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Conserved domains on  [gi|1830851349|ref|XP_033236523|]
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neural-cadherin isoform X10 [Drosophila pseudoobscura]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2398-2583 7.17e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 7.17e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2398 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdemliSDFIALELERGYPRLLIDFGSGTLELR 2476
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2477 VKTkkTLDDGEWHRIDLFWDTEDIRMVVDFCKSAEISEmedgtppefddmscqargqiPPFSEYLNVNSPLQVGGLYREQ 2556
Cdd:cd00110     73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                          170       180
                   ....*....|....*....|....*..
gi 1830851349 2557 FDQSLyywhymPTAKGFDGCIRNLVHN 2583
Cdd:cd00110    131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3042-3101 3.04e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.72  E-value: 3.04e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 3042 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3101
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 992-1093 2.83e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.83e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  992 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1071
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1830851349 1072 QGDPSLEGVCSFTVEITDVNDN 1093
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1884-1979 1.10e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1884 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1962
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1830851349 1963 KTATATLTVIVQDINDN 1979
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2650-2810 3.19e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 3.19e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2650 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNSI 2729
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2730 V-VNDGQWHVVRVNRYGSAATLELDGGegrRYNETFEFSGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2808
Cdd:cd00110     75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                   ..
gi 1830851349 2809 RL 2810
Cdd:cd00110    149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1102-1194 6.27e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 6.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1102 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1178
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1830851349 1179 YPPLSRTVEVQIDVVD 1194
Cdd:cd11304     79 GPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1438-1528 7.26e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.26e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1438 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1513
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*.
gi 1830851349 1514 -ENQTTIVINVRDVND 1528
Cdd:cd11304     82 lSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1537-1643 5.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 5.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1537 SYNRTLDEELTTPFTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFT 1616
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 1830851349 1617 VFAQDEGGEGLVGYADVQVNLKDINDN 1643
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1651-1754 1.12e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1651 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1730
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*.
gi 1830851349 1731 VVAMDGGG--LKGTGTASIRVKDIND 1754
Cdd:cd11304     72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 784-872 7.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 7.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  784 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 858
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....
gi 1830851349  859 GVATVRVYTKNKND 872
Cdd:cd11304     84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1325-1429 1.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.44e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1325 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1404
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1405 arpnsNGPNSVTKFIRIGIADKNDN 1429
Cdd:cd11304     79 -----GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 674-771 9.99e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  674 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 750
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 1830851349  751 DSGG--FSTSVDLTIRVTDVNDN 771
Cdd:cd11304     76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 881-983 1.19e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  881 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHSKaitLDR---DKYELNVTAMD 954
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAKP---LDReeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|....*....
gi 1830851349  955 DGSccvngdqTIHTSTAVVVVFITDVNDN 983
Cdd:cd11304     77 GGG-------PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1210-1313 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1210 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1288
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1289 RVENNGAQQLASEATVYIMLEDVND 1313
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2096 6.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1987 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2065
Cdd:cd11304      2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1830851349 2066 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2096
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-644 2.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  568 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 641
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                   ...
gi 1830851349  642 QNG 644
Cdd:cd11304     77 GGG 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-320 5.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 5.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  197 SGEVRENHPAGTRVrgvPLMQAFsgsilDEELAKPKKVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgNDESGVw 276
Cdd:cd11304      3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1830851349  277 LVTNRPLDRELRAHYDLSVEASDVDGLDKTVS-RIQIAVLDENDN 320
Cdd:cd11304     54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2882-2920 1.93e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 60.73  E-value: 1.93e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1830851349 2882 DRNECLDM-PCMNGATCINLEPRlrYRCICPDGFWGENCE 2920
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2363-2393 1.03e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 58.55  E-value: 1.03e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1830851349 2363 CRTNPCHNGGRCIDTRFGPHCSCPVGYTGPR 2393
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1783-1876 3.89e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.89e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1783 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1862
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 1830851349  1863 WVVVKLRDINDNKP 1876
Cdd:smart00112   68 TVTITVLDVNDNAP 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2618-2644 2.29e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 1830851349 2618 CWEHGNCVGSlsEARCHCRPGWTGPAC 2644
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-560 4.24e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   468 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 547
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 1830851349   548 VIILVKDVNDEPP 560
Cdd:smart00112   69 VTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2398-2583 7.17e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 7.17e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2398 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdemliSDFIALELERGYPRLLIDFGSGTLELR 2476
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2477 VKTkkTLDDGEWHRIDLFWDTEDIRMVVDFCKSAEISEmedgtppefddmscqargqiPPFSEYLNVNSPLQVGGLYREQ 2556
Cdd:cd00110     73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                          170       180
                   ....*....|....*....|....*..
gi 1830851349 2557 FDQSLyywhymPTAKGFDGCIRNLVHN 2583
Cdd:cd00110    131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3042-3101 3.04e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.72  E-value: 3.04e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 3042 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3101
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 992-1093 2.83e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.83e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  992 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1071
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1830851349 1072 QGDPSLEGVCSFTVEITDVNDN 1093
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1884-1979 1.10e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1884 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1962
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1830851349 1963 KTATATLTVIVQDINDN 1979
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2419-2585 2.05e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.43  E-value: 2.05e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2419 HLSLEFITRKPDGLIIYNGPIVPperdemliSDFIALELERGYPRLLIDFGSGTLELRVKTKKtLDDGEWHRIDLFWDTE 2498
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2499 DIRMVVDFCKSAEISemedgtppefddmscqargqIPPFSEYLNVNSPLQVGGLYREQFDQSLyywhymPTAKGFDGCIR 2578
Cdd:smart00282   72 SVTLSVDGGNRVSGE--------------------SPGGLTILNLDGPLYLGGLPEDLKLPPL------PVTPGFRGCIR 125


