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Conserved domains on  [gi|1835283865|gb|KAF4329907|]
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ATP-dependent RNA helicase DHR1 [Plasmodium falciparum NF54]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 458-587 3.39e-54

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd17982:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 191  Bit Score: 187.56  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDY----FIGITQPRKIAVKSICNRLNDELN--EE 531
Cdd:cd17982      1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNvfGK 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865  532 ICGYQIRFEKSYFlKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17982     81 EVSYQIRYDSTVS-ENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTD 135
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 876-994 2.50e-36

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 135.74  E-value: 2.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  876 SDGSGTLKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKRKIYSNLNDYSYYIIDNIS 955
Cdd:cd18791     69 SPDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWIS 148

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1835283865  956 KCSAIQRKGRAGRIlyllkknkknkkkmenEKGHVYKLY 994
Cdd:cd18791    149 KASAEQRAGRAGRT----------------RPGKCYRLY 171
PRK11131 super family cl32644
ATP-dependent RNA helicase HrpA; Provisional
 446-1042 1.19e-33

ATP-dependent RNA helicase HrpA; Provisional


The actual alignment was detected with superfamily member PRK11131:

Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 142.12  E-value: 1.19e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  446 NRKEHIDKVR--ASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFtSNDYFIGITQPRKIAVKSICNR 523
Cdd:PRK11131    59 LREAARPEITypENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR-GVKGLIGHTQPRRLAARTVANR 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  524 LNDELNEEI---CGYQIRFeKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINmdiiigilsiiskir 600
Cdd:PRK11131   138 IAEELETELggcVGYKVRF-NDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLN--------------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  601 ndnyynfksdiipikiiimsatindnnlfqnkifqnfttvniptqkvqvIDHFLSYtpkdyveeakrkiiqIHKKLPQGS 680
Cdd:PRK11131   202 -------------------------------------------------IDFILGY---------------LKELLPRRP 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  681 IL-VFLTSQeeiyrlynmlsnlKITNSEFNQQGENKIMDEVNfdifdlsegeqNKDEKVSLFFREtdeneekkilfdVSE 759
Cdd:PRK11131   218 DLkVIITSA-------------TIDPERFSRHFNNAPIIEVS-----------GRTYPVEVRYRP------------IVE 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  760 EENSVESDIKESDIKESDYIKE---GDIkesdYIKESNieesnidesnieesdieesdvkesdvkesdikESDIKESDnd 836
Cdd:PRK11131   262 EADDTERDQLQAIFDAVDELGRegpGDI----LIFMSG--------------------------------EREIRDTA-- 303

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  837 vydkelhdddhmdDEPKKSNINTYElnnntkkkssiwkgsdgsgtlkVFKLYSKLPMKDQMELFHnPKENERVcILSTNI 916
Cdd:PRK11131   304 -------------DALNKLNLRHTE----------------------ILPLYARLSNSEQNRVFQ-SHSGRRI-VLATNV 346

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  917 AETSLTLPNIRYVIDCGkekrkiYSNLNDYSYYI------IDNISKCSAIQRKGRAGRIlyllkknkknkkkmenEKGHV 990
Cdd:PRK11131   347 AETSLTVPGIKYVIDPG------TARISRYSYRTkvqrlpIEPISQASANQRKGRCGRV----------------SEGIC 404

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  991 YKLYSSNYYNY---FfkndNDYPILNYPLDSLILYLLSFNIKNVENFPFINKPDK 1042
Cdd:PRK11131   405 IRLYSEDDFLSrpeF----TDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDK 455
OB_NTP_bind super family cl06657
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1324-1413 8.94e-04

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


The actual alignment was detected with superfamily member pfam07717:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 39.54  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865 1324 IHYAVIQGFIDHLAIRSDlvhnqytrnqnitynSKKAYITQNMNMPIYINSSSVLYQNRPY-PKYILYNYITKNRNSYvM 1402
Cdd:pfam07717    1 LRAALAAGLYPNVARRDP---------------KGKGYTTLSDNQRVFIHPSSVLFNEKTFpPEWVVYQELVETTKVY-I 64

                           90
                   ....*....|.
gi 1835283865 1403 FDCLKIDDAEL 1413
Cdd:pfam07717   65 RTVTAISPEWL 75
 
