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Conserved domains on  [gi|1829551757|gb|QIV89852|]
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ROK family protein [Enterococcus hirae]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 7-255 5.59e-62

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24152:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 286  Bit Score: 196.63  E-value: 5.59e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   7 DLKNYLNEQQQYLD--ISGVGISLPGVIN-HDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNG 83
Cdd:cd24152    38 EFLDYIKKIIKRYDeeIDGIAISAPGVIDpETGIIYGGGALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  84 ANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGreNQEYKLNSTSLHAGvVGGLCRKYSLAIGKEVKDAKY 163
Cdd:cd24152   118 KGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD--DDDKDLLFFSGLAS-MFGLVKRYNKAKGLEPLDGEE 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 164 IFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHeyRVLSSVQMPQVIPC 243
Cdd:cd24152   195 IFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGGGISEQPLFIEDLKKEVNEILA--NRPGSIPKPEIKAC 272

                         250
                  ....*....|..
gi 1829551757 244 KLANDAGVIGSV 255
Cdd:cd24152   273 KFGNDANLLGAL 284
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 7-255 5.59e-62

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 196.63  E-value: 5.59e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   7 DLKNYLNEQQQYLD--ISGVGISLPGVIN-HDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNG 83
Cdd:cd24152    38 EFLDYIKKIIKRYDeeIDGIAISAPGVIDpETGIIYGGGALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  84 ANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGreNQEYKLNSTSLHAGvVGGLCRKYSLAIGKEVKDAKY 163
Cdd:cd24152   118 KGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD--DDDKDLLFFSGLAS-MFGLVKRYNKAKGLEPLDGEE 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 164 IFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHeyRVLSSVQMPQVIPC 243
Cdd:cd24152   195 IFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGGGISEQPLFIEDLKKEVNEILA--NRPGSIPKPEIKAC 272

                         250
                  ....*....|..
gi 1829551757 244 KLANDAGVIGSV 255
Cdd:cd24152   273 KFGNDANLLGAL 284
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 20-253 6.63e-51

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 168.92  E-value: 6.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  20 DISGVGISLPGVINHD-GTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAI 98
Cdd:COG1940    66 RILGIGIGVPGPVDPEtGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGI 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  99 GGAIVIDRKLYWGQGGLAGEFG-VSLMGRENQEYKLNSTSLHAgVVGG--LCRKYSLAIGKEVKDAKYIFDLAAQKDALA 175
Cdd:COG1940   146 GGGIVINGKLLRGANGNAGEIGhMPVDPDGPLCGCGNRGCLET-YASGpaLLRRARELGGAEKLTAEELFAAARAGDPLA 224

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1829551757 176 KKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQ-IMAEIQAVytriIHEYRVLSSVQMPQVIPCKLANDAGVIG 253
Cdd:COG1940   225 LEVLDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDlLLEPIREA----LAKYALPPAREDPRIVPASLGDDAGLLG 299
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 12-253 3.84e-32

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 119.75  E-value: 3.84e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  12 LNEQQQYLD-ISGVGISLPGVINHDgtMQTAGSLKKLIGLN--VKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSN 88
Cdd:pfam00480  46 VDSAQRKFGeLIAVGIGSPGLISPK--YGYITNTPNIGWDNfdLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  89 YVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGRENQEyklnSTSLHAGVVGGLC-----RKYSLAIGKEVkDAKY 163
Cdd:pfam00480 124 VIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLDPNGPK----CGCGNHGCLETIAsgralEKRYQQKGEDL-EGKD 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 164 IFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHEYrvlSSVQMPQVIPC 243
Cdd:pfam00480 199 IIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGGGVSNADGLLEAIRSLVKKYLNGY---LPVPPVIIVAA 275

                         250
                  ....*....|
gi 1829551757 244 KLANDAGVIG 253
Cdd:pfam00480 276 SLGDNAGALG 285
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 3-254 9.36e-15