                    ....*..
gi 1830851349  2579 NLVHNSK 2585
Cdd:smart00282  126 NLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2424-2585 3.33e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 111.74  E-value: 3.33e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2424 FITRKPDGLIIYNGPivpperdemLISDFIALELERGYPRLLIDFGSGTLELRVkTKKTLDDGEWHRIDLFWDTEDIRMV 2503
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2504 VDFCKsaeisemedgtppefddmscQARGQIPPFSEYLNVNSPLQVGGLyreqfdQSLYYWHYMPTAKGFDGCIRNLVHN 2583
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 1830851349 2584 SK 2585
Cdd:pfam02210  125 GE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2650-2810 3.19e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 3.19e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2650 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNSI 2729
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2730 V-VNDGQWHVVRVNRYGSAATLELDGGegrRYNETFEFSGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2808
Cdd:cd00110     75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                   ..
gi 1830851349 2809 RL 2810
Cdd:cd00110    149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1102-1194 6.27e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 6.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1102 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1178
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1830851349 1179 YPPLSRTVEVQIDVVD 1194
Cdd:cd11304     79 GPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1438-1528 7.26e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.26e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1438 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1513
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*.
gi 1830851349 1514 -ENQTTIVINVRDVND 1528
Cdd:cd11304     82 lSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1011-1095 3.91e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.91e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1011 VATDEDKGVNGQVKYSIVQQPNqkGTKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPSLEGVCSFTVEITDV 1090
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1830851349  1091 NDNPP 1095
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1537-1643 5.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 5.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1537 SYNRTLDEELTTPFTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFT 1616
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 1830851349 1617 VFAQDEGGEGLVGYADVQVNLKDINDN 1643
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1901-1981 8.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 8.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1901 KATDPDQGGKSKVSYSIDRSSDrQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDN 1979
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1830851349  1980 AP 1981
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1651-1754 1.12e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1651 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1730
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*.
gi 1830851349 1731 VVAMDGGG--LKGTGTASIRVKDIND 1754
Cdd:cd11304     72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 784-872 7.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 7.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  784 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 858
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....
gi 1830851349  859 GVATVRVYTKNKND 872
Cdd:cd11304     84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1325-1429 1.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.44e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1325 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1404
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1405 arpnsNGPNSVTKFIRIGIADKNDN 1429
Cdd:cd11304     79 -----GPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2673-2813 2.38e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 2.38e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2673 QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrtEEKDLWLNSIVVNDGQWHVVRVNRYGSAATLEL 2752
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830851349  2753 DGGEgRRYNETFEfsGHQWLLVDkqEGVYAGGKAEyTGVRTFEVYADYQKSCLDDIRLEGK 2813
Cdd:smart00282   78 DGGN-RVSGESPG--GLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
997-1088 2.23e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 2.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  997 VEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPS 1076
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIDPDTGDISTTKPLDRE--SIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1830851349 1077 LEGVCSFTVEIT 1088
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 674-771 9.99e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  674 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 750
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 1830851349  751 DSGG--FSTSVDLTIRVTDVNDN 771
Cdd:cd11304     76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 881-983 1.19e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  881 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHSKaitLDR---DKYELNVTAMD 954
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAKP---LDReeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|....*....
gi 1830851349  955 DGSccvngdqTIHTSTAVVVVFITDVNDN 983
Cdd:cd11304     77 GGG-------PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1102-1192 3.29e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1102 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRE---TYKLEAMAQDKG 1178
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDREsigEYELTVEATDSG 77

