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Conserved domains on  [gi|1827625810|ref|NP_001366374|]
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uncharacterized protein LOC100044193 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.13e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 5.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827625810   4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNLKAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-534 5.25e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 128 KKPYKCNQCGKAFAQPRTLQIHKRAHTGEKPYKCNECGKIFAQYNT--LKRHKKTHTGEKPYECNQC---SKAFADHDql 202
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSlplSNSKASSS-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 203 rKHERVHTGE-KPYKCNECGKVFAQYSTLKRHEKTHFGEKPYECKQC-GKAFTQKAHLKIHIITHTgekpykcHQCDKAF 280
Cdd:COG5048   109 -SLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 281 ASHGNLQVHKRTHTGEKPYECDQCGKAFAHHCHFRVHKRIHTGEKPYKCDQCVKAFADHGQLRKHERVHTGEKPYKCNEC 360
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 361 GKAFVCNASLQAHKVTHS-------RVKPYECKQCSKSFASHGQLQAHER--IHTGE--KPYKC--NQCGKAFIEHNTLK 427
Cdd:COG5048   261 PRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 428 RHKITHTGEKPYEC--NQCSKSF------ASHGQLRKHERIHTGEKPYKC-NQCGKAFAEHGQLLKHERIHTGEKP--YK 496
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1827625810 497 CNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFAS 534
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
409-720 5.76e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 409 KPYKCNQCGKAFIEHNTLKRHKITHTGEKPYECNQ--CSKSFASHGQLRKHERIHTGEKPYKCN-QCGKAFAEHGQLLKH 485
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 486 ERIHTGEKPYKCNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFA-------SHGQLRKHERIHTGEKpykcnqcgk 558
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnsLHPPLPANSLSKDPSS--------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 559 vfgrHSHLRIHKRIHTGEKPYKCDQCGKAFP-YSNTLQVHKRTHTgEKPYACGQCGKAFA----NQSYLHVHKRIHTGEK 633
Cdd:COG5048   183 ----NLSLLISSNVSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPksllSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 634 P--YECKQCSKSFVSNGQLQRHERIHTG-EKPYKCDQCGKAFAYHYHLQMHKRM--HTGE--KPYEC--KQCGKFFASHG 704
Cdd:COG5048   258 SesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRND 337

                         330
                  ....*....|....*.
gi 1827625810 705 QLRKHERIHTGEKPYK 720
Cdd:COG5048   338 ALKRHILLHTSISPAK 353
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.13e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 5.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827625810   4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNLKAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 4.09e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 4.09e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1827625810    4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNLKAVGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 1.21e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.21e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1827625810   4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNL 40
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-534 5.25e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 128 KKPYKCNQCGKAFAQPRTLQIHKRAHTGEKPYKCNECGKIFAQYNT--LKRHKKTHTGEKPYECNQC---SKAFADHDql 202
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSlplSNSKASSS-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 203 rKHERVHTGE-KPYKCNECGKVFAQYSTLKRHEKTHFGEKPYECKQC-GKAFTQKAHLKIHIITHTgekpykcHQCDKAF 280
Cdd:COG5048   109 -SLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 281 ASHGNLQVHKRTHTGEKPYECDQCGKAFAHHCHFRVHKRIHTGEKPYKCDQCVKAFADHGQLRKHERVHTGEKPYKCNEC 360
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 361 GKAFVCNASLQAHKVTHS-------RVKPYECKQCSKSFASHGQLQAHER--IHTGE--KPYKC--NQCGKAFIEHNTLK 427
Cdd:COG5048   261 PRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 428 RHKITHTGEKPYEC--NQCSKSF------ASHGQLRKHERIHTGEKPYKC-NQCGKAFAEHGQLLKHERIHTGEKP--YK 496
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1827625810 497 CNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFAS 534
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
409-720 5.76e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 409 KPYKCNQCGKAFIEHNTLKRHKITHTGEKPYECNQ--CSKSFASHGQLRKHERIHTGEKPYKCN-QCGKAFAEHGQLLKH 485
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 486 ERIHTGEKPYKCNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFA-------SHGQLRKHERIHTGEKpykcnqcgk 558
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnsLHPPLPANSLSKDPSS--------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 559 vfgrHSHLRIHKRIHTGEKPYKCDQCGKAFP-YSNTLQVHKRTHTgEKPYACGQCGKAFA----NQSYLHVHKRIHTGEK 633
Cdd:COG5048   183 ----NLSLLISSNVSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPksllSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 634 P--YECKQCSKSFVSNGQLQRHERIHTG-EKPYKCDQCGKAFAYHYHLQMHKRM--HTGE--KPYEC--KQCGKFFASHG 704
Cdd:COG5048   258 SesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRND 337

                         330
                  ....*....|....*.