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 72.33  E-value: 9.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   3 QILTDLKNYLNEQQQYLDISG-VGISLPGVINH-DGTMQTAgslkkliglNV-----KEIAQD---HLQLPVEIITDSKA 72
Cdd:PRK13310   38 AFLDAVCELVAEADQRFGCKGsVGIGIPGMPETeDGTLYAA---------NVpaasgKPLRADlsaRLGRDVRLDNDANC 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  73 VALAEGWLGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG--------VSLMGRENQEYKL---NSTSLHAG 141
Cdd:PRK13310  109 FALSEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRSYITGEFGhmrlpvdaLTLLGWDAPLRRCgcgQKGCIENY 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 142 VVG-GLCRKYSLAIGkEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQA 220
Cdd:PRK13310  189 LSGrGFEWLYQHYYG-EPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLSNFDAIYEQLPK 267

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1829551757 221 VYTRiiheyRVLSSVQMPQVIPCKLANDAGVIGS 254
Cdd:PRK13310  268 RLPR-----HLLPVARVPRIEKARHGDAGGVRGA 296
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 7-255 5.59e-62

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 196.63  E-value: 5.59e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   7 DLKNYLNEQQQYLD--ISGVGISLPGVIN-HDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNG 83
Cdd:cd24152    38 EFLDYIKKIIKRYDeeIDGIAISAPGVIDpETGIIYGGGALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  84 ANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGreNQEYKLNSTSLHAGvVGGLCRKYSLAIGKEVKDAKY 163
Cdd:cd24152   118 KGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD--DDDKDLLFFSGLAS-MFGLVKRYNKAKGLEPLDGEE 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 164 IFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHeyRVLSSVQMPQVIPC 243
Cdd:cd24152   195 IFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGGGISEQPLFIEDLKKEVNEILA--NRPGSIPKPEIKAC 272

                         250
                  ....*....|..
gi 1829551757 244 KLANDAGVIGSV 255
Cdd:cd24152   273 KFGNDANLLGAL 284
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 4-257 8.82e-54

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 175.82  E-value: 8.82e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   4 ILTDLKNYLNEQQQYLDISGVGISLPGVINHD-GT-MQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLG 81
Cdd:cd24068    40 ILERLLEIIAELKEKYDIEGIGISSAGQVDPKtGEvIYATDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLG 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  82 NGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGREnqeyKLNSTSLHAGVVG------GLCRKYSLAIG 155
Cdd:cd24068   120 AAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDPG----GRPCCCGGKGCLEqyasgtALVRRVAEALG 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 156 KEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNIsVYI-APEAILIGGGVSGNSQIMAE--IQAVYTRIIHEYRvl 232
Cdd:cd24068   196 EPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANL-VHIfDPEVIVIGGGISAQGELFLEelREELRKLLMPPLL-- 272

                         250       260
                  ....*....|....*....|....*
gi 1829551757 233 ssvQMPQVIPCKLANDAGVIGSVKQ 257
Cdd:cd24068   273 ---DATKIEPAKLGNDAGLLGAAYL 294
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 20-253 6.63e-51

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 168.92  E-value: 6.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  20 DISGVGISLPGVINHD-GTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAI 98
Cdd:COG1940    66 RILGIGIGVPGPVDPEtGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGI 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  99 GGAIVIDRKLYWGQGGLAGEFG-VSLMGRENQEYKLNSTSLHAgVVGG--LCRKYSLAIGKEVKDAKYIFDLAAQKDALA 175
Cdd:COG1940   146 GGGIVINGKLLRGANGNAGEIGhMPVDPDGPLCGCGNRGCLET-YASGpaLLRRARELGGAEKLTAEELFAAARAGDPLA 224

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1829551757 176 KKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQ-IMAEIQAVytriIHEYRVLSSVQMPQVIPCKLANDAGVIG 253
Cdd:COG1940   225 LEVLDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDlLLEPIREA----LAKYALPPAREDPRIVPASLGDDAGLLG 299
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 3-253 2.47e-32