                           90
                   ....*....|....
gi 1830851349 1179 YPPLSRTVEVQIDV 1192
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1438-1523 6.70e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 6.70e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1438 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLNEN 1515
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1830851349 1516 Q---TTIVINV 1523
Cdd:pfam00028   81 LsstATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2678-2813 7.02e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.16  E-value: 7.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2678 FRTREEYGELFrVSDQHNREYGILEIKDGHLHFRYNLNSLRTEekdLWLNSIVVNDGQWHVVRVNRYGSAATLELDGGEG 2757
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVNGRLVLRYDLGSGPES---LLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1830851349 2758 RRYNETFEFsghqwLLVDKQEGVYAGGkAEYTGVRTFEVYADYQKSCLDDIRLEGK 2813
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1120-1200 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1120 SASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRET---YKLEAMAQDKGYPPLSRTVEVQIDVVDRA 1196
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEqpeYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1830851349  1197 NNPP 1200
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1556-1645 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1556 TATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADVQV 1635
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 1830851349  1636 NLKDINDNAP 1645
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1884-1974 1.24e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1884 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIdRSSDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILAIDDGSPP 1962
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1830851349 1963 KTATATLTVIVQ 1974
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1210-1313 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1210 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1288
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1289 RVENNGAQQLASEATVYIMLEDVND 1313
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1676-1757 6.80e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.80e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1676 DPNEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDIN 1753
Cdd:smart00112    4 DADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVN 77


                    ....
gi 1830851349  1754 DMPP 1757
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1454-1531 1.13e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.13e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1454 TVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN---ENQTTIVINVRDVNDLP 1530
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNA 80


                    .
gi 1830851349  1531 P 1531
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
785-865 1.57e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  785 VDEDIPLGTSILRVKAMDSDSGSNAEIEYLVS----DDHFAVD-SNGIIVNNKQLDADNNNaYYEFIVTAKDKGEPPKSG 859
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggpGGNFRIDpDTGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*.
gi 1830851349  860 VATVRV 865
Cdd:pfam00028   84 TATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2096 6.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1987 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2065
Cdd:cd11304      2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1830851349 2066 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2096
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1538-1637 1.15e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 1.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1538 YNRTLDEELTTPFTIMQVTATDgdKDRPQN--IVYFLTGQGIDPdnpansKFDINRTTGEIFVLKPLDRDQpngRPQWRF 1615
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD--PDLGPNgrIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 1830851349 1616 TVFAQDEGGEGLVGYADVQVNL 1637
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1340-1431 1.34e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.34e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1340 NAIDKDGTfPNNQVYYYIVDsprNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSarpnsngPNSVTKFI 1419
Cdd:smart00112    1 SATDADSG-ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-------PLSSTATV 69

                            90
                    ....*....|..
gi 1830851349  1420 RIGIADKNDNPP 1431
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 799-875 1.69e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   799 KAMDSDSGSNAEIEYLVS----DDHFAVDSN-GIIVNNKQLDADNNnAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDE 873
Cdd:smart00112    1 SATDADSGENGKVTYSILsgndDGLFSIDPEtGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1830851349   874 EP 875
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1325-1406 2.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1325 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPRNEgkeFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPS 1404
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 1830851349 1405 AR 1406
Cdd:pfam00028   80 PL 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-644 2.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  568 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 641
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                   ...
gi 1830851349  642 QNG 644
Cdd:cd11304     77 GGG 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-320 5.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 5.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  197 SGEVRENHPAGTRVrgvPLMQAFsgsilDEELAKPKKVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgNDESGVw 276
Cdd:cd11304      3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1830851349  277 LVTNRPLDRELRAHYDLSVEASDVDGLDKTVS-RIQIAVLDENDN 320
Cdd:cd11304     54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1652-1750 6.73e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1652 YFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIeknvIEEETGsPIFEIEPDTGVIKTAVCcLDRERTPDYSIQV 1731
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 1830851349 1732 VAMDGGGLKGTGTASIRVK 1750
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 701-773 7.23e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 7.23e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830851349   701 EIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQphvYSLIVTATeDSGG--FSTSVDLTIRVTDVNDNAP 773
Cdd:smart00112   12 KVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPE---YTLTVEAT-DGGGppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 233-322 1.82e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 1.82e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   233 KVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgNDESGvWLVTNRPLDRELRAHYDLSVEASDVDGLDK-TVSRIQ 311
Cdd:smart00112   12 KVTYSILSGNDDGLFSI--------------------DPETG-EITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVT 70

                            90
                    ....*....|.
gi 1830851349   312 IAVLDENDNRP 322
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1209-1306 2.81e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1209 PIYVKENMPVGGKVVSIKASSGIEG-NPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLT 1287
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-----GPGGNFRID--PDTGD----ISTTKPLDRESIGEYELT 70

                           90
                   ....*....|....*....
gi 1830851349 1288 IRVENNGAQQLASEATVYI 1306
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2005-2096 6.18e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.18e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2005 ATDDDDRSKSNgppFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTS 2084
Cdd:smart00112    2 ATDADSGENGK---VTYSILSGNDDGL---FSIDPE----TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 1830851349  2085 TLTVIIGDVNDN 2096
Cdd:smart00112   68 TVTITVLDVNDN 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 900-985 6.48e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.48e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   900 VASDKD-GDN--VRFGFVGGGTSsGQFVIEDITGVIRLhskAITLDRDK---YELNVTAMDdgsccvnGDQTIHTSTAVV 973
Cdd:smart00112    1 SATDADsGENgkVTYSILSGNDD-GLFSIDPETGEITT---TKPLDREEqpeYTLTVEATD-------GGGPPLSSTATV 69