gi 1827625810 705 QLRKHERIHTGEKPYK 720
Cdd:COG5048   338 ALKRHILLHTSISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
650-674 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*
gi 1827625810 650 LQRHERIHTGEKPYKCDQCGKAFAY 674
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 285 NLQVHKRTHTGEKPYECDQCGKAFAH 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.13e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 5.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827625810   4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNLKAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 4.09e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 4.09e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1827625810    4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNLKAVGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 1.21e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.21e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1827625810   4 LTYDDVHVNFTQEEWALLNPTQRNLYKDVMLEIYRNL 40
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-534 5.25e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 128 KKPYKCNQCGKAFAQPRTLQIHKRAHTGEKPYKCNECGKIFAQYNT--LKRHKKTHTGEKPYECNQC---SKAFADHDql 202
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSlplSNSKASSS-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 203 rKHERVHTGE-KPYKCNECGKVFAQYSTLKRHEKTHFGEKPYECKQC-GKAFTQKAHLKIHIITHTgekpykcHQCDKAF 280
Cdd:COG5048   109 -SLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 281 ASHGNLQVHKRTHTGEKPYECDQCGKAFAHHCHFRVHKRIHTGEKPYKCDQCVKAFADHGQLRKHERVHTGEKPYKCNEC 360
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 361 GKAFVCNASLQAHKVTHS-------RVKPYECKQCSKSFASHGQLQAHER--IHTGE--KPYKC--NQCGKAFIEHNTLK 427
Cdd:COG5048   261 PRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 428 RHKITHTGEKPYEC--NQCSKSF------ASHGQLRKHERIHTGEKPYKC-NQCGKAFAEHGQLLKHERIHTGEKP--YK 496
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1827625810 497 CNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFAS 534
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-653 2.34e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 2.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 241 KPYECKQCGKAFTQKAHLKIHIITHTGEKPYKCHQ--CDKAFASHGNLQVHKRTHTGEKPYEC-DQCGKAFAHHCHFRVH 317
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 318 KRIHTGEKPYKCDQCVKAFADHGQLRKHERVHT--GEKPYKcnecgkafVCNASLQAHKVTHSRVKPYECKQCSKSFASH 395
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlRNNPLP--------GNNSSSVNTPQSNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 396 GQLQAHERIHTGEKPYKCNQCGKAFIEHNTLKRHKITHTGEKPYECNQCSKSF------ASHGQLRKHERIHTGEKPYKC 469
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 470 NQCGKAFAEHGQLLKHERIHTG-EKPYKCNQCGKAFAYHYELQMHKR--IHTGE--KPYEC--KQCGKFFASHGQLRKHE 542
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 543 RIHTGEKPYKC--NQCGKVFG------RHSHLRIHKRIHTGEKPYKCDQ-CGKAFPYSNTLQVHKRTHTGEKPYAC--GQ 611
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1827625810 612 CGKAFANQSYLHVHKRIHTGEKPYECkQCSKSFVSNGQLQRH 653
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-626 1.07e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 185 KPYECNQCSKAFADHDQLRKHERVHTGEKPYKCNECGKVFAQYSTLKRH---EKTHFGEKPYECKQCGKAFTQKAHLKIH 261
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 262 IITHTGEKPYKCHQCDKAFASHGNLQVHKRTHTGEKPYECDQCGKAFAHH-CHFRVHKRIHTGEKPykcdqcvKAFADHG 340
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 341 QLRKHERVHTGEKPYKCNECGKAFVCNASLQAHKVTHSRVKPYECKQCskSFASHGQLQAHERIHTGEKPYKCNQCgkaf 420
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSAS---- 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 421 iehntlkrhkithtgeKPYECNQCSKSFASHGQLRKHERIHTG-EKPYKCNQCGKAFAEHGQLLKHER--IHTGE--KPY 495
Cdd:COG5048   259 ----------------ESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 496 KC--NQCGKAFAYHYELQMHKRIHTGEKPYECKQC-------GKFFASHGQLRKHERIHTGEKPYKC--NQCGKVFGRHS 564
Cdd:COG5048   323 SCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDS 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827625810 565 HLRIHKRIHTGEKP--YKCDQCGKAFPYSNTLQVHKRTHTGEKPYACGQCGKAFANQSYLHVHK 626
Cdd:COG5048   403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
409-720 5.76e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 409 KPYKCNQCGKAFIEHNTLKRHKITHTGEKPYECNQ--CSKSFASHGQLRKHERIHTGEKPYKCN-QCGKAFAEHGQLLKH 485
