|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
133-371 |
2.50e-98 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 313.07 E-value: 2.50e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQGFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18004 1 LRPHQREGVQFLYDCLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRC-NVTCVNDNAKEKIVSKLEgFKYDIQSTVLICSYECFRIN-NEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYN 290
Cdd:cd18004 81 WLGLRRiKVVTADGNAKDVKASLDF-FSSASTYPVLIISYETLRRHaEKLSKKISIDLLICDEGHRLKNSESKTTKALNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 291 LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASERLTELSNITNKFILR 370
Cdd:cd18004 160 LPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILR 239
|
.
gi 1835284405 371 R 371
Cdd:cd18004 240 R 240
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
133-759 |
6.72e-94 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 316.78 E-value: 6.72e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFV-FECLMNIkddkisGCILADDMGLGKTLQSITVLYTLLKQGfhkkcAVRRCLILCPASLINNWNDEIS 211
Cdd:COG0553 242 LRPYQLEGAAWLlFLRRLGL------GGLLADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQRELA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KWIPNRcNVTCVNDNAKEKivSKLEGFKydiQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNL 291
Cdd:COG0553 311 KFAPGL-RVLVLDGTRERA--KGANPFE---DADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRAL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 292 TAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPIligrdkdatEKEQEIASERLTELsniTNKFILRR 371
Cdd:COG0553 385 KARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI---------EKGDEEALERLRRL---LRPFLLRR 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 372 TNNLLSKVLPVKYLINIFIKLNPIQEALY--VLFLKDKKILKNDNTNNKVNVLINIKKLEKICNHPLLLnvndIKEIGQV 449
Cdd:COG0553 453 TKEDVLKDLPEKTEETLYVELTPEQRALYeaVLEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALL----LEEGAEL 528
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 450 TLWkliedvifemqtnmkicnrgnkrdnkndskSGcvlKVDKsmssisnnnmkngndmnntnnntnnntnnntnnntnnn 529
Cdd:COG0553 529 SGR------------------------------SA---KLEA-------------------------------------- 537
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 530 insninnninnninsninnninsnmnnntnlrcgsrgnqndasgyvgnkrkpieldynkpVKRIIEECKRDiyrsyynfs 609
Cdd:COG0553 538 ------------------------------------------------------------LLELLEELLAE--------- 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 610 ckflllhfllknikqntNDKVVIVSNYTQTLDYMEILCKENMYKFVRLDGGINIKKRHKVINDFTHSADIFIFLLSSKSG 689
Cdd:COG0553 549 -----------------GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAG 611
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 690 GCGINLISSNRLILLDPDWNPANDKQALARVWREGQKKICYIYRLFCTGTIDEKVYQRQISKDGLSNMIV 759
Cdd:COG0553 612 GEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
133-371 |
9.64e-81 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 264.72 E-value: 9.64e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQGFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRRIRGSHGCIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNAKEKIVSKLEGF----KYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSI 288
Cdd:cd18067 81 WLGGRLQPLAIDGGSKKEIDRKLVQWasqqGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 289 YNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASERLTELSNITNKFI 368
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCI 240
|
...
gi 1835284405 369 LRR 371
Cdd:cd18067 241 IRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
133-371 |
1.54e-69 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 232.81 E-value: 1.54e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQG-FHKKCAVRRCLILCPASLINNWNDEIS 211
Cdd:cd18066 1 LRPHQREGIEFLYECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGpYGGKPVIKRALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KWI-PNRCNVTCVNDNakekivSKLEGFKYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYN 290
Cdd:cd18066 81 KWLgSERIKVFTVDQD------HKVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 291 LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASERLTELSNITNKFILR 370
Cdd:cd18066 155 LSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILR 234
|
.
gi 1835284405 371 R 371
Cdd:cd18066 235 R 235
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
136-438 |
3.82e-65 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 222.56 E-value: 3.82e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 136 HQREGVQFVFECLMNIKddkiSGCILADDMGLGKTLQSITVLYTLLKQgfhKKCAVRRCLILCPASLINNWNDEISKWI- 214
Cdd:pfam00176 1 YQIEGVNWMLSLENNLG----RGGILADEMGLGKTLQTISLLLYLKHV---DKNWGGPTLIVVPLSLLHNWMNEFERWVs 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 215 PNRCNVTCVNDNAKEKIVSKLEG---FKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNL 291
Cdd:pfam00176 74 PPALRVVVLHGNKRPQERWKNDPnflADFD----VVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 292 TAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDatekeqeiaseRLTELSNITNKFILRR 371
Cdd:pfam00176 150 KTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKK-----------GVSRLHKLLKPFLLRR 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835284405 372 TNNLLSKVLPVKYLINIFIKLNPIQEALYVLFLKDKKILKNDNTN----NKVNVLINIKKLEKICNHPLLL 438
Cdd:pfam00176 219 TKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEggreIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
133-323 |
5.74e-59 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 200.48 E-value: 5.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKddkisGCILADDMGLGKTLQSITVLYTLLKQGFhkkcAVRRCLILCPASLINNWNDEISK 212
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGP-----GGILADEMGLGKTLQAIAFLAYLLKEGK----ERGPVLVVCPLSVLENWEREFEK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNrCNVTCVNDNAKEKivSKLEGFKYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLT 292
Cdd:cd17919 72 WTPD-LRVVVYHGSQRER--AQIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALR 148
|
170 180 190
....*....|....*....|....*....|.