                            90
                    ....*....|..
gi 1830851349   974 VVFITDVNDNKP 985
Cdd:smart00112   70 TITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2882-2920 1.93e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 60.73  E-value: 1.93e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1830851349 2882 DRNECLDM-PCMNGATCINLEPRlrYRCICPDGFWGENCE 2920
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
576-645 3.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 3.28e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830851349  576 NAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 645
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK----PLDREsigeYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1234-1316 4.39e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 4.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1234 NPTVFYRLMPGSTAQtnkfhtfYLQQRPDNGDtwadIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLEDVND 1313
Cdd:smart00112   10 NGKVTYSILSGNDDG-------LFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1830851349  1314 EIP 1316
Cdd:smart00112   79 NAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2363-2393 1.03e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 58.55  E-value: 1.03e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1830851349 2363 CRTNPCHNGGRCIDTRFGPHCSCPVGYTGPR 2393
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2363-2395 1.96e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 1.96e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1830851349 2363 CRT-NPCHNGGRCIDTRFGPHCSCPVGYTGPRCQ 2395
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
882-978 5.87e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 5.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  882 YTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLhskAITLDR---DKYELNVTAMDD 955
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNgrIFYSILGGG-PGGNFRIDPDTGDIST---TKPLDResiGEYELTVEATDS 76

                           90       100
                   ....*....|....*....|...
gi 1830851349  956 GSccvngdqTIHTSTAVVVVFIT 978
Cdd:pfam00028   77 GG-------PPLSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
2882-2920 7.75e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 7.75e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1830851349  2882 DRNECLDM-PCMNGATCINLEPrlRYRCICPDGFW-GENCE 2920
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
675-766 1.98e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  675 YEAEIPENQKKDSDIISIKAKSfADRE----IRYTLKAQGQGaGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 750
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGpngrIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRE---SIGEYELTVEAT- 74

                           90
                   ....*....|....*...
gi 1830851349  751 DSGGF--STSVDLTIRVT 766
Cdd:pfam00028   75 DSGGPplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1783-1876 3.89e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.89e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1783 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1862
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 1830851349  1863 WVVVKLRDINDNKP 1876
Cdd:smart00112   68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
197-315 8.41e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 8.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  197 SGEVRENHPAGTRVRGVplmqafsgSILDEELAKPKKVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgnDESGVW 276
Cdd:pfam00028    2 SASVPENAPVGTEVLTV--------TATDPDLGPNGRIFYSILGGGPGGNFRI---------------------DPDTGD 52

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1830851349  277 LVTNRPLDRELRAHYDLSVEASDVDGLDKT-VSRIQIAVL 315
Cdd:pfam00028   53 ISTTKPLDRESIGEYELTVEATDSGGPPLSsTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1991-2090 1.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1991 LPEHVPP-RKVVEILATDDDDrsKSNGPPFQFRLDPSADDIirasFKVEQDqkgaNGDgmavISSLRSFDREQQKEYMIP 2069
Cdd:pfam00028    5 VPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN----FRIDPD----TGD----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|.
gi 1830851349 2070 IVIKDHGSPAMTGTSTLTVII 2090
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITV 91
EGF_CA smart00179
Calcium-binding EGF-like domain;
2363-2395 1.95e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 1.95e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1830851349  2363 CRT-NPCHNGGRCIDTRFGPHCSCPVGYT-GPRCQ 2395
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2886-2918 8.43e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 8.43e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1830851349 2886 CLDMPCMNGATCINLEPrlRYRCICPDGFWGEN 2918
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 587-645 5.38e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.57  E-value: 5.38e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830851349   587 QARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 645
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTK----PLDREeqpeYTLTVEATDGGGP 61
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2618-2644 2.29e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 1830851349 2618 CWEHGNCVGSlsEARCHCRPGWTGPAC 2644
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 468-560 4.24e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   468 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 547
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 1830851349   548 VIILVKDVNDEPP 560
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-557 5.64e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.83  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  464 RIEFTEADGDTEGKSVFQLEKETDKETFKIRddnpwvtvETNGAVRVKKKWDYEELgpeKTIDFWVIITNMGHNAgikYT 543
Cdd:cd11304     18 TVSATDPDSGENGEVTYSIVSGNEDGLFSID--------PSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LS 83