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 486 ERIHTGEKPYKCNQCGKAFAYHYELQMHKRIHTGEKPYECKQCGKFFA-------SHGQLRKHERIHTGEKpykcnqcgk 558
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnsLHPPLPANSLSKDPSS--------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 559 vfgrHSHLRIHKRIHTGEKPYKCDQCGKAFP-YSNTLQVHKRTHTgEKPYACGQCGKAFA----NQSYLHVHKRIHTGEK 633
Cdd:COG5048   183 ----NLSLLISSNVSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPksllSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 634 P--YECKQCSKSFVSNGQLQRHERIHTG-EKPYKCDQCGKAFAYHYHLQMHKRM--HTGE--KPYEC--KQCGKFFASHG 704
Cdd:COG5048   258 SesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRND 337

                         330
                  ....*....|....*.
gi 1827625810 705 QLRKHERIHTGEKPYK 720
Cdd:COG5048   338 ALKRHILLHTSISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
650-674 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*
gi 1827625810 650 LQRHERIHTGEKPYKCDQCGKAFAY 674
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 285 NLQVHKRTHTGEKPYECDQCGKAFAH 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-235 6.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 155 GEKPYKCN--ECGKIFAQYNTLKRHKKTHtgekpyECNQCSKAFADHDqlrKHERVHTGEKPYKCNECGKVFAQYSTLKR 232
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHG------HQNQKLHENPSPE---KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827625810 233 HEK 235
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-702 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 677 HLQMHKRMHTGEKPYECKQCGKFFAS 702
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-197 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....
gi 1827625810 174 LKRHKKTHTGEKPYECNQCSKAFA 197
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-588 1.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....
gi 1827625810 565 HLRIHKRIHTGEKPYKCDQCGKAF 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-477 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....
gi 1827625810 454 LRKHERIHTGEKPYKCNQCGKAFA 477
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-366 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1827625810 342 LRKHERVHTGEKPYKCNECGKAFVC 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 2.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 509 ELQMHKRIHTGEKPYECKQCGKFFAS 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 2.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1827625810 426 LKRHKITHTGEKPYECNQCSKSFAS 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 2.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.65e-03
                          10        20
                  ....*....|....*....|....*
gi 1827625810 230 LKRHEKTHFGEKPYECKQCGKAFTQ 254
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 3.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 257 HLKIHIITHTGEKPYKCHQCDKAFAS 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 3.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.59e-03
                          10        20
                  ....*....|....*....|....*
gi 1827625810 202 LRKHERVHTGEKPYKCNECGKVFAQ 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 3.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.81e-03
                          10        20
                  ....*....|....*....|....*
gi 1827625810 482 LLKHERIHTGEKPYKCNQCGKAFAY 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-142 4.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625810 117 SLQMHKIIHTGKKPYKCNQCGKAFAQ 142
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-560 5.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.26e-03
                          10        20
                  ....*....|....*....|...
gi 1827625810 538 LRKHERIHTGEKPYKCNQCGKVF 560
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 575-653 7.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625810 575 GEKPYKCD--QCGKAFPYSNTLQVHKRThtgekpyacGQCGKAFANQSYLHVHKRIHTGEKPYECKQCSKSFVSNGQLQR 652
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1827625810 653 H 653
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-420 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|...
gi 1827625810 398 LQAHERIHTGEKPYKCNQCGKAF 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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