gi 1835284405 293 AKKRLLLSGTPIQNDLGEFYALISLCNPDLF 323
Cdd:cd17919 149 AKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
133-356 |
6.53e-57 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 197.13 E-value: 6.53e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECL--MNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQgfHKKcaVRRCLILCPASLINNWNDEI 210
Cdd:cd18007 1 LKPHQVEGVRFLWSNLvgTDVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAA--APR--RSRPLVLCPASTLYNWEDEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 211 SKWIPNRCNV--TCVNDNAKEKIVSKLEGF-KYDIQSTVLICSYECFRI-----NNEFLDKSSI---------DMIICDE 273
Cdd:cd18007 77 KKWLPPDLRPllVLVSLSASKRADARLRKInKWHKEGGVLLIGYELFRNlasnaTTDPRLKQEFiaalldpgpDLLVLDE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 274 AHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIA 353
Cdd:cd18007 157 GHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLM 236
|
...
gi 1835284405 354 SER 356
Cdd:cd18007 237 LKR 239
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
133-371 |
1.20e-53 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 187.97 E-value: 1.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKddkisGCILADDMGLGKTLQSITVLYTLL----------------KQGFHKKCAVRRCLI 196
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGR-----GGILGDDMGLGKTVQVIAFLAAVLgktgtrrdrennrprfKKKPPASSAKKPVLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 197 LCPASLINNWNDEISKWipNRCNVTCVNDNAKEKIV-SKLEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAH 275
Cdd:cd18005 76 VAPLSVLYNWKDELDTW--GHFEVGVYHGSRKDDELeGRLKAGRLE----VVVTTYDTLRRCIDSLNSINWSAVIADEAH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 276 RLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASE 355
Cdd:cd18005 150 RIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRK 229
|
250
....*....|....*.
gi 1835284405 356 RLTELSNITNKFILRR 371
Cdd:cd18005 230 RKQELAVKLSKFFLRR 245
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
133-372 |
1.32e-50 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 178.14 E-value: 1.32e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQ-FVFECLMNIkddkisGCILADDMGLGKTLQSITVLytllkQGFHKKCAVRRCLILCPASLINNWNDEIS 211
Cdd:cd18012 5 LRPYQKEGFNwLSFLRHYGL------GGILADDMGLGKTLQTLALL-----LSRKEEGRKGPSLVVAPTSLIYNWEEEAA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KWIPNrcnVTCV---NDNAKEKIVSKLEgfKYDIqstvLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSI 288
Cdd:cd18012 74 KFAPE---LKVLvihGTKRKREKLRALE--DYDL----VITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 289 YNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEkeqeiaserltELSNITNKFI 368
Cdd:cd18012 145 KALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEALE-----------ELKKLISPFI 213
|
....
gi 1835284405 369 LRRT 372
Cdd:cd18012 214 LRRL 217
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
133-371 |
2.25e-50 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 177.95 E-value: 2.25e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKddkisGCILADDMGLGKTLQSITVLytllkQGFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGK-----GGILADDMGLGKTVQICAFL-----SGMFDSGLIKSVLVVMPTSLIPHWVKEFAK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRcNVTC---VNDNAKEKIVSK-LEGFkydiqsTVLICSYECFRINNEFL-----DKSSIDMIICDEAHRLKNDKTK 283
Cdd:cd18001 71 WTPGL-RVKVfhgTSKKERERNLERiQRGG------GVLLTTYGMVLSNTEQLsaddhDEFKWDYVILDEGHKIKNSKTK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 284 TYTSIYNLTAKKRLLLSGTPIQNDLGEFYALIS-LCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASERLTELSN 362
Cdd:cd18001 144 SAKSLREIPAKNRIILTGTPIQNNLKELWALFDfACNGSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQ 223
|
....*....
gi 1835284405 363 ITNKFILRR 371
Cdd:cd18001 224 IIKPYFLRR 232
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
627-735 |
2.55e-45 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 159.56 E-value: 2.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 627 NDKVVIVSNYTQTLDYMEILCKENMYKFVRLDGGINIKKRHKVINDFTHSADIFIFLLSSKSGGCGINLISSNRLILLDP 706
Cdd:cd18793 27 GEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDP 106
|
90 100
....*....|....*....|....*....
gi 1835284405 707 DWNPANDKQALARVWREGQKKICYIYRLF 735
Cdd:cd18793 107 WWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
133-371 |
5.34e-45 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 162.52 E-value: 5.34e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYtlLKQGFHK---KCAVRRCLILCPASLINNWNDE 209
Cdd:cd17999 1 LRPYQQEGINW----LAFLNKYNLHG-ILCDDMGLGKTLQTLCILA--SDHHKRAnsfNSENLPSLVVCPPTLVGHWVAE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 210 ISKWIPNRCNVTCVNDNAKEKIVSKLEGFKydiQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIY 289
Cdd:cd17999 74 IKKYFPNAFLKPLAYVGPPQERRRLREQGE---KHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 290 NLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASERLTELSNITNKFIL 369
Cdd:cd17999 151 QLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLL 230
|
..
gi 1835284405 370 RR 371
Cdd:cd17999 231 RR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
133-356 |
1.70e-40 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 150.04 E-value: 1.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFEC----LMNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQgfHKKCAVRRCLILCPASLINNWND 208
Cdd:cd18068 1 LKPHQVDGVQFMWDCccesLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLC--EKLENFSRVLVVCPLNTVLNWLN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIP--NRCNVTCVNDNA--KEKIVSKLEGFKYDIQSTVLICSYECFRI----------------NNEFLDKSSIDM 268
Cdd:cd18068 79 EFEKWQEglKDEEKIEVNELAtyKRPQERSYKLQRWQEEGGVMIIGYDMYRIlaqernvksreklkeiFNKALVDPGPDF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 269 IICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEK 348
Cdd:cd18068 159 VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLV 238
|
....*...