Name Accession Description Interval E-value
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 458-587 3.39e-54

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 187.56  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDY----FIGITQPRKIAVKSICNRLNDELN--EE 531
Cdd:cd17982      1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNvfGK 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865  532 ICGYQIRFEKSYFlKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17982     81 EVSYQIRYDSTVS-ENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTD 135
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 876-994 2.50e-36

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 135.74  E-value: 2.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  876 SDGSGTLKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKRKIYSNLNDYSYYIIDNIS 955
Cdd:cd18791     69 SPDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWIS 148

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1835283865  956 KCSAIQRKGRAGRIlyllkknkknkkkmenEKGHVYKLY 994
Cdd:cd18791    149 KASAEQRAGRAGRT----------------RPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 446-1042 1.19e-33

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 142.12  E-value: 1.19e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  446 NRKEHIDKVR--ASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFtSNDYFIGITQPRKIAVKSICNR 523
Cdd:PRK11131    59 LREAARPEITypENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR-GVKGLIGHTQPRRLAARTVANR 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  524 LNDELNEEI---CGYQIRFeKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINmdiiigilsiiskir 600
Cdd:PRK11131   138 IAEELETELggcVGYKVRF-NDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLN--------------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  601 ndnyynfksdiipikiiimsatindnnlfqnkifqnfttvniptqkvqvIDHFLSYtpkdyveeakrkiiqIHKKLPQGS 680
Cdd:PRK11131   202 -------------------------------------------------IDFILGY---------------LKELLPRRP 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  681 IL-VFLTSQeeiyrlynmlsnlKITNSEFNQQGENKIMDEVNfdifdlsegeqNKDEKVSLFFREtdeneekkilfdVSE 759
Cdd:PRK11131   218 DLkVIITSA-------------TIDPERFSRHFNNAPIIEVS-----------GRTYPVEVRYRP------------IVE 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  760 EENSVESDIKESDIKESDYIKE---GDIkesdYIKESNieesnidesnieesdieesdvkesdvkesdikESDIKESDnd 836
Cdd:PRK11131   262 EADDTERDQLQAIFDAVDELGRegpGDI----LIFMSG--------------------------------EREIRDTA-- 303

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  837 vydkelhdddhmdDEPKKSNINTYElnnntkkkssiwkgsdgsgtlkVFKLYSKLPMKDQMELFHnPKENERVcILSTNI 916
Cdd:PRK11131   304 -------------DALNKLNLRHTE----------------------ILPLYARLSNSEQNRVFQ-SHSGRRI-VLATNV 346

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  917 AETSLTLPNIRYVIDCGkekrkiYSNLNDYSYYI------IDNISKCSAIQRKGRAGRIlyllkknkknkkkmenEKGHV 990
Cdd:PRK11131   347 AETSLTVPGIKYVIDPG------TARISRYSYRTkvqrlpIEPISQASANQRKGRCGRV----------------SEGIC 404

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  991 YKLYSSNYYNY---FfkndNDYPILNYPLDSLILYLLSFNIKNVENFPFINKPDK 1042
Cdd:PRK11131   405 IRLYSEDDFLSrpeF----TDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDK 455
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
456-587 9.74e-31

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 131.74  E-value: 9.74e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  456 ASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYfIGITQPRKIAVKSICNRLNDELNEEI--- 532
Cdd:COG1643      8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVget 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835283865  533 CGYQIRFEK--SyflKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:COG1643     87 VGYRVRFEDkvS---AATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNAD 140
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
884-1052 7.47e-21

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 99.77  E-value: 7.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  884 VFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKRKIYSNLNDYSYYIIDNISKCSAIQRK 963
Cdd:COG1643    250 ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRA 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  964 GRAGRIlyllkknkknkkkmenEKGHVYKLYSsnyynyffKND----NDYP---ILNYPLDSLILYLLSFNIKNVENFPF 1036
Cdd:COG1643    330 GRAGRL----------------APGICYRLWS--------EEDfarrPAFTdpeILRADLASLILELAAWGLGDPEDLPF 385

                          170
                   ....*....|....*.
gi 1835283865 1037 INKPDKSKFIEAKKRL 1052
Cdd:COG1643    386 LDPPPARAIADARALL 401
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 457-587 6.56e-17