                           90
                   ....*....|....
gi 1830851349  544 DNQRVIILVKDVND 557
Cdd:cd11304     84 STATVTITVLDVND 97
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2398-2583 7.17e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 7.17e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2398 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdemliSDFIALELERGYPRLLIDFGSGTLELR 2476
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2477 VKTkkTLDDGEWHRIDLFWDTEDIRMVVDFCKSAEISEmedgtppefddmscqargqiPPFSEYLNVNSPLQVGGLYREQ 2556
Cdd:cd00110     73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                          170       180
                   ....*....|....*....|....*..
gi 1830851349 2557 FDQSLyywhymPTAKGFDGCIRNLVHN 2583
Cdd:cd00110    131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3042-3101 3.04e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.72  E-value: 3.04e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 3042 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3101
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 992-1093 2.83e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.83e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  992 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1071
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1830851349 1072 QGDPSLEGVCSFTVEITDVNDN 1093
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1884-1979 1.10e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1884 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1962
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1830851349 1963 KTATATLTVIVQDINDN 1979
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2419-2585 2.05e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.43  E-value: 2.05e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2419 HLSLEFITRKPDGLIIYNGPIVPperdemliSDFIALELERGYPRLLIDFGSGTLELRVKTKKtLDDGEWHRIDLFWDTE 2498
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2499 DIRMVVDFCKSAEISemedgtppefddmscqargqIPPFSEYLNVNSPLQVGGLYREQFDQSLyywhymPTAKGFDGCIR 2578
Cdd:smart00282   72 SVTLSVDGGNRVSGE--------------------SPGGLTILNLDGPLYLGGLPEDLKLPPL------PVTPGFRGCIR 125


                    ....*..
gi 1830851349  2579 NLVHNSK 2585
Cdd:smart00282  126 NLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2424-2585 3.33e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 111.74  E-value: 3.33e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2424 FITRKPDGLIIYNGPivpperdemLISDFIALELERGYPRLLIDFGSGTLELRVkTKKTLDDGEWHRIDLFWDTEDIRMV 2503
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2504 VDFCKsaeisemedgtppefddmscQARGQIPPFSEYLNVNSPLQVGGLyreqfdQSLYYWHYMPTAKGFDGCIRNLVHN 2583
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 1830851349 2584 SK 2585
Cdd:pfam02210  125 GE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2650-2810 3.19e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 3.19e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2650 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNSI 2729
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2730 V-VNDGQWHVVRVNRYGSAATLELDGGegrRYNETFEFSGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2808
Cdd:cd00110     75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                   ..
gi 1830851349 2809 RL 2810
Cdd:cd00110    149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1102-1194 6.27e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 6.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1102 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1178
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1830851349 1179 YPPLSRTVEVQIDVVD 1194
Cdd:cd11304     79 GPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1438-1528 7.26e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.26e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1438 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1513
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*.
gi 1830851349 1514 -ENQTTIVINVRDVND 1528
Cdd:cd11304     82 lSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1011-1095 3.91e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.91e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1011 VATDEDKGVNGQVKYSIVQQPNqkGTKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPSLEGVCSFTVEITDV 1090
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1830851349  1091 NDNPP 1095
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1537-1643 5.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 5.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1537 SYNRTLDEELTTPFTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFT 1616
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 1830851349 1617 VFAQDEGGEGLVGYADVQVNLKDINDN 1643
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1901-1981 8.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 8.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1901 KATDPDQGGKSKVSYSIDRSSDrQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDN 1979
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1830851349  1980 AP 1981
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1651-1754 1.12e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1651 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1730
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*.
gi 1830851349 1731 VVAMDGGG--LKGTGTASIRVKDIND 1754
Cdd:cd11304     72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 784-872 7.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 7.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  784 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 858
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....
gi 1830851349  859 GVATVRVYTKNKND 872
Cdd:cd11304     84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1325-1429 1.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.44e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1325 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1404
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1405 arpnsNGPNSVTKFIRIGIADKNDN 1429
Cdd:cd11304     79 -----GPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2673-2813 2.38e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 2.38e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2673 QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrtEEKDLWLNSIVVNDGQWHVVRVNRYGSAATLEL 2752
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830851349  2753 DGGEgRRYNETFEfsGHQWLLVDkqEGVYAGGKAEyTGVRTFEVYADYQKSCLDDIRLEGK 2813
Cdd:smart00282   78 DGGN-RVSGESPG--GLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
997-1088 2.23e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 2.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  997 VEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPS 1076
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIDPDTGDISTTKPLDRE--SIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1830851349 1077 LEGVCSFTVEIT 1088
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 674-771 9.99e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  674 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 750
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 1830851349  751 DSGG--FSTSVDLTIRVTDVNDN 771
Cdd:cd11304     76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 881-983 1.19e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  881 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHSKaitLDR---DKYELNVTAMD 954
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAKP---LDReeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|....*....
gi 1830851349  955 DGSccvngdqTIHTSTAVVVVFITDVNDN 983
Cdd:cd11304     77 GGG-------PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1102-1192 3.29e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1102 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRE---TYKLEAMAQDKG 1178
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDREsigEYELTVEATDSG 77