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 118.72  E-value: 2.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   3 QILTDLKNYLNEQQQYLDISGVGISLPGVINHD-GTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLG 81
Cdd:cd23763    41 RIAELIEELLAEAGVRERILGIGIGVPGPVDPEtGIVLFAPNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  82 NGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGvslmgrenqeyklnstslHAGVvgglcrkyslaigkevkda 161
Cdd:cd23763   121 AGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG------------------HITV------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 162 kyifdlaaqkdalakkyVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQ-IMAEIQavytRIIHEYRVLSSVQMPQV 240
Cdd:cd23763   164 -----------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDlLLEPIR----EAVRRRALPPLRRRVRI 222

                         250
                  ....*....|...
gi 1829551757 241 IPCKLANDAGVIG 253
Cdd:cd23763   223 VPSELGDDAGLLG 235
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 12-253 3.84e-32

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 119.75  E-value: 3.84e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  12 LNEQQQYLD-ISGVGISLPGVINHDgtMQTAGSLKKLIGLN--VKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSN 88
Cdd:pfam00480  46 VDSAQRKFGeLIAVGIGSPGLISPK--YGYITNTPNIGWDNfdLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  89 YVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGRENQEyklnSTSLHAGVVGGLC-----RKYSLAIGKEVkDAKY 163
Cdd:pfam00480 124 VIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLDPNGPK----CGCGNHGCLETIAsgralEKRYQQKGEDL-EGKD 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 164 IFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHEYrvlSSVQMPQVIPC 243
Cdd:pfam00480 199 IIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGGGVSNADGLLEAIRSLVKKYLNGY---LPVPPVIIVAA 275

                         250
                  ....*....|
gi 1829551757 244 KLANDAGVIG 253
Cdd:pfam00480 276 SLGDNAGALG 285
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 2-256 2.99e-28

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 109.69  E-value: 2.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   2 TQILTDLKNYLNEQQQYL-DISGVGISLPGVIN-HDGTMQTAGSLKkLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGW 79
Cdd:cd24062    42 TDIAESIQQLLEELGYSKeDLIGIGVGVPGPVDvETGTVEVAVNLG-WKNFPLKDKLEALTGIPVVIDNDANAAALGEMW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  80 LGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG-----------------------VSLMG--RENQEYKLN 134
Cdd:cd24062   121 KGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIGhitvnpeggapcncgktgcletvASATGivRIAREELEE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 135 STSLHagvvgglcRKYSLAIGKEVkDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVS-GNSQ 213
Cdd:cd24062   201 GKGSS--------ALRILALGGEL-TAKDVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKIVIGGGVSaAGEF 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1829551757 214 IMAEIQAVYTRiiheYRVLSSVQMPQVIPCKLANDAGVIGSVK 256
Cdd:cd24062   272 LLSPVKEYFDR----FTFPRVRQDTEIVLATLGNDAGVIGAAW 310
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 24-253 3.74e-28

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 109.24  E-value: 3.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  24 VGISLPGVIN-HDGTMQTAgSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIGGAI 102
Cdd:cd24057    60 VGIGIPGVIDpEDGTLITA-NIPAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 103 VIDRKLYWGQGGLAGEFGvslmgrenqEYKLNSTSLHAG------------------VVG--GLCRKYSlAIGKEVKDAK 162
Cdd:cd24057   139 VVNGRLVGGRSGIAGEWG---------HGPLPADALLLGydlpvlrcgcgqtgcletYLSgrGLERLYA-HLYGEELDAP 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 163 YIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRiiheyRVLSSVQMPQVIP 242
Cdd:cd24057   209 EIIAAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGGGLSNFPALIAELPAALPA-----HLLSGARTPRIVP 283