gi 1835284405 349 EQEIASER 356
Cdd:cd18068 239 DVRVMKKR 246
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
133-371 |
1.78e-39 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 146.04 E-value: 1.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKddkisGCILADDMGLGKTLQSITVLYTLLKqgfhKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQH-----GCILGDEMGLGKTCQTISLLWYLAG----RLKLLGPFLVLCPLSVLDNWKEELNR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDnaKEKIVSKLEGFKYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLT 292
Cdd:cd18006 72 FAPDLSVITYMGD--KEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 293 AKKRLLLSGTPIQNDLGEFYALISLCNPDLF--DDINLFRKKFANpiligrdkdaTEKEQEIASerltELSNITNKFILR 370
Cdd:cd18006 150 VDFRLLLTGTPIQNSLQELYALLSFIEPNVFpkDKLDDFIKAYSE----------TDDESETVE----ELHLLLQPFLLR 215
|
.
gi 1835284405 371 R 371
Cdd:cd18006 216 R 216
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
133-371 |
8.57e-37 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 139.34 E-value: 8.57e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfeclMNIKddkisGCILADDMGLGKTLQSITVLYTLLKQGF----------HKKCAVRRC---LILCP 199
Cdd:cd18008 1 LLPYQKQGLAW-----MLPR-----GGILADEMGLGKTIQALALILATRPQDPkipeeleensSDPKKLYLSkttLIVVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 200 ASLINNWNDEISKWIPNRCNVTCVNDNAKEKI-VSKLEgfKYDIqstVLIcSYEcfRINNEFLDKSSIDM---------- 268
Cdd:cd18008 71 LSLLSQWKDEIEKHTKPGSLKVYVYHGSKRIKsIEELS--DYDI---VIT-TYG--TLASEFPKNKKGGGrdskekeasp 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 269 --------IICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIG 340
Cdd:cd18008 143 lhrirwyrVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKN 222
|
250 260 270
....*....|....*....|....*....|.
gi 1835284405 341 RDKdatekeqeiASERlteLSNITNKFILRR 371
Cdd:cd18008 223 DRK---------ALER---LQALLKPILLRR 241
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
133-372 |
7.72e-36 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 135.91 E-value: 7.72e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLyTLLKQ-----GFHkkcavrrcLILCPASLINNWN 207
Cdd:cd17997 4 MRDYQIRGLNW----LISLFENGING-ILADEMGLGKTLQTISLL-GYLKHykninGPH--------LIIVPKSTLDNWM 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 208 DEISKWIPNrCNVTCVNDNAKEK---IVSKLEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKT 284
Cdd:cd17997 70 REFKRWCPS-LRVVVLIGDKEERadiIRDVLLPGKFD----VCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 285 YTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKdatekeqeiasERLTELSNIT 364
Cdd:cd17997 145 SQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQ-----------EVVQRLHKVL 213
|
....*...
gi 1835284405 365 NKFILRRT 372
Cdd:cd17997 214 RPFLLRRI 221
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
133-356 |
5.00e-35 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 133.79 E-value: 5.00e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVF----ECLMNIKDDKISGCILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWND 208
Cdd:cd18069 1 LKPHQIGGIRFLYdniiESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTV-----LAIVPVNTLQNWLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIPNRCNVTCV----------NDNAKEKIVSKLEGFKYDIQSTVLICSYECFRInnefldKSSIDMIICDEAHRLK 278
Cdd:cd18069 76 EFNKWLPPPEALPNVrprpfkvfilNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFRL------RPGPDVVICDEGHRIK 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835284405 279 NDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATEKEQEIASER 356
Cdd:cd18069 150 NCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
133-371 |
2.59e-34 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 131.32 E-value: 2.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLKQ----GFHkkcavrrcLILCPASLINNWND 208
Cdd:cd18003 1 LREYQHIGLDW----LATLYEKNLNG-ILADEMGLGKTIQTIALLAHLACEkgnwGPH--------LIVVPTSVMLNWEM 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIPNRCNVTCVNdNAKEKIVSKLEGFKYDiQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSI 288
Cdd:cd18003 68 EFKRWCPGFKILTYYG-SAKERKLKRQGWMKPN-SFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 289 YNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPIligrdKDATEKEQEIASERLTELSNITNKFI 368
Cdd:cd18003 146 LNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL-----TAMSEGSQEENEELVRRLHKVLRPFL 220
|
...
gi 1835284405 369 LRR 371
Cdd:cd18003 221 LRR 223
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
133-787 |
1.04e-33 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 141.09 E-value: 1.04e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLK----QGFHkkcavrrcLILCPASLINNWND 208
Cdd:PLN03142 170 MRDYQLAGLNW----LIRLYENGING-ILADEMGLGKTLQTISLLGYLHEyrgiTGPH--------MVVAPKSTLGNWMN 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIPnRCNVTCVNDNAKEKIVSK---LEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTY 285
Cdd:PLN03142 237 EIRRFCP-VLRAVKFHGNPEERAHQReelLVAGKFD----VCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 286 TSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANpiligrdkDATEKEQEIASerltELSNITN 365
Cdd:PLN03142 312 KTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI--------SGENDQQEVVQ----QLHKVLR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 366 KFILRRTNNLLSKVLPVKYLINIFIKLNPIQEALYvlflkdKKILKND----NTNNKVNVLINIK-KLEKICNHPLLLNV 440
Cdd:PLN03142 380 PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYY------KALLQKDldvvNAGGERKRLLNIAmQLRKCCNHPYLFQG 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 441 ndiKEIGQ--VTLWKLIEdvifemqtnmkicnrgnkrdnkndsksgcvlkvdksmssisnnnmkngndmnntnnntnnnt 518
Cdd:PLN03142 454 ---AEPGPpyTTGEHLVE-------------------------------------------------------------- 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 519 nnntnnntnnninsninnninnninsninnninsnmnnntnlrcgsrgnqndasgyvgNKRKPIELDynKPVKRIIEECK 598
Cdd:PLN03142 469 ----------------------------------------------------------NSGKMVLLD--KLLPKLKERDS 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 599 RdiyrsyynfsckflllhfllknikqntndkVVIVSNYTQTLDYMEILCKENMYKFVRLDGGINIKKRHKVINDFTH-SA 677
Cdd:PLN03142 489 R------------------------------VLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpGS 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 678 DIFIFLLSSKSGGCGINLISSNRLILLDPDWNPANDKQALARVWREGQKKICYIYRlFCT-GTIDEKVYQRQISKDGLSN 756