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 86.90  E-value: 6.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  457 SLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVP-QFLYEYGFTSNdyfIGITQPRKIAVKSICNRLNDELNEEI--- 532
Cdd:PRK11664     3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINGK---IIMLEPRRLAARNVAQRLAEQLGEKPget 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  533 CGYQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:PRK11664    80 VGYRMRAE-SKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQAD 133
DEXDc smart00487
DEAD-like helicases superfamily;
458-583 1.46e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 79.84  E-value: 1.46e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865   458 LPVLDYEQELIEAVL-NYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYFIGITQPRKIAVKSICNRLNDELNE------ 530
Cdd:smart00487    7 EPLRPYQKEAIEALLsGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSlglkvv 86

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865   531 -EICGYQIRFEKSYFLK-HSKIKVMTEGILLKEIMSDFI-LSKYSVIILDEAHERS 583
Cdd:smart00487   87 gLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLL 142
HELICc smart00490
helicase superfamily c-terminal domain;
882-969 9.24e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 68.01  E-value: 9.24e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865   882 LKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEkrkiysnlndysyyiidnISKCSAIQ 961
Cdd:smart00490   12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLP------------------WSPASYIQ 73


                    ....*...
gi 1835283865   962 RKGRAGRI 969
Cdd:smart00490   74 RIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 882-969 1.64e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.53  E-value: 1.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  882 LKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKrkiysNLNDYsyyiidniskcsaIQ 961
Cdd:pfam00271   39 IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPW-----NPASY-------------IQ 100


                   ....*...
gi 1835283865  962 RKGRAGRI 969
Cdd:pfam00271  101 RIGRAGRA 108
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 465-581 2.14e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 46.47  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  465 QELIEAVLNYDVVFVNGDTGCGKST--QVPqFLYEYGFTSNDYFIGITQPRKI-------AVKSICNRLNDELNEEICGY 535
Cdd:pfam00270    5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRElaeqiyeELKKLGKGLGLKVASLLGGD 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1835283865  536 QIRFEKSyFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHE 581
Cdd:pfam00270   84 SRKEQLE-KLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR 128
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 744-851 8.88e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 44.15  E-value: 8.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  744 ETDEN-EEKKILFDVSEEENSVESDIKESDIKESDyikegDIKESDyikesniEESNIDEsniEESDIEESDVKESDVKE 822
Cdd:pfam04931  624 DARENpEGQQELFEDEDEDEEDDDEEEDDDDEDDE-----DSEEDD-------DEDDDDE---DEEDDDDEDVDEIDELR 688

                           90       100
                   ....*....|....*....|....*....
gi 1835283865  823 SDIKEsDIKESDNDVYDKELHDDDHMDDE 851
Cdd:pfam04931  689 AKLAE-ALGEHGDDADDDDSDSDEDMDDE 716
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1324-1413 8.94e-04

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 39.54  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865 1324 IHYAVIQGFIDHLAIRSDlvhnqytrnqnitynSKKAYITQNMNMPIYINSSSVLYQNRPY-PKYILYNYITKNRNSYvM 1402
Cdd:pfam07717    1 LRAALAAGLYPNVARRDP---------------KGKGYTTLSDNQRVFIHPSSVLFNEKTFpPEWVVYQELVETTKVY-I 64

                           90
                   ....*....|.
gi 1835283865 1403 FDCLKIDDAEL 1413
Cdd:pfam07717   65 RTVTAISPEWL 75
 
Name Accession Description Interval E-value
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 458-587 3.39e-54

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 187.56  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDY----FIGITQPRKIAVKSICNRLNDELN--EE 531
Cdd:cd17982      1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNvfGK 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865  532 ICGYQIRFEKSYFlKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17982     81 EVSYQIRYDSTVS-ENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTD 135
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 475-587 2.35e-47

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 166.87  E-value: 2.35e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  475 DVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYF-IGITQPRKIAVKSICNRLNDELNEEI---CGYQIRFEKSYfLKHSKI 550
Cdd:cd17917      2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGrIVCTQPRRIAAISVAERVAEERGEKLgeeVGYQIRFESKT-SSKTRI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1835283865  551 KVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17917     81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTD 117
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 458-587 1.11e-40