                         250
                  ....*....|.
gi 1829551757 243 CKLANDAGVIG 253
Cdd:cd24057   284 ARHGDAGGVRG 294
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 1-261 8.10e-25

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 100.35  E-value: 8.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   1 MTQILTDLKNYLNEQQQYLDISGVGISLPGVIN-HDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGW 79
Cdd:cd24059    42 LEKLYELIDRLLEKENIKSKILGIGIGAPGPLDvEKGIILNPPNFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKW 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  80 LGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGReNQEYKLNSTS----LHAGvVGGLCRKYSLAIG 155
Cdd:cd24059   122 YGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIGHTSIDI-NGPRCSCGNRgcleLYAS-IPAIEKKARSALG 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 156 KEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGG-GVSGNSQIMAEIQavytRIIHEYRVLSS 234
Cdd:cd24059   200 SGRSFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNLINLLNPEAIIIGGeLIYLGERYLEPIE----KEVNSRLFGRN 275

                         250       260
                  ....*....|....*....|....*..
gi 1829551757 235 VQMPQVIPCKLANDAGVIGSVKQIIDM 261
Cdd:cd24059   276 AREVRILKSSLGEDAPLLGAAALVLNK 302
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 19-260 1.88e-24

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 99.18  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  19 LDISGVGISLPGVINH-DGTMQTAGSLKkLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSA 97
Cdd:cd24076    61 LGILGIGVGVPGLVDSeDGVVLLAPNLG-WRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  98 IGGAIVIDRKLYWGQGGLAGEFGvslmgrenqeyklnstslHAGVV--GGLC------------------RKYSLAIGK- 156
Cdd:cd24076   140 IGAGIILDGELYRGASGFAGEIG------------------HMTVDpdGPPCscgnrgcwetyaserallRAAGRLGAGg 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 157 EVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSG-NSQIMAEIQAVYTRiiheyRVLSSV 235
Cdd:cd24076   202 EPLSLAELVEAARAGDPAALAALEEVGEYLGIGLANLVNTFNPELVVLGGALAPlGPWLLPPLRAEVAR-----RALPAP 276

                         250       260
                  ....*....|....*....|....*.
gi 1829551757 236 Q-MPQVIPCKLANDAGVIGSVKQIID 260
Cdd:cd24076   277 ArDVRIVVSRLGEDAAALGAAALAID 302
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 13-253 2.59e-23

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 96.27  E-value: 2.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  13 NEQQQYLDISGVGISLPGVINHD-GTMQTAGSLKkLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVC 91
Cdd:cd24061    46 EELREGHDVSAVGVAAAGFVDADrATVLFAPNIA-WRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVM 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  92 VTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLM--------------------GRENQEYklnSTSLHAGVVGGLCRKYS 151
Cdd:cd24061   125 ITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIRVvpdgllcgcgsrgcweqyasGRALVRY---AKEAANATPEGAAVLLA 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 152 LAIGKEVKdAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQ-IMAEIQAVYTR--IIHE 228
Cdd:cd24061   202 DGSVDGIT-GKHISEAARAGDPVALDALRELARWLGAGLASLAALLDPELFVIGGGVSDAGDlLLDPIREAFERwlPGRG 280

                         250       260
                  ....*....|....*....|....*
gi 1829551757 229 YRvlssvQMPQVIPCKLANDAGVIG 253
Cdd:cd24061   281 WR-----PIPRLRTAQLGNDAGLIG 300
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 23-260 4.25e-23

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 95.81  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  23 GVGISLPGVINHDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIGGAI 102
Cdd:cd24071    64 GIGIAVSGLVDSKKGIVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 103 VIDRKLYWGQGGLAGEFGVSLMgrenqeyKLNSTSLHAGVVGGLCRKYSL-AIGKEVKDAK-----------------YI 164
Cdd:cd24071   144 VIDGKLYTGNFGGAGEIGHMTI-------QPDGRKCYCGQKGCLEAYASFeALVNEIKELTesyplsllkeledfeieKV 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 165 FDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGgvsgnsQIMAEIQAVYTRIIHEYRVLSSVQMPQVIPCK 244
Cdd:cd24071   217 REAAEEGDSVATELFKKAGEYLGIGIKNLINIFNPEAIIIGG------EGLEFKDYFLPKIIEIAKENFFGKAGRNVIIL 290