                           90
                   ....*....|....
gi 1830851349 1179 YPPLSRTVEVQIDV 1192
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1438-1523 6.70e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 6.70e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1438 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLNEN 1515
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1830851349 1516 Q---TTIVINV 1523
Cdd:pfam00028   81 LsstATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2678-2813 7.02e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.16  E-value: 7.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2678 FRTREEYGELFrVSDQHNREYGILEIKDGHLHFRYNLNSLRTEekdLWLNSIVVNDGQWHVVRVNRYGSAATLELDGGEG 2757
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVNGRLVLRYDLGSGPES---LLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1830851349 2758 RRYNETFEFsghqwLLVDKQEGVYAGGkAEYTGVRTFEVYADYQKSCLDDIRLEGK 2813
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1120-1200 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1120 SASDEDADNNGAIVYSLSapfNPNDLEYFDIQAESGWIVLKKPLDRET---YKLEAMAQDKGYPPLSRTVEVQIDVVDRA 1196
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEqpeYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1830851349  1197 NNPP 1200
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1556-1645 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1556 TATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADVQV 1635
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 1830851349  1636 NLKDINDNAP 1645
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1884-1974 1.24e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1884 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIdRSSDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILAIDDGSPP 1962
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1830851349 1963 KTATATLTVIVQ 1974
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1210-1313 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1210 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1288
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*
gi 1830851349 1289 RVENNGAQQLASEATVYIMLEDVND 1313
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1676-1757 6.80e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.80e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1676 DPNEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDIN 1753
Cdd:smart00112    4 DADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVN 77


                    ....
gi 1830851349  1754 DMPP 1757
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1454-1531 1.13e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.13e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1454 TVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN---ENQTTIVINVRDVNDLP 1530
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNA 80


                    .
gi 1830851349  1531 P 1531
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
785-865 1.57e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  785 VDEDIPLGTSILRVKAMDSDSGSNAEIEYLVS----DDHFAVD-SNGIIVNNKQLDADNNNaYYEFIVTAKDKGEPPKSG 859
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggpGGNFRIDpDTGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*.
gi 1830851349  860 VATVRV 865
Cdd:pfam00028   84 TATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2096 6.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1987 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2065
Cdd:cd11304      2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1830851349 2066 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2096
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1538-1637 1.15e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 1.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1538 YNRTLDEELTTPFTIMQVTATDgdKDRPQN--IVYFLTGQGIDPdnpansKFDINRTTGEIFVLKPLDRDQpngRPQWRF 1615
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD--PDLGPNgrIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 1830851349 1616 TVFAQDEGGEGLVGYADVQVNL 1637
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1340-1431 1.34e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.34e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1340 NAIDKDGTfPNNQVYYYIVDsprNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSarpnsngPNSVTKFI 1419
Cdd:smart00112    1 SATDADSG-ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-------PLSSTATV 69

                            90
                    ....*....|..
gi 1830851349  1420 RIGIADKNDNPP 1431
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 799-875 1.69e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   799 KAMDSDSGSNAEIEYLVS----DDHFAVDSN-GIIVNNKQLDADNNnAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDE 873
Cdd:smart00112    1 SATDADSGENGKVTYSILsgndDGLFSIDPEtGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1830851349   874 EP 875
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1325-1406 2.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1325 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPRNEgkeFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPS 1404
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 1830851349 1405 AR 1406
Cdd:pfam00028   80 PL 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-644 2.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  568 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 641
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                   ...
gi 1830851349  642 QNG 644
Cdd:cd11304     77 GGG 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-320 5.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 5.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  197 SGEVRENHPAGTRVrgvPLMQAFsgsilDEELAKPKKVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgNDESGVw 276
Cdd:cd11304      3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1830851349  277 LVTNRPLDRELRAHYDLSVEASDVDGLDKTVS-RIQIAVLDENDN 320
Cdd:cd11304     54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1652-1750 6.73e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1652 YFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIeknvIEEETGsPIFEIEPDTGVIKTAVCcLDRERTPDYSIQV 1731
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 1830851349 1732 VAMDGGGLKGTGTASIRVK 1750
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 701-773 7.23e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 7.23e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830851349   701 EIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQphvYSLIVTATeDSGG--FSTSVDLTIRVTDVNDNAP 773
Cdd:smart00112   12 KVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPE---YTLTVEAT-DGGGppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 233-322 1.82e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 1.82e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   233 KVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgNDESGvWLVTNRPLDRELRAHYDLSVEASDVDGLDK-TVSRIQ 311
Cdd:smart00112   12 KVTYSILSGNDDGLFSI--------------------DPETG-EITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVT 70

                            90
                    ....*....|.
gi 1830851349   312 IAVLDENDNRP 322
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1209-1306 2.81e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1209 PIYVKENMPVGGKVVSIKASSGIEG-NPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLT 1287
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-----GPGGNFRID--PDTGD----ISTTKPLDRESIGEYELT 70

                           90
                   ....*....|....*....
gi 1830851349 1288 IRVENNGAQQLASEATVYI 1306
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2005-2096 6.18e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.18e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  2005 ATDDDDRSKSNgppFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTS 2084
Cdd:smart00112    2 ATDADSGENGK---VTYSILSGNDDGL---FSIDPE----TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 1830851349  2085 TLTVIIGDVNDN 2096
Cdd:smart00112   68 TVTITVLDVNDN 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 900-985 6.48e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.48e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   900 VASDKD-GDN--VRFGFVGGGTSsGQFVIEDITGVIRLhskAITLDRDK---YELNVTAMDdgsccvnGDQTIHTSTAVV 973
Cdd:smart00112    1 SATDADsGENgkVTYSILSGNDD-GLFSIDPETGEITT---TKPLDREEqpeYTLTVEATD-------GGGPPLSSTATV 69