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 148.27  E-value: 1.11e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDyFIGITQPRKIAVKSICNRLNDELNEEI---CG 534
Cdd:cd17978      1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-MIGITQPRRVAAVSVAKRVAEEMGVELgqlVG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1835283865  535 YQIRFEKSYfLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17978     80 YSVRFDDVT-SEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTD 131
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 458-587 2.28e-38

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 142.22  E-value: 2.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYFIGITQPRKIAVKSICNRLNDE----LNEEIc 533
Cdd:cd17980      1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEmgavLGHEV- 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1835283865  534 GYQIRFEKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17980     80 GYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTD 133
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 876-994 2.50e-36

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 135.74  E-value: 2.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  876 SDGSGTLKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKRKIYSNLNDYSYYIIDNIS 955
Cdd:cd18791     69 SPDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWIS 148

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1835283865  956 KCSAIQRKGRAGRIlyllkknkknkkkmenEKGHVYKLY 994
Cdd:cd18791    149 KASAEQRAGRAGRT----------------RPGKCYRLY 171
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 458-624 1.32e-35

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 133.72  E-value: 1.32e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSndyfIGITQPRKIAVKSICNRLNDE-LNE--EICG 534
Cdd:cd17979      1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFEsLNQygSKVA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  535 YQIRFEKSYFLKhSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMDIIIGILSIISKIRNDnyynfksdiipI 614
Cdd:cd17979     77 YQIRFERTRTLA-TKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD-----------L 144

                          170
                   ....*....|
gi 1835283865  615 KIIIMSATIN 624
Cdd:cd17979    145 KLILMSATIN 154
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 458-587 2.08e-35

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 133.44  E-value: 2.08e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDyFIGITQPRKIAVKSICNRLNDELN---EEICG 534
Cdd:cd17984      1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG-MIGVTQPRRVAAISVAQRVAEEMKctlGSKVG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1835283865  535 YQIRFEKSYfLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17984     80 YQVRFDDCS-SKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTD 131
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 458-587 2.14e-35

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 133.01  E-value: 2.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYFIGITQPRKIAVKSICNRLNDE----LNEEIc 533
Cdd:cd17974      1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEmgvkLGNEV- 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1835283865  534 GYQIRFEKSYFLKhSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17974     80 GYSIRFEDCTSEK-TVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTD 132
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 455-587 9.75e-35

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 131.45  E-value: 9.75e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  455 RASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDyFIGITQPRKIAVKSICNRLNDE----LNE 530
Cdd:cd17971      3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRRVAAMSVAKRVAEEfgccLGQ 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835283865  531 EIcGYQIRFEKSYFlKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17971     82 EV-GYTIRFEDCTS-PETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTD 136
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 458-587 1.21e-34

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 131.04  E-value: 1.21e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDyFIGITQPRKIAVKSICNRLNDELNEEI---CG 534
Cdd:cd17989      1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELggaVG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1835283865  535 YQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17989     80 YKVRFT-DQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNID 131
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 458-587 4.62e-34

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 129.12  E-value: 4.62e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDyFIGITQPRKIAVKSICNRLNDELNEEI---CG 534
Cdd:cd17983      1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELgeeVG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1835283865  535 YQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17983     80 YAIRFE-DCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTD 131
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 446-1042 1.19e-33

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 142.12  E-value: 1.19e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  446 NRKEHIDKVR--ASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFtSNDYFIGITQPRKIAVKSICNR 523
Cdd:PRK11131    59 LREAARPEITypENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR-GVKGLIGHTQPRRLAARTVANR 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  524 LNDELNEEI---CGYQIRFeKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINmdiiigilsiiskir 600
Cdd:PRK11131   138 IAEELETELggcVGYKVRF-NDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLN--------------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  601 ndnyynfksdiipikiiimsatindnnlfqnkifqnfttvniptqkvqvIDHFLSYtpkdyveeakrkiiqIHKKLPQGS 680
Cdd:PRK11131   202 -------------------------------------------------IDFILGY---------------LKELLPRRP 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  681 IL-VFLTSQeeiyrlynmlsnlKITNSEFNQQGENKIMDEVNfdifdlsegeqNKDEKVSLFFREtdeneekkilfdVSE 759
Cdd:PRK11131   218 DLkVIITSA-------------TIDPERFSRHFNNAPIIEVS-----------GRTYPVEVRYRP------------IVE 261