                         250
                  ....*....|....*....
gi 1829551757 245 ---LANDAGVIGSVKQIID 260
Cdd:cd24071   291 vdsLGEDAWVLGAALLVID 309
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 20-253 1.30e-20

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 88.94  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  20 DISGVGISLPG-VINHDGTMQTAGSLK-KLIGLnvKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSA 97
Cdd:cd24063    59 SIEGIGVSSAGpLDLRKGTIVNSPNIKgKEIPL--VEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTG 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  98 IGGAIVIDRKLYWGQGGLAGEFG----------------------------VSLMGRENQEYKLNSTSLHAGVVGGlcrk 149
Cdd:cd24063   137 IGGGVIVDGRLLLGKNGNAAEVGhlvvdtesglkcgcggyghweafasgrgIPRFAREWAEGFSSRTSLKLRNPGG---- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 150 yslaigkEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEiqavytRIIHEY 229
Cdd:cd24063   213 -------EGITAKEVFSAARKGDPLALKIIEKLARYNGRGIANVINAYDPELIVIGGSVFNNNKDILD------PLIEYL 279

                         250       260
                  ....*....|....*....|....*
gi 1829551757 230 -RVLSSVQMPQVIPCKLANDAGVIG 253
Cdd:cd24063   280 eKNPAISKGPEIVLSELGDDVGLIG 304
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 24-253 3.83e-20

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 87.26  E-value: 3.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  24 VGISLPGVIN-HDGTMQTAGSLKkLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIGGAI 102
Cdd:cd24066    59 VGIGTPGSISpRTGLVKNANSTW-LNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 103 VIDRKLYWGQGGLAGEFGVSLMGREnQEYKLNSTSLHAGVVG---------GLCRKYSLAIGKEVKdAKYIFDLAAQKDA 173
Cdd:cd24066   138 VVNGRVLTGANGIAGEWGHNPLPWP-DEDELPGPPCYCGKRGcvetflsgpALERDYARLTGKTLS-AEEIVALARAGDA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 174 LAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSgnsqimaEIQAVYTRIIHEYR--VLSSVQMPQVIPCKLANDAGV 251
Cdd:cd24066   216 AAVATLDRFLDRLGRALANVINILDPDVIVLGGGLS-------NIDELYTEGPAALAryVFSDEVETPIVKNKHGDSSGV 288


                  ..
gi 1829551757 252 IG 253
Cdd:cd24066   289 RG 290
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 24-253 4.99e-20

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 87.00  E-value: 4.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  24 VGISLPGVINH-DGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLG--NGANYSNYVCVTLGsaIGG 100
Cdd:cd24065    59 VGLGVPGPLDFrRGRVRFAPNIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGaaRGTESSVYVTISTG--IGG 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 101 AIVIDRKLYWGQGGLAGEFGVSLMGrenqeykLNSTSLHAGVVGGL---------CRKYSLAIGKEVKDAKyIFDLAAQK 171
Cdd:cd24065   137 GLVLGGRVLRGRHGQAGEIGHTTVL-------PGGPMCGCGLVGCLealasgralARDASFAYGRPMSTAE-LFELAQQG 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 172 DALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAE-IQAVYTRIIHEYRVlssvqmPQVIPCKLANDAG 250
Cdd:cd24065   209 EPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLpVQEAARRYTEGWHA------PPLRLAHLGTDAG 282


                  ...
gi 1829551757 251 VIG 253
Cdd:cd24065   283 VIG 285
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 12-254 3.24e-19

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 84.86  E-value: 3.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  12 LNEQQQYLDISGVGISLPGVINH-DGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYV 90
Cdd:cd24064    47 VNELIEEMELLGIGIGSPGSIDReNGIVRFSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHII 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  91 CVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLM---------GRENQEYKLNSTSLHAGVVGGLCRKY--SLAIGKEVK 159
Cdd:cd24064   127 GLTLGTGVGSGVICHGQLLTGYDGIAAELGHVIVepngpicgcGNRGCVEAFASATAIIRYARESRKRYpdSLAGESEKI 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 160 DAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAE-IQAVYtriiHEYRVLSSVQMP 238
Cdd:cd24064   207 NAKHVFDAARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDpIREKT----KKYVMLSFQDTY 282

                         250
                  ....*....|....*.
gi 1829551757 239 QVIPCKLANDAGVIGS 254
Cdd:cd24064   283 SIELSNLVEDAGILGA 298
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 24-253 1.49e-18

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 82.72  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  24 VGISLPGVINHDGTmqTAGSLKKLIGLNVKEIA---QDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIGG 100
Cdd:cd24069    55 VAVASTGIIRDGVL--TALNPKNLGGLSGFPLAdalQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 101 AIVIDRKLYWGQGGLAGEFGvslmgrenqeyklNSTSLHAGVVGGLCR--------------KYSLAIGKEVKDAKYIFD 166
Cdd:cd24069   133 GLVLNGQLLTGPNGLAGHIG-------------HTLADPPGPVCGCGRrgcveaiasgtaiaAAASEILGEPVDAKDVFE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 167 LAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHEYRVLssvqmpqVIPCKLA 246
Cdd:cd24069   200 RARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIGGSVGLAEGFLERVEQYLADEPAIFRVS-------LEPARLG 272


                  ....*..
gi 1829551757 247 NDAGVIG 253
Cdd:cd24069   273 QDAGLLG 279
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 20-120 5.68e-17

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 78.75  E-value: 5.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  20 DISGVGISLPGVINHDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIG 99
Cdd:cd24073    61 RLLGIGVGLPGLVDAETGICRWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIG 140

                          90       100
                  ....*....|....*....|.
gi 1829551757 100 GAIVIDRKLYWGQGGLAGEFG 120
Cdd:cd24073   141 CGLVVDGRLYRGAHGGAGEIG 161
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 2-218 6.07e-16

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 75.65  E-value: 6.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   2 TQILTDLKNYLNEQQQYLD-----ISGVGISLPGVINHDGTMQTAGSLkkLIGLNVKEIAQDHLQLPVEIITDSKAVALA 76
Cdd:cd24077    38 ENILEILKSIIQELISQAPktpygLVGIGIGIHGIVDENEIIFTPYYD--LEDIDLKEKLEEKFNVPVYLENEANLSALA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  77 EGWLGNgaNYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLM---GRE----NQ----EYKLNSTslhagvvgg 145
Cdd:cd24077   116 ERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIGHMIIvpnGKPcpcgNKgcleQYASEKA--------- 184

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829551757 146 LCRKYSLAIGKEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIgggvsgNSQIMAEI 218
Cdd:cd24077   185 LLKELSEKKGLETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIINTFNPEIIII------NSSLINEI 251
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 3-254 9.36e-15

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 72.33  E-value: 9.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   3 QILTDLKNYLNEQQQYLDISG-VGISLPGVINH-DGTMQTAgslkkliglNV-----KEIAQD---HLQLPVEIITDSKA 72
Cdd:PRK13310   38 AFLDAVCELVAEADQRFGCKGsVGIGIPGMPETeDGTLYAA---------NVpaasgKPLRADlsaRLGRDVRLDNDANC 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  73 VALAEGWLGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG--------VSLMGRENQEYKL---NSTSLHAG 141
Cdd:PRK13310  109 FALSEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRSYITGEFGhmrlpvdaLTLLGWDAPLRRCgcgQKGCIENY 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 142 VVG-GLCRKYSLAIGkEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQA 220
Cdd:PRK13310  189 LSGrGFEWLYQHYYG-EPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLSNFDAIYEQLPK 267

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1829551757 221 VYTRiiheyRVLSSVQMPQVIPCKLANDAGVIGS 254
Cdd:PRK13310  268 RLPR-----HLLPVARVPRIEKARHGDAGGVRGA 296
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 1-253 7.10e-14

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 69.94  E-value: 7.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   1 MTQILTDLKNylneqqqylDISGVGISLPGVINHDGTmqTAGSLKKLIGLN---VKEIAQDHLQLPVEIITDSKAVALAE 77
Cdd:PRK05082   45 LSALVSPLQA---------QADRVAVASTGIINDGIL--TALNPHNLGGLLhfpLVQTLEQLTDLPTIALNDAQAAAWAE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  78 gWLGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLmgrenqeyklnstslhAGVVGGLC---RKYSL-- 152
Cdd:PRK05082  114 -YQALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTL----------------ADPHGPVCgcgRRGCVea 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 153 -----AIGKEVK------DAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAV 221
Cdd:PRK05082  177 iasgrAIAAAAQgwlagcDAKTIFERAGQGDEQAQALINRSAQAIARLIADLKATLDCQCVVLGGSVGLAEGYLELVQAY 256

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1829551757 222 YTRIIHEYRVlssvqmpQVIPCKLANDAGVIG 253
Cdd:PRK05082  257 LAQEPAIYHV-------PLLAAHYRHDAGLLG 281
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-253 8.05e-13

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 66.05  E-value: 8.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  24 VGISLPGVINHdGTMQTAGSL-KKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCV-TLGSAIGGA 101
Cdd:cd24058    58 VGVGFPGVVRR-GVVRTAANLdKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVlTLGTGIGSA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 102 IVIDRKLYWGQgglagEFGvslmgrenqeyklnstslHagvvgglcrkysLAIGKEVKDaKYIFDLAAQKDALAKK---- 177
Cdd:cd24058   137 LFVDGHLVPNT-----ELG------------------H------------LEIRGKDAE-ERASLGVRAREDLGWKrwak 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829551757 178 YVDEFLDDVARLLTnisvyiaPEAILIGGGVSgnsqimaeiqavytRIIHEYRVLSSVQMPqVIPCKLANDAGVIG 253
Cdd:cd24058   181 RVNKYLQYLERLFN-------PDLFIIGGGNS--------------KKADKFLPLLDVKTP-VVPAVLRNDAGIVG 234
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 8-208 1.30e-12

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 66.42  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   8 LKNYLNEQ--QQYLDISGVGISLPGVINHDG-TMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGA 84
Cdd:cd24070    45 LADLIREYieEAGLKPAAIVIGVPGTVDKDRrTVISTPNIPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLD 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  85 NYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG-VSLMGRENQEYKLNSTSLHAgVVGGlcrKYSLAIGKEvKDAKY 163
Cdd:cd24070   125 DEGVVLGFYIGTGIGNAILINGKPLRGKNGVAGELGhIPVYGNGKPCGCGNTGCLET-YASG---RALEEIAEE-HYPDT 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1829551757 164 IFDLAAQKDALAKKyVDEFLDDVARLLTNISVYIAPEAILIGGGV 208
Cdd:cd24070   200 PILDIFVDHGDEPE-LDEFVEDLALAIATEINILDPDAVILGGGV 243
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 5-254 1.35e-12