                            90
                    ....*....|..
gi 1830851349   974 VVFITDVNDNKP 985
Cdd:smart00112   70 TITVLDVNDNAP 81
Laminin_G_1 pfam00054
Laminin G domain;
2424-2588 8.09e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 65.03  E-value: 8.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2424 FITRKPDGLIIYNGPIVPPerdemlisDFIALELERGYPRLLIDFGSGTLELRVKTKktLDDGEWHRIDLFWDTEDIRMV 2503
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--------DFLALELRDGRLEVSYDLGSGAAVVRSGDK--LNDGKWHSVELERNGRSGTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2504 VDFCksaeisEMEDGTPPEFDDMScqargqippfseyLNVNSPLQVGGLYREQFDQSLyywhyMPTAKGFDGCIRNLVHN 2583
Cdd:pfam00054   71 VDGE------ARPTGESPLGATTD-------------LDVDGPLYVGGLPSLGVKKRR-----LAISPSFDGCIRDVIVN 126


                   ....*
gi 1830851349 2584 SKLYD 2588
Cdd:pfam00054  127 GKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2882-2920 1.93e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 60.73  E-value: 1.93e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1830851349 2882 DRNECLDM-PCMNGATCINLEPRlrYRCICPDGFWGENCE 2920
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
576-645 3.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 3.28e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830851349  576 NAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 645
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK----PLDREsigeYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1234-1316 4.39e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 4.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1234 NPTVFYRLMPGSTAQtnkfhtfYLQQRPDNGDtwadIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLEDVND 1313
Cdd:smart00112   10 NGKVTYSILSGNDDG-------LFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1830851349  1314 EIP 1316
Cdd:smart00112   79 NAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2363-2393 1.03e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 58.55  E-value: 1.03e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1830851349 2363 CRTNPCHNGGRCIDTRFGPHCSCPVGYTGPR 2393
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2363-2395 1.96e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 1.96e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1830851349 2363 CRT-NPCHNGGRCIDTRFGPHCSCPVGYTGPRCQ 2395
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
882-978 5.87e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 5.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  882 YTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLhskAITLDR---DKYELNVTAMDD 955
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNgrIFYSILGGG-PGGNFRIDPDTGDIST---TKPLDResiGEYELTVEATDS 76

                           90       100
                   ....*....|....*....|...
gi 1830851349  956 GSccvngdqTIHTSTAVVVVFIT 978
Cdd:pfam00028   77 GG-------PPLSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
2882-2920 7.75e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 7.75e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1830851349  2882 DRNECLDM-PCMNGATCINLEPrlRYRCICPDGFW-GENCE 2920
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
Laminin_G_1 pfam00054
Laminin G domain;
2678-2815 2.03e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.10  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2678 FRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNL--NSLRTEEKDLwlnsivVNDGQWHVVRVNRYGSAATLELDGG 2755
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLgsGAAVVRSGDK------LNDGKWHSVELERNGRSGTLSVDGE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 2756 EGRRYNEtfEFSGHQWLLVDKQegVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHL 2815
Cdd:pfam00054   75 ARPTGES--PLGATTDLDVDGP--LYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPL 130
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2363-2395 3.09e-09

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 54.40  E-value: 3.09e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1830851349 2363 CRT-NPCHNGGRCIDTRFGPHCSCPVGYTGP-RCQ 2395
Cdd:cd00053      2 CAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
675-766 1.98e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  675 YEAEIPENQKKDSDIISIKAKSfADRE----IRYTLKAQGQGaGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 750
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGpngrIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRE---SIGEYELTVEAT- 74

                           90
                   ....*....|....*...
gi 1830851349  751 DSGGF--STSVDLTIRVT 766
Cdd:pfam00028   75 DSGGPplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1783-1876 3.89e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.89e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  1783 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1862
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 1830851349  1863 WVVVKLRDINDNKP 1876
Cdd:smart00112   68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
197-315 8.41e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 8.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  197 SGEVRENHPAGTRVRGVplmqafsgSILDEELAKPKKVRYTIIDGNVDDAFALqerkanqnvqlnarslvidgnDESGVW 276
Cdd:pfam00028    2 SASVPENAPVGTEVLTV--------TATDPDLGPNGRIFYSILGGGPGGNFRI---------------------DPDTGD 52