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  760 EENSVESDIKESDIKESDYIKE---GDIkesdYIKESNieesnidesnieesdieesdvkesdvkesdikESDIKESDnd 836
Cdd:PRK11131   262 EADDTERDQLQAIFDAVDELGRegpGDI----LIFMSG--------------------------------EREIRDTA-- 303

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  837 vydkelhdddhmdDEPKKSNINTYElnnntkkkssiwkgsdgsgtlkVFKLYSKLPMKDQMELFHnPKENERVcILSTNI 916
Cdd:PRK11131   304 -------------DALNKLNLRHTE----------------------ILPLYARLSNSEQNRVFQ-SHSGRRI-VLATNV 346

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  917 AETSLTLPNIRYVIDCGkekrkiYSNLNDYSYYI------IDNISKCSAIQRKGRAGRIlyllkknkknkkkmenEKGHV 990
Cdd:PRK11131   347 AETSLTVPGIKYVIDPG------TARISRYSYRTkvqrlpIEPISQASANQRKGRCGRV----------------SEGIC 404

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  991 YKLYSSNYYNY---FfkndNDYPILNYPLDSLILYLLSFNIKNVENFPFINKPDK 1042
Cdd:PRK11131   405 IRLYSEDDFLSrpeF----TDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDK 455
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 446-587 3.94e-32

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 124.45  E-value: 3.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  446 NRKEHIDKVRASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSND-YFIGITQPRKIAVKSICNRL 524
Cdd:cd17973      1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPkKLVACTQPRRVAAMSVAQRV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1835283865  525 NDE----LNEEIcGYQIRFEKSYFLKhSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17973     81 AEEmdvkLGEEV-GYSIRFEDCSSAK-TILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATD 145
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
456-587 9.74e-31

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 131.74  E-value: 9.74e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  456 ASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYfIGITQPRKIAVKSICNRLNDELNEEI--- 532
Cdd:COG1643      8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVget 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835283865  533 CGYQIRFEK--SyflKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:COG1643     87 VGYRVRFEDkvS---AATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNAD 140
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 435-587 5.50e-28

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 113.78  E-value: 5.50e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  435 KRKVCYKNVQVNRKEHIDKVRASLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEyGFTSND---YF-IGIT 510
Cdd:cd17972     36 KNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILD-DFIQNDraaECnIVVT 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  511 QPRKIAVKSICNRLNDELNEEI---CGYQIRFEKSYFLKHSKIKVMTEGILLKEIMSDfiLSKYSVIILDEAHERSINMD 587
Cdd:cd17972    115 QPRRISAVSVAERVAFERGEEVgksCGYSVRFESVLPRPHASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTD 192
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 458-587 4.63e-26

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 106.54  E-value: 4.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYE----YGFTSNDYFIGITQPRKIAVKSICNRLNDELNEE-- 531
Cdd:cd17975      1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1835283865  532 ------ICGYQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17975     81 pggknsLCGYQIRME-SRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSD 141
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 458-587 6.18e-26

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 106.05  E-value: 6.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYF-IGITQPRKIAVKSICNRLNDE----LNeEI 532
Cdd:cd17988      1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCnIVVTQPRRIAAISIARRVSQErewtLG-SL 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  533 CGYQIRFEKSYfLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17988     80 VGYQVGLERPA-SEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELD 133
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 458-587 4.81e-25

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 103.77  E-value: 4.81e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLY----EYGFTSNDYFIgITQPRKIAVKSICNRLNDELNEEI- 532
Cdd:cd17981      1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGSSCRIV-CTQPRRISAISVAERVAAERAESCg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835283865  533 ----CGYQIRFEKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17981     80 lgnsTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSD 138
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 458-587 7.31e-23

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 97.17  E-value: 7.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSN---DYFIGITQPRKIAVKSICNRLNDELNEEI-- 532
Cdd:cd17976      1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGrgaRCNVVITQPRRISAVSVAQRVAHELGPNLrr 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865  533 -CGYQIRFEKSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17976     81 nVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTD 136
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
884-1052 7.47e-21