Cdd:PLN03142 539 EKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFR-FCTeYTIEEKVIERAYKKLALDA 617
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1835284405 757 MIVT------TTNLSKD---QMSDENVKKLFNYKMNTVSE 787
Cdd:PLN03142 618 LVIQqgrlaeQKTVNKDellQMVRYGAEMVFSSKDSTITD 657
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
133-335 |
1.25e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 125.63 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDdkisgCILADDMGLGKTLQSITVLYTLLKQGfHKKCAVrrcLILCPASLINNWNDEISK 212
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTD-----TILADEMGLGKTIQTIVFLYSLYKEG-HSKGPF---LVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNakekivsklegfkydiqstVLICSYECFRINNEFLdkSSID--MIICDEAHRLKNDKTKTYTSIYN 290
Cdd:cd17994 72 WAPDFYVVTYVGDH-------------------VLLTSYELISIDQAIL--GSIDwaVLVVDEAHRLKNNQSKFFRILNS 130
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1835284405 291 LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd17994 131 YKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD 175
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
133-371 |
3.24e-32 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 125.96 E-value: 3.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVqfvfECLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLKQG----FhkkcavrrcLILCPASLINNWND 208
Cdd:cd18009 4 MRPYQLEGM----EWLRMLWENGING-ILADEMGLGKTIQTIALLAHLRERGvwgpF---------LVIAPLSTLPNWVN 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIPNrCNVTCVNDNAKEK--IVSKLEGFKYDIQST-VLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTY 285
Cdd:cd18009 70 EFARFTPS-VPVLLYHGTKEERerLRKKIMKREGTLQDFpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 286 TSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAnpilIGRDKDATEKEQEIASER----LTELS 361
Cdd:cd18009 149 QELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFD----FSSLSDNAADISNLSEEReqniVHMLH 224
|
250
....*....|
gi 1835284405 362 NITNKFILRR 371
Cdd:cd18009 225 AILKPFLLRR 234
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
133-332 |
9.59e-32 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 123.55 E-value: 9.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFeclmnikDDKISGCILADDMGLGKTLQSITVLYTLLKQGfhkkcAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18011 1 PLPHQIDAVLRAL-------RKPPVRLLLADEVGLGKTIEAGLIIKELLLRG-----DAKRVLILCPASLVEQWQDELQD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 --WIPNRCnvtCVNDNAKEKIVSKLEGFKydiQSTVLICSYECFRINNE---FLDKSSIDMIICDEAHRLKNDKTKTYTS 287
Cdd:cd18011 69 kfGLPFLI---LDRETAAQLRRLIGNPFE---EFPIVIVSLDLLKRSEErrgLLLSEEWDLVVVDEAHKLRNSGGGKETK 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1835284405 288 IYNL------TAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKK 332
Cdd:cd18011 143 RYKLgrllakRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRL 193
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
133-371 |
1.17e-30 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 120.77 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFEclmnikddkISG-CILADDMGLGKTLQSITVLYTllkqgFHKKCAVrrcLILCPASLINNWNDEIS 211
Cdd:cd18010 1 LLPFQREGVCFALR---------RGGrVLIADEMGLGKTVQAIAIAAY-----YREEWPL---LIVCPSSLRLTWADEIE 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KWIPN--RCNVTCVNdNAKEKIvsklegfkYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIY 289
Cdd:cd18010 64 RWLPSlpPDDIQVIV-KSKDGL--------RDGDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAAL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 290 NLT--AKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKDATekeqeiASERLTELSNI-TNK 366
Cdd:cd18010 135 PLLkrAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYS------GSSNLEELHLLlLAT 208
|
....*
gi 1835284405 367 FILRR 371
Cdd:cd18010 209 IMIRR 213
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
133-333 |
1.32e-30 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 120.82 E-value: 1.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKddkisGCILADDMGLGKTLQSITVLYTLLKQGFHKKCAvrrcLILCPASLINNWNDEISK 212
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRR-----NCILADEMGLGKTIQSIAFLEHLYQVEGIRGPF----LVIAPLSTIPNWQREFET 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPnrCNVTCVNDNAKEK-IVSKLEGFKYD---------IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKT 282
Cdd:cd17995 72 WTD--MNVVVYHGSGESRqIIQQYEMYFKDaqgrkkkgvYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNS 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1835284405 283 KTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKF 333
Cdd:cd17995 150 KLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
133-315 |
3.23e-30 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 118.58 E-value: 3.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFEclmniKDDKISGCILADDMGLGKTLQSITVLYTLlkqgFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18000 1 LFKYQQTGVQWLWE-----LHCQRVGGILGDEMGLGKTIQIIAFLAAL----HHSKLGLGPSLIVCPATVLKQWVKEFHR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPN-RCNV---TCVNDNAKEKIVSKLEGFKYDIQST----VLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKT 284
Cdd:cd18000 72 WWPPfRVVVlhsSGSGTGSEEKLGSIERKSQLIRKVVgdggILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEI 151
|
170 180 190
....*....|....*....|....*....|.
gi 1835284405 285 YTSIYNLTAKKRLLLSGTPIQNDLGEFYALI 315
Cdd:cd18000 152 TLACKQLRTPHRLILSGTPIQNNLKELWSLF 182
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
133-371 |
4.51e-30 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 119.53 E-value: 4.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLKqgfhKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18002 1 LKEYQLKGLNW----LANLYEQGING-ILADEMGLGKTVQSIAVLAHLAE----EHNIWGPFLVIAPASTLHNWQQEISR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNAKEKIVSKLEGFKY----DIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSI 288
Cdd:cd18002 72 FVPQFKVLPYWGNPKDRKVLRKFWDRKNlytrDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 289 YNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPIligrdKDATEKEQEIASERLTELSNITNKFI 368
Cdd:cd18002 152 LSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDI-----ESHAENKTGLNEHQLKRLHMILKPFM 226
|
...