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1830851349  277 LVTNRPLDRELRAHYDLSVEASDVDGLDKT-VSRIQIAVL 315
Cdd:pfam00028   53 ISTTKPLDRESIGEYELTVEATDSGGPPLSsTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1991-2090 1.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349 1991 LPEHVPP-RKVVEILATDDDDrsKSNGPPFQFRLDPSADDIirasFKVEQDqkgaNGDgmavISSLRSFDREQQKEYMIP 2069
Cdd:pfam00028    5 VPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN----FRIDPD----TGD----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|.
gi 1830851349 2070 IVIKDHGSPAMTGTSTLTVII 2090
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITV 91
EGF_CA smart00179
Calcium-binding EGF-like domain;
2363-2395 1.95e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 1.95e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1830851349  2363 CRT-NPCHNGGRCIDTRFGPHCSCPVGYT-GPRCQ 2395
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2885-2920 7.49e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 47.86  E-value: 7.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1830851349 2885 ECLDM-PCMNGATCINLEPRlrYRCICPDGFWGE-NCE 2920
Cdd:cd00053      1 ECAASnPCSNGGTCVNTPGS--YRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2886-2918 8.43e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 8.43e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1830851349 2886 CLDMPCMNGATCINLEPrlRYRCICPDGFWGEN 2918
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTGKR 31
EGF smart00181
Epidermal growth factor-like domain;
2363-2395 2.73e-06

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 46.36  E-value: 2.73e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1830851349  2363 CRT-NPCHNGgRCIDTRFGPHCSCPVGYTG-PRCQ 2395
Cdd:smart00181    2 CASgGPCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 587-645 5.38e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.57  E-value: 5.38e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830851349   587 QARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 645
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTK----PLDREeqpeYTLTVEATDGGGP 61
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 672-771 4.17e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.64  E-value: 4.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  672 MPSYEAeiPENQKKDSDIISIKAKSFADREIRYTLKAQGQGA--GTFNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTAT 749
Cdd:cd00031      1 IPDGSA--VEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                           90       100
                   ....*....|....*....|..
gi 1830851349  750 EDSggFSTSVDLTIRVTDVNDN 771
Cdd:cd00031     79 ANV--PQTSSVFSIEVYDENDN 98
Cadherin_3 pfam16184
Cadherin-like;
548-637 4.89e-05

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 44.90  E-value: 4.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  548 VIILVKDVNDEPPY-FINRPLPMQ--AVVQLNAppntpvFTLQARDPDT-DHNIHYFIVRDRTGGRFEVDERSGVVRTRG 623
Cdd:pfam16184    7 FNITIIPVNDEAPVlTTNTGLRLWegSSRPITP------DLLQAEDPDTpPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90
                   ....*....|....
gi 1830851349  624 TdLFQLDMEYVLYV 637
Cdd:pfam16184   81 T-QADIDSGLVVYV 93
EGF smart00181
Epidermal growth factor-like domain;
2885-2920 9.82e-05

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 41.73  E-value: 9.82e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1830851349  2885 ECLDM-PCMNGaTCINLEPRlrYRCICPDGFWG-ENCE 2920
Cdd:smart00181    1 ECASGgPCSNG-TCINTPGS--YTCSCPPGYTGdKRCE 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2368-2389 1.12e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 41.55  E-value: 1.12e-04
                           10        20
                   ....*....|....*....|..
gi 1830851349 2368 CHNGGRCIDTRFGPHCSCPVGY 2389
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2618-2644 2.29e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 1830851349 2618 CWEHGNCVGSlsEARCHCRPGWTGPAC 2644
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 468-560 4.24e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349   468 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 547
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 1830851349   548 VIILVKDVNDEPP 560
Cdd:smart00112   69 VTITVLDVNDNAP 81
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2891-2914 1.17e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 1.17e-03
                           10        20
                   ....*....|....*....|....
gi 1830851349 2891 CMNGATCINLEPRlrYRCICPDGF 2914
Cdd:pfam12661    1 CQNGGTCVDGVNG--YKCQCPPGY 22
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2368-2394 3.14e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 3.14e-03
                           10        20
                   ....*....|....*....|....*..
gi 1830851349 2368 CHNGGRCIDTRFGphCSCPVGYTGPRC 2394
Cdd:pfam07974    2 CSGRGTCVNQCGK--CVCDSGYQGATC 26
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-557 5.64e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.83  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830851349  464 RIEFTEADGDTEGKSVFQLEKETDKETFKIRddnpwvtvETNGAVRVKKKWDYEELgpeKTIDFWVIITNMGHNAgikYT 543
Cdd:cd11304     18 TVSATDPDSGENGEVTYSIVSGNEDGLFSID--------PSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LS 83

                           90
                   ....*....|....
gi 1830851349  544 DNQRVIILVKDVND 557
Cdd:cd11304     84 STATVTITVLDVND 97
Cadherin_3 pfam16184
Cadherin-like;
1303-1363 6.12e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.12  E-value: 6.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1830851349 1303 TVYIMLEDVNDEIPLFTEREQETVLEGE--PIGTKvtQVNAIDKDgTfPNNQVYYYIVDSPRN 1363
Cdd:pfam16184    6 TFNITIIPVNDEAPVLTTNTGLRLWEGSsrPITPD--LLQAEDPD-T-PPEDLTYTVVQGPSH 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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