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 66.03  E-value: 1.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   5 LTDLKNYLNEQQQYLDisGVGISLPGVINHDGTMQTAGSL-----KKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGW 79
Cdd:cd24067    37 LQAVIDFFREQEEPID--AIGIASFGPIDLNPTSPTYGYItttpkPGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  80 LGNGANYSNYVCVTLGSAIGGAIVIDRKLYwgQGGLAGEFGVSLMGR-ENQEYKLNSTSLHAGVVGGLCRKYSLA----- 153
Cdd:cd24067   115 WGAAKGLDSLAYITVGTGIGVGLVVNGKPV--HGLLHPEMGHIRVPRhPDDDGFPGVCPFHGDCLEGLASGPAIAarwgi 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757 154 IGKEVKDAKYIFDLAAqkdalakkyvdeflDDVARLLTNISVYIAPEAILIGGGVSGNSQIMAEIQAVYTRIIHEY--RV 231
Cdd:cd24067   193 PAEELPDDHPAWDLEA--------------YYLAQACANLTLTLSPERIVLGGGVMQRPGLFPRIREKFRKLLNGYleVP 258

                         250       260
                  ....*....|....*....|....
gi 1829551757 232 LSSVQMPQVI-PCKLANDAGVIGS 254
Cdd:cd24067   259 RLLPDIDEYIvPPALGNDAGILGA 282
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 21-120 2.44e-12

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 65.51  E-value: 2.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  21 ISGVGISLPGVIN-HDGTMQTAGSLKkLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAIG 99
Cdd:cd24072    60 VKGIALAIQGLVDsHKGVSLWSPGAP-WRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIG 138

                          90       100
                  ....*....|....*....|.
gi 1829551757 100 GAIVIDRKLYWGQGGLAGEFG 120
Cdd:cd24072   139 SAIVIDNKLYIGASSGSGEIG 159
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 21-127 5.37e-12

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 64.74  E-value: 5.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  21 ISGVGISLPGVIN-HDG-TMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLGNGANYSNYVCVTLGSAI 98
Cdd:cd24060    60 ILGVGISTGGRVNpREGiVLHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGI 139

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1829551757  99 GGAIVIDRKLYWGQGGLAGEFG---VSLMGRE 127
Cdd:cd24060   140 GGGIILNHELIHGSSFCAAELGhivVSLDGPD 171
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 3-120 1.13e-09

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 57.76  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   3 QILTDLKNYLNEQQQYLD-ISGVGISLPGVINHDGTMQTAGSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWLG 81
Cdd:cd24075    43 QLIEEIAQFLKSHRRKTQrLIAISITLPGLINPKTGVVHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFG 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1829551757  82 NGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG 120
Cdd:cd24075   123 ASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 3-120 5.56e-09

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 55.42  E-value: 5.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   3 QILTDLKNYLNEQQQYLDISG-VGISLPGVIN-HDGTMQTAgSLKKLIGLNVKEIAQDHLQLPVEIITDSKAVALAEGWL 80
Cdd:PRK13311   38 QLLQILRDLTEEADTYCGVQGsVGIGIPGLPNaDDGTVFTA-NVPSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWD 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1829551757  81 GNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFG 120
Cdd:PRK13311  117 PEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEFG 156
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 2-206 1.03e-05

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 46.15  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757   2 TQILTDLKNYLNEQQQYLD-ISGVGISLPGVINhdgtmQTAGSLKKLIGLNVKEIA-----QDHLQLPVEIITDSKAVAL 75
Cdd:cd24074    43 DRLLESISEFFSRHQKKLErLTAIAITLPGIID-----PESGIVHRLPFYDIKNLPlgealEQHTGLPVYVQHDISAWTL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829551757  76 AEGWLGNGANYSNYVCVTLGSAIGGAIVIDRKLYWGQGGLAGEFGVSLMGRENQ----------EYKLNSTSLHAGVVGG 145
Cdd:cd24074   118 AERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHTQIDPYGKrcycgnhgclETVASIPAILEQANQL 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829551757 146 LCRKYSLAIGKEVKDAKYIFDLAAQKDALAKKYVDEFLDDVARLLTNISVYIAPEAILIGG 206
Cdd:cd24074   198 LEQSPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLGRILAILVNLFNPEKILIGS 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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