gi 1835284405 369 LRR 371
Cdd:cd18002 227 LRR 229
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
133-371 |
5.94e-30 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 119.40 E-value: 5.94e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLK----QGFHkkcavrrcLILCPASLINNWND 208
Cdd:cd17996 4 LKEYQLKGLQW----MVSLYNNNLNG-ILADEMGLGKTIQTISLITYLMEkkknNGPY--------LVIVPLSTLSNWVS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 209 EISKWIPN-RCNVTCVNDNAKEKIVSKLEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTK---T 284
Cdd:cd17996 71 EFEKWAPSvSKIVYKGTPDVRKKLQSQIRAGKFN----VLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKltqT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 285 YTSIYNltAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILI--GRDKDA-TEKEQEIASERLTEls 361
Cdd:cd17996 147 LNTYYH--ARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANtgEQVKIElNEEETLLIIRRLHK-- 222
|
250
....*....|
gi 1835284405 362 nITNKFILRR 371
Cdd:cd17996 223 -VLRPFLLRR 231
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
159-323 |
2.90e-27 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 109.78 E-value: 2.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 159 CILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWNDEISKWIPNrCNVTCVNDNAKEK------IV 232
Cdd:cd17998 22 GILADEMGLGKTIQVIAFLAYLKEIGIPGPH-----LVVVPSSTLDNWLREFKRWCPS-LKVEPYYGSQEERkhlrydIL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 233 SKLEGFKydiqstVLICSYECFRINNE---FLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLG 309
Cdd:cd17998 96 KGLEDFD------VIVTTYNLATSNPDdrsFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLL 169
|
170
....*....|....
gi 1835284405 310 EFYALISLCNPDLF 323
Cdd:cd17998 170 ELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
133-371 |
4.45e-27 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 110.52 E-value: 4.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfeclMNIKDDKISGCILADDMGLGKTLQSITVLYTLlkqgFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd17993 2 LRDYQLTGLNW-----LAHSWCKGNNGILADEMGLGKTVQTISFLSYL----FHSQQQYGPFLVVVPLSTMPAWQREFAK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNAKEKIVSKLEGFKYD---IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIY 289
Cdd:cd17993 73 WAPDMNVIVYLGDIKSRDTIREYEFYFSQtkkLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 290 NLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDdinlFRKKFanpiligrdKDATEKEQEiasERLTELSNITNKFIL 369
Cdd:cd17993 153 EFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFD----IWEEF---------EEEHDEEQE---KGIADLHKELEPFIL 216
|
..
gi 1835284405 370 RR 371
Cdd:cd17993 217 RR 218
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
133-321 |
1.45e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 108.35 E-value: 1.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNikddkisgCILADDMGLGKTLQSITVLYTLLKQGFHKkcavrRCLILCP-ASLINNWNDEIS 211
Cdd:smart00487 9 LRPYQKEAIEALLSGLRD--------VILAAPTGSGKTLAALLPALEALKRGKGG-----RVLVLVPtRELAEQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KWIPNRC--NVTCVNDNAKEKIVSKLEGFKYDIqstvLICSYECFR--INNEFLDKSSIDMIICDEAHRLKNDK-TKTYT 286
Cdd:smart00487 76 KLGPSLGlkVVGLYGGDSKREQLRKLESGKTDI----LVTTPGRLLdlLENDKLSLSNVDLVILDEAHRLLDGGfGDQLE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1835284405 287 SIYNLTAK--KRLLLSGTP---IQNDLGEFYALISLCNPD 321
Cdd:smart00487 152 KLLKLLPKnvQLLLLSATPpeeIENLLELFLNDPVFIDVG 191
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
160-335 |
8.67e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 107.40 E-value: 8.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 160 ILADDMGLGKTLQSITVLYTLLKQGfHKKCAVrrcLILCPASLINNWNDEISKWIPNRCNVTCVNDNAKEKIVSKLEgFK 239
Cdd:cd18055 23 ILADEMGLGKTIQTIVFLYSLYKEG-HTKGPF---LVSAPLSTIINWEREFQMWAPDFYVVTYTGDKDSRAIIRENE-FS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 240 YD------------------IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSG 301
Cdd:cd18055 98 FDdnavkggkkafkmkreaqVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTG 177
|
170 180 190
....*....|....*....|....*....|....
gi 1835284405 302 TPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd18055 178 TPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD 211
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
160-335 |
9.19e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 107.07 E-value: 9.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 160 ILADDMGLGKTLQSITVLYTLLKQGfHKKCAVrrcLILCPASLINNWNDEISKWIPNRCNVTCVNDNAKEKIVSKLEgFK 239
Cdd:cd18056 23 ILADEMGLGKTVQTAVFLYSLYKEG-HSKGPF---LVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENE-FS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 240 YD------------------IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSG 301
Cdd:cd18056 98 FEdnairggkkasrmkkeasVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTG 177
|
170 180 190
....*....|....*....|....*....|....
gi 1835284405 302 TPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd18056 178 TPLQNNLEELFHLLNFLTPERFHNLEGFLEEFAD 211
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
133-324 |
1.39e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 106.63 E-value: 1.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFE--ClmnikddKISGCILADDMGLGKTLQSITVLYTLlkqgFHKKCAVRRCLILCPASLINNWNDEI 210
Cdd:cd18054 21 LRDYQLEGLNWLAHswC-------KNNSVILADEMGLGKTIQTISFLSYL----FHQHQLYGPFLLVVPLSTLTSWQREF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 211 SKWIPNRCNVTCVNDNAKEKIVSKLEGFKYD---IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTS 287
Cdd:cd18054 90 EIWAPEINVVVYIGDLMSRNTIREYEWIHSQtkrLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKT 169
|
170 180 190
....*....|....*....|....*....|....*..
