NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1821113804|gb|QIK54875|]
View 

winged helix-turn-helix transcriptional regulator [Dysgonomonas sp. HDW5B]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-96 2.85e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.32  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821113804   1 MSKkdlTKEQEQLARFAKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCI 80
Cdd:COG0640     1 MSE---TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRL 76

                          90
                  ....*....|....*.
gi 1821113804  81 HRGNWETAQRLFSAFF 96
Cdd:COG0640    77 ADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-96 2.85e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.32  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821113804   1 MSKkdlTKEQEQLARFAKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCI 80
Cdd:COG0640     1 MSE---TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRL 76

                          90
                  ....*....|....*.
gi 1821113804  81 HRGNWETAQRLFSAFF 96
Cdd:COG0640    77 ADEALAELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-83 7.44e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 61.16  E-value: 7.44e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821113804  17 AKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCIHRG 83
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-69 1.15e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.55  E-value: 1.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1821113804  13 LARFAKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQG 69
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTS 56
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-67 1.09e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 55.24  E-value: 1.09e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1821113804  14 ARFAKAMGHPVRIAILQLLASQTCCYHGDMSEILPVAKSTLSQHLNELKDARLI 67
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLV 54
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-78 1.64e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.21  E-value: 1.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1821113804   28 ILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKY 78
Cdd:smart00418   2 ILKLLAEGELCV-CELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYY 51
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-96 2.85e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.32  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821113804   1 MSKkdlTKEQEQLARFAKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCI 80
Cdd:COG0640     1 MSE---TKELEELAELFKALADPTRLRILRLLAEGELCV-GELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRL 76

                          90
                  ....*....|....*.
gi 1821113804  81 HRGNWETAQRLFSAFF 96
Cdd:COG0640    77 ADEALAELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-83 7.44e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 61.16  E-value: 7.44e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821113804  17 AKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCIHRG 83
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-69 1.15e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.55  E-value: 1.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1821113804  13 LARFAKAMGHPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQG 69
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTS 56
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-67 1.09e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 55.24  E-value: 1.09e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1821113804  14 ARFAKAMGHPVRIAILQLLASQTCCYHGDMSEILPVAKSTLSQHLNELKDARLI 67
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLV 54
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-68 5.51e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 54.20  E-value: 5.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821113804   7 TKEQEQLARFAKAMGHPVRIAILQLLA--SQTCcyhGDMSEILPVAKSTLSQHLNELKDARLIQ 68
Cdd:COG4189     3 VLDDEESLEVLKALASETRLRILRLLAeePLNV---NELAEALGLPKSTVSYHIRKLEEAGLIR 63
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-78 1.64e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.21  E-value: 1.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1821113804   28 ILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKY 78
Cdd:smart00418   2 ILKLLAEGELCV-CELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYY 51
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 22-67 1.92e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 46.28  E-value: 1.92e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1821113804  22 HPVRIAILQLLASQTCCYhGDMSEILPVAKSTLSQHLNELKDARLI 67
Cdd:pfam01022   1 DPTRLKILKLLAEGELCV-CELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
28-80 7.47e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.17  E-value: 7.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1821113804  28 ILQLLASQTCCYHGDMSEILPVAKSTLSQHLNELKDARLIQGTITPPTVKYCI 80
Cdd:COG3398   102 ILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYL 154
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
23-67 2.18e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 35.64  E-value: 2.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1821113804  23 PVRIAILQLLASQTCcyhgDMSEI---LPVAKSTLSQHLNELKDARLI 67
Cdd:COG4742    16 EKRKNILLLLAEGPK----TRSELaesLDVSRSTILRQLKELEERGLI 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH