTYPECGKSFNHKSNLRKHEKIHTTEKRYTC--PECDKNFNRQSNLKRHKRIHTGEKPYACpeceksfSQQSILR 254
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN-------SKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 255 RHKRIHTGEKAYICSECgKRFNCQSNLKKHQRIH-TGEKLYTCPECGKNFNRQSNLKSHKRIHTGEKPYTCP--ECGKSF 331
Cdd:COG5048   102 NSKASSSSLSSSSSNSN-DNNLLSSHSLPPSSRDpQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 332 SQQSVLRRHKRIHTGEKPYTCPECGKSFRQQSILRTHKRIHTGEKPYICPECGKCYNHKAHLKLHYSIHTGEKPYTCPEC 411
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 412 GKSFNGQSHLKRHRRIHTGE-------KPYTCPECGKSFSQQSILRRHKR--IHTGE--KAYICSE--CGKRFNCQSNLK 478
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 479 KHQRIHTGEKLYTCPECGKSFNRQSNLKS-------HKRIHTGEKPYTC--PECGKSFSQQSVLRRHKRIHTGEKP--YT 547
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1835638659 548 CPECGKSFRQQSILRTHKRIHTgEKPNICPECGKCYNHKAHLKLH 592
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
404-708 9.13e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 9.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 404 KPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTC--PECGKSFSQQSILRRHKRIHTGEKAYICSECGKRFN--------- 472
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 473 -----------CQSNLKKHQRIH-TGEKLYTCPECGKSFNRQSNLKSHKRIHTGEKPYTCP--ECGKSFSQQSVLRRHKR 538
Cdd:COG5048   112 ssssnsndnnlLSSHSLPPSSRDpQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 539 IHTGEKPYTCPECGKSFRQQSILRTHKRIHTGEKPNICPECGKCYNHKAHLKLHYSIHTGEKPYTCPECGKSFNGQSHLK 618
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 619 RHRRIHTGE-------KPYTCPECGKSFSQQSILQRHNR--IHTGE--KAYICSE--CGKSFNCQSNLKIHERIHTGEKP 685
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340
                  ....*....|....*....|....*
gi 1835638659 686 YTCP--ECGKNFNRQSHLKSHKRIH 708
Cdd:COG5048   352 AKEKllNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
492-716 1.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 492 CPECGKSFNRQSNLKSHKRIHTGEKPYTC--PECGKSFSQQSVLRRHKRIHTGEKPYTC----------------PECGK 553
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 554 SFRQQSILRTHKRIHTGEKPNICPECGKCYNHKAHLK-----------------------------------LHYSIHTG 598
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpanslskdpssnlsllISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 599 EKPYTCPECGKSFNGQSHLKRHRRIHTGEKPYTCPECGKSFSQQSILQRHNRIHTGEKAYICSECGKSFNCQSNLKIHER 678
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835638659 679 IHTGE-------KPYTCPECGKNFNRQSHLKSHKR--IHTGEKSLPF 716
Cdd:COG5048   276 NESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPF 322
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-341 2.58e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 185 PECGKSFNHKSNLRKH--EKIHTTEKRYT--CPE--CDKNFNRQSNLKRHKRIHTGEKPYACPECEKSFSQQSIL----- 253
Cdd:COG5048   293 KQCNISFSRSSPLTRHlrSVNHSGESLKPfsCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepp 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 254 --RRHKRIHTGEKAYICSECGKRFNC--QSNLKKHQRIHT--GEKLYTCPECGKNFNRQSNLKSHKRIHTGEKPYTCPEC 327
Cdd:COG5048   373 qsLQQYKDLKNDKKSETLSNSCIRNFkrDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                         170
                  ....*....|....