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 99.77  E-value: 7.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  884 VFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKRKIYSNLNDYSYYIIDNISKCSAIQRK 963
Cdd:COG1643    250 ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRA 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  964 GRAGRIlyllkknkknkkkmenEKGHVYKLYSsnyynyffKND----NDYP---ILNYPLDSLILYLLSFNIKNVENFPF 1036
Cdd:COG1643    330 GRAGRL----------------APGICYRLWS--------EEDfarrPAFTdpeILRADLASLILELAAWGLGDPEDLPF 385

                          170
                   ....*....|....*.
gi 1835283865 1037 INKPDKSKFIEAKKRL 1052
Cdd:COG1643    386 LDPPPARAIADARALL 401
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 458-587 1.69e-19

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 87.59  E-value: 1.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYE-YGFTSNDYFIGI--TQPRKIAVKSICNRLNDELNEEI-- 532
Cdd:cd17985      1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnSLQGPPLPVANIicTQPRRISAISVAERVAQERAERVgq 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283865  533 -CGYQIRFEKsyfLKHSKIKVM--TEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17985     81 sVGYQIRLES---VKSSATRLLycTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESD 135
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 458-582 2.48e-19

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 87.19  E-value: 2.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFTSN-DYFIGITQPRKIAVKSICNRLNDELNEEI---C 533
Cdd:cd17987      1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGiPCRIFCTQPRRLAAIAVAERVAAERGEKIgqtV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1835283865  534 GYQIRFEkSYFLKHSKIKVMTEGILLKEIMS-DFILSKYSVIILDEAHER 582
Cdd:cd17987     81 GYQIRLE-SRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHER 129
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 458-587 1.64e-18

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 84.88  E-value: 1.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVPQFLYEYGFtSNDYFIGI---TQPRKIAVKSICNRLNDELNEEI-- 532
Cdd:cd17977      1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCL-SAHYQHGVvvcTQVHKQTAVWLALRVADEMDVNIgh 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865  533 -CGYQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17977     80 eVGYVIPFE-NCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTD 134
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 458-587 4.03e-18

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 83.54  E-value: 4.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVP-QFLYEYGFTSNDyfIGITQPRKIAVKSICNRLNDELNEEI---C 533
Cdd:cd17990      1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWIAGGK--IIVLEPRRVAARAAARRLATLLGEAPgetV 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1835283865  534 GYQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17990     79 GYRVRGE-SRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDAD 131
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 457-587 6.56e-17

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 86.90  E-value: 6.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  457 SLPVLDYEQELIEAVLNYDVVFVNGDTGCGKSTQVP-QFLYEYGFTSNdyfIGITQPRKIAVKSICNRLNDELNEEI--- 532
Cdd:PRK11664     3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINGK---IIMLEPRRLAARNVAQRLAEQLGEKPget 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1835283865  533 CGYQIRFEkSYFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:PRK11664    80 VGYRMRAE-SKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQAD 133
DEXDc smart00487
DEAD-like helicases superfamily;
458-583 1.46e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 79.84  E-value: 1.46e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865   458 LPVLDYEQELIEAVL-NYDVVFVNGDTGCGKSTQVPQFLYEYGFTSNDYFIGITQPRKIAVKSICNRLNDELNE------ 530
Cdd:smart00487    7 EPLRPYQKEAIEALLsGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSlglkvv 86

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283865   531 -EICGYQIRFEKSYFLK-HSKIKVMTEGILLKEIMSDFI-LSKYSVIILDEAHERS 583
Cdd:smart00487   87 gLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLL 142
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 458-587 7.27e-14

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 71.47  E-value: 7.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  458 LPVLDYEQELIEAVLNY-DVVFVNGDTGCGKSTQVPQFLYEY----GFTSNDyfIGITQPRKIAVKSICNRLNDE----L 528
Cdd:cd17986      1 LPIWAAKFTFLEQLESPsGIVLVSGEPGSGKSTQVPQWCAEFalsrGFQKGQ--VTVTQPHPLAARSLALRVADEmdlnL 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835283865  529 NEEIcGYQIRFEK----SYFLKHSkikvmTEGILLKEIMSDFILSKYSVIILDEAHERSINMD 587
Cdd:cd17986     79 GHEV-GYSIPQEDctgpNTILRFC-----WDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASD 135
HELICc smart00490
helicase superfamily c-terminal domain;
882-969 9.24e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 68.01  E-value: 9.24e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865   882 LKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEkrkiysnlndysyyiidnISKCSAIQ 961
Cdd:smart00490   12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLP------------------WSPASYIQ 73