gi 1835284405 288 IYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFD 324
Cdd:cd18054 170 LIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFE 206
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
133-383 |
1.59e-25 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 106.67 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLkqgfHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18064 16 LRDYQVRGLNW----LISLYENGING-ILADEMGLGKTLQTISLLGYMK----HYRNIPGPHMVLVPKSTLHNWMAEFKR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDnaKEKIVSKLEGFKYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLT 292
Cdd:cd18064 87 WVPTLRAVCLIGD--KDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 293 AKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGrDKDATEKeqeiaserlteLSNITNKFILRRT 372
Cdd:cd18064 165 TTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLG-DQKLVER-----------LHMVLRPFLLRRI 232
|
250
....*....|.
gi 1835284405 373 NNLLSKVLPVK 383
Cdd:cd18064 233 KADVEKSLPPK 243
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
133-371 |
1.83e-25 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 106.69 E-value: 1.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLKqgfHKKCAvRRCLILCPASLINNWNDEISK 212
Cdd:cd18063 24 LKHYQLQGLEW----MVSLYNNNLNG-ILADEMGLGKTIQTIALITYLME---HKRLN-GPYLIIVPLSTLSNWTYEFDK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNA-KEKIVSKLEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKtYTSIYN- 290
Cdd:cd18063 95 WAPSVVKISYKGTPAmRRSLVPQLRSGKFN----VLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCK-LTQVLNt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 291 -LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPI-LIGRDKDATEKEQEIASERLTElsnITNKFI 368
Cdd:cd18063 170 hYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNEEETILIIRRLHK---VLRPFL 246
|
...
gi 1835284405 369 LRR 371
Cdd:cd18063 247 LRR 249
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
160-335 |
2.85e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 105.92 E-value: 2.85e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 160 ILADDMGLGKTLQSITVLYTLLKQGfHKKCAVrrcLILCPASLINNWNDEISKWIPNRCNVTCVNDNAKEKIVSKLEgFK 239
Cdd:cd18057 23 ILADEMGLGKTVQTIVFLYSLYKEG-HSKGPY---LVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENE-FS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 240 YD------------------IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSG 301
Cdd:cd18057 98 FEdnairsgkkvfrmkkeaqIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTG 177
|
170 180 190
....*....|....*....|....*....|....
gi 1835284405 302 TPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd18057 178 TPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD 211
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
133-335 |
4.99e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 104.73 E-value: 4.99e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDdkisgCILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWNDEISK 212
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRN-----CILADEMGLGKTIQSITFLYEIYLKGIHGPF-----LVIAPLSTIPNWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WipNRCNVTCVN-DNAKEKIVSKLEGFKYDIQSTVLICSYECFRINNEF---------LDKSSIDMIICDEAHRLKNDKT 282
Cdd:cd18059 71 W--TELNVVVYHgSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFemiltdcpeLRNIPWRCVVIDEAHRLKNRNC 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1835284405 283 KTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd18059 149 KLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGD 201
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
133-371 |
8.35e-25 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 105.13 E-value: 8.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLKqgfHKKCAvRRCLILCPASLINNWNDEISK 212
Cdd:cd18062 24 LKQYQIKGLEW----LVSLYNNNLNG-ILADEMGLGKTIQTIALITYLME---HKRIN-GPFLIIVPLSTLSNWVYEFDK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVND-NAKEKIVSKLEGFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKtYTSIYN- 290
Cdd:cd18062 95 WAPSVVKVSYKGSpAARRAFVPQLRSGKFN----VLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCK-LTQVLNt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 291 -LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPI-LIGRDKDATEKEQEIASERLTElsnITNKFI 368
Cdd:cd18062 170 hYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGEKVDLNEEETILIIRRLHK---VLRPFL 246
|
...
gi 1835284405 369 LRR 371
Cdd:cd18062 247 LRR 249
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
133-371 |
1.15e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 103.58 E-value: 1.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDdkisgCILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWNDEISK 212
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKN-----CILADEMGLGKTIQSITFLSEIFLMGIRGPF-----LIIAPLSTITNWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WipNRCNVTCVNDNA-KEKIVSKLEGFKYDIQST---------VLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKT 282
Cdd:cd18058 71 W--TEMNAIVYHGSQiSRQMIQQYEMYYRDEQGNplsgifkfqVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNC 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 283 KTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAnpiligrdkDATEKEQeiaserLTELSN 362
Cdd:cd18058 149 KLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG---------DLKTEEQ------VKKLQS 213
|
....*....
gi 1835284405 363 ITNKFILRR 371
Cdd:cd18058 214 ILKPMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
155-371 |
1.35e-24 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 104.10 E-value: 1.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 155 KISGCILADDMGLGKTLQSIT-VLYTLLKQ---GFHKK------------CAVRRC--LILCPASLINNWNDEI-SKWIP 215
Cdd:cd18072 19 KPRGGILADDMGLGKTLTMIAlILAQKNTQnrkEEEKEkalteweskkdsTLVPSAgtLVVCPASLVHQWKNEVeSRVAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 216 NRCNVTCVNDNAKEKIVSKLEgfKYDIQ-STVLICSYECFRINNEFLDKSSIDM----IICDEAHRLKNDKTKTYTSIYN 290
Cdd:cd18072 99 NKLRVCLYHGPNRERIGEVLR--DYDIViTTYSLVAKEIPTYKEESRSSPLFRIawarIILDEAHNIKNPKVQASIAVCK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 291 LTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANpiligrdkdatekEQEIASERlteLSNITNKFILR 370
Cdd:cd18072 177 LRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDN-------------KSRKGGER---LNILTKSLLLR 240
|
.