gi 1835638659 328 GKSFSQQSVLRRHK 341
Cdd:COG5048   453 KSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-249 2.26e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 224 NLKRHKRIHTGEKPYACPECEKSFSQ 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 3.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.12e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 420 HLKRHRRIHTGEKPYTCPECGKSFSQ 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-641 3.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.12e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 616 HLKRHRRIHTGEKPYTCPECGKSFSQ 641
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-529 3.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 504 NLKSHKRIHTGEKPYTCPECGKSFSQ 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 3.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 308 NLKSHKRIHTGEKPYTCPECGKSFSQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 4.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.53e-05
                          10        20
                  ....*....|....*....|....*
gi 1835638659 337 LRRHKRIHTGEKPYTCPECGKSFRQ 361
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
533-557 4.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.53e-05
                          10        20
                  ....*....|....*....|....*
gi 1835638659 533 LRRHKRIHTGEKPYTCPECGKSFRQ 557
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-425 3.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 346 GEKPYTCP--ECGKSFRQQSILRTHKRI-HTGEKPYICPECGKcynhkahlklHYSIHTGEKPYTCPECGKSFNGQSHLK 422
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1835638659 423 RHR 425
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 542-621 3.53e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 542 GEKPYTCP--ECGKSFRQQSILRTHKRI-HTGEKPNICPECGKcynhkahlklHYSIHTGEKPYTCPECGKSFNGQSHLK 618
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1835638659 619 RHR 621
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 234-313 4.90e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 234 GEKPYACP--ECEKSFSQQSILRRHkRIHtgekayicSECGKRFNCQSNLKKHQRIHTGEKLYTCPECGKNFNRQSNLKS 311
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1835638659 312 HK 313
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-501 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 476 NLKKHQRIHTGEKLYTCPECGKSFNR 501
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
672-697 5.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 672 NLKIHERIHTGEKPYTCPECGKNFNR 697
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
transpos_ISL3 NF033550
ISL3 family transposase;
396-455 1.51e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 41.42  E-value: 1.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835638659 396 HYSIHTGEKPYTCPECGKSfNGQSHLKRHRRIH---TGEKP---------YTCPECGKSFSQQ-SILRRHKRI 455
Cdd:NF033550    1 VVEAELTRGDATCPECGKP-SRRVHDTGKRRIRhlpIFGRPvylelrvrrFKCPECGKTFTEElPWARKRSRI 72
PHA00733 PHA00733
hypothetical protein
 517-576 2.16e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 2.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 517 PYTCPECGKSFSQQSVLRRHKRIHTGEKpyTCPECGKSFRQQSILRThkriHTGEKPNIC 576
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLD----HVCKKHNIC 126
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 2.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.75e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 490 YTCPECGKSFNRQSNLKSHKRIH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 280 NLKKHQRIHTGEKLYTCPECGKNFNR 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
588-612 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1835638659 588 HLKLHYSIHTGEKPYTCPECGKSFN 612
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-416 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1835638659 392 HLKLHYSIHTGEKPYTCPECGKSFN 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 210-232 4.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 210 YTCPECDKNFNRQSNLKRHKRIH 232
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 406-428 4.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 406 YTCPECGKSFNGQSHLKRHRRIH 428
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 602-624 4.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 602 YTCPECGKSFNGQSHLKRHRRIH 624
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 409-509 4.91e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 409 PECGKSFNGQSHLKRHRRIHT--------GEKPYTCP--ECGKSFSQQSILRRHkRIHtgekayicSECGKRFNCQSNLK 478
Cdd:COG5189   317 PCTNSSSNGKLAHGGERNIDTpsrmlkvkDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPE 387

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1835638659 479 KHQRIHTGEKLYTCPECGKSFNRQSNLKSHK 509
Cdd:COG5189   388 KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
transpos_ISL3 NF033550
ISL3 family transposase;
592-651 5.56e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.49  E-value: 5.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835638659 592 HYSIHTGEKPYTCPECGKSfNGQSHLKRHRRIH---TGEKP---------YTCPECGKSFSQQ-SILQRHNRI 651
Cdd:NF033550    1 VVEAELTRGDATCPECGKP-SRRVHDTGKRRIRhlpIFGRPvylelrvrrFKCPECGKTFTEElPWARKRSRI 72
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-221 6.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1835638659 196 NLRKHEKIHTTEKRYTCPECDKNFNR 221
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 605-705 7.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 605 PECGKSFNGQSHLKRHRRIHT--------GEKPYTCP--ECGKSFSQQSILQRHnRIHtgekayicSECGKSFNCQSNLK 674
Cdd:COG5189   317 PCTNSSSNGKLAHGGERNIDTpsrmlkvkDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPE 387

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1835638659 675 IHERIHTGEKPYTCPECGKNFNRQSHLKSHK 705
Cdd:COG5189   388 KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 294-316 7.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.41e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 294 YTCPECGKNFNRQSNLKSHKRIH 316
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 686-708 7.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|...
gi 1835638659 686 YTCPECGKNFNRQSHLKSHKRIH 708
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-473 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1835638659 449 LRRHKRIHTGEKAYICSECGKRFNC 473
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-277 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1835638659 253 LRRHKRIHTGEKAYICSECGKRFNC 277
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 321-368 7.87e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1835638659 321 PYTCPECGKSFSQQSVLRRHKRIHTGEKpyTCPECGKSFRQQSILRTH 368
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 207-284 9.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835638659 207 EKRYTCP--ECDKNFNRQSNLKRHKRI-HTGEKPYACPECEKsfsqqsilrrHKRIHTGEKAYICSECGKRFNCQSNLKK 283
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1835638659 284 H 284
Cdd:COG5189   417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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