                    ....*...
gi 1835283865   962 RKGRAGRI 969
Cdd:smart00490   74 RIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 882-969 1.64e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.53  E-value: 1.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  882 LKVFKLYSKLPMKDQMELFHNPKENERVCILSTNIAETSLTLPNIRYVIDCGKEKrkiysNLNDYsyyiidniskcsaIQ 961
Cdd:pfam00271   39 IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPW-----NPASY-------------IQ 100


                   ....*...
gi 1835283865  962 RKGRAGRI 969
Cdd:pfam00271  101 RIGRAGRA 108
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 465-581 2.14e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 46.47  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  465 QELIEAVLNYDVVFVNGDTGCGKST--QVPqFLYEYGFTSNDYFIGITQPRKI-------AVKSICNRLNDELNEEICGY 535
Cdd:pfam00270    5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRElaeqiyeELKKLGKGLGLKVASLLGGD 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1835283865  536 QIRFEKSyFLKHSKIKVMTEGILLKEIMSDFILSKYSVIILDEAHE 581
Cdd:pfam00270   84 SRKEQLE-KLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR 128
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 477-587 2.84e-05

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 45.86  E-value: 2.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  477 VFVNGDTGCGKSTQVPQFLYEYgFTSNDYFIGITQPRKIAVKSICNRLNDELNEEI-CGYQIRFEKS-----YFLKHSKI 550
Cdd:cd00046      4 VLITAPTGSGKTLAALLAALLL-LLKKGKKVLVLVPTKALALQTAERLRELFGPGIrVAVLVGGSSAeerekNKLGDADI 82

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1835283865  551 KVMTEGILLKEIMSD--FILSKYSVIILDEAHERSINMD 587
Cdd:cd00046     83 IIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSR 121
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 663-851 5.98e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 44.22  E-value: 5.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  663 EEAKRKIIQI-HKKLPQGSIlvfltSQEEIYRLYNMlSNLKITNSEFNQQGENKIMDEVNfdifDLSEGEQNKDEKVSLF 741
Cdd:PRK05901    14 EEAKKKLKKLaAKSKSKGFI-----TKEEIKEALES-KKKTPEQIDQVLIFLSGMVKDTD----DATESDIPKKKTKTAA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  742 FRETDENEEKKILFDVSEEENSVESDIKESDIKESDYIKEGDIKESDYIKESNIEESNIDESNIEESDIEESDVKESDVK 821
Cdd:PRK05901    84 KAAAAKAPAKKKLKDELDSSKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDDDLDDDDIDDDDDDEDDDEDDDDD 163

                          170       180       190
                   ....*....|....*....|....*....|
gi 1835283865  822 ESDIKESDIKESDNDVYDKELHDDDHMDDE 851
Cdd:PRK05901   164 DVDDEDEEKKEAKELEKLSDDDDFVWDEDD 193
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 744-851 8.88e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 44.15  E-value: 8.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865  744 ETDEN-EEKKILFDVSEEENSVESDIKESDIKESDyikegDIKESDyikesniEESNIDEsniEESDIEESDVKESDVKE 822
Cdd:pfam04931  624 DARENpEGQQELFEDEDEDEEDDDEEEDDDDEDDE-----DSEEDD-------DEDDDDE---DEEDDDDEDVDEIDELR 688

                           90       100
                   ....*....|....*....|....*....
gi 1835283865  823 SDIKEsDIKESDNDVYDKELHDDDHMDDE 851
Cdd:pfam04931  689 AKLAE-ALGEHGDDADDDDSDSDEDMDDE 716
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1324-1413 8.94e-04

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 39.54  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283865 1324 IHYAVIQGFIDHLAIRSDlvhnqytrnqnitynSKKAYITQNMNMPIYINSSSVLYQNRPY-PKYILYNYITKNRNSYvM 1402
Cdd:pfam07717    1 LRAALAAGLYPNVARRDP---------------KGKGYTTLSDNQRVFIHPSSVLFNEKTFpPEWVVYQELVETTKVY-I 64

                           90
                   ....*....|.
gi 1835283865 1403 FDCLKIDDAEL 1413
Cdd:pfam07717   65 RTVTAISPEWL 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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