gi 1835284405 371 R 371
Cdd:cd18072 241 R 241
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
133-352 |
1.48e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 103.98 E-value: 1.48e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMnikddKISGCILADDMGLGKTLQSITVLYTLlkqgFHKKCAVRRCLILCPASLINNWNDEISK 212
Cdd:cd18053 21 LRDYQLNGLNWLAHSWC-----KGNSCILADEMGLGKTIQTISFLNYL----FHEHQLYGPFLLVVPLSTLTSWQREIQT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WIPNRCNVTCVNDNAKEKIVSKLEGFKYD---IQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIY 289
Cdd:cd18053 92 WAPQMNAVVYLGDINSRNMIRTHEWMHPQtkrLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLI 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835284405 290 NLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANpiliGRDKDATEKEQEI 352
Cdd:cd18053 172 DFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK----GREYGYASLHKEL 230
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
122-343 |
3.05e-24 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 102.79 E-value: 3.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 122 KIEVDP--ILAQYLREHQREGVQFvfecLMNIKDDKISGcILADDMGLGKTLQSITVLYTLLkqgfHKKCAVRRCLILCP 199
Cdd:cd18065 3 RFEESPsyVKGGTLRDYQVRGLNW----MISLYENGVNG-ILADEMGLGKTLQTIALLGYLK----HYRNIPGPHMVLVP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 200 ASLINNWNDEISKWIPNRCNVTCVNDnaKEKIVSKLEGFKYDIQSTVLICSYECFRINNEFLDKSSIDMIICDEAHRLKN 279
Cdd:cd18065 74 KSTLHNWMNEFKRWVPSLRAVCLIGD--KDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKN 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835284405 280 DKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDK 343
Cdd:cd18065 152 EKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQK 215
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
154-371 |
7.65e-23 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 98.70 E-value: 7.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 154 DKISGCILADDMGLGKTLQSITVLytllkqgfhkkcAVRRCLILCPASLINNWNDEISKWI-PNRCNVTCVNDNAKEKIV 232
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLI------------LANFTLIVCPLSVLSNWETQFEEHVkPGQLKVYTYHGGERNRDP 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 233 SKLEgfKYDIqstvLICSYECfrINNEFLDKSSIDM-------IICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQ 305
Cdd:cd18071 114 KLLS--KYDI----VLTTYNT--LASDFGAKGDSPLhtinwlrVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQ 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1835284405 306 NDLGEFYALISLCNPDLFDDINLFRKKFANPILIGRDKdatekeqeiASERLTEL-SNITnkfiLRR 371
Cdd:cd18071 186 NSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPT---------GLKRLQVLmKQIT----LRR 239
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
133-371 |
1.45e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 97.43 E-value: 1.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDdkisgCILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWNDEISK 212
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQN-----CILADEMGLGKTIQSIAFLQEVYNVGIHGPF-----LVIAPLSTITNWEREFNT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WipNRCNVTCVNDN-AKEKIVSKLE-------------GFKYDiqstVLICSYECFRINNEFLDKSSIDMIICDEAHRLK 278
Cdd:cd18060 71 W--TEMNTIVYHGSlASRQMIQQYEmyckdsrgrlipgAYKFD----ALITTFEMILSDCPELREIEWRCVIIDEAHRLK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 279 NDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAnpiligrdkDATEKEQeiaserLT 358
Cdd:cd18060 145 NRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG---------DLKTEEQ------VQ 209
|
250
....*....|...
gi 1835284405 359 ELSNITNKFILRR 371
Cdd:cd18060 210 KLQAILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
133-335 |
9.53e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 95.07 E-value: 9.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFVFECLMNIKDdkisgCILADDMGLGKTLQSITVLYTLLKQGFHKKCavrrcLILCPASLINNWNDEISK 212
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRN-----CILADEMGLGKTIQSITFLYEILLTGIRGPF-----LIIAPLSTIANWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 213 WipNRCNVTCVNDN-AKEKIVSKLEGFKYDIQSTVLICSYECFRINNEF---------LDKSSIDMIICDEAHRLKNDKT 282
Cdd:cd18061 71 W--TDLNVVVYHGSlISRQMIQQYEMYFRDSQGRIIRGAYRFQAIITTFemilggcpeLNAIDWRCVIIDEAHRLKNKNC 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1835284405 283 KTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDDINLFRKKFAN 335
Cdd:cd18061 149 KLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGD 201
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
622-724 |
1.01e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 85.73 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 622 IKQNTNDKVVIVSNYTQTLDyMEILCKENMYKFVRLDGGINIKKRHKVINDFTHSAdiFIFLLSSKSGGCGINLISSNRL 701
Cdd:pfam00271 10 LKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAERGLDLPDVDLV 86
|
90 100
....*....|....*....|...
