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Conserved domains on  [gi|1833303480|ref|NP_001368849|]
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synaptophysin-like protein 1 isoform k [Homo sapiens]

Protein Classification

MARVEL domain-containing protein( domain architecture ID 10472694)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing protein may be involved in membrane apposition and vesicle-trafficking events

Gene Ontology:  GO:0016020
PubMed:  12468223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 91-185 3.07e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.49  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  91 GDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSlYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATGHNiiD 170
Cdd:pfam01284  32 GSYPSAVNFAVFVAVFSFLIALFFLLLYLFGYS-YFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSENQGSG--D 108

                          90
                  ....*....|....*
gi 1833303480 171 ELPPCKKKAVLCYFG 185
Cdd:pfam01284 109 LTRRCRAAQAAIAFG 123
TRAP_alpha super family cl04314
Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex ...
 49-130 5.18e-03

Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane.


The actual alignment was detected with superfamily member pfam03896:

Pssm-ID: 461085  Cd Length: 279  Bit Score: 36.99  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  49 AVTENKTVT----ATFGYPFRLNEASFQPPPGVNIcDVNWKDYVliGDYSSSAQFYVT--------------FAVFVFLY 110
Cdd:pfam03896 130 ALPYNTVVKpghqATFAYSFIPAEAFAGRPFGLVI-NLNYRDTE--GNQFQEAVFNETvniveveegldgetFFLYVFLA 206

                          90       100
                  ....*....|....*....|
gi 1833303480 111 CIAALLLYVGYTSLYLDSRK 130
Cdd:pfam03896 207 ALVVLLLVGGQQVLESRGKR 226
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 91-185 3.07e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.49  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  91 GDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSlYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATGHNiiD 170
Cdd:pfam01284  32 GSYPSAVNFAVFVAVFSFLIALFFLLLYLFGYS-YFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSENQGSG--D 108

                          90
                  ....*....|....*
gi 1833303480 171 ELPPCKKKAVLCYFG 185
Cdd:pfam01284 109 LTRRCRAAQAAIAFG 123
TRAP_alpha pfam03896
Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex ...
 49-130 5.18e-03

Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane.


Pssm-ID: 461085  Cd Length: 279  Bit Score: 36.99  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  49 AVTENKTVT----ATFGYPFRLNEASFQPPPGVNIcDVNWKDYVliGDYSSSAQFYVT--------------FAVFVFLY 110
Cdd:pfam03896 130 ALPYNTVVKpghqATFAYSFIPAEAFAGRPFGLVI-NLNYRDTE--GNQFQEAVFNETvniveveegldgetFFLYVFLA 206

                          90       100
                  ....*....|....*....|
gi 1833303480 111 CIAALLLYVGYTSLYLDSRK 130
Cdd:pfam03896 207 ALVVLLLVGGQQVLESRGKR 226
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 91-185 3.07e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.49  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  91 GDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSlYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATGHNiiD 170
Cdd:pfam01284  32 GSYPSAVNFAVFVAVFSFLIALFFLLLYLFGYS-YFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSENQGSG--D 108

                          90
                  ....*....|....*
gi 1833303480 171 ELPPCKKKAVLCYFG 185
Cdd:pfam01284 109 LTRRCRAAQAAIAFG 123
TRAP_alpha pfam03896
Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex ...
 49-130 5.18e-03

Translocon-associated protein (TRAP), alpha subunit; The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane.


Pssm-ID: 461085  Cd Length: 279  Bit Score: 36.99  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303480  49 AVTENKTVT----ATFGYPFRLNEASFQPPPGVNIcDVNWKDYVliGDYSSSAQFYVT--------------FAVFVFLY 110
Cdd:pfam03896 130 ALPYNTVVKpghqATFAYSFIPAEAFAGRPFGLVI-NLNYRDTE--GNQFQEAVFNETvniveveegldgetFFLYVFLA 206

                          90       100
                  ....*....|....*....|
gi 1833303480 111 CIAALLLYVGYTSLYLDSRK 130
Cdd:pfam03896 207 ALVVLLLVGGQQVLESRGKR 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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