gi 1835284405 702 ILLDPDWNPANDKQALARVWREG 724
Cdd:pfam00271 87 INYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
133-340 |
2.49e-14 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 73.54 E-value: 2.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfeclmnIKDDKISGCILadDMGLGKTLQSITVLYTLLKQGFHkkcavRRCLILCPASLI-NNWNDEIS 211
Cdd:cd18013 1 PHPYQKVAINF-------IIEHPYCGLFL--DMGLGKTVTTLTALSDLQLDDFT-----RRVLVIAPLRVArSTWPDEVE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 212 KW-IPNRCNVTCVNDNAKEKIVSklegfkYDIQSTVLICSYECFR-INNEFLDKSSIDMIICDEAHRLKNDKTKTYTSIY 289
Cdd:cd18013 67 KWnHLRNLTVSVAVGTERQRSKA------ANTPADLYVINRENLKwLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALR 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1835284405 290 NL--TAKKRLLLSGTPIQNDLGEFYALISLCN--PDLFDDINLFRKKFANPILIG 340
Cdd:cd18013 141 KVrpVIKRLIGLTGTPSPNGLMDLWAQIALLDqgERLGRSITAYRERWFDPDKRN 195
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
641-724 |
4.17e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 68.78 E-value: 4.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 641 DYMEILCKENMYKFVRLDGGINIKKRHKVINDFThsADIFIFLLSSKSGGCGINLISSNRLILLDPDWNPANDKQALARV 720
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1835284405 721 WREG 724
Cdd:smart00490 79 GRAG 82
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
133-325 |
2.61e-13 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 71.22 E-value: 2.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQFvfeclMnikddKISGCILADDMGLGKTLQSITVLYT-------LLKQGFHKKCA-----------VRRC 194
Cdd:cd18070 1 LLPYQRRAVNW-----M-----LVPGGILADEMGLGKTVEVLALILLhprpdndLDAADDDSDEMvccpdclvaetPVSS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 195 ---LILCPASLINNWNDEISKWIPNRCNVTCVNDNAKEKIVSKLEGFK---YDIqstvLICSYECFRI---------NNE 259
Cdd:cd18070 71 katLIVCPSAILAQWLDEINRHVPSSLKVLTYQGVKKDGALASPAPEIlaeYDI----VVTTYDVLRTelhyaeanrSNR 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835284405 260 FLDKSSIDM-------------IICDEAHRLKNDKTKTYTSIYNLTAKKRLLLSGTPIQNDLGEFYALISLCNPDLFDD 325
Cdd:cd18070 147 RRRRQKRYEappsplvlvewwrVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCD 225
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
92-389 |
7.94e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 69.67 E-value: 7.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 92 RRSDETEEQEKIEEVIKKHEPLILYKDENDKIEVDPILAQY-------------LREHQREGVQFVFECLMNIKDDkisG 158
Cdd:COG1061 27 ELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEAleagdeasgtsfeLRPYQQEALEALLAALERGGGR---G 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 159 CILADdMGLGKTLQSITVLYTLLkqgfhkkcAVRRCLILCP-ASLINNWNDEISKWIPNRCNVtcvndnakekivskleG 237
Cdd:COG1061 104 LVVAP-TGTGKTVLALALAAELL--------RGKRVLVLVPrRELLEQWAEELRRFLGDPLAG----------------G 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 238 FKYDIQSTVLICSYECFRINNEFLD-KSSIDMIICDEAHRLkndKTKTYTSIYN-LTAKKRLLLSGTPIQNDLGEFYAli 315
Cdd:COG1061 159 GKKDSDAPITVATYQSLARRAHLDElGDRFGLVIIDEAHHA---GAPSYRRILEaFPAAYRLGLTATPFRSDGREILL-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 316 slcnpDLFDDI-------NLFRKKF-ANPILIGRDKDATEKEQE--IASERLTELSNITNKFILRRTNNLLSKVLPVKYL 385
Cdd:COG1061 234 -----FLFDGIvyeyslkEAIEDGYlAPPEYYGIRVDLTDERAEydALSERLREALAADAERKDKILRELLREHPDDRKT 308
|
....
gi 1835284405 386 InIF 389
Cdd:COG1061 309 L-VF 311
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
133-304 |
1.44e-07 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 52.29 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVQfvfECLMNIKDDKISGCIladDM--GLGKTLQSITVLYTLLKQGFhkkcaVRRCLILCP-ASLINNWNDE 209
Cdd:pfam04851 4 LRPYQIEAIE---NLLESIKNGQKRGLI---VMatGSGKTLTAAKLIARLFKKGP-----IKKVLFLVPrKDLLEQALEE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 210 ISKWIPNrcnvtcvndnaKEKIVSKLEGFKYDIQST---VLICSYE----CFRINNEFLDKSSIDMIICDEAHRLkndKT 282
Cdd:pfam04851 73 FKKFLPN-----------YVEIGEIISGDKKDESVDdnkIVVTTIQslykALELASLELLPDFFDVIIIDEAHRS---GA 138
|
170 180
....*....|....*....|...
gi 1835284405 283 KTYTSIYN-LTAKKRLLLSGTPI 304
Cdd:pfam04851 139 SSYRNILEyFKPAFLLGLTATPE 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
157-302 |
2.09e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 45.86 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 157 SGCILADDMGLGKTLQ-SITVLYTLLKQGFhkkcavrRCLILCP-ASLINNWNDEISKWIPNRCNVTCVNDNAKEKIVSK 234
Cdd:cd00046 2 ENVLITAPTGSGKTLAaLLAALLLLLKKGK-------KVLVLVPtKALALQTAERLRELFGPGIRVAVLVGGSSAEEREK 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1835284405 235 LEGFKYDIqstvLICSYECFRINNEFLDKSS---IDMIICDEAHRLKNDKTKTYTSIYNLTAK-----KRLLLSGT 302
Cdd:cd00046 75 NKLGDADI----IIATPDMLLNLLLREDRLFlkdLKLIIVDEAHALLIDSRGALILDLAVRKAglknaQVILLSAT 146
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
133-303 |
6.66e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 44.22 E-value: 6.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 133 LREHQREGVqfvFECLMNIKDDKisGCIladDM--GLGKTLQSITVLytllkqgfhKKCAVRRCLILCP-ASLINNWNDE 209
Cdd:cd17926 1 LRPYQEEAL---EAWLAHKNNRR--GIL---VLptGSGKTLTALALI---------AYLKELRTLIVVPtDALLDQWKER 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835284405 210 ISKWIPNR--CNVTCVNDNAKEKIVSKLegfkYDIQSTVlICSYECFRINNEFldkssiDMIICDEAHRLkndKTKTYTS 287
Cdd:cd17926 64 FEDFLGDSsiGLIGGGKKKDFDDANVVV----ATYQSLS-NLAEEEKDLFDQF------GLLIVDEAHHL---PAKTFSE 129
|
170
....*....|....*..
gi 1835284405 288 IY-NLTAKKRLLLSGTP 303
Cdd:cd17926 130 ILkELNAKYRLGLTATP 146
|
|
| |
